Research - Research groups - GC05 Systemic and chronic inflammatory autoimmune diseases of the locomotor system and connective tissue

GC05 Systemic and chronic inflammatory autoimmune diseases of the locomotor system and connective tissue

Our team is integrated in the Scientific Program on Chronic and Inflammatory Diseases, oriented to the study of the most relevant chronic processes of the modern society, with special emphasis on those of an inflammatory and autoimmune nature. This area mainly covers the study of chronic inflammatory and systemic autoimmune diseases, cardiovascular diseases, neurological diseases, renal and urological diseases, liver and digestive diseases.

Our research team employs synergistically clinical-therapeutic approaches and cellular and molecular approaches, and has as main objectives to:

Analyze molecular and cellular mechanisms of atherothrombosis development in systemic autoimmune diseases (EAS), and to identify new biomarkers and regulatory mechanisms promoted by new therapeutic approaches.
Analyze the role of the chronic systemic inflammation in the glucose and lipid metabolism in rheumatoid and psoriatic arthritis.
Study of the effects of conventional therapies (DMARDs), new agents (Apremilast) and other biologic drugs (anti-TNFa) on the metabolic syndrome associated with chronic inflammatory diseases.
Record, describe, and analyze clinical, epidemiological, demographic, genetic, radiographic, pathophysiological and of therapeutic response in patients with spondyloarthritis (AS) in Spain.
Design, develop and validate a new system of measurement of mobility (most important expression of structural damage) of AS patients.

Ours research contributes to improved patient care by adding to our knowledge and discovering new biological therapies for e.g. Rheumatoid Arthritis, Spondyloarthritis, or for other Autoimmune Diseases. New biological therapies are selected for patients who do not respond adequately to conventional treatments. The biological therapy helps chronic patients to spend long asymptomatic periods, and to reduce disease outbreaks. This allows better control of these diseases, as well as improved prognosis and quality of life of patients and, therefore, a modern and effective alternative in cases of difficult control of the rheumatologic diseases.

We have long-lasting and wide network of collaborations with researchers at the St. Thomas NHS Foundation Trust (UK), University of Cambridge (UK), IDIVAL, Genyo, University of Murcia, and Center of Research of Immunopathology and Rare Diseases (Italy), among others.

Research Lines

Systemic Autoimmune Diseases

Characterisation of the mechanisms underlying the development of organ damage and cardiovascular disease in Rheumatoid Arthritis , Systemic Lupus Erythematosus and Antiphospholipid Syndrome and the search for new therapeutic alternatives in patients refractory to conventional treatment.
Identification and characterisation of new biomarkers as predictors of response to biological therapies in patients with rheumatoid arthritis with inadequate response to disease-modifying drugs.
This line of research includes the European Innovative Medicines Initiative (IMI 3TR), entitled "Identification of the molecular mechanisms of non-response to treatments, relapses and remission in autoimmune, inflammatory and allergic conditions".
In this project, the GC05 group coordinates all the participating centres of the Andalusian Health System. This study aims to identify in autoimmune, inflammatory and allergic diseases, different molecular patterns that predict response to treatment and disease progression. This project is a continuation of the already completed EU project PRECISESADS, which aimed to reclassify Systemic Autoimmune Diseases using omics and bioinformatics tools and has resulted in several publications in high impact journals.

Metabolic comorbidities associated with chronic inflammatory arthritis

Study of the epigenetic and molecular mechanisms involved in the development of metabolic syndrome associated with rheumatoid arthritis and psoriatic arthritis.
Evaluation of epigenetic changes underlying the development of insulin resistance associated with both pathologies.
Assessment of the effect of conventional immunosuppressive therapies and new drugs on the components of the metabolic syndrome and the molecular mechanisms involved in metabolic alterations in rheumatoid arthritis and psoriatic arthritis

Spondyloarthritis: Analysis of clinical, epidemiological and demographic characteristics and associated comorbidities; identification of new disease biomarkers and their modulation by different therapeutic approaches

Monitoring and full evaluation from a clinical point of view, ultrasound, radiological and assessment of co-morbidities in patients with spondyloarthritis through the creation of the CASTRO cohort (Córdoba AxSpa Task forcé, Registry and Outcomes).
Development and validation of the use of inertial sensors applied to metrology in patients with axial spondyloarthritis as part of the previous development of a computerised motion capture system using artificial vision UCOTRACK, (patent application no.: RPI201399901094447).
Identification of new molecular biomarkers - alternative splicing and microRNAs - involved in the development of atherosclerosis, inflammation and osteoproliferation, as well as the analysis of the beneficial effects of new therapies on these processes.
Determination of the involvement of the intestinal microbiota and intestinal immune barrier in radiographic progression in patients with axial spondyloarthritis and their possible modification after treatment with biologic drugs.
Start-up and development of REGISPON-3. A national project led by the group that has two main objectives: the first is to find out, 17 years later, the clinical evolution, treatment used and disease burden (comorbidities, surgical interventions and disability) of the patients included in the REGISPONSER I-II study (a project also led by the group in 2004-2006). The second objective is to characterise for the first time the complete transcriptomic profile of peripheral blood CD4+ T lymphocytes from these patients by massive RNA sequencing and advanced bioinformatics techniques. In addition, they will try to identify gene signatures associated with clinical features independent of the current diagnosis, which will molecularly classify patients with spondyloarthritis.

Networks

RIER - Research network in inflammation and rheumatic diseases - The Spanish National Institute of Health Carlos III (Instituto de Salud Carlos III)

APS Action International - Antiphospholipid Syndrome Alliance for Clinical Trials & International Networking

PAIDI CTS-1004 Chronic inflammatory diseases of musculoskeletal system and connective tissue (Andalusian Plan for Research, Development and Innovation - PAIDI)

Keywords

autoimmune diseases
spondiloarthropathies
inflammation
atherothrombosis
metabolic syndrome
organ damage
biomarkers
new therapies

Additional Information

Our website: PASIC

Highlighted publications

Perez-Sanchez C, Cecchi I, Barbarroja N, Patino-Trives AM, Luque-Tevar M, Perez-Sanchez L, Ibanez-Costa A, de la Rosa IA, Ortega R, Escudero A, Castro MC, Radin M, Roccatello D, Sciascia S, Aguirre MA, Collantes E, Lopez-Pedrera C. Early restoration of immune and vascular phenotypes in systemic lupus erythematosus and rheumatoid arthritis patients after B cell depletion. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2019. 23. 9. 6308-6318. DOI:10.1111/jcmm.14517. Article; Early Access. IMIBIC GROUPS: GC05
IF:4,658 Q1

Ruiz-Limon P, Ortega-Castro R, Barbarroja N, Perez-Sanchez C, Jamin C, Patino-Trives AM, Luque-Tevar M, Ibanez-Costa A, Perez-Sanchez L, de la Rosa IA, Abalos-Aguilera M, Jimenez-Gomez Y, Calvo-Gutierrez J, Font P, Escudero-Contreras A, Alarcon-Riquelme M. Molecular Characterization of Monocyte Subsets Reveals Specific and Distinctive Molecular Signatures Associated With Cardiovascular Disease in Rheumatoid Arthritis. FRONTIERS IN IMMUNOLOGY. 2019. 10. DOI:10.3389/fimmu.2019.01111. Article. IMIBIC GROUPS: GC05
IF:4,716 Q2

Lopez-Pedrera C, Barbarroja N, Patino-Trives AM, Collantes E, Aguirre MA, Perez-Sanchez C. New Biomarkers for Atherothrombosis in Antiphospholipid Syndrome: Genomics and Epigenetics Approaches. FRONTIERS IN IMMUNOLOGY. 2019. 10. DOI:10.3389/fimmu.2019.00764. Review. IMIBIC GROUPS: GC05
IF:4,716 Q2

Sanmarti R, Veale DJ, Martin-Mola E, Escudero-Contreras A, González C, Ercole L, Alonso R, Fonseca JE; ToSpace Study Group. Reducing or Maintaining the Dose of Subcutaneous Tocilizumab in Patients With Rheumatoid Arthritis in Clinical Remission: A Randomized, Open-Label Trial. Arthritis & Rheumatology. 2019 Oct. Doi: 10.1002/art.40905. Article. IMIBIC GROUPS: GC05
IF:9.002 Q1 D1

