Publicaciones en 2022
Navarrete C, Garcia-Martin A, Correa-Saez A, Prados ME, Fernandez F, Pineda R, Mazzone M, Alvarez-Benito M, Calzado MA, Munoz E. JOURNAL OF NEUROINFLAMMATION. 2022. DOI: 10.1186/s12974-022-02540-9
Lara-Chica M, Correa-Saez A, Jimenez-Izquierdo R, Garrido-Rodriguez M, Ponce FJ, Moreno R, Morrison K, Di Vona C, Arato K, Jimenez-Jimenez C, Morrugares R, Schmitz ML, de la Luna S, de la Vega L, Calzado MA. CELL DEATH AND DIFFERENTIATION. 2022. DOI: 10.1038/s41418-021-00845-5
Chianese G, Sirignano C, Benetti E, Marzaroli V, Collado JA, de la Vega L, Appendino G, Munoz E, Taglialatela-Scafati O. JOURNAL OF NATURAL PRODUCTS. 2022. DOI: 10.1021/acs.jnatprod.1c01198
Appendino G, Taglialatela-Scafati O, Munoz E. NATURAL PRODUCT COMMUNICATIONS. 2022. DOI: 10.1177/1934578X221098843
del Rio C, Ruiz-Pino F, Prados ME, Fiebich BL, Tena-Sempere M, Munoz E. FRONTIERS IN PHARMACOLOGY. 2022. DOI: 10.3389/fphar.2022.981817
Apweiler M, Streyczek J, Saliba SW, Collado JA, Hurrle T, Grassle S, Munoz E, Normann C, Hellwig S, Brase S, Fiebich BL. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022. DOI: 10.3390/ijms23020959
Caprioglio D, Amin HIM, Taglialatela-Scafati O, Munoz E, Appendino G. BIOMOLECULES. 2022. DOI: 10.3390/biom12081084
Del Pozo A, Silva L, Romero A, De Hoz-Rivera M, Villa M, Martinez-Vega M, Prados ME, Munoz E, Martinez-Orgado J. NUTRIENTS. 2022. DOI: 10.3390/nu14245286
Caprioglio D, Mattoteia D, Munoz E, Taglialatela-Scafati O, Appendino G. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2022. DOI: 10.1002/ejoc.202101410
Rao ZG, Caprioglio D, Gollowitzer A, Kretzer C, Imperio D, Collado JA, Waltl L, Lackner S, Appendino G, Munoz E, Temml V, Werz O, Minassi A, Koeberle A. BIOCHEMICAL PHARMACOLOGY. 2022. DOI: 10.1016/j.bcp.2022.115202
Prieto-Garcia C, Hartmann O, Reissland M, Braun F, Bozkurt S, Pahor N, Fuss C, Schirbel A, Schulein-Volk C, Buchberger A, Canale MAC, Rosenfeldt M, Dikic I, Munch C, Diefenbacher ME. MOLECULAR ONCOLOGY. 2022. DOI: 10.1002/1878-0261.13217
Publicaciones en 2021
Gonzalez-Mariscal I, Carmona-Hidalgo B, Winkler M, Unciti-Broceta JD, Escamilla A, Gomez-Canas M, Fernandez-Ruiz J, Fiebich BL, Romero-Zerbo SY, Bermudez-Silva FJ, Collado JA, Munoz E. (+)-trans-Cannabidiol-2-hydroxy pentyl is a dual CB1R antagonist/CB2R agonist that prevents diabetic nephropathy in mice. PHARMACOLOGICAL RESEARCH. 202 169():-. DOI: 10.1016/j.phrs.202105492. IF: 7,658 Q1 D1
Salamone S, Appendino G, Khalili A, Pollastro F, Munoz E, Unciti-Broceta JD. Agathadiol, a labdane diterpenoid from juniper berries, is a positive allosteric modulator of CB1R. FITOTERAPIA. 2021. 155():-. DOI: 10.1016/j.fitote.2021.105059.
