Research groups

GC23 Metabolism in childhood

The GC23 group is a group of clinical researchers, mostly medical specialists in various areas of Pediatrics, related to nutrition and metabolism. It is a consolidated group of young researchers, PhDs, medical doctors and professors from the University of Córdoba, with assistance activity at the Reina Sofía University Hospital in Cordoba, Spain.

The main research area of development is Nutrition and Metabolism during childhood, although is related with other pediatric specialties such as Oncology, Neuropediatrics, Endocrinology, Inborn Errors of Metabolism or Nephrology. In addition, it stands out for its research on childhood obesity.

Our objectives are based on the development of quality research oriented to the most prevalent pediatric health problems, in order to achieve results that have applicability and influence clinical practice.

Specifically, we intend to identify nutritional, cardiovascular and metabolic risk factors for the prevention of childhood-onset diseases, especially cardiovascular disease and the metabolic syndrome in relation to obesity and malnutrition or underlying diseases. The prevention of these diseases controlling risk factors in childhood can have a high impact on later stages of life in health.

In addition, we participate in alliances with other national and international researchers, who are leaders in nutritional research applied to the clinic, as well as with companies in the food sector or through clinical trials for new therapies.

Among our relevant results, we highlight the research of the metabolic syndrome in prepubertal children, and risk factors associated with genetic polymorphisms, as well as the use of probiotics and therapies in rare metabolic diseases.

Research Lines

Three featured projects within this line of study include:

1- Mediterranean diet and lifestyle habits for prevention of pediatric obesity (MELIPOP. https://melipop.es/)

We aim to perform a randomized control multi-centre clinical trial, in order to assess the effect of an intensive intervention program in the prevention of obesity in children. We will recruit children, aged 3 to 6 years, at high risk of obesity, defined as at least the mother with obesity.

2- Longitudinal study to determine risk factors associated with childhood obesity (CORALS. https://corals.es/)

Our group coordinates this national study with other CIBEROBN groups to get a cohort of Spanish children aged 3 to 6 years with a follow up for at least 10 years.

3- Research for biomarkers of cardiovascular risk and antioxidant defense system in prepubertal children with a history of extrauterine growth retardation (BIORICA).

This is a cohort of children with a history of extrauterine growth retardation that was studied at prepubertal age with a higher metabolic risk, and subjects are being followed up after puberty.

Clinical Trial: Lactoprem Project: Randomized Controlled Clinical Trial for the Evaluation of the Efficacy of Lactoferrin in the Prevention of Sepsis in Premature Newborns.

Our research activities in this area include a project titled Biomonitoring of possible markers of inflammation, oxidative stress, intestinal microbiota and exposure to heavy metals in autism spectrum disorder in childhood, and aClinical Trial: Randomized parallel group, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of docoxahenoic acid in the adjuvant treatment of children with autism spectrum disorder (AUTISmΩ3).

European Project, H2020: Paediatric Hepatic International Tumour Trial (PHITT)

Networks

    CIBERobn - CIBER on Obesity and Nutrition 

    CIBERer - CIBER on Rare Diseases 

    RECLIP - Spanish Pediatric Clinical Trials Network

    PAIDI CTS-639 - Pediatrics. Research in specific areas

Keywords

  • autism
  • children
  • childhood
  • metabolic syndrome
  • metabolic diseases
  • obesity
  • oncology
  • physical activity
  • pre-probiotics
  • renal disease
  • nutrition

Additional Information

The group coordinates the Spanish participation of the Paediatric Hepatic international Tumor Trial (PHITT) within the H2020 funded Project ChiLTERN

Dra. María Mercedes Gil Campos

Principal Investigator

Projects

PROJECTS IN 2020

Ongoing projects

Regional

María Dolores Ordóñez Díaz; Proyecto Lactoprem: Ensayo Clínico Controlado Aleatorizado para la Valoración de la Eficacia de la Lactoferrina en la Prevención de la Sepsis en Recién Nacidos Prematuros. Biomonitorización de Los Mecanismos Antinflamatorios, Antioxidantes y de la Microbi; Funding Agency: CONSEJERÍA DE SALUD Y FAMILIAS; Reference: PI-0323-2016

National

María Mercedes Gil Campos; Mediterranean Lifestyle in pediatric obesity prevention: MELI-POP; Funding Agency: INSTITUTO DE SALUD CARLOS III; Reference: PI18/00930

International

María Elena Mateos González; ChiLTERN - Children's Liver Tumour European Research Network; Funding Agency: COMISIÓN EUROPEA; Reference: PHC-18-2015-001

PROJECTS IN 2019

Ongoing projects

Regional

Anton Gamero, M. Developing of clinical decision supports system for management chronic kidney disease no terminal in children based on data mining about REPIR I. Funding Agency: Regional Ministry of Equality, Health and Social Policies (CISPS). Reference: PIN-0385-2016

