Research groups

GA05 Study of Growth. Endocrinology and Child Nutrition

Our research group is an associated research group of IMIBIC, formed by clinical and basic researchers and pre-doctoral students. The group is currently formed by 11 clinical and basic researchers: 9 Phd MD, 1 Phd and 1 Pre-Doctoral Researcher.

The line of research that we have been developing for many years on growth disorders focuses on improving both the follow up and specialized care for children with deficits in Growth Hormone treated at the Pediatric Endocrinology Unit.

Many of our projects have resulted in publications and doctoral theses, contributing to our knowledge about the metabolic consequences of growth hormone related diseases in children, as well as the possible secondary and long-term alterations caused by them.

We have recently gained experience in the study of the human serum proteome with the completion of a doctoral thesis entitled "Proteomic alterations in serum of newborns with intrauterine growth retardation" by Dr. Dolores Ruiz González.

The group leader is responsible of the PAIDI CTS-329 group on Study of Growth, Endocrinology and Nutrition (Andalusian Plan for Research, Development and Innovation (PAIDI)), as well as member of the Network of Physiopathology of Obesity and Nutrition (CIBERobn) of the Spanish National Institute of Health Carlos III (ISCIII).

Research Lines

The main line of research of our group focuses on studying growth and nutrition in prepubertal children. It includes studies of growth and obesity in prepubertal children, focusing on children with metabolic syndrome, inflammatory factors, biomarkers of vascular risk and gene expression of adipose tissue, effects of diet on these factors, study of steatohepatitis and physical activity.

Our research related to nutrition in children with extrauterine growth retardation focuses especially in those children that could develop metabolic syndrome later in their lives. Our group also investigates the growth hormone producing cells and morphological modifications in animals.

We conduct comparative proteomic analyzes of umbilical cord blood from preterm and term infants with intrauterine growth retardation (IUGR) to identify possible differences in proteins they might have with newborns suitable for their gestational age and the likelihood of adverse nutritional effects.

Finally, our group is developing a line of research focused on food allergies, and more specifically on the possible impact on health of workers of solar thermal plants exposed daily to polycyclic aromatic hydrocarbons.



  • Child obesity
  • metabolic syndrome
  • diet
  • endothelium
  • inflammation
  • cardiovascular biomarkers
  • gene expression
  • proteomics
  • intrauterine-growth-retardation (IUGR)
  • growth hormone (GH)
  • food allergy

Additional Information

Highlighted publications, in collaboration

GA05 Study of Growth. Endocrinology and Child Nutrition

Principal Investigator
Ramón Cañete Estrada

Luis Jiménez Reina
Rosario Martos Estepa
Mª José Párraga Quiles
Inés Tofé Valera
Javier Torres Borrego
Miguel Valle Jiménez
Fernando Vázquez Rueda
Elena García Martínez
Mª Dolores Ruiz González

Pre-Doctoral Researchers
Elena Gómez Guzmán

Nursing, Technical, and Administrative Staff
Mª Dolores Cañete Vázquez


Active in 2019


Tofé Valera, IM. Research grant. D-PREM: INFLUENCIA DEL ESTATUS MATERNO-FILIAL DE VITAMINA D EN RECIÉN NACIDOS PREMATUROS < 32 SEMANAS Y < 1500 g Y MORBILIDAD RESPIRATORIA. Funding Agency: Asociación Española Pediatría. Reference: AEP/2017


Tofé Valera, IM. ALBINO - Effect of allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome. Funding Agency: European Commission. Reference: PHC18-2015-001

Finished projects

Tofe Valera, IM. Research grant. Funding Agency: Asociación Española Pediatría. Reference: AEP/2017

Cañete Estrada, R. Short-term effects on body composition of growth hormone treatment in prepubertal children with growth hormone (GH) deficiency. Funding Agency: UNIVERSIDAD DE CÓRDOBA-OTRI. Reference: 103343



Anguita-Ruiz A, Pastor-Villaescusa B, Leis R, Bueno G, Hoyos R, Vazquez-Cobela R, Latorre-Millan M, Canete MD, Caballero-Villarraso J, Gil A, Cañete R, Aguilera CM; Common Variants in 22 Genes Regulate Response to Metformin Intervention in Children with Obesity: A Pharmacogenetic Study of a Randomized Controlled Trial. JOURNAL OF CLINICAL MEDICINE. 2019 Sep 16;8(9):1471. doi: 10.3390/jcm8091471.
IF: 5,688

Anguita-Ruiz A, Plaza-Diaz J, Ruiz-Ojeda FJ, Ruperez AI, Leis R, Bueno G, Gil-Campos M, Vazquez-Cobela R, Cañete R, Moreno LA, Gil A, Aguilera CM; X chromosome genetic data in a Spanish children cohort, dataset description and analysis pipeline. SCIENTIFIC DATA. 2019 Jul 22;6(1):130. doi: 10.1038/s41597-019-0109-3.
IF: 5,929
Q: 1 