Lopez-Isac E, Acosta-Herrera M, Kerick M, Assassi S, Satpathy AT, Granja J, Mumbach MR, Beretta L, Simeon CP, Carreira P, Ortego-Centeno N, Castellvi I, Bossini-Castillo L, Carmona FD, Orozco G, Hunzelmann N, Distler JHW, Franke A, Lunardi C, Moroncini G, Gabrielli A, de Vries-Bouwstra J, Wijmenga C, Koeleman BPC, Nordin A, Padyukov L, Hoffmann-Vold AM, Lie B. European Scleroderma Grp; ASIG: Rios, R; Callejas, JL; Vargas-Hitos, JA; Garcia-Portales, R; Camps, MT; Fernandez-Nebro, A; Gonzalez-Escribano, MF; Garcia-Hernandez, FJ; Castillo, MJ; Aguirre, MA; Gomez-Gracia, I; Fernandez-Gutierrez, B; Rodriguez-Rodriguez, L; de la Pena, PG; Vicente, E; Andreu, JL; de Castro, MF; Lopez-Longo, FJ; Martinez, L; Fonollosa, V; Guillen, A; Espinosa, G; Tolosa, C; Pros, A; Rodriguez-Carballeira, M; Narvaez, FJ; Rubio-Rivas, M; Ortiz-Santamaria, V; Madronero, AB; Gonzalez-Gay, MA; Diaz, B; Trapiella, L; Sousa, A; Egurbide, MV; Fanlo-Mateo, P; Saez-Comet, L; Diaz, F; Hernandez, V; Beltran, E; Roman-Ivorra, JA; Grau, E; Alegre-Sancho, JJ; Freire, M; Blanco-Garcia, FJ; Oreiro, N; Witte, T; Kreuter, A; Riemekasten, G; Airo, P; Magro, C; Voskuyl, AE; Vonk, MC; Hesselstrand, R; Proudman, S; Stevens, W; Nikpour, M; Zochling, J; Sahhar, J; Roddy, J; Nash, P; Tymms, K; Rischmueller, M; Lester, S; Vyse, T; Herrick, AL; Worthington, J; Denton, CP; Allanore, Y; Brown, MA; Radstake, TRDJ; Fonseca, C; Chang, HY; Mayes, MD; Martin, JGWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. Nature Communications. 2019 Oct 31. Doi: 10.1038/s41467-019-12760-y. Article.IMIBIC GROUPS: GC05
IF:11.878 Q1 D1

Cecchi I, Arias de la Rosa I, Menegatti E, et al. Neutrophils: Novel key players in Rheumatoid Arthritis. Current and future therapeutic targets. Autoimmun Rev. 2018 Nov;17(11):1138-1149. doi: 10.1016/j.autrev.2018.06.006. Epub 2018 Sep 11. Review.

Del Rio C, Cantarero I, Palomares B, Gómez-Cañas M, et al. VCE-004.3, a cannabidiol aminoquinone derivative, prevents bleomycin-induced skin fibrosis and inflammation through PPARγ- and CB2 receptor-dependent pathways. Br J Pharmacol. 2018 Oct;175(19):3813-3831. doi: 10.1111/bph.14450. Epub 2018 Aug 23.

Pérez-Sánchez C, Arias-de la Rosa I, Aguirre MÁ, et al. Circulating microRNAs as biomarkers of disease and typification of the atherothrombotic status in antiphospholipid syndrome. Haematologica. 2018 May;103(5):908-918. doi: 10.3324/haematol.2017.184416. Epub 2018 Mar 15.

Arias de la Rosa I, Escudero-Contreras A, Rodríguez-Cuenca S, et al. Defective glucose and lipid metabolism in rheumatoid arthritis is determined by chronic inflammation in metabolic tissues. J Intern Med. 2018 Jul;284(1):61-77. doi: 10.1111/joim.12743. Epub 2018 Mar 12.

Perez-Sanchez C, Font-Ugalde P, Ruiz-Limon P, et al. Circulating microRNAs as potential biomarkers of disease activity and structural damage in ankylosing spondylitis patients. Hum Mol Genet. 2018 Mar 1;27(5):875-890. doi: 10.1093/hmg/ddy008.

Pérez-Sánchez C, Aguirre MÁ, Ruiz-Limón P, et al. Ubiquinol Effects on Antiphospholipid Syndrome Prothrombotic Profile: A Randomized, Placebo-Controlled Trial. Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1923-1932. doi: 10.1161/ATVBAHA.117.309225. Epub 2017 Jul 6.

Pérez-Sánchez C, Ruiz-Limón P, Aguirre MA, et al. Diagnostic potential of NETosis derived products for disease activity, atherosclerosis and therapeutic effectiveness in Rheumatoid Arthritis patients. J Autoimmun. 2017 Aug;82:31-40. doi: 10.1016/j.jaut.2017.04.007. Epub 2017 Apr 29

Pérez-Sánchez C, Aguirre MA, Ruiz-Limón P, et al. Atherothrombosis associated microRNAs in Antiphospholipid syndrome and Systemic Lupus erythematosus patients. Sci Rep. 2016 Aug 9;6:31375. doi: 10.1038/srep31375

Ruiz-Limón P, Ortega R, Arias de la Rosa I, et al. Tocilizumab improves the proatherothrombotic profile of rheumatoid arthritis patients modulating endothelial dysfunction, NETosis and inflammation. Transl Res. 2017 May;183:87-103. doi: 10.1016/j.trsl.2016.12.003. Epub 2016 Dec 9

Castro-Villegas C, Pérez-Sánchez C, Escudero A, et al. Circulating miRNAs as potential biomarkers of therapy effectiveness in Rheumatoid Arthritis patients treated with antiTNFα. Arthritis Res Ther. 2015 Mar 9;17:49. doi: 10.1186/s13075-015-0555-z.

Perez-Sanchez C, Barbarroja N, Messineo S, et al. Gene profiling reveals specific molecular pathways in the pathogenesis of atherosclerosis and cardiovascular disease in antiphospholipid syndrome, systemic lupus erythematosus and antiphospholipidsyndrome with lupus. Ann Rheum Dis. 2015 Jul;74(7):1441-9. doi: 10.1136/annrheumdis-2013-204600. Epub 2014 Mar 11

Ruiz-Limon P, Barbarroja N, Perez-Sanchez C, et al. Atherosclerosis and cardiovascular disease in systemic lupus erythematosus: effects of in vivo statin treatment. Ann Rheum Dis. 2015 Jul;74(7):1450-8. doi: 10.1136/annrheumdis-2013-204351. Epub 2014 Mar 21

Barbarroja N, Pérez-Sanchez C, Ruiz-Limon P, et al. Anticyclic citrullinated protein antibodies are implicated in the development of cardiovascular disease in rheumatoid arthritis. Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2706-16. doi: 10.1161/ATVBAHA.114.304475. Epub 2014 Sep 25

Perez-Sanchez C, Ruiz-Limon P, Aguirre MA, et al. Mitochondrial dysfunction in Antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q10 treatment. Blood. 2012 Jun 14;119(24):5859-70. doi: 10.1182/blood-2011-12-400986. Epub 2012 Apr 23.

López-Pedrera C, Ruiz-Limón P, Aguirre MÁ, et al. Global effects of fluvastatin on the prothrombotic status of patients with antiphospholipid syndrome. Ann Rheum Dis. 2011 Apr;70(4):675-82. doi: 10.1136/ard.2010.135525. Epub 2010 Dec 20.

Patents

Título propiedad industrial registrada: Método de obtención de datos útiles para el diagnóstico, estratificación y/o seguimiento de pacientes con artritis reumatoide.
Inventores/autores/obtentores: Rosario López Pedrera; Raul Luque Huertas, Carlos Perez-Sanchez, Eduardo Collantes Estevez, Rafaela Ortega Castro, Justo Pastor Castaño Fuentes, Alejandro Ibañez Costa, Sergio Pedraza Arevalo, Mercedes del Rio Moreno, Nuria Barbarroja Puerto, Yolanda Jimenez Gomez.
Entidad titular de derechos: Servicio Andaluz de Salud y Universidad de Córdoba.
Nº de solicitud: P201930123.
País de inscripción: España, Andalucía.
Fecha de registro: 15/02/2019

Título propiedad industrial registrada: MiRNAs circulantes como biomarcadores del Síndrome Antifosfolípido Primario.
Inventores/autores/obtentores: Rosario López Pedrera; María Ángeles Aguirre Zamorano; Eduardo Collantes Estévez; Nuria Barbarroja Puerto; Carlos Pérez Sánchez; Yolanda Jiménez Gómez.
Entidad titular de derechos: Servicio Andaluz de Salud, Universidad de Córdoba.
Nº de solicitud: P201630725.
País de inscripción: España, Andalucía.
Fecha de registro: 01/06/2016

Título propiedad industrial registrada: MiRNAs como biomarcadores para el diagnóstico de cáncer de pulmón.
Inventores/autores/obtentores: Antonio Rodríguez Ariza, Rosario López Pedrera; Nuria Barbarroja Puerto; Carlos Pérez Sánchez.
Entidad titular de derechos: Servicio Andaluz de Salud, Universidad de Córdoba.
Nº de solicitud: P201630628.
País de inscripción: España, Andalucía.
Fecha de registro: 13/03/2016.

