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GC17 Physiopathology of Endocrine Vitamin D System Biotechnology and Aging

Our research group is a consolidated group of the IMIBIC, bringing together clinical and basic research to form the critical mass needed to undertake projects that improve the knowledge and treatment of pathologies associated with human health.

The group’s research falls into two main areas: (1) Stem cells and regenerative medicine; 2) Metabolomics and biomarker identification.

In the first area, our research is focused on studying differentiation of mesenchymal stem cells (MSCs) into osteoblasts and adipocytes and evaluating the way in which this process can be affected by drugs, culture conditions or natural compounds. To this end, our aim is to develop innovative therapeutic strategies to treat pathologies such as osteoporosis, obesity, and diabetes. Our group also includes studies on the mobilization of progenitor cells to improve regenerative capacity in chronically ill patients and the old. In the second area, our research is directed at the search for metabolites that can be used as a diagnostic tool for predicting the likelihood of suffering bone diseases, obesity and age-related bone fragility. Our group also identifies stem cell factors that induce and reactivate the regenerative capacity of tissue. This activity connects the two areas of research.

Our research activity is directed at clinical applications and transferability. Our results have shown the potential of natural compounds for treating pathologies such as osteoporosis and obesity. We recently described the possible application of teriparatide (an anabolic agent used in osteoporosis to promote bone formation) to regenerative medicine and aging. Also deriving from the group’s research activity, a clinical trial is currently being conducted with a new product containing olive leaf extract for healing chronic skin ulcers.

To optimize and expand the research capability of the group, we are collaborating intramurally with IMIBIC groups such as GC13, GC14 and GC21, departments at the University of Cordoba, such as Biochemistry and Molecular Biology and Nursing, groups from the IFAPA Center (Alameda del Obispo), the Faculty of Sports Science at the University of Extremadura, and the Institute of Biomedical Research in A Coruña (INIBIC). Extramurally, our group is also integrated into the Andalusian Research Plan (Code CTS-413), as well as the CIBER for Frailty and Healthy Aging (CIBERFES)  [CB16/10/00501], where we work to find answers and solutions that improve the quality of life of older people, and understanding aging as a process that begins a long time before old age.

As a result of these collaborations, we have received funding for various research projects and published scientific studies.

Research Lines

  • Evaluation of natural or pharmacological compounds for application in human clinical practice in pathologies such as osteoporosis, diabetes or obesity.
  • Functional genomics and associated factors. 

Analysis of factors inducing progenitor cell mobilisation of progenitor cells and their application in regenerative medicine applied to chronic skin healing ulcers in diabetics and the elderly.

  • Metabolomics and proteomics.
  • Identification of biomarkers of bone metabolism and metabolites of the vitamin D endocrine system

Networks

    CIBERFES - CIBER for Frailty and Healthy Aging

    PAIDI CTS-413 Scientific Group - Sistema Endocrino de la Vitamina D. Biotecnología y Envejecimiento

Keywords

  • osteoporosis
  • vitamin D
  • carotenoids
  • fatty acids
  • human mesenchymal stem cells (MSCh) of adult adipocytes
  • osteoblasts
  • polyphenols
  • gene expression
  • proteomics
  • nutrigenetics
  • nutrigenomics
  • endothelial progenitor cells
  • exosomes
  • aging
  • regenerative medicine
  • wound healing
Dr. José Manuel Quesada Gómez
Dr. José Manuel Quesada Gómez

Principal Investigator

Projects

PROJECTS IN 2020

Ongoing projects

National

Antonio Casado Díaz; Efecto de la PTH(1-34) y Vitamina D3 en la movilización de células precursoras endoteliales y su papel en medicina regenerativa aplicada a la cicatrización de úlceras cutáneas en diabéticos; Funding Agency: INSTITUTO DE SALUD CARLOS III; Reference: PI15/01857

José Manuel Quesada Gómez; Caracterización de exosomas derivados de MSC y su efecto combinado con 25 hidroxivitamina D3 e inhibidores de la DPP4 sobre la cicatrización en diabéticos de úlceras cutáneas; Funding Agency: INSTITUTO DE SALUD CARLOS III; Reference: PI18/01659