Ruiz-Ojeda FJ, Anguita-Ruiz A, Ruperez AI, Gomez-Llorente C, Olza J, Vazquez-Cobela R, Gil-Campos M, Bueno G, Leis R, Cañete R, Moreno LA, Gil A, Aguilera CM; Effects of X-chromosome Tenomodulin Genetic Variants on Obesity in a Children's Cohort and Implications of the Gene in Adipocyte Metabolism. SCIENTIFIC REPORTS. 2019 Mar 8;9(1):3979. doi: 10.1038/s41598-019-40482-0.
IF: 4,011
Q: 1 

Moreno M, Castillo-Corullon S, Perez-Ruiz E, Luna MC, Anton-Pacheco JL, Mondejar-Lopez P, De-la-Serna O, Villa JR, Osona B, Torres-Borrego J, Santiago-Burruchaga M, Asensio O, Andres-Martin A, Delgado-Pecellin I, Gonzalez Y, Palmero A, Escribano A; Spanish multicentre study on morbidity and pathogenicity of tracheal bronchus in children. PEDIATRIC PULMONOLOGY. 2019 Oct;54(10):1610-1616. doi: 10.1002/ppul.24435.
IF: 2,801
Q: 1

Nuñez-Ramiro A, Benavente-Fernandez I, Valverde E, Cordeiro M, Blanco D, Boix H, Cabanas F, Chaffanel M, Fernandez-Colomer B, Fernandez-Lorenzo JR, Kuligowski J, Loureiro B, Moral-Pumarega MT, Pavon A, Sanchez-Illana A, Tofe I, Hervas D, Garcia-Robles A, ; Topiramate plus Cooling for Hypoxic-Ischemic Encephalopathy: A Randomized, Controlled, Multicenter, Double-Blinded Trial. NEONATOLOGY. 2019;116(1):76-84. doi: 10.1159/000499084.
IF: 2,688 
Q: 1 

Canete MD, Valle-Martos R, Martos R, Canete R, Valle M, Jimenez-Reina L; Effects of growth hormone therapy on metabolic parameters, adipokine and endothelial dysfunction in prepuberal children. ACTA PAEDIATRICA. Nov;108(11):2027-2033. doi: 10.1111/apa.14849. 
IF: 2,265
Q: 2

Perez-Navero JL, Merino-Cejas C, de la Rosa II, Jaraba-Caballero S, Frias-Perez M, Gomez-Guzman E, Gil-Campos M, de la Torre-Aguilar MJ; Evaluation of the vasoactive-inotropic score, mid-regional pro-adrenomedullin and cardiac troponin I as predictors of low cardiac output syndrome in children after congenital heart disease surgery. MEDICINA INTENSIVA. Aug-Sep 2019;43(6):329-336. doi: 10.1016/j.medin.2018.04.005.
IF: 1,982
Q: 3

Caballero-Villarraso J, Aguado R, Canete MD, Roldan L, Canete R, Santamaria M; Hormone replacement therapy in children with growth hormone deficiency: impact on immune profile. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY. 2019 Jun 19;1-5. doi: 10.1080/13813455.2019.1628070.
IF: 2,11
Q: 3

Moral L, Vizmanos G, Torres-Borrego J, Praena-Crespo M, Tortajada-Girbes M, Pellegrini FJ, Asensio O; Asthma diagnosis in infants and preschool children: a systematic review of clinical guidelines. ALLERGOLOGIA ET IMMUNOPATHOLOGIA. Mar-Apr 2019;47(2):107-121. doi: 10.1016/j.aller.2018.05.002.
IF: 1,64
Q: 4 


Ortea I, Ruiz-Sanchez I, Canete R, Caballero-Villarraso J, Canete MD. Identification of candidate serum biomarkers of childhood-onset growth hormone deficiency using SWATH-MS and feature selection. JOURNAL OF PROTEOMICS. 2018; 175:105-113.
IF: 3,722
Q: 1 

Gomez-Guzman E, Canete MD, Valle-Mertos R, Canete R, Valle M, Jimenez-Reina L, Caballero-Villarraso J. Short-Term Evaluation of Left Ventricular Mass and Function in Children With Growth Hormone Deficiency After Replacement Treatment. FRONTIERS IN PEDIATRICS. 2018; 6:Núm artículo 174
IF: 2,335
Q: 2 

Castillo-Fernandez AL, Vazquez-Rueda F, Canete MD, Caballero-Villarraso J. Retroperitoneal gastric duplication mimicking a prenatal adrenal cyst. CONGENITAL ANOMALIES. 2018; 58(4):141-142.
IF: 1,149
Q: 3 