Título propiedad industrial registrada: MiRNAs circulantes como biomarcadores de efectividad terapéutica en pacientes con Artritis Reumatoide tratados con anti-TNFalpha.
Inventores/autores/obtentores: Rosario López Pedrera; Carlos Pérez Sánchez; Carmen Castro Villegas; Eduardo Collantes Estévez; Nuria Barbarroja Puerto; Patricia Ruiz Limón; Yolanda Jiménez Gómez
Entidad titular de derechos: Fundación Progreso y Salud.
Nº de solicitud: EP14382178.3.
País de inscripción: España, Andalucía.
Fecha de registro: 22/05/2014.

Título propiedad industrial registrada: Dispositivo y métodos de captura y análisis de movimiento.
Inventores/autores/obtentores: Eduardo Collantes Estévez, Juan Luis Garrido Castro
Entidad titular de derechos: Servicio Andaluz de Salud, Universidad de Córdoba.
Nº de solicitud: RPI201399901094447.
País de inscripción: España, Andalucía.
Fecha de registro: 08/10/2013.

Título propiedad industrial registrada: Dispositivo y métodos de captura y análisis de movimiento UCOTRACK.
Inventores/autores/obtentores: Eduardo Collantes Estévez, Juan Luis Garrido Castro
Entidad titular de derechos: Servicio Andaluz de Salud, Universidad de Córdoba.
Nº de solicitud: P201130413.
País de inscripción: España, Andalucía.
Fecha de registro: 22/03/2011.

Relevant projects

Identification of the Molecular Mechanisms of non-response to Treatments, Relapses and Remission in Autoimmune, Inflammatory, and Allergic Conditions. 3TR.

Implicación de la microbiota intestinal en la progresión radiográfica en pacientes con Espondiloartritis axial. PI19/00701

Desarrollo y validación del uso de sensores inerciales aplicados a la metrología de pacientes con espondiloartritis axial.. Funding agency: Institute Carlos III Health (ISCIII). Reference: DTS18/00046. 2019-2021

Identification of the molecular heterogeneity associated with cardiovascular disease, clinical evolution and therapeutic response in systemic autoimmune pathologies. PI18/00837. 2019-2021.

Study of the epigenetic mechanisms involved in the development of insulin resistance and obesity associated with rheumatoid arthritis and psoriatic arthritis Funding agency: Institute Carlos III Health (ISCIII). PI17/01316. 2018-2020.

Molecular reclassification to find clinically useful biomarkers for systemic autoinmunediseases (PRECISESADS) IMI 15565. 2014-2019.

Dra. Rosario López Pedrera

Principal Investigator

Dr. Eduardo Collantes Estévez

Co-Principal Investigator

Projects

PROJECTS IN 2020

Ongoing projects

Regional

Eduardo Collantes Estévez; Microbiota Intestinal: Impacto en la etiopatogénesis de la espondiloartritis axial radiográfica. Nuevas aproximaciones terapéuticas; Funding Agency: CONSEJERÍA DE TRANSFORMACIÓN ECONÓMICA, INDUSTRIA, CONOCIMIENTO Y UNIVERSIDADES; Reference: 1261147-R

Eduardo Collantes Estévez; Nuevos Mecanismos de Regulación Génica Post-Transcripcional Involucrados en la Patogenia de la Espondilitis Anquilosante (Ea): Micrornas y Splicing Alternativo. Nuevas Aproximaciones Terapéuticas.; Funding Agency: CONSEJERÍA DE SALUD Y FAMILIAS; Reference: PI-0139-2017

María Ángeles Aguirre Zamorano; Identificacion y Caracterizacion de Nuevos Biomarcadores Como Predictores de Respuesta A Terapias Biologicas en la Artritis Reumatoide; Funding Agency: CONSEJERÍA DE SALUD Y FAMILIAS; Reference: PI-0285-2017

Francisco Alburquerque Sendín; Evaluación Clinimétrica de Los Sensores Inerciales de Movimiento en la Columna Cervical de Pacientes Con Parálisis Cerebral: Validez, Fiabilidad y Patrones de Comportamiento; Funding Agency: CONSEJERÍA DE SALUD Y FAMILIAS; Reference: PI-0324-2017

Nacional

Eduardo Collantes Estévez; Desarrollo y validación del uso de sensores inerciales aplicados a la metrología de pacientes con espondiloartritis axial.; Funding Agency: INSTITUTO DE SALUD CARLOS III; Reference: DTS18/00046

Nuria Barbarroja Puerto; Estudio de los mecanismos epigeneticos involucrados en el desarrollo de resistencia a la insulina y obesidad asociadas a la artritis reumatoide y la artritis psoriasica; Funding Agency: INSTITUTO DE SALUD CARLOS III; Reference: PI17/01316

Rosario López Pedrera; Identificación de la heterogeneidad molecular asociada a la enfermedad cardiovascular, la evolución clínica y la respuesta terapeútica en patologías autoinmunes sistémicas.; Funding Agency: INSTITUTO DE SALUD CARLOS III; Reference: PI18/00837

Eduardo Collantes Estévez; Implicación de la microbiota intestinal en la progresión radiográfica en pacientes con Espondiloartritis axial.; Funding Agency: INSTITUTO DE SALUD CARLOS III; Reference: PI19/00701

International

Eduardo Collantes Estévez; Can Inertial Movement Sensors (IMUs) provide a valid and reliable way of measuring Spinal Mobility in Axial Spondyloarthritis (axSpa): a Clinimetric Evaluation; Funding Agency: FOUNDATION FOR RESEARCH IN RHEUMATOLOGY; Reference: FOREUM-2015-001

Eduardo Collantes Estévez; 3TR - Identification of the Molecular Mechanisms of non-response to Treatments, Relapses and Remission in Autoimmune, Inflammatory, and Allergic Conditions; Funding Agency: COMISIÓN EUROPEA; Reference: IMI2-2018-14-01-F2

Nuria Barbarroja Puerto; Impact of Jack-Stat inhibition of the metabolic syndrome and cardiovascular risk associated with rheumatoid arthritis; Funding Agency: PFIZER, S.A; Reference: Pfizer-ISR-2019-01

PROJECTS IN 2019

Ongoing projects

Regional

Jiménez Gómez, Y. Nuevos Mecanismos de Regulación Génica Post-Transcripcional Involucrados en la Patogenia de la Espondilitis Anquilosante (Ea): Micrornas y Splicing Alternativo. Nuevas AproximacionesTerapéuticas. Funding agency: Regional Ministry of Equality, Health and Social Policies (CISPS). Reference: PI-0139-2017

Aguirre Zamorano, Mª A. Identificación y Caracterización de Nuevos Biomarcadores Como Predictores de Respuesta A Terapias Biologicas en la Artritis Reumatoide. Funding agency: Regional Ministry of Equality, Health and Social Policies (CISPS). Reference: PI-0285-2017

Alburquerque Sendín, F. Evaluación Clinimétrica de Los Sensores Inerciales de Movimiento en la Columna Cervical de Pacientes Con Parálisis Cerebral: Validez, Fiabilidad y Patrones de Comportamiento. Funding agency: Regional Ministry of Equality, Health and Social Policies (CISPS). Reference: PI-0324-2017

National

Collantes Estévez, E. Implicación de la microbiota intestinal en la progresión radiográfica en pacientes con Espondiloartritis axial. PI19/00701

Lopez Pedrera, R. Identification of the molecular heterogeneity associated with cardiovascular disease, clinical evolution and therapeutic response in systemic autoimmune pathologies. PI18/00837

Collantes Estevez, E. Spanish Network for Research in inflammation and rheumatic disease (RIER). Funding agency: Institute Carlos III Health (ISCIII). Reference: RD16/0012/0015

Barbarroja Puerto, N – Escudero Contreras, A. Study of the epigenetic mechanisms involved in the development of insulin resistance and obesity associated with rheumatoid arthritis and psoriatic arthritis Funding agency: Institute Carlos III Health (ISCIII). Reference: PI17/01316

Collantes Estevez, E. Development and validation of the use of inertial sensors applied to the metrology of patients with axial spondyloarthritis. Funding agency: Institute Carlos III Health (ISCIII). Reference: DTS18/00046

International

Collantes Estevez, E. Can Inertial Movement Sensors (IMUs) provide a valid and reliable way of measuring Spinal Mobility in Axial Spondyloarthritis (axSpa): a Clinimetric Evaluation. Funding Agency: Foundation for Research in Rheumatology. Reference: FOREUM-2015-001

