Research groups

GE07 Visual Quality

The group GE07 Visual Quality is an emerging research group focused on biomedical engineering and advanced therapies in ophthalmology and reconstructive surgery. Our team aspires to develop new diagnostic and therapeutic strategies to improve health and welfare of our patients using novel bioengineering approaches. Our expertise includes tissue engineering and regenerative medicine, biomaterials, bioadhesives, nanoparticles, drug delivery systems, prosthesis, and diagnostic tools, among others, having always the emphasis on a successful translation to the patient. This requires a very multidisciplinary team composed of biologists, chemists, engineers and clinicians. The team is lead by Miguel González-Andrades, MD, PhD, a clinician-scientist currently working as an ophthalmologist in the Reina Sofia University Hospital, as senior scientist at the Maimonides Biomedical Research Institute of Córdoba (IMIBIC), and as adjunct scientist at the Schepens Eye Research Institute and Mass Eye and Ear Infirmary (SERI-MEEI), Harvard Medical School (Boston, USA). In recognition of the laboratory’s achievements and contributions to the field, Dr González-Andrades and his team have been awarded multiple accolades.

Research Lines

Networks

Keywords

  • Ophthalmology
  • cornea
  • retina
  • glaucoma
  • tissue engineering
  • regenerative medicine
  • biomedical engineering
  • reconstructive surgery
  • drug delivery
  • nanomedicine
  • nanoparticles
  • biomaterials

Additional Information

Recent Publications

Chitnis GD, Verma MKS, Lamazouade J, Gonzalez-Andrades M, Dergham A, Jones PA, Mead BE, Cruzat A, Tong Z, Martyn K, Solanki A, London-Brace N, Karp JM. A Resistance-Sensing Mechanical Injector for the Precise Delivery of Liquids to Target Tissue. Nat Biomed Eng. 2019 Aug;3(8):621-631. doi: 10.1038/s41551-019-0350-2
IF: 17.135

Rico-Sánchez L, Garzón I, González-Andrades M, Ruíz-García A, Punzano M, Lizana-Moreno A, Muñoz-Ávila JI, Sánchez-Quevedo MDC, Martínez-Atienza J, Lopez-Navas L, Sanchez-Pernaute R, Oruezabal RI, Medialdea S, Gonzalez-Gallardo MDC, Carmona G, Sanbonmatsu-Gámez S, Perez M, Jimenez P, Cuende N, Campos A, Alaminos M. Successful development and clinical translation of a novel anterior lamellar artificial cornea. J Tissue Eng Regen Med. 2019;13(12):2142-2154. doi: 10.1002/term.2951

Islam MM, Sharifi R, Mamodaly S, Islam R, Nahra D, Abusamra DB, Hui PC, Adibnia Y, Goulamaly M, Paschalis EI, Cruzat A, Kong J, Nilsson PH, Argüeso P, Mollnes TE, Chodosh J, Dohlman CH, Gonzalez-Andrades M. Effects of gamma radiation sterilization on the structural and biological properties of decellularized corneal xenografts. Acta Biomater. 2019 Sep 15;96:330-344.  doi: 10.1016/j.actbio.2019.07.002
IF: 6.638

Sharifi R, Yang Y, Adibnia Y, Dohlman CH, Chodosh J, Gonzalez-Andrades M. Finding an Optimal Corneal Xenograft: Comparative Analysis of Corneal Matrix Proteins Across Species. Sci Rep. 2019; 9;1:1876. doi: 10.1038/s41598-018-38342-4
IF: 4.011

Fotografía genérica para grupo

Principal Investigator
Miguel González Andrades

Researchers
Manuel García Martín 
Rafael Giménez Gómez
Eva Mª Martín Suárez
Ana María Sánchez León

Pre-Doctoral Researchers
Pedro Naranjo Bonilla

Clinical Researcher
Francisco Javier Giménez-Almenara Amo

Technical and Administrative Staff
Inmaculada Osuna Jiménez

Projects

Active in 2019

Gallardo Galera, JM. Prevention, Early detection, Treatment and Rehabilitation of Ocular Pathologies. Funding agency: National Institute of Health Carlos III (ISCIII). Reference: RD16/0008/0018

Finished projects

Gallardo Galera, JM. Improved patient wellbeing and safety in management procedures using collaborative systems. m-LISTABLE.Funding agency: Spanish Ministry of Economy and Competitiveness (MINECO). Reference: RTC-2016-5149_001

 

Publications

Publications 2019

Chitnis GD, Verma MKS, Lamazouade J, Gonzalez-Andrades M, Yan K, Dergham A, Jones PA, Mead BE, Cruzat A, Tong ZX, Martyn K, Solanki A, Landon-Brace N, Karp JM; A resistance-sensing mechanical injector for the precise delivery of liquids to target tissue. NATURE BIOMEDICAL ENGINEERING. 2019 Aug;3(8):621-631. doi: 10.1038/s41551-019-0350-2.
IF: 17,135
D: 1 

