Publications in 2025
G-García ME, De la Rosa-Herencia AS, Flores-Martínez A, Ortega-Bellido M, Sánchez-Sánchez R, Blanco-Acevedo C, Gahete MD, Solivera J, Luque RM, Fuentes-Fayos AC. Assessing the diagnostic, prognostic, and therapeutic potential of the somatostatin/cortistatin system in glioblastoma. CELLULAR AND MOLECULAR LIFE SCIENCES. 2025. -. DOI:10.1007/s00018-025-05687-9. IF: 6,2 Q1 D2
Porcel-Pastrana F, Montero-Hidalgo AJ, G-García ME, Gil-Duque I, Prats-Escribano A, Gahete MD, Sarmento-Cabral A, Luque RM, León-González AJ. Cellular and Molecular Evidence of the Synergistic Antitumour Effects of Hydroxytyrosol and Metformin in Prostate Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2025. -. DOI:10.3390/ijms26031341. IF: 4,9 Q1 D3
Sarmento-Cabral A, Fuentes-Fayos AC, Ordoñez FM, León-González AJ, Martínez-Fuentes AJ, Gahete MD, Luque RM. From pituitary cells to prostate gland in health and disease: direct and indirect endocrine connections. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS. 2025. 187-203. DOI:10.1007/s11154-025-09948-7. IF: 8 Q1 D1
Fuentes-Fayos AC, G-García ME, Sánchez-Medianero T, Apps J, Flores-Martínez A, De la Rosa-Herencia AS, Gil-Duque I, Otto G, Venegas-Moreno E, Ruiz-Valdepeñas EC, Herrera-Martínez AD, Solivera J, Gahete MD, Cano DA, Ortega R, Soto-Moreno A, Gálvez-Moreno MA, Martínez-Barberá JP, Luque RM. Impaired splicing machinery in craniopharyngiomas unveils PRPF8 and RAVER1 as novel biomarkers and therapeutic targets. ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2025. -. DOI:10.1186/s40478-025-02040-w. IF: 5,7 Q1 D2
Torrecilla-Parra M, Pardo-Marqués V, Fuentes-Fayos AC, G-García ME, Fernández-de Frutos M, López-Aceituno JL, Puigdueta C, Zamora C, Pérez-García A, Aranda JF, Busto R, Gahete MD, Luque RM, Ramírez CM. MiR-7 inhibits progression of glioblastoma by impairing autophagy resolution, energy metabolism and ECM remodeling. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2025. -. DOI:10.1186/s13046-025-03504-6. IF: 12,8 Q1 D1
Hermán-Sánchez N, del Rio-Moreno M, Ciria R, Sánchez-Frias ME, Fernández-Barrena MG, Uriarte I, Chicano-Galvez E, Ortea I, Peralbo-Molina A, Briceño J, Avila MA, Rodríguez-Perálvarez M, Luque RM, López-Cánovas JL, Gahete MD. Quantitative proteomic analysis unveils a critical role of VARS1 in hepatocellular carcinoma aggressiveness through the modulation of MAGI1 expression. MOLECULAR CANCER. 2025. -. DOI:10.1186/s12943-024-02206-5. IF: 33,9 Q1 D1
Martinez-López S, Garcia-Gutiérrez MS, Navarrete F, Gómez-Hurtado I, Zapater P, AAngel E, Juanola O, López-Cánovas J, Boix P, Hadid MC, Puig-Kröger A, Gahete MD, Manzanares J, Caparrós E, Francés R. Aging Deteriorates Blood Brain Barrier Function and Polarizes Adaptive T Cell Expansion Contributing to Neurocognitive Damage in Experimental Cirrhosis. AGING AND DISEASE. 2025. 3112-3127. DOI:10.14336/AD.2024.0932. IF: 6,9 Q1 D1
Publications in 2024