Ordóñez MD. Lactoprem: Clinical trial to effectiveness lactoferrin assessment in the prevention of sepsis in preterm neonates. Biomonitoring antiinflamtories mechanisms, antioxidants, and the intestine microbiota. Regional Ministry of Equality, Health and Social Policies (CISPS). Reference: PI-0323-2016

National

Gil Campos, M. CIBERObn. Funding agency: National Institute of Health Carlos III (ISCIII). Reference: CB15/00131

Roa Rivas, J. Ethiopathogenic role and diagnostic/therapeutic implications of microRNAs on early puberty in obesity". Proyecto Convocatoria Miguel Servet I. 2015 CP15/0004 

Roa Rivas J. Puberty and metabolic risk in obese children: Epigenetic alterations and pathophysiological and diagnostic implications. PUBMEP Study. Funding agency: National Institute of Health Carlos III (ISCIII). Reference: PI16/01243  

Gil Campos, M. Mediterranean lifestyle in pediatric obesity prevention: MELI-POP. Funding Agency: National Institute of Health Carlos III (ISCIII).Reference: PI18/00930

International

Mateos Gonzalez, ME. ChiLTERN - Children's Liver Tumour European Research Network. Funding Agency: European Commission.

Finished projects

Gil Campos, M. Volumetric Measuring System.Funding agency: Spanish Ministry of Economy and Competitiveness (MINECO). Reference: RTC-2016-5661-1_02

Pérez Navero, JL. Randomized double-blind, parallel-control, placebo-controlled clinical trial to assess the efficacy and safety of docoxahenoic acid in the adjuvant treatment of children with autism spectrum disorder". Funding Agency: Premio Ambito de la Infancia XX Convocatoria 2016. Premio Fundació Agrupación. Reference: F.AGRUPACIO_002

Gil Campos, M. Mediterranean LIfestyle in Pediatric Obesity Prevention (MELI-POP). Funding agency: proyectos intramurales CIBEROBN 2017.

Publications

Publications in 2020

Gomez-Llorente MA, Martinez-Canavate A, Chueca N, Rico MD, Romero R, Anguita-Ruiz A, Aguilera CM, Gil-Campos M, Mesa MD, Khakimov B, Morillo JA, Gil A, Camacho J, Gomez-Llorente C. A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children. BIOMEDICINES. 2020. 8 (9):- DOI: 10.3390/biomedicines8090359 
IF: 4,717 Q: 1

Ranchal-Sanchez A, Diaz-Bernier VM, de la Florida-Villagran CA, Llorente-Cantarero FJ, Campos-Perez J, Jurado-Castro JM. Acute Effects of Beetroot Juice Supplements on Resistance Training: A Randomized Double-Blind Crossover. NUTRIENTS. 2020. 12 (7):- DOI: 10.3390/nu12071912 
IF: 4,546 Q: 1

Ruperez AI, Mesa MD, Anguita-Ruiz A, Gonzalez-Gil EM, Vazquez-Cobela R, Moreno LA, Gil A, Gil-Campos M, Leis R, Bueno G, Aguilera CM. Antioxidants and Oxidative Stress in Children: Influence of Puberty and Metabolically Unhealthy Status. ANTIOXIDANTS. 2020. 9 (7):- DOI: 10.3390/antiox9070618 
IF: 5,014 Q: 1 D: 1

Llorente-Cantarero FJ, Aguilar-Gomez FJ, Anguita-Ruiz A, Ruperez AI, Vazquez-Cobela R, Flores-Rojas K, Aguilera CM, Gonzalez-Gil EM, Gil-Campos M, Bueno-Lozano G, Leis R. Changes in Physical Activity Patterns from Childhood to Adolescence: Genobox Longitudinal Study. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2020. 17 (19):- DOI: 10.3390/ijerph17197227 
IF: 2,849 Q: 1

Leis R, Jurado-Castro JM, Llorente-Cantarero FJ, Anguita-Ruiz A, Ruperez AI, Bedoya-Carpente JJ, Vazquez-Cobela R, Aguilera CM, Bueno G, Gil-Campos M. Cluster Analysis of Physical Activity Patterns, and Relationship with Sedentary Behavior and Healthy Lifestyles in Prepubertal Children: Genobox Cohort. NUTRIENTS. 2020. 12 (5):- DOI: 10.3390/nu12051288 
IF: 4,546 Q: 1

de Pipaon MS, Flores-Rojas K, Gil A, Gil-Campos M. Commentary: Consumer Reports of ""Keto Flu"" Associated With the Ketogenic Diet. FRONTIERS IN NUTRITION. 2020. 7 ():- DOI: 10.3389/fnut.2020.00113 
IF: 3,365 Q: 2

Martinez-Jimenez MD, Gomez-Garcia FJ, Gil-Campos M, Perez-Navero JL. Comorbidities in childhood associated with extrauterine growth restriction in preterm infants: a scoping review. EUROPEAN JOURNAL OF PEDIATRICS. 2020. 179 (8):1255-1265 DOI: 10.1007/s00431-020-03613-8 
IF: 2,305 Q: 2

