Research groups

GE07 Visual Quality

The group GE07 Visual Quality is an emerging research group focused on biomedical engineering and advanced therapies in ophthalmology and reconstructive surgery. Our team aspires to develop new diagnostic and therapeutic strategies to improve health and welfare of our patients using novel bioengineering approaches. Our expertise includes tissue engineering and regenerative medicine, biomaterials, bioadhesives, nanoparticles, drug delivery systems, prosthesis, and diagnostic tools, among others, having always the emphasis on a successful translation to the patient. This requires a very multidisciplinary team composed of biologists, chemists, engineers and clinicians. The team is lead by Miguel González-Andrades, MD, PhD, a clinician-scientist currently working as an ophthalmologist in the Reina Sofia University Hospital, as senior scientist at the Maimonides Biomedical Research Institute of Córdoba (IMIBIC), and as adjunct scientist at the Schepens Eye Research Institute and Mass Eye and Ear Infirmary (SERI-MEEI), Harvard Medical School (Boston, USA). In recognition of the laboratory’s achievements and contributions to the field, Dr González-Andrades and his team have been awarded multiple accolades.

Research Lines

Networks

    OFTARED ISCIII - Ocular Diseases: Prevention, early detection and treatment of prevalent, degenerative and chronic ocular pathology

Keywords

  • ophthalmology
  • cornea
  • retina
  • glaucoma
  • tissue engineering
  • regenerative medicine
  • biomedical engineering
  • reconstructive surgery
  • drug delivery
  • nanomedicine
  • nanoparticles
  • biomaterials

Additional Information

Recent publications

Chitnis GD, Verma MKS, Lamazouade J, Gonzalez-Andrades M, Dergham A, Jones PA, Mead BE, Cruzat A, Tong Z, Martyn K, Solanki A, London-Brace N, Karp JM. A Resistance-Sensing Mechanical Injector for the Precise Delivery of Liquids to Target Tissue. Nat Biomed Eng. 2019 Aug;3(8):621-631. doi: 10.1038/s41551-019-0350-2
IF: 17.135

Rico-Sánchez L, Garzón I, González-Andrades M, Ruíz-García A, Punzano M, Lizana-Moreno A, Muñoz-Ávila JI, Sánchez-Quevedo MDC, Martínez-Atienza J, Lopez-Navas L, Sanchez-Pernaute R, Oruezabal RI, Medialdea S, Gonzalez-Gallardo MDC, Carmona G, Sanbonmatsu-Gámez S, Perez M, Jimenez P, Cuende N, Campos A, Alaminos M. Successful development and clinical translation of a novel anterior lamellar artificial cornea. J Tissue Eng Regen Med. 2019;13(12):2142-2154. doi: 10.1002/term.2951

Islam MM, Sharifi R, Mamodaly S, Islam R, Nahra D, Abusamra DB, Hui PC, Adibnia Y, Goulamaly M, Paschalis EI, Cruzat A, Kong J, Nilsson PH, Argüeso P, Mollnes TE, Chodosh J, Dohlman CH, Gonzalez-Andrades M. Effects of gamma radiation sterilization on the structural and biological properties of decellularized corneal xenografts. Acta Biomater. 2019 Sep 15;96:330-344.  doi: 10.1016/j.actbio.2019.07.002
IF: 6.638

Sharifi R, Yang Y, Adibnia Y, Dohlman CH, Chodosh J, Gonzalez-Andrades M. Finding an Optimal Corneal Xenograft: Comparative Analysis of Corneal Matrix Proteins Across Species. Sci Rep. 2019; 9;1:1876. doi: 10.1038/s41598-018-38342-4
IF: 4.011

Projects

PROJECTS IN 2020

Ongoing projects

Regional

Miguel González Andrades; Generación y evaluación in vivo de matrices bioartificiales descelularizadas y gamma irradiadas a partir de xenoinjertos porcinos para su aplicación en terapias avanzadas en córnea y cartílago; Funding Agency: CONSEJERÍA DE SALUD Y FAMILIAS; Reference: 116190130194

National

Miguel González Andrades; Ensayo clínico fase I-II multicéntrico para evaluar la seguridad y eficacia de un medicamento de terapia avanzada basado en una córnea artificial de péptidos similares al colágeno con células epiteliales para el tratamiento de enfermedades corneales severas; Funding Agency: INSTITUTO DE SALUD CARLOS III; Reference: ICI19/00006