Alors-Pérez E, Pedraza-Arevalo S, Blázquez-Encinas R, García-Vioque V, Agraz-Doblas A, Yubero-Serrano EM, Sánchez-Frías ME, Serrano-Blanch R, Gálvez-Moreno MA, Gracia-Navarro F, Gahete MD, Arjona-Sánchez A, Luque RM, Ibáñez-Costa A, Castaño JP. Altered CELF4 splicing factor enhances pancreatic neuroendocrine tumors aggressiveness influencing mTOR and everolimus response. MOLECULAR THERAPY NUCLEIC ACIDS. 2024. DOI: 10.1016/j.omtn.2023.102090. IF: 6,5 Q1 D2
Herrera-Martínez AD, Fuentes-Fayos AC, Sanchez-Sanchez R, Montero AJ, Sarmento-Cabral A, Gálvez-Moreno MA, Gahete MD, Luque RM. Does Telotristat Have a Role in Preventing Carcinoid Heart Disease?. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024. DOI: 10.3390/ijms25042036. IF: 4,9 Q1 D3
Sáez-Martínez P, Porcel-Pastrana F, Montero-Hidalgo AJ, de la Haba SL, Sanchez-Sanchez R, González-Serrano T, Gómez-Gómez E, Martínez-Fuentes AJ, Jiménez-Vacas JM, Gahete MD, Luque RM. Dysregulation of RNA-Exosome machinery is directly linked to major cancer hallmarks in prostate cancer: Oncogenic role of PABPN1. CANCER LETTERS. 2024. DOI: 10.1016/j.canlet.2023.216604. IF: 9,1 Q1 D2
Alvarado-Tapias E, Maya-Miles D, Albillos A, Aller R, Ampuero J, Andrade RJ, Arechederra M, Aspichueta P, Banales JM, Blas-Garcia A, Caparros E, Delgado TC, Carrillo-Vico A, Claria J, Cubero FJ, Diaz-Ruiz A, Fernandez-Barrena MG, Fernandez-Iglesias A, Fernandez-Veledo S, Frances R, Gallego-Duran R, Gracia-Sancho J, Irimia M, Lens S, Martinez-Chantar ML, Minguez B, Munoz-Hernandez R, Nogueiras R, Ramos-Molina B, Riveiro-Barciela M, Rodriguez-Peralvarez ML, Romero-Gomez M, Sabio G, Sancho-Bru P, Ventura-Cots M, Vidal S, Gahete MD. Proceedings of the 5th Meeting of Translational Hepatology, organized by the Spanish Association for the Study of the Liver (AEEH). GASTROENTEROLOGIA Y HEPATOLOGIA. 2024. DOI: 10.1016/j.gastrohep.2024.502207. IF: 2,2 Q3 D
Alors-Pérez E, Blázquez-Encinas R, Moreno-Montilla MT, García-Vioque V, Jiménez-Vacas JM, Mafficini A, González-Borja I, Luchini C, Sánchez-Hidalgo JM, Sánchez-Frías ME, Pedraza-Arevalo S, Romero-Ruiz A, Lawlor RT, Viúdez A, Gahete MD, Scarpa A, Arjona-Sánchez A, Luque RM, Ibáñez-Costa A, Castaño JP. Spliceosomic dysregulation in pancreatic cancer uncovers splicing factors PRPF8 and RBMX as novel candidate actionable targets. MOLECULAR ONCOLOGY. 2024. 2524-2540. DOI: 10.1002/1878-0261.13658. IF: 5 Q1 D3
Montero-Hidalgo AJ, Jiménez-Vacas JM, Gómez-Gómez E, Porcel-Pastrana F, Sáez-Martinez P, Pérez-Gómez JM, Fuentes-Fayos AC, Blázquez-Encinas R, Sánchez-Sánchez R, González-Serrano T, Castro E, López-Soto PJ, Carrasco-Valiente J, Sarmento-Cabral A, Martinez-Fuentes AJ, Eyras E, Castaño JP, Sharp A, Olmos D, Gahete MD, Luque RM. SRSF6 modulates histone-chaperone HIRA splicing to orchestrate AR and E2F activity in prostate cancer. SCIENCE ADVANCES. 2024. DOI: 10.1126/sciadv.ado8231. IF: 11,7 Q1 D1