Opladen T, Lopez-Laso E, Cortes-Saladelafont E, Pearson TS, Sivri HS, Yildiz Y, Assmann B, Kurian MA, Leuzzi V, Heales S, Pope S, Porta F, Garcia-Cazorla A, Honzik T, Pons R, Regal L, Goez H, Artuch R, Hoffmann GF, Horvath G, Thony B, Scholl-Burgi S, Burl. Consensus guideline for the diagnosis and treatment of tetrahydrobiopterin (BH4) deficiencies. ORPHANET JOURNAL OF RARE DISEASES. 2020. 15 (1):- DOI: 10.1186/s13023-020-01379-8 
IF: 3,523 Q: 2

Latorre-Millan M, Ruperez AI, Gonzalez-Gil EM, Santaliestra-Pasias A, Vazquez-Cobela R, Gil-Campos M, Aguilera CM, Gil A, Moreno LA, Leis R, Bueno G. Dietary Patterns and Their Association with Body Composition and Cardiometabolic Markers in Children and Adolescents: Genobox Cohort. NUTRIENTS. 2020. 12 (11):- DOI: 10.3390/nu12113424 
IF: 4,546 Q: 1

Pastor-Villaescusa B, Hurtado JA, Gil-Campos M, Uberos J, Maldonado-Lobon JA, Diaz-Ropero MP, Banuelos O, Fonolla J, Olivares M. Effects of Lactobacillus fermentum CECT5716 Lc40 on infant growth and health: a randomised clinical trial in nursing women. BENEFICIAL MICROBES. 2020. 11 (3):235-244 DOI: 10.3920/BM2019.0180 
IF: 3,37 Q: 2

Leis R, de Lamas C, de Castro MJ, Picans R, Gil-Campos M, Couce ML. Effects of Nutritional Education Interventions on Metabolic Risk in Children and Adolescents: A Systematic Review of Controlled Trials. NUTRIENTS. 2020. 12 (1):- DOI: 10.3390/nu12010031 
IF: 4,546 Q: 1

Perez-Gimeno G, Ruperez AI, Vazquez-Cobela R, Herraiz-Gastesi G, Gil-Campos M, Aguilera CM, Moreno LA, Leis Trabazo MR, Bueno-Lozano G. Energy Dense Salty Food Consumption Frequency Is Associated with Diastolic Hypertension in Spanish Children. NUTRIENTS. 2020. 12 (4):1027- DOI: 10.3390/nu12041027 
IF: 4,546 Q: 1

Carrillo-Reixach J, Torrens L, Simon-Coma M, Royo L, Domingo-Sabat M, Abril-Fornaguera J, Akers N, Sala M, Ragull S, Arnal M, Villalmanzo N, Cairo S, Villanueva A, Kappler R, Garrido M, Guerra L, Sabado C, Guillen G, Mallo M, Pineyro D, Vazquez-Vitali M, . Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications. JOURNAL OF HEPATOLOGY. 2020. 73 (2):328-341 DOI: 10.1016/j.jhep.2020.03.025 
IF: 20,582 Q: 1 D: 1

Jurado-Castro JM, Gil-Campos M, Gonzalez-Gonzalez H, Llorente-Cantarero FJ. Evaluation of Physical Activity and Lifestyle Interventions Focused on School Children with Obesity Using Accelerometry: A Systematic Review and Meta-Analysis. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2020. 17 (17):- DOI: 10.3390/ijerph17176031 
IF: 2,849 Q: 1

Anguita-Ruiz A, Gonzalez-Gil EM, Ruperez AI, Llorente-Cantarero FJ, Pastor-Villaescusa B, Alcala-Fdez J, Moreno LA, Gil A, Gil-Campos M, Bueno G, Leis R, Aguilera CM. Evaluation of the Predictive Ability, Environmental Regulation and Pharmacogenetics Utility of a BMI-Predisposing Genetic Risk Score during Childhood and Puberty. JOURNAL OF CLINICAL MEDICINE. 2020. 9 (6):- DOI: 10.3390/jcm9061705 
IF: 3,303 Q: 1

Ranchal-Sanchez A, Romero-Rodriguez E, Jurado-Castro JM, Ruiz-Gandara A, Vaquero-Abellan M. Impact of a Comprehensive Anti-Smoking Program at a Regional University Hospital and Predictive Variables of Being a Smoker among Hospital Workers. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2020. 17 (22):- DOI: 10.3390/ijerph17228432 
IF: 2,849 Q: 1

Emperador S, Garrido-Perez N, Amezcua-Gil J, Gaudo P, Andres-Sanz JA, Yubero D, Fernandez-Marmiesse A, O'Callaghan MM, Ortigoza-Escobar JD, Iriondo M, Ruiz-Pesini E, Garcia-Cazorla A, Gil-Campos M, Artuch R, Montoya J, Bayona-Bafaluy MP. Molecular Characterization of New FBXL4 Mutations in Patients With mtDNA Depletion Syndrome. FRONTIERS IN GENETICS. 2020. 10 ():- DOI: 10.3389/fgene.2019.01300 
IF: 3,258 Q: 2

