Research groups

GC20 Genetics and behavioural diseases

The group GC20 is a consolidated research group composed of over twenty researchers on genetics and behavioural diseases both from the clinical applied field and from the academic and basic research. Our research group is interprofessional and it gathers specialist from areas such as genetics, early attention, clinical and health Psychology, Artificial Intelligence and physiotherapy. Due to the multidisciplinary nature of the group, members are divided into several research lines, mainly:

  • Genetics and explanatory models for autism following model organisms based on the nematode Caenorhabditis elegans.
  • Early detection of developmental disorders and other issues of human behaviour, as well as the development of a procedure to teach verbal and cognoscitive behaviours on children with developmental disabilities.
  • Clinical and health psychology, and the assessment of EST (Empirically Supported Treatments) for anxiety and depression on Primary Care services.
  • Psycho-oncology applied to cancer survivors and their families.
  • Artificial Intelligence applied to the evaluation of developmental disorders from a physiotherapeutic and psychological perspective.

Our research has potential impact on several health areas. Research on genetics implies generating more knowledge regarding pathologies such as autism and its genetic base. Concerning early attention, our studies may improve some of the current assessment methods through the development of IT systems for the analysis of children's development. These advances may be applied in paediatric services and in the context of child clinical Psychology as well as to improve learning procedures. Our team also endeavours to early detection of developmental disorders and neuropsychological alterations in children affected with cerebellar tumours and ataxias (cerebellum pathologies). Our studies on psychological treatments for anxiety and depression may increase actual knowledge of effective treatments, which may lead to reducing the costs associated with the treatment of depression and anxiety. In this context, we have conducted a clinical essay to demonstrate that brief therapy is a better and more efficient strategy in comparison to pharmacological treatment for anxiety and depression. To conclude, in the oncology area our research focuses on improving the psychological health of cancer patients and their families.

Research Lines

Networks

    Excellence research and interdisciplinary Network for the diagnosis and promotion of youth issues, emotions and psychological well-being (MINEICO PSI2015-70943-REDT)

Keywords

  • behaviour genetics
  • autism spectrum disorder
  • C. elegans
  • oncology
  • clinical psychology
  • psycho-oncology
  • psychological treatment
  • primary care
  • depression
  • anxiety
  • based-evidence psychology
  • early attention
  • developmental disorders
  • neuropsychological alterations
  • rare diseases
  • developmental disability
  • verbal behaviour
  • cognoscitive behaviour

Additional Information

Highlighted publications

Moreno E, Muñoz R, Medrano L, González C, Ruiz P, Limonero J, Moretti L, Cano A, Moriana JA. (2019). Factorial invariance of a computerized version of the GAD-7 across various demographic groups and over time in primary care patients. Journal of Affective Disorders, 252, 114-121. JCR IF: 4,084 (Q1), 32/146 Psychiatry. 44/199 Clinical Neurology

Rodríguez-Ramos A, García-Torres F, Moriana JA & Ruiz-Rubio M. (2019). Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women. Brain Behavior; 019;00:e01376.  https ://doi.org/10.1002/brb3.1376. JCR IF=2,072. Q3. 38/53 Behavior Sciences.

Gálvez Lara M, Corpas J & Moriana JA. (2019). Evidence-based brief psychological treatment for emotional disorders in primary and specialized care: study protocol of a randomized controlled trial. Frontiers in Psychology, 9:2674. Doi: 10.3389/fpsyg.2018.02674. JCR IF=2,129. Q2. 40/137 Psychology Multidisciplinar.

Gálvez Lara M, Corpas J, Velasco J &  Moriana JA. (2019). El conocimiento y el uso en la práctica clínica de los tratamientos psicológicos basados en la evidencia. Clínica y Salud, 30 (3), 115-122. JCR IF=0,632. Q4. Clinical Psychology.

Molero A, Martin R, Moriana JA, Nitsche MA & Rivera GN. (2019). Bilateral Prefrontal Cortex Anodal tDCS Effects on Self-reported Aggressiveness in Imprisoned Violent Offenders. Neuroscience, 397, 31-40. JCR IF= 3,244 (Q2) 114/267, Clinical Neurology.

García-Torres F, Jabłoński M, Gómez A, Moriana JA, Jaén-Moreno MJ, Moreno-Díaz MJ  & Aranda E. (2019). Social support as predictor of anxiety and depression in cancer caregivers six months after cancer diagnosis: A longitudinal study. Journal of Clinical Nursing, 0, 1-7. Doi: 10.1111/jocn.15123. JCR IF=1,757. Q1. 28/120. Nursing.