Miguel González Andrades; CVD Graphene as an Artificial Basement Membrane for Tissue Regeneration.; Funding Agency: FUNDACIÓN LA CAIXA; Reference: MIT18_001

PROJECTS IN 2019

Ongoing projects

Gallardo Galera, JM. Prevention, Early detection, Treatment and Rehabilitation of Ocular Pathologies. Funding agency: National Institute of Health Carlos III (ISCIII). Reference: RD16/0008/0018

Finished projects

Gallardo Galera, JM. Improved patient wellbeing and safety in management procedures using collaborative systems. m-LISTABLE.Funding agency: Spanish Ministry of Economy and Competitiveness (MINECO). Reference: RTC-2016-5149_001

 

Publications

Publications in 2020

Yazdi AA, Melchor J, Torres J, Faris I, Callejas A, Gonzalez-Andrades M, Rus G. Characterization of non-linear mechanical behavior of the cornea. SCIENTIFIC REPORTS. 2020. 10 (1):- DOI: 10.1038/s41598-020-68391-7 
IF: 3,998 Q: 1

Sharifi R, Mahmoudzadeh S, Islam MM, Koza D, Dohlman CH, Chodosh J, Gonzalez-Andrades M. Covalent Functionalization of PMMA Surface with L-3,4-Dihydroxyphenylalanine (L-DOPA) to Enhance its Biocompatibility and Adhesion to Corneal Tissue. ADVANCED MATERIALS INTERFACES. 2020. 7 (1):- DOI: 10.1002/admi.201900767 
IF: 4,948 Q: 1

Gonzalez-Andrades M, Jalimarada SS, Rodriguez-Benavente M, Feeley MN, Woodward AM, AbuSamra DB, Argueso P. Golgi alpha 1,2-mannosidase I induces clustering and compartmentalization of CD147 during epithelial cell migration. CELL ADHESION & MIGRATION. 2020. 14 (1):96-105 DOI: 10.1080/19336918.2020.1764170 
IF: 3,694 Q: 2

Villalba M, Linares-Sicilia MJ, Gonzalez-Andrades M, Eisman M, Gimenez-Almenara J, Arias M, Villalba R. In vitro susceptibility of microorganisms isolated from cold stored corneas: increased gentamicin-resistance in cornea banking. CELL AND TISSUE BANKING. 2020. 21 (1):159-165 DOI: 10.1007/s10561-020-09811-w 
IF: 1,149 Q: 4

Publications in 2019

Chitnis GD, Verma MKS, Lamazouade J, Gonzalez-Andrades M, Yan K, Dergham A, Jones PA, Mead BE, Cruzat A, Tong ZX, Martyn K, Solanki A, Landon-Brace N, Karp JM; A resistance-sensing mechanical injector for the precise delivery of liquids to target tissue. NATURE BIOMEDICAL ENGINEERING. 2019 Aug;3(8):621-631. doi: 10.1038/s41551-019-0350-2.
IF: 17,135 D: 1 

Islam MM, Sharifi R, Mamodaly S, Islam R, Nahra D, Abusamra DB, Hui PC, Adibnia Y, Goulamaly M, Paschalis EI, Cruzat A, Kong J, Nilsson PH, Argileso P, Mollnes TE, Chodosh J, Dohlman CH, Gonzalez-Andrades M; Effects of gamma radiation sterilization on the structural and biological properties of decellularized corneal xenografts. ACTA BIOMATERIALIA. 2019 Sep 15;96:330-344. doi: 10.1016/j.actbio.2019.07.002.
IF: 6,638 D: 1 

Sharifi R, Yang Y, Adibnia Y, Dohlman CH, Chodosh J, Gonzalez-Andrades M; Finding an Optimal Corneal Xenograft Using Comparative Analysis of Corneal Matrix Proteins Across Species. SCIENTIFIC REPORTS. 2019 Feb 12;9(1):1876. doi: 10.1038/s41598-018-38342-4.
IF: 4,011 Q: 1 

Rico-Sanchez L, Garzon I, Gonzalez-Andrades M, Ruiz-Garcia A, Punzano M, Lizana-Moreno A, Munoz-Avila JI, Sanchez-Quevedo MD, Martinez-Atienza J, Lopez-Navas L, Sanchez-Pernaute R, Oruezabal RI, Medialdea S, Gonzalez-Gallardo MD, Carmona G, Sanbonmatsu-Ga; Successful development and clinical translation of a novel anterior lamellar artificial cornea. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 2019 Dec;13(12):2142-2154. doi: 10.1002/term.2951.
IF: 3,319 Q: 2 