Gil-Hernandez F, Gomez-Fernandez AR, Josede la Torre-Aguilar M, Perez-Navero JL, Flores-Rojas K, Martin-Borreguero P, Gil-Campos M. Neurotoxicity by mercury is not associated with autism spectrum disorders in Spanish children. ITALIAN JOURNAL OF PEDIATRICS. 2020. 46 (1):- DOI: 10.1186/s13052-020-0780-1 
IF: 2,185 Q: 2

Garcia-Castano A, Madariaga L, Anton-Gamero M, Mejia N, Ponce J, Gomez-Conde S, de Nanclares GP, De la Hoz AB, Martinez R, Saso L, de LaPiscina IM, Urrutia I, Velasco O, Aguayo A, Castano L, Gaztambide S. Novel variant in theCNNM2gene associated with dominant hypomagnesemia. PLOS ONE. 2020. 15 (9):- DOI: 10.1371/journal.pone.0239965 
IF: 2,74 Q: 2

Anguita-Ruiz A, Mendez-Gutierrez A, Ruperez AI, Leis R, Bueno G, Gil-Campos M, Tofe I, Gomez-Llorente C, Moreno LA, Gil A, Aguilera CM. The protein S100A4 as a novel marker of insulin resistance in prepubertal and pubertal children with obesity. METABOLISM-CLINICAL AND EXPERIMENTAL. 2020. 105 ():- DOI: 10.1016/j.metabol.2020.154187 
IF: 6,159 Q: 1

Ordonez-Diaz MD, Gil-Campos M, Flores-Rojas K, Munoz-Villanueva MC, Aguilera-Garcia CM, de la Torre-Aguilar MJ, Perez-Navero JL. Plasma Adipokines Profile in Prepubertal Children with a History of Prematurity or Extrauterine Growth Restriction. NUTRIENTS. 2020. 12 (4):1201- DOI: 10.3390/nu12041201 
IF: 4,546 Q: 1

Ordonez-Diaz MD, Perez-Navero JL, Flores-Rojas K, Olza-Meneses J, Munoz-Villanueva MC, Aguilera-Garcia CM, Gil-Campos M. Prematurity With Extrauterine Growth Restriction Increases the Risk of Higher Levels of Glucose, Low-Grade of Inflammation and Hypertension in Prepubertal Children. FRONTIERS IN PEDIATRICS. 2020. 8 ():- DOI: 10.3389/fped.2020.00180 
IF: 2,634 Q: 1

Mateos ME, Lopez-Laso E, Vicente J, Ortega R, Vazquez F, Perez-Navero JL. Response to everolimus of a progressive plexiform neurofibroma in Neurofibromatosis type 1. PEDIATRICS INTERNATIONAL. 2020. 62 (7):857-859 DOI: 10.1111/ped.14183 
IF: 1,139 Q: 4

Gil-Cosano JJ, Ubago-Guisado E, Sanchez MJ, Ortega-Acosta MJ, Mateos ME, Benito-Bernal AI, Llorente-Cantarero FJ, Ortega FB, Ruiz JR, Labayen I, Martinez-Vizcaino V, Vlachopoulos D, Arroyo-Morales M, Munoz-Torres M, Pascual-Gazquez JF, Vicho-Gonzalez MC, Gracia-Marco L. The effect of an online exercise programme on bone health in paediatric cancer survivors (iBoneFIT): study protocol of a multi-centre randomized controlled trial. BMC PUBLIC HEALTH. 2020. 20 (1):- DOI: 10.1186/s12889-020-09607-3 
IF: 2,521 Q: 2

Hernandez MAT, Guzman EG, Marin MJA. Pericardial mass: What lies behind?. ANALES DE PEDIATRIA. 2020. 93 (1):62-63 DOI: 10.1016/j.anpedi.2019.05.009 
IF: 1,313 Q: 3

Hennermann JB, Guffon N, Cattaneo F, Ceravolo F, Borgwardt L, Lund AM, Gil-Campos M, Tylki-Szymanska A, Muschol NM. The SPARKLE registry: protocol for an international prospective cohort study in patients with alpha-mannosidosis. ORPHANET JOURNAL OF RARE DISEASES. 2020. 15 (1):- DOI: 10.1186/s13023-020-01549-8 
IF: 3,523 Q: 2

Phillips D, Hennermann JB, Tylki-Szymanska A, Borgwardt L, Gil-Campos M, Guffon N, Amraoui Y, Geraci S, Ardigo D, Cattaneo F, Lund AM. Use of the Bruininks-Oseretsky test of motor proficiency (BOT-2) to assess efficacy of velmanase alfa as enzyme therapy for alpha-mannosidosis. MOLECULAR GENETICS AND METABOLISM REPORTS. 2020. 23 ():- DOI: 10.1016/j.ymgmr.2020.100586 
IF: 2,022 Q: 3