Gonzalez-Blanch C, Medrano LA, Munoz-Navarro R, Ruiz-Rodriguez P, Moriana JA, Limonero JT, Schmitz F, Cano-Vindel A. (2018). Factor structure and measurement invariance across various demographic groups and over time for the PHQ-9 in primary care patients in Spain. Plos One. FI = 2.766, Q1, (15/64).

Rodriguez-Ramos A, Gamez MM, Porta M, Ceron J, Ruiz-Rubio M. (2017). Impaired dopamine-dependent locomotory Behavior of C-elegans neuroligin mutants depends on the catechol-O-methyltransferase COMT-4. Behavior Genetics, 47, 596-608.

Moriana JA, Gálvez Lara M. & Corpas J. (2017). Psychological treatments for mental disorders in adults: A review of the evidence of leading international organizations. Clinical Psychology Review, 54, 29 – 43.  JCR, IF: 8.897. Q1 (2/121).

Muñoz R, Cano-Vindel A., Moriana JA, Medrano L, Ruiz-Rodríguez P, Agüero L, Rodríguez M, Pizà MR, Ramírez-Manent JI. (2017). Screening for generalized anxiety disorder in Spanish primary care centers with GAD-7. Psychiatry Research, 256, 312-317. JCR, IF: 2.528. Q2 (65/142)

Moriana JA, Moreno-Osella E. (2016). User involvement in the implementation of clinical guidelines for common mental health disorders: a review and compilation of strategies and resources. Health Research Policy and Systems, 14 – 61, 0 – 8. JCR, IF: 2.271. Q2 (20/77)

Moreno-Osella E, Moriana JA. (2016). Estrategias para la implementación de guías clínicas de trastornos comunes de salud mental. Revista de Psiquiatría y Salud Mental, 9 – 1, 51 – 62. JCR, IF: 1.650. Q3 (94/425)

Langer AI, Stanghellini G, Cangas AJ, Luysaker P, Nieto L, Moriana JA., Barrigón, M, Abrosini A. (2015). Interpretation emotional reactions and daily life implications of hallucination-like experiences in clinical and nonclinical populations. Psicothema, 27 – 1, 19 – 25. JCR, IF: 1.245. Q2 (57/129)

Moriana JA, Liberman R, Kopelowicz A, Luque B, Cangas AJ,  Alós FJ. (2015). El entrenamiento en habilidades sociales de la esquizofrenia. Behavioral Psychology/Psicología Conductual, 23 – 1, 5 – 24. JCR, IF: 0.766. Q4 (95/122)

Guerrero M, Alós F, Moriana JA. (2015). Emergent relations with compound stimuli in conditional and simple discriminations: an experimental application in children. Psychological Record, 65 – 3, 475 – 486. JCR, IF: 0.761. Q3 (79/129)

Gálvez M, Moriana JA, Villar R, Fayez A, Hidalgo-Ruzzante N, Pérez-García M. (2015). Validation of the Cross-Linguistic Naming Test: A naming test for different cultures? A Preliminary study in the spanish population. Journal of Clinical and Experimental Neuropsychology, 37 – 1, 102 – 112. JCR, IF: 1.839. Q3 (131/139)

Alós FJ, Falla D. (2016). Contextual control in visuospatial perspective-taking skills in adults with intellectual disabilities. Behavioral Interventions, 31 - 1, 44 - 61. JCR, IF: 0.404. Q4 (112/121)

García-Torres F, Alós FJ, Pérez-Dueñas C. (2016). Anxiety in common situations of everyday life and depression in women with mastectomies. Psycho-Oncology 25(12), 1512-1514. JCF IF: 3.095 Q1 (3/40).

Spangerberg L, Zenger M, García-Torres F, Mueller V, Reck M, Mehnert A, Vehling S. (2016). Dimensionality, Stability and Validity of the Beck Hopelessness Scale in Cancer Patients Receiving curative and paliative treatment. Journal of Pain and Symptom Management, 51(3), 615-622. JCR IF: 2.905, Q1 (22/90).

García-Torres F & Alós FJ. (2014). Anxiety in common situations of everyday life in breast cancer survivors. Psycho-Oncology 23(8), 953-955. JCF IF: 2.443, Q1 (3/40).