Publications in 2018

Cruzat A, Gonzalez-Andrades M, Mauris J, Abusamra D, Chidambaram P, Kenyon K, Chodosh J, Dohlman C, Argueso P. Colocalization Of Galectin-3 With CD147 Is Associated With Increased Gelatinolytic Activity In Ulcerating Human Corneas. IOVS. 2018;59:223-230.
IF: 3.303

Gonzalez-Andrades M, Sharifi R, Islam MM, Divoux T, Haist M, Paschalis EI, Gelfand L, Mamodaly S, Di Cecilia L, Cruzat A, Ulm FJ, Chodosh J, Delori F, Dohlman CH. Improving the practicality and safety of artificial corneas: Pre-assembly and gamma-rays sterilization of the Boston Keratoprosthesis. Ocul Surf. 2018;16:322-330.
IF: 9.108

Martin-Suarez E, Galan A, Morgaz J, Guisado A, Gallardo JM, Gomez-Villamandos RJ. Comparison of central corneal thickness in dogs measured by ultrasound pachymetry and ultrasound biomicroscopy. VETERINARY JOURNAL. 2018; 232:13-14.
IF: 1,773

Dohlman CH, Cade F, Regatieri CV, Zhou C, Lei F, Crnej A, Harissi-Dagher M, Robert MC, Papaliodis GN, Chen D, Aquavella JV, Akpek EK, Aldave AJ, Sippel KC, DʼAmico DJ, Dohlman JG, Fagerholm P, Wang L, Shen LQ, González-Andrades M, Chodosh J, Kenyon KR, Foster CS, Pineda R, Melki S, Colby KA, Ciolino JB, Vavvas DG, Kinoshita S, Dana R, Paschalis EI. Chemical Burns of the Eye: The Role of Retinal Injury and New Therapeutic Possibilities. Cornea. 2018; 37(2):248-251.
IF: 2,01

Clinical Research

Active in 2019

The Efficacy and Safety of Bimatoprost SR in Patients With Open-angle Glaucoma or Ocular Hypertension.
PI: Dr. Rafael Giménez Gómez

Estudio prospectivo, con doble enmascaramiento, aleatorizado, multicéntrico, con comparador activo y grupos paralelos de 6 meses de duración para evaluar la seguridad y la eficacia hipotensora ocular de PG324 solución oftálmica en comparación con GANFORT® (bimatoprost 0,03 %/timolol 0,5 %) solución oftálmica en sujetos con presión intraocular elevada (MERCURY 3).
PI: Dr. Rafael Giménez Gómez

Estudio retrospectivo para evaluar las diferencias en torno a la agudeza visual y parámetros morfológicos retinianos en pacientes con degeneración macular asociada a la edad exudativa tratados en diferentes tiempos tras el diagnóstico.
PI: Dr. Miguel González Andrades

Members

Principal Investigator
Miguel González Andrades

Researchers
Juan Manuel Domínguez Pérez
José María Gallardo Galera
Rafael Giménez Gómez
Juan José Giner Casares
Carmen González Gallardo
María Del Mar Granados Machuca
Francisco Martín Martínez
Eva María  Martín Suárez
Santiago Ortiz Pérez
Rafael Villalba Montoro

Post-Doctoral Researchers
David Alba Molina
Roberto Anaya Alaminos
Manuel Arias Alcalá
Carmen Avilés Mora
Rafael Caballos Castilla
Fabio Contieri Lambiese
José Ignacio Fernández Choquet De Isla
Francisco José Fernández Molina
Manuel García Martín
Francisco Javier Giménez-Almenara Amo
José Manuel Hens Gutiérrez
María de los Ángeles Herrador Montiel
Encarnación Ibarra De La Rosa
Yolanda Jiménez Gómez
Mohammad Mirazul Islam
José María Mohedano Rincón
María José Pérez Cordobés
Francisco Antonio Plugiese Rojas
Felisa Reyes Ortega
Indira Stoikow Pino
Marta Villalba González

Pre-Doctoral Researcher
Mario Blanco Blanco

Nursing, Technical, and Administrative Staff
Rosa Baños Gil
Ángela Ordóñez Villaizán
Lorena Pérez Fajardo