IF: 2,882 Q3
Prados ME, Correa-Saez A, Unciti-Broceta JD, Garrido-Rodriguez M, Jimenez-Jimenez C, Mazzone M, Minassi A, Appendino G, Calzado MA, Munoz E. Betulinic Acid Hydroxamate is Neuroprotective and Induces Protein Phosphatase 2A-Dependent HIF-1 alpha Stabilization and Post-transcriptional Dephosphorylation of Prolyl Hydrolase 2. NEUROTHERAPEUTICS. 202 18(3):1849-186 DOI: 10.1007/s13311-021-01089-4. IF: 7,62 Q1 D1
Prados ME, Garcia-Martin A, Unciti-Broceta JD, Palomares B, Collado JA, Minassi A, Calzado MA, Appendino G, Munoz E. Betulinic acid hydroxamate prevents colonic inflammation and fibrosis in murine models of inflammatory bowel disease. ACTA PHARMACOLOGICA SINICA. 2021. 42(7):1124-1138. DOI: 10.1038/s41401-020-0497-0. IF: 6,15 Q1 D2
Navarrete C, Garcia-Martin A, Rolland A, DeMesa J, Munoz E. Cannabidiol and Other Cannabinoids in Demyelinating Diseases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021. 22(6):-. DOI: 10.3390/ijms22062992.
IF: 5,923 Q1 D3
Caprioglio D, Mattoteia D, Taglialatela-Scafati O, Munoz E, Appendino G. Cannabinoquinones: Synthesis and Biological Profile. BIOMOLECULES. 2021. 11(7):-. DOI: 10.3390/biom11070991.
IF: 4,879 Q2 D4
Carmona-Hidalgo B, Gonzalez-Mariscal I, Garcia-Martin A, Prados ME, Ruiz-Pino F, Appendino G, Tena-Sempere M, Munoz E. Delta 9-Tetrahydrocannabinolic Acid markedly alleviates liver fibrosis and inflammation in mice. PHYTOMEDICINE. 2021. 81():-. DOI: 10.1016/j.phymed.2020.153426.
IF: 5,34 Q1 D1
Carmona-Hidalgo B, Garcia-Martin A, Munoz E, Gonzalez-Mariscal I. Detrimental Effect of Cannabidiol on the Early Onset of Diabetic Nephropathy in Male Mice. PHARMACEUTICALS. 2021. 14(9):-. DOI: 10.3390/ph14090863.
IF: 5,863 Q1 D2
Garcia-Martin A, Navarrete C, Garrido-Rodriguez M, Prados ME, Caprioglio D, Appendino G, Munoz E. EHP-101 alleviates angiotensin II-induced fibrosis and inflammation in mice. BIOMEDICINE & PHARMACOTHERAPY. 2021. 142():-. DOI: 10.1016/j.biopha.2021.11200
IF: 6,529 Q1 D1
Garrido-Rodriguez M, Lopez-Lopez D, Ortuno FM, Pena-Chilet M, Munoz E, Calzado MA, Dopazo J. A versatile workflow to integrate RNA-seq genomic and transcriptomic data into mechanistic models of signaling pathways. PLOS COMPUTATIONAL BIOLOGY. 202 17(2):-. DOI: 10.1371/journal.pcbi.1008748.
IF: 4,475 Q1 D2
Apweiler M, Streyczek J, Saliba SW, Ditrich J, Munoz E, Fiebich BL. Anti-Inflammatory and Anti-Oxidative Effects of AM404 in IL-1 beta-Stimulated SK-N-SH Neuroblastoma Cells. FRONTIERS IN PHARMACOLOGY. 2021. 12():-. DOI: 10.3389/fphar.2021.789074. IF: 5,811 Q1 D2
Hartmann O, Reissland M, Maier CR, Fischer T, Prieto-Garcia C, Baluapuri A, Schwarz J, Schmitz W, Garrido-Rodriguez M, Pahor N, Davies CC, Bassermann F, Orian A, Wolf E, Schulze A, Calzado MA, Rosenfeldt MT, Diefenbacher ME. Implementation of CRISPR/Cas9 Genome Editing to Generate Murine Lung Cancer Models That Depict the Mutational Landscape of Human Disease. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021. 9():-. DOI: 10.3389/fcell.2021.641618.