Collantes Estevez, E. 3TR - Identification of the Molecular Mechanisms of non-response to Treatments, Relapses and Remission in Autoimmune, Inflammatory, and Allergic Conditions. General coordinator: Marta Alarcón-Riquelme, FPS. Financial entity: Innovative Medicined Initiative (IMI) – EU + EFPIA. Reference: 831434. Duration: 01/09/2019-31/08/2026. Budget IMIBIC: 900.000 € (Collaborative project, global Budget: 80 million €)

Publications

Publications in 2020

Vazquez-Borrego MC, Gupta V, Ibanez-Costa A, Gahete MD, Venegas-Moreno E, Toledano-Delgado A, Cano DA, Blanco-Acevedo C, Ortega-Salas R, Japon MA, Barrera-Martin A, Vasiljevic A, Hill J, Zhang SW, Halem H, Solivera J, Raverot G, Galvez MA, Soto-Moreno A, . A Somatostatin Receptor Subtype-3 (SST3) Peptide Agonist Shows Antitumor Effects in Experimental Models of Nonfunctioning Pituitary Tumors. CLINICAL CANCER RESEARCH. 2020. 26 (4):957-969 DOI: 10.1158/1078-0432.CCR-19-2154
IF: 10,107 Q: 1

do Nascimento JDS, Alburquerque-Sendin F, Vigolvino LP, de Oliveira WF, Sousa CD. Absolute and Relative Reliability of Pressure Pain Threshold Assessments in the Shoulder Muscles of Participants With and Without Unilateral Subacromial Impingement Syndrome. JOURNAL OF MANIPULATIVE AND PHYSIOLOGICAL THERAPEUTICS. 2020. 43 (1):57-67 DOI: 10.1016/j.jmpt.2019.04.002
IF: 1,23 Q: 3

Zafra M, Uceda P, Munoz-Luna F, Munoz-Lopez RC, Font P. Arthroscopic repair of partial-thickness articular surface rotator cuff tears: single-row transtendon technique versus double-row suture bridge (transosseous equivalent) fixation: results from a prospective randomized study. ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY. 2020. 140 (8):1065-1071 DOI: 10.1007/s00402-020-03387-6
IF: 2,021 Q: 2

Ladehesa-Pineda ML, de la Rosa IA, Medina CL, Castro-Villegas MD, Abalos-Aguilera MD, Ortega-Castro R, Gomez-Garcia I, Segui-Azpilcueta P, Jimenez-Gomez Y, Escudero-Contreras A, Pedrera CL, Barbarroja N, Collantes-Estevez E. Assessment of the relationship between estimated cardiovascular risk and structural damage in patients with axial spondyloarthritis. THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE. 2020. 12 ():- DOI: 10.1177/1759720X20982837
IF: 5,043 Q: 1

Haik MN, Alburquerque-Sendin F, Fernandes RAS, Kamonseki DH, Almeida LA, Liebano RE, Camargo PR. Biopsychosocial Aspects in Individuals with Acute and Chronic Rotator Cuff Related Shoulder Pain: Classification Based on a Decision Tree Analysis. DIAGNOSTICS. 2020. 10 (11):- DOI: 10.3390/diagnostics10110928
IF: 3,11 Q: 1

Ruiz-Villaverde R, Galan-Gutierrez M, Armario-Hita JC, Ruiz-Carrascosa JC, Font-Ugalde P. Brodalumab: short-term effectiveness and safety in real clinical practice. INTERNATIONAL JOURNAL OF DERMATOLOGY. 2020. 59 (9):E340-E341 DOI: 10.1111/ijd.14866
IF: 2,067 Q: 3

Cecchi I, Perez-Sanchez C, Sciascia S, Radin M, de la Rosa IA, Puerto NB, Scudeler L, Perez-Sanchez L, Trives AMP, Zamorano MAA, Menegatti E, Roccatello D, Lopez-Pedrera C. Circulating microRNAs as potential biomarkers for monitoring the response to in vivo treatment with Rituximab in systemic lupus erythematosus patients. AUTOIMMUNITY REVIEWS. 2020. 19 (4):- DOI: 10.1016/j.autrev.2020.102488
IF: 7,767 Q: 1

Zuily S, Clerc-Urmes I, Bauman C, Andrade D, Sciascia S, Pengo V, Tektonidou MG, Ugarte A, Gerosa M, Belmont HM, Zamorano MAA, Fortin P, Ji LL, Efthymiou M, Cohen H, Branch DW, de Jesus GR, Nalli C, Petri M, Rodriguez E, Cervera R, Knight JS, Atsumi T, Wi. Cluster analysis for the identification of clinical phenotypes among antiphospholipid antibody-positive patients from the APS ACTION Registry. LUPUS. . 29 (11):1353-1363 DOI: 10.1177/0961203320940776
IF: 2,251 Q: 3

Lopez-Medina C, Molto A. Comorbid pain in axial spondyloarthritis, including fibromyalgia. THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE. 2020. 12 ():- DOI: 10.1177/1759720X20966123
IF: 5,043 Q: 1

de la Rosa IA, Font P, Escudero-Contreras A, Lopez-Montilla MD, Perez-Sanchez C, Abalos-Aguilera MC, Ladehesa-Pineda L, Ibanez-Costa A, Torres-Granados C, Jimenez-Gomez Y, Patino-Trives A, Luque-Tevar M, Castro-Villegas MC, Calvo-Gutierrez J, Ortega-Castro R, Lopez-Pedrera C, Collantes-Estevez E, Barbarroja N. Complement component 3 as biomarker of disease activity and cardiometabolic risk factor in rheumatoid arthritis and spondyloarthritis. THERAPEUTIC ADVANCES IN CHRONIC DISEASE. 2020. 11 ():- DOI: 10.1177/2040622320965067
IF: 3,257 Q: 1

Carmona-Perez C, Garrido-Castro JL, Vidal FT, Alcaraz-Clariana S, Garcia-Luque L, Alburquerque-Sendin F, Priscila Rodrigues-de-Souza D. Concurrent Validity and Reliability of an Inertial Measurement Unit for the Assessment of Craniocervical Range of Motion in Subjects with Cerebral Palsy. DIAGNOSTICS. 2020. 10 (2):- DOI: 10.3390/diagnostics10020080
IF: 3,11 Q: 1

Dantas LO, Jorge AES, Serrao PRMD, Aburquerque-Sendin F, Salvini TD. Cryotherapy associated with tailored land-based exercises for knee osteoarthritis: a protocol for a double-blind sham-controlled randomised trial. BMJ OPEN. 2020. 10 (6):- DOI: 10.1136/bmjopen-2019-035610
IF: 2,496 Q: 2

Carmona-Perez C, Perez-Ruiz A, Garrido-Castro JL, Vidal FT, Alcaraz-Clariana S, Garcia-Luque L, Rodrigues-de-Souza DP, Alburquerque-Sendin F. Design, Validity, and Reliability of a New Test, Based on an Inertial Measurement Unit System, for Measuring Cervical Posture and Motor Control in Children with Cerebral Palsy. DIAGNOSTICS. 2020. 10 (9):- DOI: 10.3390/diagnostics10090661
IF: 3,11 Q: 1

Garrido-Cumbrera M, Chacon-Garcia J, Navarro-Compan V, Gratacos J, Sanz-Gomez S, Collantes-Estevez E. Does Belonging to a Patient Association Is of Help for Patients with Axial Spondyloarthritis? Results from the Atlas Survey. CURRENT RHEUMATOLOGY REPORTS. 2020. 22 (6):- DOI: 10.1007/s11926-020-00897-5
IF: 3,873 Q: 2

Ruiz-Villaverde R, Galan-Gutierrez M, Armario-Hita JC, Ruiz-Carrascosa JC, Font-Ugalde P. Does obesity prevent occurrence of genital ulcers in women with Behcet's disease? A striking observation in 17 consecutive patients. INTERNATIONAL JOURNAL OF DERMATOLOGY. 2020. 59 (9):E341-E342 DOI: 10.1111/ijd.14992
IF: 2,067 Q: 3

Lopez-Pedrera C, Barbarroja N, Patino-Trives AM, Luque-Tevar M, Collantes-Estevez E, Escudero-Contreras A, Perez-Sanchez C. Effects of Biological Therapies on Molecular Features of Rheumatoid Arthritis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020. 21 (23):- DOI: 10.3390/ijms21239067
IF: 4,556 Q: 1

Ruiz-Limon P, Ladehesa-Pineda ML, Castro-Villegas MD, Abalos-Aguilera MD, Lopez-Medina C, Lopez-Pedrera C, Barbarroja N, Espejo-Peralbo D, Gonzalez-Reyes JA, Villalba JM, Perez-Sanchez C, Escudero-Contreras A, Collantes-Estevez E, Font-Ugalde P, Jimenez-G. Enhanced NETosis generation in radiographic axial spondyloarthritis: utility as biomarker for disease activity and anti-TNF-alpha therapy effectiveness. JOURNAL OF BIOMEDICAL SCIENCE. 2020. 27 (1):- DOI: 10.1186/s12929-020-00634-1
IF: 5,762 Q: 1