Hernandez MAT, Martinez EG, Marin MJA, Guzman EG. Tolvaptan in a pediatric cardiorenal syndrome. What is its role?. ARCHIVOS ARGENTINOS DE PEDIATRIA. 2018; 116(2):E279-E282.
IF: 0,405
Q: 4 

Burgos AMC, Torres-Borrego J, Teran ABM, Corzo JL, Garcia BE, Pacheco RR, Aguilar CM, Davila I. Molecular sensitization patterns and influence of molecular diagnosis in immunotherapy prescription in children sensitized to both grass and olive pollen. PEDIATRIC ALLERGY AND IMMUNOLOGY. 2018; 29(4):369-374.
IF: 4,137
Q: 1  D: 1

Tortajada-Girbes M, Bousquet R, Bosque M, Martinez JJC, Ibanez MD, Moreira A, Nieto A, Plaza AM, Rivas C, Requena G, Sanchez-Solis M, Tabar A, Torres-Borrego J, Zapatero L. Efficacy and effectiveness of omalizumab in the treatment of childhood asthma. EXPERT REVIEW OF RESPIRATORY MEDICINE. 2018; 12(9):745-754.
IF: 2,607
Q: 2

TTofe I, Ruiz-Gonzalez MD, Canete MD, Pino A, Rueda RL, Parraga MJ, Perez-Navero JL. Efficacy of Paracetamol in Closure of Ductus Arteriosus in Infants under 32 Weeks of Gestation. FRONTIERS IN PEDIATRICS. 2018; 6:Núm artículo 25
IF: 2,335
Q: 2


Cabezas OR, Flanagan SE, Stanescu H, Garcia-Martinez E, Caswell R, Lango-Allen H, Anton-Gamero M, Argente J, Busse AM, Brandli A, Cheshire C, Crowne E, Dumitriu S, Drynda R, Hamilton-Shield JP, Hayes W, Hofherr A, Iancu D, Issler N, Jefferies C, Jones P, Johnson M, Kesselheim A, Klootwijk E, Koettgen M, Lewis W, Martos JM, Mozere M, Norman J, Patel V, Parrish A, Perez-Cerda C, Pozo J, Rahman SA, Sebire N, Tekman M, Turnpenny PD, van't Hoff W, Viering DHHM, Weedon MN, Wilson P, Guay-Woodford L, Kleta R, Hussain K, Ellard S, Bockenhauer D. Polycystic Kidney Disease with Hyperinsulinemic Hypoglycemia Caused by a Promoter Mutation in Phosphomannomutase 2. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2017.28(8):2529-2539.
IF: 8,966
Q: 1  D: 1

Pastor-Villaescusa B, Canete MD, Caballero-Villarraso J, Hoyos R, Latorre M, Vazquez-Cobela R, Plaza-Diaz J, Maldonado J, Bueno G, Leis R, Gil A, Canete R, Aguilera CM. Metformin for Obesity in Prepubertal and Pubertal Children: A Randomized Controlled Trial. PEDIATRICS. 2017.140(1):-e20164285.
IF: 5,705
Q: 1  D: 1

Sanchez-Illana A, Nunez-Ramiro A, Cernada M, Parra-Llorca A, Valverde E, Blanco D, Moral-Pumarega MT, Cabanas F, Boix H, Pavon A, Chaffanel M, Benavente-Fernandez I, Tofe I, Loureiro B, Fernandez-Lorenzo JR, Fernandez-Colomer B, Garcia-Robles A, Kuligowski J, Vento M. HYPOTOP Study GroupEvolution of Energy Related Metabolites in Plasma from Newborns with Hypoxic-Ischemic Encephalopathy during Hypothermia Treatment. SCIENTIFIC REPORTS. 2017.7():-17039.
IF: 4,259
Q: 1 

Ibáñez-Costa A, López-Sánchez LM, Gahete MD, Rivero-Cortés E, Vázquez-Borrego MC, Gálvez MA, de la Riva A, Venegas-Moreno E, Jiménez-Reina L, Moreno-Carazo A, Tinahones FJ, Maraver-Selfa S, Japón MA, García-Arnés JA, Soto-Moreno A, Webb SM, Kineman RD, Culler MD, Castaño JP, Luque RM. BIM-23A760 influences key functional endpoints in pituitary adenomas and normal pituitaries: molecular mechanisms underlying the differential response in adenomas. SCI REP. 2017 Feb 9;7:42002.
IF: 4,25
Q: 1 

Perez-Navero JL, de la Torre-Aguilar MJ, de la Rosa II, Gil-Campos M, Gomez-Guzman E, Merino-Cejas C, Munoz-Villanueva MC, Llorente-Cantarero FJ. Cardiac Biomarkers of Low Cardiac Output Syndrome in the Postoperative Period After Congenital Heart Disease Surgery in Children. REVISTA ESPANOLA DE CARDIOLOGIA. 2017.70(4):267-274.
IF: 4,485
Q: 1 