IF: 6,684 Q1 D2
Burgaz S, Garcia C, Gomez-Canas M, Rolland A, Munoz E, Fernandez-Ruiz J. Neuroprotection with the Cannabidiol Quinone Derivative VCE-008 (EHP-101) against 6-Hydroxydopamine in Cell and Murine Models of Parkinson's Disease. MOLECULES. 2021. 26(11):-. DOI: 10.3390/molecules26113245.
IF: 4,411 Q2 D4
Burgaz S, Garcia C, Gomez-Canas M, Navarrete C, Garcia-Martin A, Rolland A, del Rio C, Casarejos MJ, Munoz E, Gonzalo-Consuegra C, Munoz E, Fernandez-Ruiz J. Neuroprotection with the cannabigerol quinone derivative VCE-003.2 and its analogs CBGA-Q and CBGA-Q-Salt in Parkinson's disease using 6-hydroxydopamine-lesioned mice. MOLECULAR AND CELLULAR NEUROSCIENCE. 2021. 110():-. DOI: 10.1016/j.mcn.2020.103583.
IF: 4,314 Q2 D4
Rodriguez-Soacha DA, Fender J, Ramirez YA, Collado JA, Munoz E, Maitra R, Sotriffer C, Lorenz K, Decker M. Photo-Rimonabant: Synthesis and Biological Evaluation of Novel Photoswitchable Molecules Derived from Rimonabant Lead to a Highly Selective and Nanomolar "Cis-On" CB1R Antagonist. ACS CHEMICAL NEUROSCIENCE. 2021. 12(9):1632-1647. DOI: 10.1021/acschemneuro.1c0008
IF: 4,418 Q2 D3
Fallas MEA, Pedraza-Arevalo S, Cujba AM, Manea T, Lambert C, Morrugares R, Sancho R. Stem/progenitor cells in normal physiology and disease of the pancreas. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2021. 538():-. DOI: 10.1016/j.mce.2021.111459. IF: 4,102 Q2 D5
Publicaciones 2020
Flores-Giubi ME, Botubol-Ares JM, Duran-Pena MJ, Escobar-Montano F, Zorrilla D, Sanchez-Marquez J, Munoz E, Macias-Sanchez AJ, Hernandez-Galan R. Bond reactivity indices approach analysis of the [2+2] cycloaddition of jatrophane skeleton diterpenoids from Euphorbia gaditana Coss to tetracyclic gaditanone. PHYTOCHEMISTRY. 2020. 180 ():- DOI: 10.1016/j.phytochem.2020.112519
IF: 3,044 Q: 1
Casares L, Garcia V, Garrido-Rodriguez M, Millan E, Collado JA, Garcia-Martin A, Penarando J, Calzado MA, de la Vega L, Munoz E. Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. REDOX BIOLOGY. 2020. 28 ():- DOI: 10.1016/j.redox.2019.101321
IF: 9,986 Q: 1 D: 1
Navarrete C, Garcia-Martin A, DeMesa J, Munoz E. Cannabinoids in Metabolic Syndrome and Cardiac Fibrosis. CURRENT HYPERTENSION REPORTS. 2020. 22 (12):- DOI: 10.1007/s11906-020-01112-7
IF: 3,856 Q: 2
Palomares B, Garrido-Rodriguez M, Gonzalo-Consuegra C, Gomez-Canas M, Saen-oon S, Soliva R, Collado JA, Fernandez-Ruiz J, Morello G, Calzado MA, Appendino G, Munoz E. Delta(9)-Tetrahydrocannabinolic acid alleviates collagen-induced arthritis: Role of PPAR gamma and CB(1)receptors. BRITISH JOURNAL OF PHARMACOLOGY. 2020. 177 (17):4034-4054 DOI: 10.1111/bph.15155
IF: 7,73 Q: 1 D: 1
Navarrete C, Garcia-Martin A, Garrido-Rodriguez M, Mestre L, Feliu A, Guaza C, Calzado MA, Munoz E. Effects of EHP-101 on inflammation and remyelination in murine models of Multiple sclerosis. NEUROBIOLOGY OF DISEASE. 2020. 143 ():- DOI: 10.1016/j.nbd.2020.104994
IF: 5,332 Q: 1