Beretta L, Barturen G, Vigone B, Bellocchi C, Hunzelmann N, De Langhe E, Cervera R, Gerosa M, Kovacs L, Castro RO, Almeida I, Cornec D, Chizzolini C, Pers JO, Makowska Z, Lesche R, Kerick M, Alarcon-Riquelme ME, Martin J. Genome-wide whole blood transcriptome profiling in a large European cohort of systemic sclerosis patients. ANNALS OF THE RHEUMATIC DISEASES. 2020. 79 (9):1218-1226 DOI: 10.1136/annrheumdis-2020-217116
IF: 16,102 Q: 1 D: 1

Lopez-Medina C, Castro-Villegas MC, Collantes-Estevez E. Hip and Shoulder Involvement and Their Management in Axial Spondyloarthritis: a Current Review. CURRENT RHEUMATOLOGY REPORTS. 2020. 22 (9):- DOI: 10.1007/s11926-020-00930-7
IF: 3,873 Q: 2

Aranda-Valera IC, Garrido-Castro JL, Ladehesa-Pineda L, Vazquez-Mellado J, Zarco P, Juanola X, Gonzalez-Navas C, Font-Ugalde P, Castro-Villegas MC. How to calculate the ASDAS based on C-reactive protein without individual questions from the BASDAI: the BASDAI-based ASDAS formula. RHEUMATOLOGY. 2020. 59 (7):1545-1549 DOI: 10.1093/rheumatology/kez480
IF: 5,606 Q: 1

de la Rosa IA, Perez-Sanchez C, Ruiz-Limon P, Patino-Trives A, Torres-Granados C, Jimenez-Gomez Y, Abalos-Aguilera MD, Cecchi I, Ortega R, Caracuel MA, Calvo-Gutierrez J, Escudero-Contreras A, Collantes-Estevez E, Lopez-Pedrera C, Barbarroja N. Impaired microRNA processing in neutrophils from rheumatoid arthritis patients confers their pathogenic profile. Modulation by biological therapies. HAEMATOLOGICA. 2020. 105 (9):2250-2261 DOI: 10.3324/haematol.2018.205047
IF: 7,116 Q: 1 D: 1

Belizna C, Meroni PL, Shoenfeld Y, Devreese K, Alijotas-Reig J, Esteve-Valverde E, Chighizola C, Pregnolato F, Cohen H, Fassot C, Mattera PM, Peretti P, Levy A, Bernard L, Saiet M, Lagarce L, Briet M, Riviere M, Pellier I, Gascoin G, Rakotonjanahary J, Bo. In utero exposure to Azathioprine in autoimmune disease. Where do we stand?. AUTOIMMUNITY REVIEWS. 2020. 19 (9):- DOI: 10.1016/j.autrev.2020.102525
IF: 7,767 Q: 1

Rodrigues-de-Souza DP, Paz-Vega J, Fernandez-de-las-Penas C, Cleland JA, Alburquerque-Sendin F. Is Irritable Bowel Syndrome Considered in Clinical Trials on Physical Therapy Applied to Patients with Temporo-Mandibular Disorders? A Scoping Review. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2020. 17 (22):- DOI: 10.3390/ijerph17228533
IF: 2,849 Q: 1

Garcia-Magallon B, Castro-Villegas C, Rosello-Pardo R, Salvador-Olivan JA, Navarro-Compan V. Is the new ASDAS nomenclature in agreement with therapeutic decision making in patients with axial spondyloarthritis?. SEMINARS IN ARTHRITIS AND RHEUMATISM. 2020. 50 (5):854-857 DOI: 10.1016/j.semarthrit.2020.07.10
IF: 4,751 Q: 1

Aranda-Valera IC, Cuesta-Vargas A, Garrido-Castro JL, Gardiner PV, Lopez-Medina C, Machado PM, Condell J, Connolly J, Williams JM, Munoz-Esquivel K, O'Dwyer T, Castro-Villegas MC, Gonzalez-Navas C, Collantes-Estevez E. Measuring Spinal Mobility Using an Inertial Measurement Unit System: A Validation Study in Axial Spondyloarthritis. DIAGNOSTICS. 2020. 10 (6):- DOI: 10.3390/diagnostics10060426
IF: 3,11 Q: 1

Sanchez-Maldonado JM, Martinez-Bueno M, Canhao H, ter Horst R, Munoz-Pena S, Moniz-Diez A, Rodriguez-Ramos A, Escudero A, Sorensen SB, Hetland ML, Ferrer MA, Glintborg B, Filipescu I, Perez-Pampin E, Conesa-Zamora P, Garcia A, den Broeder A, De Vita S, Ja. NFKB2 polymorphisms associate with the risk of developing rheumatoid arthritis and response to TNF inhibitors: Results from the REPAIR consortium. SCIENTIFIC REPORTS. 2020. 10 (1):- DOI: 10.1038/s41598-020-61331-5
IF: 3,998 Q: 1

Michelena X, Lopez-Medina C, Marzo-Ortega H. Non-radiographic versus radiographic axSpA: what's in a name?. RHEUMATOLOGY. 2020. 59 ():18-24 DOI: 10.1093/rheumatology/keaa422
IF: 5,606 Q: 1

Bote SM, Martinez NP, Amarilla CE, Ugalde PF, Gonzalez-Bermejo J, Collado NF, Gamez BJ. Overnight Pulse Oximetry to Determine Prognostic Factors in Subjects With Amyotrophic Lateral Sclerosis. RESPIRATORY CARE. 2020. 65 (8):1128-1134 DOI: 10.4187/respcare.07154
IF: 2,066 Q: 3

Jorge AES, Dantas LO, Serrao PRMS, Alburquerque-Sendin F, Salvini TF. Photobiomodulation therapy associated with supervised therapeutic exercises for people with knee osteoarthritis: a randomised controlled trial protocol. BMJ OPEN. 2020. 10 (6):- DOI: 10.1136/bmjopen-2019-035711
IF: 2,496 Q: 2

Cano-Garcia L, Mena-Vazquez N, Arija SM, Hernandez-Sanchez MD, Segura-Ruiz R, Dominguez-Quesada C, Fernandez-Nebro A. Psychological factors associated with sleep disorders in patients with axial spondyloarthritis or psoriatic arthritis: A multicenter cross-sectional observational study. JOURNAL OF CLINICAL NURSING. 2021. 30 (44228):266-275 DOI: 10.1111/jocn.15546
IF: 1,972 Q: 1

Arevalo M, Lopez-Medina C, Martinez-Losa MM, Molto A, Font P, Collantes-Estevez E, Gratacos J. Role of HLA-B27 in the comorbidities observed in Axial Spondyloarthritis: Data from COMOSPA. JOINT BONE SPINE. 2020. 87 (5):445-448 DOI: 10.1016/j.jbspin.2020.03.012
IF: 3,741 Q: 2

Lopez-Pedrera C, Barbarroja N, Patino-Trives AM, Luque-Tevar M, Torres-Granados C, Aguirre-Zamorano MA, Collantes-Estevez E, Perez-Sanchez C. Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune Disorders. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020. 21 (6):- DOI: 10.3390/ijms21062012
IF: 4,556 Q: 1

Aranda-Valera IC, de la Rosa IA, Roldan-Molina R, Abalos-Aguilera MD, Torres-Granados C, Patino-Trives A, Luque-Tevar M, Ibanez-Costa A, Guzman-Ruiz R, Malagon MD, Escudero-Contreras A, Lopez-Pedrera C, Collantes-Estevez E, Barbarroja N. Subclinical cardiovascular risk signs in adults with juvenile idiopathic arthritis in sustained remission. PEDIATRIC RHEUMATOLOGY. 2020. 18 (1):- DOI: 10.1186/s12969-020-00448-3
IF: 2,595 Q: 1

Sciascia S, Cecchi I, Massara C, Rossi D, Radin M, Ladehesa PL, Guinazu F, Rubini E, Foddai SG, Alba P, Escudero A, Menegatti E, Roccatello D. Thermography in systemic sclerosis patients and other rheumatic diseases: Diagnosis, disease activity assessment, and therapeutic monitoring. AUTOIMMUNITY REVIEWS. 2020. 19 (2):- DOI: 10.1016/j.autrev.2019.102449
IF: 7,767 Q: 1

Calixtre LB, Oliveira AB, Alburquerque-Sendin F, Armijo-Olivo S. What is the minimal important difference of pain intensity, mandibular function, and headache impact in patients with temporomandibular disorders? Clinical significance analysis of a randomized controlled trial. MUSCULOSKELETAL SCIENCE AND PRACTICE. 2020. 46 ():- DOI: 10.1016/j.msksp.2020.102108
IF: 1,911 Q: 2