Publications in 2019

de Lamas C, de Castro MJ, Gil-Campos M, Gil A, Couce ML, Leis R; Effects of Dairy Product Consumption on Height and BoneMineral Content in Children: A Systematic Review of Controlled Trials. ADVANCES IN NUTRITION. 2019 May 1;10(suppl_2):S88-S96. doi: 10.1093/advances/nmy096.
IF: 7,24 D: 1

Plaza-Diaz J, Ruiz-Ojeda FJ, Gil-Campos M, Gil A; Mechanisms of Action of Probiotics. ADVANCES IN NUTRITION. 2019 Jan 1;10(suppl_1):S49-S66. doi: 10.1093/advances/nmy063.
IF: 7,24 D: 1

Anguita-Ruiz A, Plaza-Diaz J, Ruiz-Ojeda FJ, Ruperez AI, Leis R, Bueno G, Gil-Campos M, Vazquez-Cobela R, Canete R, Moreno LA, Gil A, Aguilera CM; X chromosome genetic data in a Spanish children cohort, dataset description and analysis pipeline. SCIENTIFIC DATA. 2019 Jul 22;6(1):130. doi: 10.1038/s41597-019-0109-3. 
IF: 5,929 Q: 1

Martinez-Monseny A, Cuadras D, Bolasell M, Muchart J, Arjona C, Borregan M, Algrabli A, Montero R, Artuch R, Velazquez-Fragua R, Macaya A, Perez-Cerda C, Perez-Duenas B, Perez B, Serrano M, Aguilera-Albesa S, Gutierrez-Solana LG, Lopez L, Felipe A, Mirand; From gestalt to gene: early predictive dysmorphic features of PMM2-CDG. JOURNAL OF MEDICAL GENETICS. 2019 Apr;56(4):236-245. doi: 10.1136/jmedgenet-2018-105588. (As Collaborator)
IF: 5,899 Q: 1

Gomis-Perez C, Urrutia J, Marce-Grau A, Malo C, Lopez-Laso E, Felipe-Rucian A, Raspall-Chaure M, Macaya A, Villarroel A; Homomeric Kv7.2 current suppression is a common feature in KCNQ2 epileptic encephalopathy. EPILEPSIA. 2019 Jan;60(1):139-148. doi: 10.1111/epi.14609. 
IF: 5,562 Q: 1

Barja-Fernandez S, Folgueira C, Castelao C, Pena-Leon V, Gonzalez-Saenz P, Vazquez-Cobela R, Aguilera CM, Gil-Campos M, Bueno G, Gil A, Moreno LA, Ruiz-Pinon M, Garcia-Palacios M, Casanueva FF, Dieguez C, Nogueiras R, Leis R, Seoane LM; ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents. NUTRIENTS. 2019 Jun 14;11(6). pii: E1340. doi: 10.3390/nu11061340. 
IF: 4,171 Q: 1

Plaza-Diaz J, Gomez-Fernandez A, Chueca N, de la Torre-Aguilar MJ, Gil A, Perez-Navero JL, Flores-Rojas K, Martin-Borreguero P, Solis-Urra P, Ruiz-Ojeda FJ, Garcia F, Gil-Campos M; Autism Spectrum Disorder (ASD) with and without Mental Regression Is Associated with Changes in the Fecal Microbiota. NUTRIENTS. 2019 Feb 5;11(2). pii: E337. doi: 10.3390/nu11020337. 
IF: 4,171 Q: 1

Rodriguez-Herrera A, Mulder K, Bouritius H, Rubio R, Munoz A, Agosti M, Lista G, Corvaglia L, Ludwig T, Abrahamse-Berkeveld M, Perez-Navero JL; Gastrointestinal Tolerance, Growth and Safety of a Partly Fermented Formula with Specific Prebiotics in Healthy Infants: A Double-Blind, Randomized, Controlled Trial. NUTRIENTS. 2019 Jul 5;11(7). pii: E1530. doi: 10.3390/nu11071530.
IF: 4,171 Q: 1

Ruiz-Ojeda FJ, Anguita-Ruiz A, Ruperez AI, Gomez-Llorente C, Olza J, Vazquez-Cobela R, Gil-Campos M, Bueno G, Leis R, Canete R, Moreno LA, Gil A, Aguilera CM; Effects of X-chromosome Tenomodulin Genetic Variants on Obesity in a Children's Cohort and Implications of the Gene in Adipocyte Metabolism. SCIENTIFIC REPORTS. 2019 Mar 8;9(1):3979. doi: 10.1038/s41598-019-40482-0.
IF: 4,011 Q: 1

Guffon N, Tylki-Szymanska A, Borgwardt L, Lund AM, Gil-Campos M, Parini R, Hennermann JB; Recognition of alpha-mannosidosis in paediatric and adult patients: Presentation of a diagnostic algorithm from an international working group. MOLECULAR GENETICS AND METABOLISM. 2019 Apr;126(4):470-474. doi: 10.1016/j.ymgme.2019.01.024.
IF: 3,61 Q: 2