Casares L, Unciti-Broceta JD, Prados ME, Caprioglio D, Mattoteia D, Higgins M, Apendino G, Dinkova-Kostova AT, Munoz E, de la Vega L. Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity. REDOX BIOLOGY. 2020. 37 ():- DOI: 10.1016/j.redox.2020.101689
IF: 9,986 Q: 1 D: 1
Prieto-Garcia C, Hartmann O, Reissland M, Braun F, Fischer T, Walz S, Schulein-Volk C, Eilers U, Ade CP, Calzado MA, Orian A, Maric HM, Munch C, Rosenfeldt M, Eilers M, Diefenbacher ME. Maintaining protein stability of increment Np63 via USP28 is required by squamous cancer cells. EMBO MOLECULAR MEDICINE. 2020. 12 (4):- DOI: 10.15252/emmm.201911101
IF: 8,821 Q: 1 D: 1
Morrugares R, Correa-Saez A, Moreno R, Garrido-Rodriguez M, Munoz E, de la Vega L, Calzado MA. Phosphorylation-dependent regulation of the NOTCH1 intracellular domain by dual-specificity tyrosine-regulated kinase 2. CELLULAR AND MOLECULAR LIFE SCIENCES. 2020. 77 (13):2621-2639 DOI: 10.1007/s00018-019-03309-9
IF: 6,496 Q: 1
Floris I, Rose T, Rojas JAC, Appel K, Roesch C, Lejeune B. Pro-Inflammatory Cytokines at Ultra-Low Dose Exert Anti-Inflammatory Effect In Vitro: A Possible Mode of Action Involving Sub-Micron Particles?. DOSE-RESPONSE. 2020. 18 (4):- DOI: 10.1177/1559325820961723
IF: 2,438 Q: 2
Mattoteia D, Taglialatela-Scafati O, Munoz E, de la Vega L, Caprioglio D, Appendino G. Regiodivergent Synthesis of ortho- and para-Cannabinoquinones. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2020. 2020 (48):7429-7434 DOI: 10.1002/ejoc.202001258
IF: 2,889 Q: 2
Palomares B, Ruiz-Pino F, Garrido-Rodriguez M, Prados ME, Sanchez-Garrido MA, Velasco I, Vazquez MJ, Nadal X, Ferreiro-Vera C, Morrugares R, Appendino G, Calzado MA, Tena-Sempere M, Munoz E. Tetrahydrocannabinolic acid A (THCA-A) reduces adiposity and prevents metabolic disease caused by diet-induced obesity. BIOCHEMICAL PHARMACOLOGY. 2020. 171 ():- DOI: 10.1016/j.bcp.2019.113693
IF: 4,96 Q: 1 D: 1
Caprioglio D, Mattoteia D, Pollastro F, Negri R, Lopatriello A, Chianese G, Minassi A, Collado JA, Munoz E, Taglialatela-Scafati O, Appendino G. The Oxidation of Phytocannabinoids to Cannabinoquinoids. JOURNAL OF NATURAL PRODUCTS. 2020. 83 (5):1711-1715 DOI: 10.1021/acs.jnatprod.9b01284
IF: 3,779 Q: 1
Correa-Saez A, Jimenez-Izquierdo R, Garrido-Rodriguez M, Morrugares R, Munoz E, Calzado MA. Updating dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2): molecular basis, functions and role in diseases. CELLULAR AND MOLECULAR LIFE SCIENCES. 2020. 77 (23):4747-4763 DOI: 10.1007/s00018-020-03556-1
IF: 6,496 Q: 1
Publicaciones 2019
Morrugares R, Correa-Sáez A, Moreno R, Garrido-Rodríguez M, Muñoz E, de la Vega L, Calzado MA. Phosphorylation-dependent regulation of the NOTCH1 intracellular domain by dual-specificity tyrosine-regulated kinase 2. Cell Mol Life Sci. 2019 Oct 11. doi: 10.1007/s00018-019-03309-9
IF: 7,014 D: 1
García-Martín A, Garrido-Rodríguez M, Navarrete C, Caprioglio D, Palomares B, DeMesa J, Rolland A, Appendino G, Muñoz E. Cannabinoid derivatives acting as dual PPARγ/CB2 agonists as therapeutic agents for systemic sclerosis. Biochem Pharmacol. 2019 May; 163:321-334. doi: 10.1016/j.bcp.2019.02.029.