PROJECTS IN 2019

Ongoing projects

National

Marín Hinojosa, C. Identification of novel therapeutic biomarkers in the progression of intima-media thickness of carotid arteries through on nutritional epigenetics. Funding agency: National Institute of Health Carlos III (ISCIII). Reference: PI15/00733

Quesada Gómez, JM. Effect of the PTH (1-34) and vitamin D3 on mobilization of endothelial precursor cells and their role in regenerative medicine applied to the skin ulcers healing in diabetics. Funding agency: National Institute of Health Carlos III (ISCIII). Reference: PI15/01857

Quesada Gómez, JM. Fragility and Healthy Aging (Ciberfes). Funding agency: National Institute of Health Carlos III (ISCIII). Reference: CB16/10/00501

Casado Díaz, A. Effect of the PTH (1-34) and vitamin D3 on mobilization of endothelial precursor cells and their role in regenerative medicine applied to the skin ulcers healing in diabetics. Funding agency: Fundación Española de investigación ósea y del metabolismo mineral. Reference: FEIOMM2016_001

Quesada Gómez, JM. Caracterización de exosomas derivados de msc y su efecto combinado con 25 hidroxivitamina d3 e inhibidores de la dpp4 sobre la cicatrización en diabéticos de úlceras cutáneas. Funding agency: National Institute of Health Carlos III (ISCIII). Reference: PI18/01659

Publications

Publications in 2020

Castillo ME, Costa LME, Barrios JMV, Diaz JFA, Miranda JL, Bouillon R, Gomez JMQ. Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2020. 203 ():- DOI: 10.1016/j.jsbmb.2020.105751 
IF: 3,813 Q: 2

Camacho-Cardenosa M, Quesada-Gomez JM, Camacho-Cardenosa A, Leal A, Dorado G, Torrecillas-Baena B, Casado-Diaz A. Effects of normobaric cyclic hypoxia exposure on mesenchymal stem-cell differentiation-pilot study on bone parameters in elderly. WORLD JOURNAL OF STEM CELLS. 2020. 12 (12):1667-1690 DOI: 10.4252/wjsc.v12.i12.1667 
IF: 3,231 Q: 3

Casado-Diaz A, Quesada-Gomez JM, Dorado G. Extracellular Vesicles Derived From Mesenchymal Stem Cells (MSC) in Regenerative Medicine: Applications in Skin Wound Healing. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY. 2020. 8 ():- DOI: 10.3389/fbioe.2020.00146 
IF: 3,644 Q: 2

Varela-Eirin M, Carpintero-Fernandez P, Sanchez-Temprano A, Varela-Vazquez A, Paino CL, Casado-Diaz A, Continente AC, Mato V, Fonseca E, Kandouz M, Blanco A, Caeiro JR, Mayan MD. Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and promotes a pro-regenerative environment in osteoarthritis. AGING-US. 2020. 12 (16):15882-15905 DOI: 10.18632/aging.103801
IF: 4,831 Q: 1

Gomez JMQ, Continente AC. The pieces of the ""vitamin"" D puzzle begin to fit: give it to those who need it. NUTRICION HOSPITALARIA. 2020. 37 (1):4-5 DOI: 10.20960/nh.03010 
IF: 0,888 Q: 4

Quesada-Gomez JM, Entrenas-Castillo M, Bouillon R. Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections Revised Ms SBMB 2020_166. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2020. 202 ():- DOI: 10.1016/j.jsbmb.2020.105719 
IF: 3,813 Q: 2

Publications in 2019

Diaz-Tocados JM, Rodriguez-Ortiz ME, Almaden Y, Pineda C, Martinez-Moreno JM, Herencia C, Vergara N, de Mier MVPR, Santamaria R, Rodelo-Haad C, Casado-Diaz A, Lorenzo V, Carvalho C, Frazao JM, Felsenfeld AJ, Richards WG, Aguilera-Tejero E, Rodriguez M, Lo; Calcimimetics maintain bone turnover in uremic rats despite the concomitant decrease in parathyroid hormone concentration. KIDNEY INTERNATIONAL. 2019 May;95(5):1064-1078. doi: 10.1016/j.kint.2018.12.015. 
IF: 8,306 D: 1