Lachiondo-Ortega S, Rejano-Gordillo CM, Simon J, Lopitz-Otsoa F, Delgado TC, Mazan-Mamczarz K, Goikoetxea-Usandizaga N, Zapata-Pavas LE, García-del Río A, Guerra P, Peña-Sanfélix P, Hermán-Sánchez N, Al-Abdulla R, Fernandez-Rodríguez C, Azkargorta M, Velázquez-Cruz A, Guyon J, Martín C, Zalamea JD, Egia-Mendikute L, Sanz-Parra A, Serrano-Maciá M, González-Recio I, Gonzalez-Lopez M, Martínez-Cruz LA, Pontisso P, Aransay AM, Barrio R, Sutherland JD, Abrescia NGA, Elortza F, Lujambio A, Banales JM, Luque RM, Gahete MD, Palazón A, Avila MA, Marin JJG, De S, Daubon T, Díaz-Quintana A, Díaz-Moreno I, Gorospe M, Rodríguez MS, Martínez-Chantar ML. SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer. CELL REPORTS. 2024. DOI: 10.1016/j.celrep.2024.113924. IF: 7,5 Q1 D2
Blázquez-Encinas R, Alors-Pérez E, Moreno-Montilla MT, García-Vioque V, Sánchez-Frias ME, Mafficini A, López-Cánovas JL, Bousquet C, Gahete MD, Lawlor RT, Luque RM, Scarpa A, Arjona-Sánchez A, Pedraza-Arevalo S, Ibáñez-Costa A, Castaño JP. The Exon Junction Complex component EIF4A3 plays a splicing-linked oncogenic role in pancreatic ductal adenocarcinoma. CANCER GENE THERAPY. 2024. 1646-1657. DOI: 10.1038/s41417-024-00814-3. IF: 4,8 Q1 D2
Hermán-Sánchez N, G-García ME, Jiménez-Vacas JM, Yubero-Serrano EM, López-Sánchez LM, Romero-Martín S, Raya-Povedano JL, Alvarez-Benito M, Castaño JP, Luque RM, Gahete MD. The splicing machinery is dysregulated and represents a therapeutic vulnerability in breast cancer. CELLULAR AND MOLECULAR LIFE SCIENCES. 2024. DOI: 10.1007/s00018-024-05515-6. IF: 6,2 Q1 D2
Publications in 2023
Montero-Hidalgo AJ, Perez-Gomez JM, Martinez-Fuentes AJ, Gomez-Gomez E, Gahete MD, Jimenez-Vacas JM, Luque RM. Alternative splicing in bladder cancer: potential strategies for cancer diagnosis, prognosis, and treatment. WILEY INTERDISCIPLINARY REVIEWS-RNA. 2023. DOI: 10.1002/wrna.1760. IF: 7,3 Q1 D3
Herrera-Martínez AD, Castillo-Peinado LLS, Molina-Puerta MJ, Calanas-Continente A, Membrives A, Castilla J, Cardenosa MC, Casado-Díaz A, Gálvez-Moreno MA, Gahete MD, Gómez JMQ, Bouillon R, Priego-Capote F, Luque RM. Bariatric surgery and calcifediol treatment, Gordian knot of severe-obesity-related comorbidities treatment. FRONTIERS IN ENDOCRINOLOGY. 2023. DOI: 10.3389/fendo.2023.1243906. IF: 5,2 Q1 D3
Arias-de la Rosa I, Ruiz-Ponce M, Cuesta-López L, Pérez-Sánchez C, Leiva-Cepas F, Gahete M, Navarro P, Ortega R, Cordoba J, Pérez-Pampin E, González A, Lucendo AJ, Collantes-Estévez E, López-Pedrera C, Escudero-Contreras A, Barbarroja N. Clinical features and immune mechanisms directly linked to the altered liver function in patients with rheumatoid arthritis. EUROPEAN JOURNAL OF INTERNAL MEDICINE. 2023. 49-58. DOI: 10.1016/j.ejim.2023.08.002. IF: 8 Q1 D2
Ruiz-Ponce M, Cuesta-López L, López-Montilla MD, Pérez-Sánchez C, Ortiz-Buitrago P, Barranco A, Gahete MD, Herman-Sánchez N, Lucendo AJ, Navarro P, López-Pedrera C, Escudero-Contreras A, Collantes-Estévez E, López-Medina C, Arias-de la Rosa I, Barbarroja N. Decoding clinical and molecular pathways of liver dysfunction in Psoriatic Arthritis: Impact of cumulative methotrexate doses. BIOMEDICINE & PHARMACOTHERAPY. 2023. DOI: 10.1016/j.biopha.2023.115779. IF: 7,5 Q1 D2