Publications in 2019

Publications in 2018

López-Mejías R, Carmona FD, Genre F, et al. A genome-wide association study identifies a 3'UTR genetic variant of RARB associated with carotid intima-media thickness in rheumatoid arthritis. Arthritis Rheumatol. 2018 Sep 24. doi: 10.1002/art.40734.
IF: 7.873 Q:1 D: 1

Lopez-Medina C, Garrido-Castro JL, Castro-Jimenez J, Gonzalez-Navas C, Calvo-Gutierrez J, Castro-Villegas MC, Ortega-Castro R, Escudero-Contreras A, Font-Ugalde P, Collantes-Estevez E. Evaluation of quality of life in patients with axial spondyloarthritis and its association with disease activity, functionality, mobility, and structural damage. CLINICAL RHEUMATOLOGY. 2018; 37(6):1581-1588.
IF: 2,141 Q: 3

Arevalo M, Masmitja JG, Moreno M, Calvet J, Orellana C, Ruiz D, Castro C, Carreto P, Larrosa M, Collantes E, Font P. Influence of HLA-B27 on the Ankylosing Spondylitis phenotype: results from the REGISPONSER database. ARTHRITIS RESEARCH & THERAPY. 2018; 20:Núm artículo 221
IF: 4,269 Q: 2

Lopez-Medina C, Jimenez-Gomez Y, Molto A, Schiotis RE, Marzo-Ortega H, van Gaalen FA, Ozgocmen S, Dougados M, Calvo-Gutierrez J, Castro-Villegas MC, Collantes-Estevez E, Font-Ugalde P. Cardiovascular risk factors in patients with spondyloarthritis from Northern European and Mediterranean countries: An ancillary study of the ASAS-COMOSPA project. JOINT BONE SPINE. 2018; 85(4):447-453.
IF: 3,304 Q: 2

Lopez-Medina C, Molto A. Update on the epidemiology, risk factors, and disease outcomes of axial spondyloarthritis. BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY.2018; 32(2):241-253.
IF: 3,198 Q: 2

Martin-Varillas JL, Calvo-Rio V, Beltran E, Sanchez-Burson J, Mesquida M, Adan A, Hernandez MV, Garfella MH, Pascual EV, Martinez-Costa L, Sellas-Fernandez A, Cordero-Coma M, Diaz-Llopis M, Gallego R, Salom D, Ortego N, Garcia-Serrano JL, Callejas-Rubio JL, Herreras JM, Garcia-Aparicio A, Maiz O, Blanco A, Torre I, Diaz-Valle D, Pato E, Aurrecoechea E, Caracuel MA, Gamero F, Minguez E, Carrasco-Cubero C, Olive A, Vazquez J, Ruiz-Moreno O, Manero J, Munoz-Fernandez S, Martinez MG, Rubio-Romero E, de Miera FJTS, Longo FJL, Nolla JM, Revenga M, Gonzalez-Vela C, Loricera J, Atienza-Mateo B, Demetrio-Pablo R, Hernandez JL, Gonzalez-Gay MA, Blanco R. Successful Optimization of Adalimumab Therapy in Refractory Uveitis Due to Behcet's Disease. OPHTHALMOLOGY. 2018; 125(9):1444-1451.
IF: 7,479 Q: 1 D: 1

del Rio C, Cantarero I, Palomares B, Gomez-Canas M, Fernandez-Ruiz J, Pavicic C, Garcia-Martin A, Bellido ML, Ortega-Castro R, Perez-Sanchez C, Lopez-Pedrera C, Appendino G, Calzado MA, Munoz E. VCE-004.3, a cannabidiol aminoquinone derivative, prevents bleomycin-induced skin fibrosis and inflammation through PPAR gamma- and CB2 receptor-dependent pathways. BRITISH JOURNAL OF PHARMACOLOGY. 2018; 175(19):3813-3831.
IF: 6,81 Q: 1 D: 1

Lopez-Medina C, Dougados M, Collantes-Estevez E, Molto A. Adherence to recommendations for the use of anti-tumour necrosis factor and its impact over 5 years of follow-up in axial spondyloarthritis. RHEUMATOLOGY. 2018; 57(5):880-890.
IF: 5,245 Q:1 D: 2

Travez A, Rabanal-Ruiz Y, Lopez-Alcala J, Molero-Murillo L, Diaz-Ruiz A, Guzman-Ruiz R, Catalan V, Rodriguez A, Fruhbeck G, Tinahones FJ, Gasman S, Vitale N, Jimenez-Gomez Y, Malagon MM. The caveolae-associated coiled-coil protein, NECC2, regulates insulin signalling in Adipocytes. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2018; 22(11):5648-5661.
IF: 4,302 Q: 1

Gomez-Gomez E, Jimenez-Vacas JM, Carrasco-Valiente J, Herrero-Aguayo V, Blanca-Pedregosa AM, Leon-Gonzalez AJ, Valero-Rosa J, Fernandez-Rueda JL, Gonzalez-Serrano T, Lopez-Miranda J, Gahete MD, Castano JP, Requena-Tapia MJ, Luque RM. Plasma ghrelin O-acyltransferase (GOAT) enzyme levels: A novel non-invasive diagnosis tool for patients with significant prostate cancer. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2018; 22(11):5688-5697.
IF: 4,302 Q: 1

Julia A, Lopez-Longo FJ, Venegas JJP, Bonas-Guarch S, Olive A, Andreu JL, Aguirre-Zamorano MA, Vela P, Nolla JM, de la Fuente JLM, Zea A, Pego-Reigosa JM, Freire M, Diez E, Rodriguez-Almaraz E, Carreira P, Blanco R, Taboada VM, Lopez-Lasanta M, Corbeto ML, Mercader JM, Torrents D, Absher D, Marsal S, Fernandez-Nebro A. Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus. ARTHRITIS RESEARCH & THERAPY. 2018; 20:Núm artículo 100
IF: 4,269 Q: 2

Garrido-Castro JL, Curbelo R, Mazzucchelli R, Dominguez-Gonzalez ME, Gonzalez-Navas C, Robles BJF, Zarco P, Mulero J, Cea-Calvo L, Arteaga MJ, Font-Ugalde P, Carmona L, Collantes-Estevez E. High Reproducibility of an Automated Measurement of Mobility for Patients with Axial Spondyloarthritis. JOURNAL OF RHEUMATOLOGY. 2018; 45(10):1383-1388.
IF: 3,47 Q: 2

Tevar-Sanchez M, Navarro-Compan V, Aznar JJ, Linares LF, Castro MC, de Miguel E. Prevalence and characteristics associated with dactylitis in patients with early spondyloarthritis: results from the ESPeranza cohort. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018; 36(5):879-883.
IF: 3,201 Q: 2

Moreno M, Gratacos J, Navarro-Compan V, de Miguel E, Font P, Clavaguera T, Linares LF, Joven B, Juanola X. Should over-treatment of axial spondyloarthritis with biologics remain a concern after the issue of the new ASAS criteria? Data from REGISPONSERBIO (Spanish Register of Biological Therapy in Spondyloarthritides). CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018; 36(6)1038-1042.
IF: 3,201 Q: 2

Florez MT, Almodovar R, Perez FG, Cambron ABR, Carmona L, Manzanero MAP, Cantalapiedra JA, Urruticoechea-Arana A, Lozano CJR, Castro C, Fernandez-Carballido C, de Miguel E, Galindez E, Vega JLA, Alonso JCT, Linares LF, Moreno M, Navarro-Compan V, Juanola X, Zarco P. The EJES-3D tool for personalized prescription of exercise in axial spondyloarthritis through multimedia animations: pilot study. RHEUMATOLOGY INTERNATIONAL. 2018; 38(7):1277-1284.
IF: 1,952 Q: 4

Munoz-Fernandez S, Oton-Sanchez T, Carmona L, Calvo-Alen J, Escudero A, Narvaez J, Heredia JMR, Yuste SR, Vela P, Valdes SL, Garcia AR, Baquero JL. Use of prognostic factors of rheumatoid arthritis in clinical practice and perception of their predictive capacity before and after exposure to evidence. RHEUMATOLOGY INTERNATIONAL. 2018; 38(12):2289-2296.
IF: 1,952 Q: 4

Gonzalez C, Rodriguez RC, Torre-Alonso JC, Collantes E, Castaneda S, Hernandez MV, Urruticoechea-Arana A, Nieto-Gonzalez JC, Garcia J, Abad MA, Ramirez J, Suarez C, Dalmau R, Martin-Arranz MD, Leon L, Hermosa JC, Obaya JC, Oton T, Carmona L. Recommendations for the Management of Comorbidity in Patients With Axial Spondyloarthritis in Clinical Practice. REUMATOLOGIA CLINICA. 2018; 14(6):346-359.