Rangel-Huerta OD, Gomez-Fernandez A, de la Torre-Aguilar MJ, Gil A, Perez-Navero JL, Flores-Rojas K, Martin-Borreguero P, Gil-Campos M; Metabolic profiling in children with autism spectrum disorder with and without mental regression: preliminary results from a cross-sectional case-control study. METABOLOMICS. 2019 Jun 27;15(7):99. doi: 10.1007/s11306-019-1562-x.
IF: 3,167 Q: 2

Maldonado J, Gil-Campos M, Maldonado-Lobon JA, Benavides MR, Flores-Rojas K, Jaldo R, del Barco IJ, Bolivar V, Valero AD, Prados E, Penalver I, Olivares M; Evaluation of the safety, tolerance and efficacy of 1-year consumption of infant formula supplemented with Lactobacillus fermentum CECT5716 Lc40 or Bifidobacterium breve CECT7263: a randomized controlled trial. BMC PEDIATRICS. 2019 Oct 21;19(1):361. doi: 10.1186/s12887-019-1753-7.
IF: 1,983 Q: 2

Perez-Navero JL, Merino-Cejas C, de la Rosa II, Jaraba-Caballero S, Frias-Perez M, Gomez-Guzman E, Gil-Campos M, de la Torre-Aguilar MJ; Evaluation of the vasoactive-inotropic score, mid-regional pro-adrenomedullin and cardiac troponin I as predictors of low cardiac output syndrome in children after congenital heart disease surgery. MEDICINA INTENSIVA. 2019 Aug - Sep;43(6):329-336. doi: 10.1016/j.medin.2018.04.005.
IF: 1,982 Q: 3

Tejada-Ortigosa EM, Flores-Rojas K, Moreno-Quintana L, Munoz-Villanueva MC, Perez-Navero JL, Gil-Campos M; Health and socio-educational needs of the families and children with rare metabolic diseases: Qualitative study in a tertiary hospital. ANALES DE PEDIATRIA. 2019 Jan;90(1):42-50. doi: 10.1016/j.anpedi.2018.03.003.
IF: 1,166 Q: 3

Gil-Campos M; Reflection on the evaluation of eating habits and physical activity in school children. NUTRICION HOSPITALARIA. 2019 Apr 10;36(2):245-246. doi: 10.20960/nh.02580.
IF: 0,759 Q: 4

Publications in 2018

Plaza-Diaz J, Ruiz-Ojeda FJ, Gil-Campos M, Gil A. Immune-MediatedMechanisms of Action of Probiotics and Synbiotics in TreatingPediatric Intestinal Diseases. NUTRIENTS. 2018; 10(1): Núm artículo 42
IF: 4,196 Q: 1

Lund AM, Borgwardt L, Cattaneo F, Ardigo D, Geraci S, Gil-Campos M, De Meirleir L, Laroche C, Dolhem P, Cole D, Tylki-Szymanska A, Lopez-Rodriguez M, Guillen-Navarro E, Dali CI, Heron B, Fogh J, Muschol N, Phillips D, Van den Hout JMH, Jones SA, Amraoui Y, Harmatz P, Guffon N. Comprehensivelong-term efficacy and safety of recombinant human alpha-mannosidase (velmanase alfa) treatment in patients with alpha-mannosidosis Keywords. JOURNAL OF INHERITED METABOLIC DISEASE. 2018; 41(6):1225-1233.
IF: 4,092 Q: 1

Borgwardt L, Guffon N, Amraoui Y, Dali CI, De Meirleir L, Gil-Campos M, Heron B, Geraci S, Ardigo D, Cattaneo F, Fogh J, Van den Hout JMH, Beck M, Jones SA, Tylki-Szymanska A, Haugsted U, Lund AM. Efficacy and safety of Velmanase alfa in the treatment of patients with alpha-mannosidosis: results from the core and extension phase analysis of a phase III multicentre, double-blind, randomised, placebo-controlled trial. JOURNAL OF INHERITED METABOLIC DISEASE. 2018; 41(6):1215-1223.
IF: 4,092 Q: 1

Tofe I, Ruiz-Gonzalez MD, Canete MD, Pino A, Rueda RL, Parraga MJ, Perez-Navero JL. Efficacy of Paracetamol in Closure of DuctusArteriosus in Infantsunder 32 Weeks of Gestation. FRONTIERS IN PEDIATRICS. 2018; 6: Núm artículo 25
IF: 2,335 Q: 2

Gomez-Fernandez A, de la Torre-Aguilar MJ, Gil-Campos M, Flores-Rojas K, Cruz-Rico MD, Martin-Borreguero P, Perez-Navero JL. ChildrenWithAutismSpectrumDisorderWithRegressionExhibit a DifferentProfile in Plasma Cytokines and AdhesionMoleculesCompared to ChildrenWithoutSuchRegression. FRONTIERS IN PEDIATRICS. 2018; 6: Núm artículo 264
IF: 2,335 Q: 2