García-Torres F & Alós FJ. (2014). Eysenck personality questionnaire revised psychoticism predicts motivational-somatic symptoms of depression in breast cancer survivors. Psycho-Oncology, 23(3), 350-352. JCF IF: 2.443, Q1 (3/40).

García-Torres F & Alós FJ. (2013). Identification of different depressive symptoms after mastectomy. Psycho-Oncology, 22(12), 2857-2859. JCF IF: 4.044, Q1 (1/37).

Pérez-Dueñas C, Acosta A, Lupiáñez J. (2014) Reduced habituation to angry faces: increased attentional capture as to override inhibition of return. Psychological Research, 78(2), 196 - 208. JCF, IF: 2.863, Q2 (22/85)

Di Stasi LL, Marchitto M, Antolí A., Cañas JJ. (2013) Saccadic peak velocity as an alternative index of operator attention: A short review. Revue Européenne de Psychologie Appliquée / European Review of Applied Psychology. 63 (6), 335–343. JCR, IF: 0.560, Q4 (64/75)

Highlighted Projects

Phone and informatics application for the detection, early diagnosis and intervention on early attention and its integration in the Alborada clinical management system. Reference: PIN-0072-2016. Consejería de Bienestar Social y Salud de la Junta de Andalucía. Subvenciones para la financiación de la I+D+i Biomédica y en Ciencias de la Salud en Andalucía.

Tratamientos psicológicos breves basados en la evidencia para trastornos/problemas comunes. Un ensayo clínico aleatorizado en Atención Primaria y Especializada. Reference: PSI2014-56368-R. MINECO. Dirección General de Investigación Científica y Técnica. Programa RETOS.

Technology Transfer

Some of the members of the research team participate in the creation and management for the Centro de Atención Infantil Temprana de la Universidad de Córdoba (CAIT-UCO) [Centre for early child attention of the University of Cordoba], institution under the Corporación Empresarial [Business Corporation] of the University of Córdoba. This centre has an agreement with the Andalusian Ministry of Health providing 70 vacancies for children with developmental disorders (or at risk for) referred by paediatric services. The centre has a private line of attention, conducts research under the IMIBIC group, and provides formal training and education.

 Web:  http://www.uco.es/cait/index.html

GC20 Genetics and behavioural diseases

Principal Investigator
Manuel Ruíz Rubio

Co-Principal Investigator
Juan Antonio Moriana Elvira

Researchers
Francisco José Alós Cívico
Adoración Antolí Cabrera
Rafael Burgos Marín
Juan Carlos Gámez Granados
Francisco Mariano García Torres
Teresa Guijarro Granados
Pilar Martín Borreguero
Eliana Moreno
Carolina Pérez-Dueñas
María Auxiliadora Romero Balsera
Mª Araceli Sánchez Raya
José Manuel Soto Hidalgo
Fátima Cuadrado Hidalgo
Mario Gálvez Lara

Clinical Researchers
José Fernando Venceslá Martínez

Pre-Doctoral Researchers
Francisco Javier Jurado González
Judith Velasco Rodríguez
Julia Vacas Ruiz
Miguel Ángel Maldonado Herves
Jorge Corpas López
Ángel Rodríguez Ramos

Technical Staff
Carmen Espejo Durán

Projects

Active projects

Regional

Sánchez Raya, A. Mobile computing application for early detection, diagnosis and intervention in health care and its integration of clinical management system. Funding Agency: Regional Ministry of Health and Social Policy (CISPS). Reference: PIN-0072-2016

Finished projects

Moriana JA. Evidence-based short psychological treatments for common disorders. A randomized trial in the specialized primary care setting. Funding agency: Spanish Ministry of Economy and Competitiveness (MINECO). Reference: PSI2014-56368-R

Publications

Publications 2019

Plaza-Diaz J, Gomez-Fernandez A, Chueca N, de la Torre-Aguilar MJ, Gil A, Perez-Navero JL, Flores-Rojas K, Martin-Borreguero P, Solis-Urra P, Ruiz-Ojeda FJ, Garcia F, Gil-Campos M; Autism Spectrum Disorder (ASD) with and without Mental Regression Is Associated with Changes in the Fecal Microbiota. NUTRIENTS. 2019 Feb 5;11(2). pii: E337. doi: 10.3390/nu11020337.
IF: 4,171
Q: 1

Limonero JT, Moretti LS, Cano-Vindel A, Moriana JA; Factorial invariance of a computerized version of the GAD-7 across various demographic groups and over time in primary care patients. JOURNAL OF AFFECTIVE DISORDERS. 2019 Jun 1;252:114-121. doi: 10.1016/j.jad.2019.04.032.
IF: 4,084
Q: 1