Islam MM, Sharifi R, Mamodaly S, Islam R, Nahra D, Abusamra DB, Hui PC, Adibnia Y, Goulamaly M, Paschalis EI, Cruzat A, Kong J, Nilsson PH, Argileso P, Mollnes TE, Chodosh J, Dohlman CH, Gonzalez-Andrades M; Effects of gamma radiation sterilization on the structural and biological properties of decellularized corneal xenografts. ACTA BIOMATERIALIA. 2019 Sep 15;96:330-344. doi: 10.1016/j.actbio.2019.07.002.
IF: 6,638
D: 1 

Sharifi R, Yang Y, Adibnia Y, Dohlman CH, Chodosh J, Gonzalez-Andrades M; Finding an Optimal Corneal Xenograft Using Comparative Analysis of Corneal Matrix Proteins Across Species. SCIENTIFIC REPORTS. 2019 Feb 12;9(1):1876. doi: 10.1038/s41598-018-38342-4.
IF: 4,011
Q: 1 

Rico-Sanchez L, Garzon I, Gonzalez-Andrades M, Ruiz-Garcia A, Punzano M, Lizana-Moreno A, Munoz-Avila JI, Sanchez-Quevedo MD, Martinez-Atienza J, Lopez-Navas L, Sanchez-Pernaute R, Oruezabal RI, Medialdea S, Gonzalez-Gallardo MD, Carmona G, Sanbonmatsu-Ga; Successful development and clinical translation of a novel anterior lamellar artificial cornea. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 2019 Dec;13(12):2142-2154. doi: 10.1002/term.2951.
IF: 3,319
Q: 2 

Main Publications 2018

Cruzat A, Gonzalez-Andrades M, Mauris J, Abusamra D, Chidambaram P, Kenyon K, Chodosh J, Dohlman C, Argueso P. Colocalization Of Galectin-3 With CD147 Is Associated With Increased Gelatinolytic Activity In Ulcerating Human Corneas. IOVS. 2018;59:223-230.
IF: 3.303

Gonzalez-Andrades M, Sharifi R, Islam MM, Divoux T, Haist M, Paschalis EI, Gelfand L, Mamodaly S, Di Cecilia L, Cruzat A, Ulm FJ, Chodosh J, Delori F, Dohlman CH. Improving the practicality and safety of artificial corneas: Pre-assembly and gamma-rays sterilization of the Boston Keratoprosthesis. Ocul Surf. 2018;16:322-330.
IF: 9.108

Other Publications 2018

Martin-Suarez E, Galan A, Morgaz J, Guisado A, Gallardo JM, Gomez-Villamandos RJ. Comparison of central corneal thickness in dogs measured by ultrasound pachymetry and ultrasound biomicroscopy. VETERINARY JOURNAL. 2018; 232:13-14.
IF: 1,773

Dohlman CH, Cade F, Regatieri CV, Zhou C, Lei F, Crnej A, Harissi-Dagher M, Robert MC, Papaliodis GN, Chen D, Aquavella JV, Akpek EK, Aldave AJ, Sippel KC, DʼAmico DJ, Dohlman JG, Fagerholm P, Wang L, Shen LQ, González-Andrades M, Chodosh J, Kenyon KR, Foster CS, Pineda R, Melki S, Colby KA, Ciolino JB, Vavvas DG, Kinoshita S, Dana R, Paschalis EI. Chemical Burns of the Eye: The Role of Retinal Injury and New Therapeutic Possibilities. Cornea. 2018; 37(2):248-251.
IF:  2,01

Clinical Research

Active in 2019

The Efficacy and Safety of Bimatoprost SR in Patients With Open-angle Glaucoma or Ocular Hypertension.
PI: Dr. Rafael Giménez Gómez

Estudio prospectivo, con doble enmascaramiento, aleatorizado, multicéntrico, con comparador activo y grupos paralelos de 6 meses de duración para evaluar la seguridad y la eficacia hipotensora ocular de PG324 solución oftálmica en comparación con GANFORT® (bimatoprost 0,03 %/timolol 0,5 %) solución oftálmica en sujetos con presión intraocular elevada (MERCURY 3).
PI: Dr. Rafael Giménez Gómez

Estudio retrospectivo para evaluar las diferencias en torno a la agudeza visual y parámetros morfológicos retinianos en pacientes con degeneración macular asociada a la edad exudativa tratados en diferentes tiempos tras el diagnóstico.
PI: Dr. Miguel González Andrades

Members

Dr. Miguel A. Gonzalez Andrades

Principal Investigator

Team

Miguel Gonzalez Andrades, Manuel García Martín, Rafael Giménez Gómez, Eva Mª Martín Suárez, Ana María Sánchez León, Pedro Naranjo Bonilla, Francisco Javier Giménez-Almenara Amo, Inmaculada Osuna Jiménez