Molina JT, Alen JC, Ballina J, Belmonte MA, Blanco FJ, Caracuel MA, Carbonell J, Corominas H, Chamizo E, Hidalgo C, Ivorra JR, Marenco JL, Muelas JVM, Munoz-Fernandez S, Nolla JM, Perez T, Sanmarti R, Trenor P, Urrego C, Vidal J, de Salazar JRG. Recommendations for the use of parenteral methotrexate in rheumatic diseases. REUMATOLOGIA CLINICA. 2018; 14(3):142-149.

Almodovar R, Alonso JCT, Batlle E, Castillo C, Collantes-Estevez E, de Miguel E, Gonzalez S, Gratacos J, Hernandez A, Juanola X, Linares LF, Moreno MJ, Moreno M, Navarro-Compan V, Lozano CR, Sanz J, Sellas A, Loza E, Zarco P. Development of a checklist for patients with axial spondyloarthritis and psoriatic arthritis in daily practice: ONLY TOOLS project. REUMATOLOGIA CLINICA. 2018; 14(3):155-159.

Publications in 2017

Perez-Sanchez C, Aguirre MA, Ruiz-Limon P, Abalos-Aguilera MC, Jimenez-Gomez Y, Arias-de la Rosa I, Rodriguez-Ariza A, Fernandez-del Rio L, Gonzalez-Reyes JA, Segui P, Collantes-Estevez E, Barbarroja N, Velasco F, Sciascia S, Cecchi I, Cuadrado MJ, Villalba JM, Lopez-PedreraC. Ubiquinol Effects on Antiphospholipid Syndrome Prothrombotic Profile A Randomized, Placebo-Controlled Trial. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2017.37(10):1923-1932.
IF: 6,607 Q: 1 D: 1

Perez-Sanchez C, Ruiz-Limon P, Aguirre MA, Jimenez-Gomez Y, Arias-de la Rosa I, Abalos-Aguilera MC, Rodriguez-Ariza A, Castro-Villegas MC, Ortega-Castro R, Segui R, Martinez C, Gonzalez-Conejero R, Rodriguez-Lopez S, Gonzalez-Reyes JA, Villalba JM, Collantes-Estevez E, Escudero A, Barbarroja N, Lopez-PedreraC. Diagnostic potential of NETosis-derived products for disease activity, atherosclerosis and therapeutic effectiveness in Rheumatoid Arthritis patients. JOURNAL OF AUTOIMMUNITY. 2017.82:31-40.
IF: 7,641 Q: 1

Ruiz Limón, P. Ortega R, Arias de la Rosa I, Abalos-Aguilera MDC, Perez-Sanchez C, Jimenez-Gomez Y, Peralbo-Santaella E, Font P, Ruiz-Vilches D, Ferrin G, Collantes-Estevez E, Escudero-Contreras A, López-Pedrera C*, Barbarroja N*. Tocilizumab improves the proatherothrombotic profile of rheumatoid arthritis patients modulating endothelial dysfunction, NETosis, and inflammation. TRASLATIONAL RESERACH: the journal of laboratory and clinical medicine. 2017. 183;87-103.
IF: 4,65 Q: 1

López-Medina C, Jiménez-Gómez Y, Moltó A, Schiotis RE, Marzo-Ortega H, van Gaalen FA, Ozgocmen S, Dougados M, Calvo-Gutiérrez J, Castro-Villegas MC, Collantes-Estévez E, Font-Ugalde P; ASAS-COMOSPA taskforce. Cardiovascular risk factors in patients with spondyloarthritis from Northern European and Mediterranean countries: An ancillary study of the ASAS-COMOSPA project. Joint Bone Spine. 2017. S1297-319X (17)30139-2.
IF: 3,329 Q: 2

Radin M, Cecchi I, Perez-Sanchez C. Antiphospholipid antibodies negativization: time for testing for non-criteria aPL? LUPUS. 2017.26(13):1457-1458.
IF: 2,454 Q: 3

Cardenas MJ, de la Fuente S, Castro-Villegas MC, Romero-Gomez M, Ruiz-Vilchez D, Calvo-Gutierrez J, Escudero-Contreras A, del Prado JR, Collantes-Estevez E, Font P. Optimization of biological therapy in rheumatoid arthritis patients: outcomes from the CREATE registry after 2 years of follow-up. RHEUMATOLOGY INTERNATIONAL. 2017.37(10):1701-1708.
IF: 1,824 Q: 3

Lopez-Pedrera C, Aguirre-Zamorano MA, Perez-Sanchez C. Mechanisms of atherosclerosis and cardiovascular disease in antiphospholipid syndrome and systemic lupus erythematosus. New therapeutic approaches. MEDICINA CLINICA. 2017.149(4):160-169.
IF: 1,125 Q: 3

Sciascia S, Coloma-Bazan E, Radin M, Bertolaccini ML, Lopez-Pedrera C, Espinosa G, Meroni PL, Cervera R, Cuadrado MJ. Can we withdraw anticoagulation in patients with antiphospholipid syndrome after seroconvertion? AUTOIMMUNITY REVIEWS. 2017.16(11):1109-1114.
IF: 8,961 Q: 1 D: 1

Arroyo AB, Salloum-Asfar S, Perez-Sanchez C, Teruel-Montoya R, Navarro S, Garcia-Barbera N, Luengo-Gil G, Roldan V, Hansen JB, Lopez-Pedrera C, Vicente V, Gonzalez-Conejero R, Martinez C. Regulation of TFPI alpha expression by miR-27a/ b-3p in human endothelial cells under normal conditions and in response to androgens. SCIENTIFIC REPORTS. 2017.7():-43500.
IF: 4,259 Q: 1

Aterido A, Julia A, Carreira P, Blanco R, Lopez-Longo JJ, Venegas JJP, Olive A, Andreu JL, Aguirre-Zamorano MA, Vela P, Nolla JM, Marenco-de la Fuente JL, Zea A, Pego JM, Freire M, Diez E, Lopez-Lasanta M, Lopez-Corbeto M, Palau N, Tortosa R, Gelpi JL, Absher D, Myers RM, Fernandez-Nebro A, Marsal S. Genome-wide pathway analysis identifies VEGF pathway association with oral ulceration in systemic lupus erythematosus. ARTHRITIS RESEARCH &THERAPY. 2017.19(1):-138.
IF: 4,121 Q: 2

Gomez-Gomez E, Carrasco-Valiente J, Blanca-Pedregosa A, Barco-Sanchez B, Fernandez-Rueda JL, Molina-Abril H, Valero-Rosa J, Font-Ugalde P, Requena-Tapia MJ. European Randomized Study of Screening for Prostate Cancer Risk Calculator: External Validation, Variability, and Clinical Significance. UROLOGY. 2017.102():85-91.
IF: 2,309 Q: 2

Fernandez-Carballido C, Navarro-Compan V, Castillo-Gallego C, Castro-Villegas MC, Collantes-Estevez E, de Miguel E. Esperanza StudyGrp. Disease Activity As a Major Determinant of Quality of Life and Physical Function in Patients With Early Axial Spondyloarthritis. ARTHRITIS CARE & RESEARCH. 2017.69(1):150-155.
IF: 3,319 Q: 3

Fernandez ASI, Roura XJ, Ruiz AA, Rosas J, Luezas JM, Estevez EC, Hernandez MAA, Benitez VC, Fisac C. Clinical utility of the ASDAS index in comparison with BASDAI in patients with ankylosing spondylitis (Axis Study). RHEUMATOLOGY INTERNATIONAL. 2017.37(11):1817-1823.
IF: 1,824 Q: 3

Torre-Alonso JC, Carmona L, Moreno M, Galindez E, Babio J, Zarco P, Linares L, Collantes-Estevez E, Barrial MF, Hermosa JC, Coto P, Suarez C, Almodovar R, Luelmo J, Castaneda S, Gratacos J. Identification and management of comorbidity in psoriatic arthritis: evidence- and expert-based recommendations from a multidisciplinary panel from Spain. RHEUMATOLOGY INTERNATIONAL. 2017.37(8):1239-1248.
IF: 1,824 Q: 3

Marras C, Monteagudo I, Salvador G, de Toro FJ, Escudero A, Alegre-Sancho JJ, Raya E, Ortiz A, Carmona L, Mestre Y, Cea-Calvo L, Calvo-Alen J. Identification of patients at risk of non-adherence to oral antirheumatic drugs in rheumatoid arthritis using the Compliance Questionnaire in Rheumatology: an ARCO sub-study. RHEUMATOLOGY INTERNATIONAL. 2017.37(7):1195-1202.
IF: 1,824 Q: 3