Pérez-Gómez JM, Porcel-Pastrana F, De La Luz-Borrero M, Montero-Hidalgo AJ, Gómez-Gómez E, Herrera-Martínez AD, Guzmán-Ruiz R, Malagón MM, Gahete MD, Luque RM. LRP10, PGK1 and RPLP0: Best Reference Genes in Periprostatic Adipose Tissue under Obesity and Prostate Cancer Conditions. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023. DOI: 10.3390/ijms242015140. IF: 5,6 Q1 D3
Fuentes-Fayos AC, G-Garcia ME, Perez-Gomez JM, Montero-Hidalgo AJ, Martin-Colom J, Doval-Rosa C, Blanco-Acevedo C, Torres E, Toledano-Delgado A, Sanchez-Sanchez R, Peralbo-Santaella E, Ortega-Salas RM, Jimenez-Vacas JM, Tena-Sempere M, Lopez M, Castano JP, Gahete MD, Solivera J, Luque RM. Metformin and simvastatin exert additive antitumour effects in glioblastoma via senescence-state: clinical and translational evidence. EBIOMEDICINE. 2023. DOI: 10.1016/j.ebiom.2023.104484. IF: 11,1 Q1 D1
Lopez-Canovas JL, Herman-Sanchez N, del Rio-Moreno M, Fuentes-Fayos AC, Lara-Lopez A, Sanchez-Frias ME, Amado V, Ciria R, Briceno J, de la Mata M, Castano JP, Rodriguez-Peralvarez M, Luque RM, Gahete MD. PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing. EXPERIMENTAL AND MOLECULAR MEDICINE. 2023. 132-142. DOI: 10.1038/s12276-022-00917-7. IF: 12,8 Q1 D1
Pedraza-Arevalo S, Alors-Perez E, Blazquez-Encinas R, Herrera-Martinez AD, Jimenz-Vacas JM, Fuentes-Fayos AC, Reyes O, Ventura S, Sanchez-Sanchez R, Ortega-Salas R, Serrano-Blanch R, Galvez-Moreno MA, Gahete MD, Ibanez-Costa A, Luque RM, Castano JP. Spliceosomic dysregulation unveils NOVA1 as a candidate actionable therapeutic target in pancreatic neuroendocrine tumors. TRANSLATIONAL RESEARCH. 2023. 63-73. DOI: 10.1016/j.trsl.2022.07.005. IF: 7,8 Q1 D2
Jimenez-Vacas JM, Montero-Hidalgo AJ, Gomez-Gomez E, Saez-Martinez P, Fuentes-Fayos AC, Closa A, Gonzalez-Serrano T, Martinez-Lopez A, Sanchez-Sanchez R, Lopez-Casas PP, Sarmento-Cabral A, Olmos D, Eyras E, Castano JP, Gahete MD, Luque RM. Tumor suppressor role of RBM22 in prostate cancer acting as a dual-factor regulating alternative splicing and transcription of key oncogenic genes. TRANSLATIONAL RESEARCH. 2023. 68-79. DOI: 10.1016/j.trsl.2022.08.016. IF: 7,8 Q1 D2
Main publications in 2022
López-Cánovas JL, Hermán-Sánchez N, Del Rio-Moreno M, Fuentes-Fayos AC, Lara-López A, Sánchez-Frias ME, Amado V, Ciria R, Briceño J, de la Mata M, Castaño JP, Rodriguez-Perálvarez M, Luque RM, Gahete MD. PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing. Exp Mol Med. 2023 Jan 6. doi: 10.1038/s12276-022-00917-7.
IF: 12,172 Q: 1 D: 1
López-Cánovas JL, Hermán-Sánchez N, Moreno-Montilla MT, Del Rio-Moreno M, Alors-Perez E, Sánchez-Frias ME, Amado V, Ciria R, Briceño J, de la Mata M, Castaño JP, Rodriguez-Perálvarez M, Luque RM, Gahete MD. Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing. Clin Transl Med. 2022 Nov;12(11):e1102. doi: 10.1002/ctm2.1102.
IF: 8,554 Q: 1
Herrera-Martínez AD, Herrero-Aguayo V, Pérez-Gómez JM, Gahete MD, Luque RM. Inflammasomes: Cause or consequence of obesity-associated comorbidities in humans. Obesity (Silver Spring). 2022 Dec;30(12):2351-2362. doi: 10.1002/oby.23581.
IF: 9,298 Q: 1 D:1