Olza J, Ruperez AI, Gil-Campos M, Leis R, Canete R, Tojo R, Gil A, Aguilera CM. Leptin Receptor Gene Variant rs11804091 Is Associated with BMI and Insulin Resistance in Spanish Female Obese Children: A Case-Control Study. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2017.18(8):-1690.
IF: 3,226
Q: 2 

Moreno-Solis G, de la Torre-Aguilar MJ, Torres-Borrego J, Llorente-Cantarero FJ, Fernandez-Gutierrez F, Gil-Campos M, Tunez-Finana I, Perez-Navero JL. Oxidative stress and inflammatory plasma biomarkers in respiratory syncytial virus bronchiolitis. CLINICAL RESPIRATORY JOURNAL. 2017.11(6):839-846.
IF: 2,356
Q: 3 

Tortajada-Girbes M, Torres-Borrego J. The influence of microorganisms in allergic diseases.  ALLERGOLOGIA ET IMMUNOPATHOLOGIA. 2017.45(6):519-520.
IF: 1,439
Q: 4 

Rodriguez JMR, Munoz ADA, Munoz JB, Rodriguez PC, Estrada RC, Lopez ID, Solis MMH, Ollero MJMA, Dehli ACR, Toda LI, en representación del Grupo de trabajo para el estudio del paciente pequeño para la edad gestacional (PEG) de la Sociedad Española de Endocrinología Pediátrica (SEEP). Growth hormone treatment in small for gestational age children in Spain. ANALES DE PEDIATRIA. 2017.86(5):249-254.
IF: 1,14
Q: 3 

Perez-Navero JL, Tejero-Hernandez MA, Gomez-Guzman E, Merino-Cejas C, De La Torre-Aguilar MJ, Llorente-Cantarero FJ. Left ventricle training before late arterial switch to correct congenital transposition of the great arteries with intact ventricular septum. GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE. 2017.176(6):359-362.

Betancourth-Alvarenga JE, Vázquez Rueda F, Siu Uribe A, Escassi Gil A, Vargas Cruz V, Sánchez Sánchez R, Ortega Salas R, Paredes Esteban RM. Clinical and immunohistochemical correlation of balanitis xerotica obliterans. CIR PEDIATR. 2017.25;30(4):211-215.

Murcia Pascual FJ, Delgado Cotán L, Jiménez Crespo V, Vázquez Rueda F, Rodríguez Cano E, Miño Mora M, Paredes Esteban RM. Correlation between prenatal ultrasound and postnatal diagnosis of birth defects. CIR PEDIATR. 2017;30(3):126-130.

Clinical Research

Active in 2019

Multicenter, Open-label study to evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics of LCZ696 followed by a 52-week randomized, double-blind, parallel group, active-controlled study to evaluate the efficacy and safety of LCZ696 compared with enalapril in pediatric patients from 1 month to < 18 years of age with heart failure due to systemic left ventricle systolic dysfunction.
PI: Dr Gómez Guzmán, E.

Efecto del Alopurinol en pacientes con encefalopatía hipóxico-isquémica tratados con hipotermia – ALBINO – ensayo clínico multicéntrico, aleatorizado, ciego, controlado con placebo.
PI: Dr. Ines M Tofé Valera 

Paracetamol versus Ibuprofeno en recién nacidos prematuros con diagnóstico de ductus arterioso persistente hemodinámicamente significativo: ensayo clínico aleatorizado.
PI: Dr. M Jose Párraga Quiles

A Double-Blind, placebo-controlled study to examine the safety and efficacy of pimavanserin for the treatment of agitation and aggression in Alzheimer's Disease.
PI: Dr Gómez Guzmán, E.

Estudio en fase III aleatorizado, doble ciego, controlado con placebo para evaluar la seguridad y la eficacia de MEDI8897, un anticuerpo monoclonal con una semivida prolongada frente al virus respiratorio sincitial, en bebés sanos nacidos prematuros tardí. 
PI: Dr. María Dolores Ruiz Gonzalez

Estudio multicéntrico para evaluar la seguridad y tolerabilidad a largo plazo de un tratamiento en abierto con sacubitrilo/valsartán en pacientes pediátricos con insuficiencia cardíaca debida a disfunción sistólica de ventrículo izquierdo sistémico, que h. 
PI: Dr. Elena Gómez Guzmán

Ensayo clínico, multicéntrico aleatoriazado y enmascarado (ciego) con topiramato versus placebo para el tratamiento de recién nacidos con asfixia perinatal tratados con hipotermia moderada corporal total.
PI: Dr. María José Párraga Quiles


Dr. Ramón Cañete Estrada

Principal Investigator