IF: 4,825 D: 1
Ruiz EJ, Diefenbacher ME, Nelson JK, Sancho R, Pucci F, Chakraborty A, Moreno P, Annibaldi A, Liccardi G, Encheva V, Mitter R, Rosenfeldt M, Snijders AP, Meier P, Calzado MA, Behrens A. LUBAC determines chemotherapy resistance in squamous cell lung cancer. J Exp Med. 2019 Feb 4;216(2):450-465. doi: 10.1084/jem.20180742
IF: 10,892 D: 1
Garrido-Rodríguez M, Ortea I, Calzado MA, Muñoz E, García V. SWATH proteomic profiling of prostate cancer cells identifies NUSAP1 as a potential molecular target for Galiellalactone. J Proteomics. 2019 Feb 20; 193:217-229. doi: 10.1016/j.jprot.2018.10.012.
IF: 3, 537 Q: 1
Aguareles J, Paraíso-Luna J, Palomares B, Bajo-Grañeras R, Navarrete C, Ruiz-Calvo A, García-Rincón D, García-Taboada E, Guzmán M, Muñoz E, Galve-Roperh I. Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-inducedneurodegeneration. Transl Neurodegener. 2019 Mar 8;8:9. doi:10.1186/s40035-019-0148-x
IF: 5,534 Q: 1
Publicaciones 2018
Ruiz EJ, Diefenbacher ME, Nelson JK, Sancho R, Pucci F, Chakraborty A, Moreno P, Annibaldi A, Liccardi G, Encheva V, Mitter R, Rosenfeldt M, Snijders AP, Meier P, Calzado MA, Behrens A. LUBAC determines chemotherapy resistance in squamous cell lung cancer. J Exp Med. 2019 Feb 4;216(2):450-465.
IF: 10.892 Q: 1 D: 1
Minassi A, Rogati F, Cruz C, Prados ME, Galera N, Jinenez C, Appendino G, Bellido ML, Calzado MA, Caprioglio D, Munoz E. Triterpenoid Hydroxamates as HIF Prolyl Hydrolase Inhibitors. JOURNAL OF NATURAL PRODUCTS. 2018; 81(10):2235-2243.
IF: 3,885 Q: 1 D: 1
Moreno P, Jimenez-Jimenez C, Garrido-Rodriguez M, Calderon-Santiago M, Molina S, Lara-Chica M, Priego-Capote F, Salvatierra A, Munoz E, Calzado MA. Metabolomic profiling of human lung tumor tissues - nucleotide metabolism as a candidate for therapeutic interventions and biomarkers. MOLECULAR ONCOLOGY. 2018; 12(10):1778-1796.
IF: 5,264 Q: 1
del Rio C, Cantarero I, Palomares B, Gomez-Canas M, Fernandez-Ruiz J, Pavicic C, Garcia-Martin A, Bellido ML, Ortega-Castro R, Perez-Sanchez C, Lopez-Pedrera C, Appendino G, Calzado MA, Munoz E. VCE-004.3, a cannabidiol aminoquinone derivative, prevents bleomycin-induced skin fibrosis and inflammation through PPAR gamma- and CB2 receptor-dependent pathways. BRITISH JOURNAL OF PHARMACOLOGY. 2018. 175(19):3813-3831.
IF: 6,81 Q: 1 D: 1
Navarrete C, Carrillo-Salinas F, Palomares B, Mecha M, Jimenez-Jimenez C, Mestre L, Feliu A, Bellido ML, Fiebich BL, Appendino G, Calzado MA, Guaza C, Munoz E. Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy. JOURNAL OF NEUROINFLAMMATION. 2018; 15:Núm artículo 64
IF: 5,193 Q: 1
Jimenez-Jimenez C, Lara-Chica M, Palomares B, Collado JA, Lopez-Miranda J, Munoz E, Calzado MA. Effect of N-acyl-dopamines on beta cell differentiation and wound healing in diabetic mice. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 2018; 1865(11):1539-1551.