Abril-Requena A, Garcia-Torres F, Alos FJ; Sexual dysfunction and phobic anxiety in breast cancer survivors. PSYCHO-ONCOLOGY. 2019 Jan;28(1):195-197. doi: 10.1002/pon.4894
IF: 3,43
D: 1

Garcia-Torres F, Castillo-Mayen R; Differences in Eysenck's Personality Dimensions between a Group of Breast Cancer Survivors and the General Population. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2019 Apr 8;16(7). pii: E1240. doi: 10.3390/ijerph16071240.
IF: 2,468
Q: 1 

Rodriguez-Ramos A, Moriana JA, Garcia-Torres F, Ruiz-Rubio M; Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women. BRAIN AND BEHAVIOR. 2019 Sep;9(9):e01376. doi: 10.1002/brb3.1376.
IF: 2,072
Q: 3 

Galvez-Lara M, Corpas J, Vencesla JF, Moriana JA; Evidence-Based Brief Psychological Treatment for Emotional Disorders in Primary and Specialized Care: Study Protocol of a Randomized Controlled Trial. FRONTIERS IN PSYCHOLOGY.  2019 Jan 8;9:2674. doi: 10.3389/fpsyg.2018.02674.
IF: 2,129
Q: 2 

Moreno E, Munoz-Navarro R, Medrano LA, Gonzalez-Blanch C, Ruiz-Rodriguez P,Rangel-Huerta OD, Gomez-Fernandez A, de la Torre-Aguilar MJ, Gil A, Perez-Navero JL, Flores-Rojas K, Martin-Borreguero P, Gil-Campos M; Metabolic profiling in children with autism spectrum disorder with and without mental regression: preliminary results from a cross-sectional case-control study. METABOLOMICS. 2019 Jun 27;15(7):99. doi: 10.1007/s11306-019-1562-x.
IF: 3,167
Q: 2

Kuba K, Weissflog G, Gotze H, Garcia-Torres F, Mehnert A, Esser P; The relationship between acceptance, fatigue, and subjective cognitive impairment in hematologic cancer survivors. INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY. 2019 May;19(2):97-106. doi: 10.1016/j.ijchp.2018.12.001.
IF: 3,317
Q: 1 

Galvez-Lara M, Corpas J, Velasco J, Moriana JA. Knowledge and use of evidence-based psychological treatments in clinical practice. CLÍNICA Y SALUD. 2019. Vol. 30. Núm. 3. - 2019. Páginas 115 – 122. Doi: 10.5093/clysa2019a12.

Egea J, Gonzalez-Rodriguez A, Gomez-Guerrero C, Moreno JA. Editorial: Role of Nrf2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches. FRONTIERS IN PHARMACOLOGY. 2019; 10: 1149. Doi: 10.3389/fphar.2019.01149.
 

Main Publications 2018

Garcia-Torres F, Castillo-Mayen R, Alos FJ. Psychoticism and employment status in breast cancer survivors. PSYCHO-ONCOLOGY. 2018; 27(1):359-361.
IF: 3,455  
Q: 1   D: 1

Galvez-Lara M, Corpas J, Moreno E, Vencesla JF, Sanchez-Raya A, Moriana JA. Psychological Treatments for Mental Disorders in Children and Adolescents: A Review of the Evidence of Leading International Organizations. CLINICAL CHILD AND FAMILY PSYCHOLOGY REVIEW. 2018; 21(3):366-387.
IF: 3,6  
Q: 1

Perez-Duenas C, Rivas MF, Oyediran OA, Garcia-Torres F. Induced Negative Mood Increases Dictator Game Giving. FRONTIERS IN PSYCHOLOGY. 2018; 9: Núm artículo 1542
IF: 2,089  
Q: 2

Diaz-Gonzalez MC, Duenas CP, Sanchez-Raya A, Moriana, JA, Vazquez VS. Mindfulness-based stress reduction in adolescents with mental disorders: A randomised clinical trial. PSICOTHEMA. 2018; 30(2):165-170.
IF: 1,516  
Q: 2

Osuna-Luque J, Rodriguez-Ramos A, Gamez-del-Estal MD, Ruiz-Rubio M. Behavioral Mechanisms That Depend on Dopamine and Serotonin in Caenorhabditis elegans Interact With the Antipsychotics Risperidone and Aripiprazole. JOURNAL OF EXPERIMENTAL NEUROSCIENCE. 2018; 12: Núm artículo UNSP 1179069518798628
IF: 0