Casado-Diaz A, Dorado G, Giner M, Montoya MJ, Navarro-Valverde C, Diez-Perez A, Quesada-Gomez JM; Proof of Concept on Functionality Improvement of Mesenchymal Stem-Cells, in Postmenopausal Osteoporotic Women Treated with Teriparatide (PTH1-34), After Suffering Atypical Fractures. CALCIFIED TISSUE INTERNATIONAL. 2019 Jun;104(6):631-640. doi: 10.1007/s00223-019-00533-0.
IF: 3,265 Q: 2 

Casado-Díaz A, Dorado G, Quesada-Gómez JM. Influence of Olive Oil and Its Components on Mesenchymal Stem Cell Biology. WORDL JOURNAL OF STEM CELLS. 2019 Dec 26;11(12):1045-1064. doi: 10.4252/wjsc.v11.i12.1045.
IF: 3.534

Bouillon R, Quesada-Gomez JM. Calcifediol or vitamin D to optimize vitamin D status: Reply to letter of M Sosas. OSTEOPOROSIS INTERNATIONAL. 2019 Dec;30(12):2521-2522. doi: 10.1007/s00198-019-05164-7.
IF: 1,13 Q: 2

Gomez JMQ, Nogues X, Henriquez MS, Bouillon R; Vitamin D supplementation and musculoskeletal health. A controversial necessity. MEDICINA CLINICA. 2019 Dec 13;153(11):432-436. doi: 10.1016/j.medcli.2019.05.010. 
IF: 1,277 Q:3 

Gomez Q, Henriquez S. Vitamin D and muscle function. REVISTA DE OSTEOPOROSIS Y METABOLISMO MINERAL. 2019;11(1):3-5. doi:10.4321/S1889-836X2019000100001.

Quesada Gómez M, Heureux N. Free vitamin D: an increasing determination. REVISTA DE OSTEOPOROSIS Y METABOLISMO MINERAL. 2019; 11 (1): 30-34. doi: 10.4321/S1889-836X2019000100006.

Publications in 2018

Quesada-Gomez JM, Santiago-Mora R, Duran-Prado M, Dorado G, Pereira-Caro G, Moreno-Rojas JM, Casado-Diaz A. β-Cryptoxanthin Inhibits Angiogenesis in Human Umbilical Vein Endothelial Cells ThroughRetinoic Acid Receptor. MOLECULAR NUTRITION & FOOD RESEARCH. 2018; 62(2): Núm artículo 1700489
IF: 5,151 Q: 1 D: 1

Quesada-Gomez JM, Bouillon R. Is calcifediol better than cholecalciferol for vitamin D supplementation?. OSTEOPOROSIS INTERNATIONAL. 2018; 29(8):1697-1711.
IF: 3,856 Q: 2

Navarro-Valverde C, Caballero-Villarraso J, Mata-Granados JM, Casado-Diaz A, Sosa-Henriquez M, Malouf-Sierra J, Nogues-Solan X, Rodriguez-Manas L, Cortes-Gil X, Delgadillo-Duarte J, Quesada-Gomez JM. High Serum Retinol as a Relevant Contributor to Low Bone Mineral Density in Postmenopausal Osteoporotic Women. CALCIFIED TISSUE INTERNATIONAL. 2018; 102(6):651-656.
IF: 3,293 Q: 2

Roca-Ayats N, Ng PY, Garcia-Giralt N, Falco-Mascaro M, Cozar M, Abril JF, Gomez JMQ, Prieto-Alhambra D, Nogues X, Dunford JE, Russell RG, Baron R, Grinberg D, Balcells S, Diez-Perez A.Functional Characterization of a GGPPS Variant Identified in Atypical Femoral Fracture Patients and Delineation of the Role of GGPPS in Bone-Relevant Cell Types.JOURNAL OF BONE AND MINERAL RESEARCH. 2018; 33(12):2091-2098.
IF: 6,314 Q: 1 D: 1