IF: 4,651 Q: 1
Garcia-Martin A, Garrido-Rodriguez M, Navarrete C, del Rio C, Bellido ML, Appendino G, Calzado MA, Munoz E. EHP-101, an oral formulation of the cannabidiol aminoquinone VCE-004.8, alleviates bleomycin-induced skin and lung fibrosis. BIOCHEMICAL PHARMACOLOGY. 2018; 157:304-313.
IF: 4,235 Q: 1
del Rio C, Millan E, Garcia V, Appendino G, DeMesa J, Munoz E. The endocannabinoid system of the skin. A potential approach for the treatment of skin disorders. BIOCHEMICAL PHARMACOLOGY. 2018; 157:122-133.
IF: 4,235 Q: 1
Palomares B, Ruiz-Pino F, Navarrete C, Velasco I, Sanchez-Garrido MA, Jimenez-Jimenez C, Pavicic C, Vazquez MJ, Appendino G, Bellido ML, Calzado MA, Tena-Sempere M, Munoz E. VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity. SCIENTIFIC REPORTS. 2018; 8:Núm artículo 16092
IF: 4,122 Q: 1
Garcia C, Gomez-Canas M, Burgaz S, Palomares B, Gomez-Galvez Y, Palomo-Garo C, Campo S, Ferrer-Hernandez J, Pavicic C, Navarrete C, Bellido ML, Garcia-Arencibia M, Pazos MR, Munoz E, Fernandez-Ruiz J. Benefits of VCE-003.2, a cannabigerol quinone derivative, against inflammation-driven neuronal deterioration in experimental Parkinson's disease: possible involvement of different binding sites at the PPAR gamma receptor. JOURNAL OF NEUROINFLAMMATION. 2018; 15:Núm artículo 19
IF: 5,193 Q: 1
Nizet S, Munoz E, Fiebich BL, Abuja PM, Kashofer K, Zatloukal K, Tangermann S, Kenner L, Tschegg C, Nagl D, Scheichl L, Meisslitzer-Ruppitsch C, Freissmuth M, Berger T. Clinoptilolite in Dextran Sulphate Sodium-Induced Murine Colitis: Efficacy and Safety of a Microparticulate Preparation. INFLAMMATORY BOWEL DISEASES. 2018; 24(1):54-66.
IF: 4,347 Q: 1
Rodriguez-Cueto C, Santos-Garcia I, Garcia-Toscano L, Espejo-Porras F, Bellido M, Fernandez-Ruiz J, Munoz E, de Lago E. Neuroprotective effects of the cannabigerol quinone derivative VCE-003.2 in SOD1(G93A) transgenic mice, an experimental model of amyotrophic lateral sclerosis. BIOCHEMICAL PHARMACOLOGY. 2018; 157:217-226.
IF: 4,235 Q: 1
Luesma MJ, Cantarero I, Castiella T, Sanchez-Cano AI, Iruzubieta P, Junquera C. Ultrastructural and immunohistochemical study of phenotypic switch in gastrointestinal smooth muscle cells. MICROSCOPY RESEARCH AND TECHNIQUE. 2018; 81(11):1233-1240.
IF: 1,087 Q: 3
Pollastro F, Caprioglio D, Del Prete D, Rogati F, Minassi A, Taglialatela-Scafati O, Munoz E, Appendino G. Cannabichromene. NATURAL PRODUCT COMMUNICATIONS. 2018; 3(9):1189-1194.
IF: 8,9 Q: 4
Appel K, Munoz E, Navarrete C, Cruz-Teno C, Biller A, Thiemann E. Immunomodulatory and Inhibitory Effect of Immulina (R), and Immunloges (R) in the Ig-E Mediated Activation of RBL-2H3 Cells. A New Role in Allergic Inflammatory Responses. PLANTS-BASEL. 2018; 7(1):Núm artículo 13