Other Publications 2018

Gonzalez-Blanch C, Medrano LA, Munoz-Navarro R, Ruiz-Rodriguez P, Moriana JA, Limonero JT, Schmitz F, Cano-Vindel A. Factor structure and measurement invariance across various demographic groups and over time for the PHQ-9 in primary care patients in Spain. PLOS ONE. 2018; 13(2): Núm artículo e0193356
IF: 2,766  
Q: 1

Gomez-Fernandez A, de la Torre-Aguilar MJ, Gil-Campos M, Flores-Rojas K, Cruz-Rico MD, Martin-Borreguero P, Perez-Navero JL. Children With Autism Spectrum Disorder With Regression Exhibit a Different Profile in Plasma Cytokines and Adhesion Molecules Compared to Children Without Such Regression. FRONTIERS IN PEDIATRICS. 2018; 6: Núm artículo 264
IF: 2,335  
Q: 2

Gonzalez-Blanch C, Hernandez-de-Hita F, Munoz-Navarro R, Ruiz-Rodriguez P, Medrano LA, Moriana JA, Cano-Vindel A. Domain-specific associations between disability and depression, anxiety, and somatization in primary care patients. PSYCHIATRY RESEARCH. 2018; 269:596-601.
IF: 2,223  
Q: 2

Main Publications 2017

Moriana JA; Galvez-Lara M; Corpas J. Psychological treatments for mental disorders in adults: A review of the evidence of leading international organizations. CLINICAL PSYCHOLOGY REVIEW. 2017.54():-.
IF: 8,897
Q: 1  D: 1

Rodriguez-Ramos A, Gamez-del-Estal MM, Porta-de-la-Riva M, Ceron J, Ruiz-Rubio M. Impaired Dopamine-Dependent Locomotory Behavior of C-elegans Neuroligin Mutants Depends on the Catechol-O-Methyltransferase COMT-4 .BEHAVIOR GENETICS. 2017.47(6):596-608.
IF: 2,385
Q: 1 

Benitez-Burraco A, Barcos-Martinez M, Espejo-Portero I, Jimenez-Romero S. Variable Penetrance of the 15q11.2 BP1-BP2 Microduplication in a Family with Cognitive and Language Impairment. MOLECULAR SYNDROMOLOGY. 2017.8(3):139-147.
IF: n/a

Other Publications 2017

Munoz-Navarro R, Cano-Vindel A, Moriana JA, Medrano LA, Ruiz-Rodriguez P, Aguero-Gento L, Rodriguez-Enriquez M, Piza MR, Ramirez-Manent JI. Screening for generalized anxiety disorder in Spanish primary care centers with the GAD-7. PSYCHIATRY RESEARCH. 2017.256():312-317.
IF: 2,528
Q: 2

Ruiz-Veguilla M, Moreno-Granados J, Salcedo-Marin MD, Barrigon ML, Blanco-Morales MJ, Igunza E, Canabate A, Garcia MD, Guijarro T, Diaz-Atienza F, Ferrin M. Sex-specific cognitive abnormalities in early-onset psychosis. REVISTA BRASILEIRA DE PSIQUIATRIA. 2017.39(1):28-35.
IF: 2,049
Q: 3

Clinical Research

Active in 2019

Evaluation of the change in emotional expression in patients with attention deficit hyperactivity disorder (ADHD) with inadequate response to methylphenidate after change in their therapeutic strategy to lisdexamfetamine dimesylate (LDX).
PI: Dr Burgos Marín, Rafael

Members

Dr. Manuel Ruíz Rubio

Principal Investigator

Dr. Juan Antonio Moriana Elvira

Co-Principal Investigator

Team

Francisco José Alós Cívico Adoración Antolí Cabrera Rafael Burgos Marín Juan Carlos Gámez Granados Francisco Mariano García Torres Teresa Guijarro Granados Pilar Martín Borreguero Eliana Moreno Carolina Pérez-Dueñas María Auxiliadora Romero Balsera Mª Araceli Sánchez Raya José Manuel Soto Hidalgo José Fernando Venceslá Martínez Francisco Javier Jurado González Fátima Cuadrado Hidalgo Mario Gálvez Lara Julia Vacas Ruiz Carmen Espejo Durán Ángel Rodríguez Ramos Judith Velasco Rodríguez