Nogues X, Nolla JM, Casado E, Jodar E, Munoz-Torres M, Quesada-Gomez JM, Canals L, Balcells M, Lizan L.Spanish consensus on treat to target for osteoporosis. OSTEOPOROSIS INTERNATIONAL. 2018; 29(2):489-499.
IF: 3,856 Q: 2

Navarro-Valverde C, Quesada-Gomez JM, Perez-Cano R, Fernandez-Palacin A, Pastor-Torres LF. Effect of calcifediol treatment on cardiovascular outcomes in patients with acute coronary syndrome and percutaneous revascularization. MEDICINA CLINICA. 2018; 151(9):345-352.
IF: 1,168 Q: 3

Roca-Ayats N, Falco-Mascaro M, Garcia-Giralt N, Cozar M, Abril JF, Duesada-Gomez JM, Prieto-Alhambra D, Nogues X, Mellibovsky L, Diez-Perez A, Grinberg D, Balcells S.Genetic study of atypical femoral fractures using exome sequencing in three affected sisters and three unrelated patients. REVISTA DE OSTEOPOROSIS Y METABOLISMO MINERAL. 2018; 10(4):108-117.

Publications in 2017

Casado-Diaz A, Anter J, Muller S, Winter P, Quesada-Gomez JM, Dorado G. Transcriptomic Analyses of Adipocyte Differentiation From Human Mesenchymal Stromal-Cells (MSC). JOURNAL OF CELLULAR PHYSIOLOGY. 2017.232(4):771-784.
IF: 4,08 Q: 2 

Casado-Diaz A, Tunez-Finana I, Mata-Granados JM, Ruiz-Mendez MV, Dorado G, Romero-Sanchez MC, Navarro-Valverde C, Quesada-Gomez JM. Serum from postmenopausal women treated with a by-product of olive-oil extraction process stimulates osteoblastogenesis and inhibits adipogenesis in human mesenchymal stem-cells (MSC). EXPERIMENTAL GERONTOLOGY. 2017.90():71-78.
IF: 3,34 Q: 1 

Casado-Diaz A, Anter J, Muller S, Winter P, Quesada-Gomez JM, Dorado G. Transcriptomic analyses of the anti-adipogenic effects of oleuropein in human mesenchymal stem cells. FOOD & FUNCTION. 2017.8(3):1254-1270.
IF: 3,247 Q: 1 

Roca-Ayats N, Balcells S, Garcia-Giralt N, Falco-Mascaro M, Martinez-Gil N, Abril JF, Urreizti R, Dopazo J, Quesada-Gomez JM, Nogues X, Mellibovsky L, Prieto-Alhambra D, Dunford JE, Javaid MK, Russell RG, Grinberg D, Diez-Perez A. GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates. NEW ENGLAND JOURNAL OF MEDICINE. 2017.376(18):1794-1795.
IF: 72,406 Q: 1 D: 1

Varsavsky M, Moreno PR, Fernandez AB, Fernandez IL, Gomez JMQ, Rubio VA, Martin AG, Berdonces MC, Cortes SN, Munoz MR, Garcia RR, Gimeno EJ, Torres M en representación del Grupo de Trabajo de Osteoporosis y Metabolismo Mineral de la Sociedad Española de Endocrinología y Nutrición. Recommended vitamin D levels in the general population. ENDOCRINOLOGIA DIABETES Y NUTRICION. 2017.64():7-14.

Clinical Research

Active in 2019

Efecto de la administración de diferentes regímenes de tratamiento de Hidroferol® Cápsulas de Gelatina Blanda (calcifediol) y colecalciferol (Dibase®) en los niveles de 25(OH)D y marcadores de remodelado óseo en mujeres postmenopáusicas con deficiencia de 25(OH)D. Influencia de factores clínicos y genéticos en la población osteoporótica y no-osteoporótica.
PI:  Dr. José Manuel Quesada Gómez

Non-interventional study with Binosto 70 mg effervescent tablets once weekly investigating gastro-int estinal events and medication errors.
PI: Dr. José Manuel Quesada Gómez

Members

Principal Investigator
José Manuel Quesada Gómez

Researcher
Antonio Casado Díaz

Pre-Doctoral Researchers
Ángel Rodríguez Ramos
Bárbara Torrecillas Baena