Leppanen MH, Henriksson P, Henriksson H, Nystrom CD, Llorente-Cantarero FJ, Lof M; Physical Activity Level Using Doubly-Labeled Water in Relation to Body Composition and Physical Fitness in Preschoolers. MEDICINA-LITHUANIA. 2018 Dec 27;55(1). pii: E2. doi: 10.3390/medicina55010002.
IF: 1,467 Q: 3

Gascon-Jimenez FJ, Gallardo-Hernandez FL, Fernandez-Ramos JA, Aguilar-Quintero M, Camino-Leon R, Lopez-Laso E. Hereditaryprimarymicrocephaly of type 5. NoteverythingisZika virus. REVISTA DE NEUROLOGIA. 2018; 66(3):101-102.
IF: 0,601 Q: 4

Sancho-Montero N, Fernandez-Ramos JA, Caballero-Rodriguez C, Camino-Leon R, Lopez-Laso E. Multiplecranialneuropathy: a case report of three paediatric patients. REVISTA DE NEUROLOGIA. 2018; 67(8):321-323.
IF: 0,601 Q: 4

Ruperez AI, Olza J, Gil-Campos M, Leis R, Bueno G, Aguilera CM, Gil A, Moreno LA. Cardiovascular risk biomarkers and metabolically unhealthy status in prepubertal children: Comparison of definitions. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. 2018; 28(5):524-530.
IF: 3,318 Q: 2

Barja-Fernandez S, Aguilera CM, Martinez-Silva I, Vazquez R, Gil-Campos M, Olza J, Bedoya J, Cadarso-Suarez C, Gil A, Seoane LM, Leis R. 25-Hydroxyvitamin D levels of children are inversely related to adiposity assessed by body mass index. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY. 2018; 74(1):111-118.
IF: 2,736 Q: 2

Sancho AL, Atance EP, Martin MJR, Gil-Campos M, Trabazo RL, Curieses MPB, Lozano GB. Spanishcollaborativestudy: Description of usual clinical practice in infant obesity. ANALES DE PEDIATRIA. 2018; 88(6):340-349.
IF: 1,318 Q: 3

J.L. Pérez-Navero, C. Merino-Cejas, I. Ibarra de la Rosa,S. Jaraba-Caballeroa, M. Frias-Pereza, E. Gómez-Guzmán, M. Gil-Campos ,M.J. de la Torre-Aguilar. Evaluation of the vasoactive-inotropic score,mid-regional pro-adrenomedullin and cardiac troponin Ias predictors of low cardiac output syndromein children after congenital heart disease surgery. Med Intensiva 2018; in press. Jun 14. pii: S0210-5691(18)30149-9. ISSN 0210-5691; DOI: 0.1016/j.medin.2018.04.005;
IF: 1.75 Q: 4

Publications in 2017

Perez-Navero JL, de la Torre-Aguilar MJ, de la Rosa II, Gil-Campos M, Gomez-Guzman E, Merino-Cejas C, Munoz-Villanueva MC, Llorente-Cantarero FJ. Cardiac Biomarkers of Low Cardiac Output Syndrome in the Postoperative Period After Congenital Heart Disease Surgery in Children. REVISTA ESPANOLA DE CARDIOLOGIA. 2017.70(4):267-274.
IF: 4,485 Q: 1 

Moreno-Solis G, de la Torre-Aguilar MJ, Torres-Borrego J, Llorente-Cantarero FJ, Fernandez-Gutierrez F, Gil-Campos M, Tunez-Finana I, Perez-Navero JL. Oxidative stress and inflammatory plasma biomarkers in respiratory syncytial virus bronchiolitis. CLINICAL RESPIRATORY JOURNAL. 2017.11(6):839-846.
IF: 2,356 Q: 3 

Gil Campos M, Blasco-Alonso J, Sierra Córcoles C, Cuevas Cervera JL, Arrabal Fernández L, Aldámiz Echevarría L, Belanger A. Spanish multicenter study: hyperammonemia not associated with inborn errors of metabolism in children. Nutr Hosp. 2017; 34(4):814-819. I
IF: 0,7 Q: 4

Perez-Navero JL, Tejero-Hernandez MA, Gomez-Guzman E, Merino-Cejas C, De La Torre-Aguilar MJ, Llorente-Cantarero FJ. Left ventricle training before late arterial switch to correct congenital transposition of the great arteries with intact ventricular septum. GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE.2017.176(6):359-362.