Bonilla PN, Gomez RG, Jimenez DR, Fabra MLV, Villanueva MDM, Catalan RG, Ugalde FF, Fernandez MSP, Alonso JLL, Galera JMG. Enhanced depth OCT imaging of the lamina cribrosa for 24 hours. INTERNATIONAL JOURNAL OF OPHTHALMOLOGY. 2017.10(2):306-309.
IF: 1,177 Q: 4

Clinical Research

Active in 2019

A multicenter, randomized, placebo-controlled, double-blind, parallel-group phase III study to assess the efficacy and safety of Apremilast (CC-10004) in the treatment of active ankylosing spondylitis.
PI: Dr Eduardo Collantes Estévez

A randomized, double-blind, placebo-controlled, 52-week duration study to assess adverse events of special interest in adults with systemic antibody positive lupus erythematosus receiving belimumab.
PI: Dr Mª Ángeles Aguirre Zamorano

A Phase III, randomized, double-blind, placebo controlled multi-center study of subcutaneous secukinumab (150 mg and 300 mg) in prefilled syringe to demonstrate efficacy (including inhibition of structural damage), safety, and tolerability up to 2 years in subjects with active psoriatic arthritis (FUTURE 5).
PI: Dr Mª Dolores López Montilla

Assessing cardiovascular risk and its determinants in patients with rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis.
PI: Dr Eduardo Collantes Estévez

Multi-Country Registry of clinical characteristics, including radiographic progression, and burden of disease over 5 years in real-life setting) PROOF.
PI: Dr Eduardo Collantes Estévez

ASCORE study about long-term experience with abatacepts.c. in habitual clinical practice.
PI: Dr Alejandro Escudero Contreras

Spanish Registry of psoriatic arthritis.
PI: Dr Mª Dolores López Montilla

Spanish Registry of adverse events in biological and biosimilar therapies in rheumatic illnesses. Phase III.
PI: Dr Eduardo Collantes Estévez

A Multi-Center Observational Study to Evaluate the Real-life effectiveness of Benepali following transition from Enbrel in patients with Rheumatoid Arthritis and Axial Spondyloarthritis. (The Benefit Study)
PI: Dr María Del Carmen Castro Villegas

Early treatment with biological therapy in axial spondyloarthritis: 5-year effectiveness.
PI: Dr María Del Carmen Castro Villegas

A multicenter, prospctive, observational cohort study to evaluate the real-world safety and effectiveness of Erelzi, an etanercept biosimilar (COMPACT)
PI: Dr María Del Carmen Castro Villegas

Estudio multicéntrico, observacional no intervencionista, transversal y retrospctivo, para evaluar el control de la actividad de la enfermedad en condiciones de práctica clínica habitual en pacientes con Espondilitis Anquilosante y Artritis Psoriásica tra
PI: Dr María Del Carmen Castro Villegas

Estudio prospectivo, multicéntrico para evaluar la eficacia y la seguridad de una inyección única de hialuronato sódico en pacientes con artrosis de rodilla
PI: Dr Miguel Ángel Caracuel Ruiz

Estudio de adaptación del cuestionario Qualisex para pacientes con artritis reumatoide en España.
PI: Dr. Miguel Ángel Caracuel Ruiz

Sensibilkidad al cambio del índice UCOASMI en pacientes con espondiloartritis axial y enfermedad activa según el índice BASDAI (estudio UCOTRACK-II).
PI: Dr. Eduardo Collantes Estévez

A Multicenter, Open-label (Part A) Followed by a Randomized, Double-blind, Parallel-group, Placebo Controlled Study (Part B) to Evaluate Maintenance of Remission in Subjects With Active Axial Spondyloarthritis (axSpA) Receiving Either Certolizumab Pegol 200 mg Q2W or 200 mg Q4W as Compared to Placebo
PI: Dr Eduardo Collantes Estévez

A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU.
PI: Dr Eduardo Collantes Estévez

A Phase 3, Randomized, Active-Controlled, Double Blind Study Comparing Upadacitinib to Abatacept in Subjects With Moderately to Severely Active Rheumatoid Arthritis With Inadequate Response or Intolerance to Biologic DMARDs (bDMARDs) on Stable Conventional Synthetic Disease Modifying Anti-Rheumatic Drugs (csDMARDs).
PI: Dr Alejandro Escudero Contreras

A Multicenter Study to Evaluate the Efficacy and Safety of Different Doses of Bimekizumab in Subjects With Active Ankylosing Spondylitis.
PI: Dr Eduardo Collantes Estévez

A Randomized, Double-blind, Active Control, Multicenter Study to Evaluate the Efficacy at Week 52 of Secukinumab Monotherapy Compared With Adalimumab Monotherapy in Patients With Active Psoriatic Arthritis
PI: Dr Mª Dolores López Montilla

Ensayo de fase IV, aleatorizado, doble ciego, controlado con placebo y de grupos paralelos para evaluar la eficacia y la seguridad de golimumab (MK-8259 [SCH 900259]) tras la retirada del tratamiento, en comparación con su continuación.
PI: Dr Eduardo Collantes Estévez

A Randomized, Double-blind, Placebo-controlled Multicenter Study of Secukinumab to Evaluate the Safety, Tolerability and Efficacy up to 2 Years in Patients With Active Non-radiographic Axial Spondyloarthritis.
PI: Dr María del Carmen Castro Villegas

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Guselkumab Administered Subcutaneously in Subjects With Active Psoriatic Arthritis.
PI: Dr Mª Dolores López Montilla

A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Phase II Study to Evaluate The Safety and Efficacy of RO7123520 as Adjunct Treatment in Patients With Moderately to Severely Active Rheumatoid Arthritis and an Inadequate Response to TNF-alpha Inhibitors.
PI: Dr Alejandro Escudero Contreras

A Phase 3, Randomized, Double-Blind, Study Comparing Upadacitinib (ABT-494) to Placebo in Subjects With Active Psoriatic Arthritis Who Have a History of Inadequate Response to at Least One Biologic Disease Modifying Anti-Rheumatic Drug (bDMARD),
PI: Dr Mª Dolores López Montilla

Estudio de Extensión, Abierto, Multicéntrico, para Evaluar la Seguridad y Eficacia a Largo Plazo de Bimekizumab en Pacientes con Espondilitis Anquilosante.
PI: Dr. Eduardo Collantes Estévez

Estudio Multicéntrico, aleatorizado, en doble ciego, controlado con placebo y grupos paralelos, de ustekinumab en sujetos con eritematoso sistemático activo.
PI: Dr Mª Ángeles Aguirre Zamorano

Estudio aleatorizado, doble ciego y controlado con placebo para evaluar la eficacia y la seguridad de sarilumab en pacientes con arteritis de células gigantes.
PI: Dr. Alejandro Escudero Contreras

Efectos de ABATACEPT enla progresión de la artritis reumatoide en pacientes con reumatismo palindrómico (PALABA).
PI: Dr. Alejandro Escudero Contreras

Ensayo fase 3b, multicéntrico, aleatorizado, doble ciego, controlado con placebo para evaluar la eficacia y seguridad de guselkumab administrado subcutáneo en pacientes con Artritis Psoriásica activa y con una respuesta inadecuada a la terapia con Factor .
PI: Dr. Mª Dolores López Montilla

Estudio de fase 3, multicéntrico, aleatorizado, en doble ciego y controlado con placebo, para evaluar la eficacia y seguridad de BIMEKIZUMAB en sujetos con espondiloartritis axial activa no radiográfica.
PI: Dr. María Del Carmen Castro Villegas

Estudio de fase 3, multicéntrico, aleatorizado, en doble ciego y controlado con placebo, para evaluar la eficacia y seguridad de BIMEKIZUMAB en sujetos con espondilitis anquilosante activa
PI: Dr. María Del Carmen Castro Villegas

Estudio multicéntrico, aleatorizado, controlado con placebo, con doble enmascaramiento, para evaluar la eficacia y la seguridad de dosis múltiples de BMS-986165 en sujetos con artritis psoriásica (AP) activa.
PI: Dr. Alejandro Escudero Contreras

Estudio en fase III, multicéntrico, aleatorizado, doble ciego, de 24 semanas de duración, para comparar la eficacia y la seguridad de GSK3196165 con placebo y con sarilumab, en combinación con FARME sintéticos convencionales, en participantes con artritis.
PI: Dr. Alejandro Escudero Contreras

Estudio en fase III, multicéntrico, aleatorizado, doble ciego, de 52 semanas de duración, para comparar la eficacia y la seguridad de GSK3196165 con placebo y con tofacitinib, en combinación con metotrexato, en participantes con artritis reumatoide con ac.
PI: Dr. Alejandro Escudero Contreras

Research groups