Cabezas OR, Flanagan SE, Stanescu H, García-Martínez E, Caswell R, Lango-Allen H, Antón-Gamero M, et al. Polycystic Kidney Disease with Hyperinsulinemic Hypoglycemia Caused by a Promoter Mutation in Phosphomannomutase 2. J AM SOC NEPHROL. 2017;28:2529-2539.
IF: 8,966 Q: 1 D: 1

Batllori M, Molero-Luis M, Arrabal L, Heras JD, Fernandez-Ramos JA, Gutierrez-Solana LG, Ibanez-Mico S, Domingo R, Campistol J, Ormazabal A, Sedel F, Opladen T, Zouvelou B, Pons R, Garcia-Cazorla A, Lopez-Laso E, Artuch R. Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients. SCIENTIFIC REPORTS. 2017.7():-14675.
IF: 4,259 Q: 1 

Olza J, Ruperez AI, Gil-Campos M, Leis R, Canete R, Tojo R, Gil A, Aguilera CM. Leptin Receptor Gene Variant rs11804091 Is Associated with BMI and Insulin Resistance in Spanish Female Obese Children: A Case-Control Study. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2017.18(8):-1690.
IF: 3,226 Q: 2 

Di Cataldo A, Agodi A, Balaguer J, Garaventa A, Barchitta M, Segura V, Bianchi M, Castel V, Castellano A, Cesaro S, Couselo JM, Cruz O, D'Angelo P, De Bernardi B, Donat J, de Andoin NG, Hernandez MI, La Spina M, Lillo M, Lopez-Almaraz R, Luksch R, Mastrangelo S, Mateos E, Molina J, Moscheo C, Mura R, Porta F, Russo G, Tondo A, Torrent M, Vetrella S, Villegas JA, Viscardi E, Zanazzo GA, Canete A. Metastatic neuroblastoma in infants: are survival rates excellent only within the stringent framework of clinical trials? CLINICAL & TRANSLATIONAL ONCOLOGY. 2017.19(1):76-83.
IF: 2,353 Q: 3 

Hurtado JA, Maldonado-Lobon JA, Diaz-Ropero MP, Flores-Rojas K, Uberos J, Leante JL, Affumicato L, Couce ML, Garrido JM, Olivares M, Fonolla J, PROLAC Grp. Oral Administration to Nursing Women of Lactobacillus fermentum CECT5716 Prevents Lactational Mastitis Development: A Randomized Controlled Trial. BREASTFEEDING MEDICINE. 2017.12(4):202-209.
IF: 1,551 Q: 3 

Rey Galán C, Alsina Manrique de Lara L, Antón Gamero M, Cano Garcinuño A, Solís Sánchez G. Anales De Pediatría: Onward and upward. An Pediatr. 2017:186-187.
IF: 1,14 Q: 3

Clinical Research

Active in 2019

An International Prospective Study on Clinically Standard-risk Medulloblastoma in Children Older Than 3 to 5 Years With Low-risk Biological Profile (PNET 5 MB-LR) or Average-risk Biological Profile (PNET 5 MB-SR).
PI: Dr  María Elena Mateos González

LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis.
PI: Dr  María Elena Mateos González

Clinical trial to assess the efficacy of lactoferrin in the prevention of sepsis in premature infants. Bimonitorization of the anti-inflammatory, antioxidant and intestinal microbiota mechanisms. LACTOPREM.
PI: Dr María Dolores Ordoñez Díaz

A Phase 3, Open-Label, Multicenter Study of ALXN1210 in Children and Adolescents With Atypical Hemolytic Uremic Syndrome (aHUS).
PI: Dr Montserrat Anton Gamero

Paediatric Hepatic International Tumour Trial.
PI: Dr María Elena Mateos Gonzalez

Estudio de fase II abierto global para evaluar el efecto de dabrafenib en combinación con trametinib en pacientes niños y adolescentes con Glioma de Alto Grado (HGG) recidivante o refractario con mutación BRAF V600 positiva.
PI: Dr María Elena Mateos Gonzalez

An international registry which collects data on disease manifestations, interventions and outcomes in patients with tuberous sclerosis complex.    
PI: Dr Eduardo López Laso

Estudio internacional aleatorizado, controlado, doble ciego y de grupos paralelos para investigar la seguridad y la toleracia de una leche de fórmula infantil parcialmente fermentada que contiene oligosacáridos prebióticos en lactantes nacidos a término sanos. VOYAGE.
PI: Dr Juan Luis Pérez Navero

Investigación integrada y guías para diagnóstico y terapia estandarizados de tumores de riñón en niños, adolescentes y adultos jóvenes. UMBRELLA. SIOP-RTSG 2016. 
PI: Dr. María Elena Mateos Gonzalez

Phase 2, open label study to evaluate the efficacy and safety of KB195 in subjects with urea cycledosrder with inadecuate control on standard of care.
PI: Dr. María Mercedes Gil Campos

Members

Principal Investigator
María Mercedes Gil Campos

Researchers
Montserrat Antón Gamero
María José De La Torre Aguilar
Katherine Flores Rojas
Ignacio Ibarra De La Rosa
Francisco Jesús Llorente Cantarero
Eduardo López Laso
María Elena Mateos González
Juan Luis Pérez Navero
María José Velasco Jabalquinto

Post-Doctoral Researchers
Ana Belén Ariza Jiménez
Antonio Rafael Gómez Fernández
María Belén Pastor Villaescusa

Pre-Doctoral Researchers
Francisco Javier Aguilar Gómez-Cárdenas
Joaquín Alejandro Fernández Ramos
José Manuel Jurado Castro
María Dolores Ordóñez Díaz
María Victoria Rodríguez Benítez
Víctor Gálvez Soto