Research - Research groups - GC01 Immunology and Allergy

GC01 Immunology and Allergy

Our group (Immunology and Allergy, GC-01) is an interdisciplinary and consolidated group, integrated by clinicians and basic researchers. Our research is focused on Immunotherapy initiatives for several pathologies from cancer to allergy treatment. We aim to improve our understanding and the treatment and prevention of different immunopathologies bringing closer immunology basic research to the clinical practice. We are specialized in finding biomarkers with a potential use as immunotherapy targets to develop new treatment strategies.

We have several research areas:

-Our group studies the process of senescence of the immune system in different models: chronological aging, cancer, cardiovascular disease, inflammatory diseases, viral infection and other situations of chronic activation of the immune system. Particularly, we analyse the receptors involved in the regulation of cytotoxicity in T (CTL) and NK cells and their ligands in these models, and the role of CMV.

-We also study the Immunological mechanisms involved in allergic diseases in response to natural sources: pollen, foods, Hymenoptera, drugs and mites. Allergy is a worldwide disease of high prevalence. There is a natural evolution to seriousness, negative impact in the life quality (childhood and adult) and a high cost in economic and health resources. Symptoms involved in this disease are associated with high airways chronic inflammation, urticaria problems, and food allergies reactions that can produce anaphylaxis and even death in severe cases.

Therefore, our research aims to solve clinical problems by studying the underlying role of the immune system. Our studies are directed towards a translational research with a high clinical applicability.

Our research contributes to the Programs “Antimicrobial Resistance” and “Infections in Transplanted Patients” of the Spanish Network for Research in Infectious Diseases (REIPI, http://reipi.org/) supported by the Institute of Health Carlos III (ISCIII) and to the Spanish Network for asthma, adverse and allergic reactions (Asma, Reacciones ADversas y ALergicas) (PI Carmen Moreno Aguilar). Furthermore, our group has stable collaborative research with national and international groups. We are in active search for new collaborations with other European groups for concurring to the H2020 framework program. Moreover, are committed to the training of students and new researchers and to incorporating and stabilizing postdoctoral researchers to enrich and expand our group research lines.

Research Lines

Immunosenescence

Our group studies the process of senescence of the immune system analyzing receptors involved in the regulation of cytotoxicity in T (CTL) and NK cells and their ligands in these models:

Chronological aging and CMV infection.
Cancer. Antitumoral immunotherapy. Role of T and NK cells Immunosenescence.
Cardiovascular immunopathology. Immunosenescence and chronic activation of the immune system.

Immunological bases of allergic disease

The focus of this line of research is the study of the immunological mechanisms underlying allergic disease and the use of immunotherapy.

Role of Microbioma by lipid transfer proteins in allergic disease.
Search for biomarkers of early response to immunotherapy.
Immunotherapy with insect venom

Networks

REIPI - Spanish Network for Research in Infectious Diseases (Collaborator)

Spanish Network for asthma, adverse and allergic reactions (ARADYAL)

PAIDI CTS-208 Molecular immunology

Keywords

Immunosenescence
aging
melanoma
NK cells
NKT cells
NK receptors
CMV
cytotoxic T lymphocytes (CTL)
pro-inflammatory cells
Allergy
anaphylaxis
pollen
Hymenoptera
food
mite
drugs
Cardiovascular disease

Dr. Rafael Solana Lara

Principal Investigator

Projects

Active in 2019

Regional

Jurado, A. Marcha alérgica polen-alimentos en el Sur de Europa a través de Proteínas Transportadoras de Lípidos (LTPs): Búsqueda de evidencias moleculares y celulares. Funding Agency: Consejeria de Salud de la Junta de Andalucía. Reference: PI-0127-2019. End date: 22/12/2022.

Espinazo, ML. Uso de técnicas -Ómicas en el diagnostico y manejo de enfermedades alérgicas altamente relevantes (Allergomics´19). Funding Agency: Consejeria de Salud de la Junta de Andalucia. Reference: PI-0162-2019. End date: 22/12/2022.

Pera, A. Papel de las células inmunes pro-inflamatorias en la estenosis de la válvula aórtica (Cipyeva). Funding agency: FIBICO. Reference: PI-0324-2018-FIB. End date: 31/12/2021.

Serrano, P. Subproyecto 1: Estudio de los perfiles de sensibilización alergenica y perfiles meta bolomicos, transcriptomicos y funcionales de plaquetas en pacientes alergicos al veneno de abeja o al polen de olivo de fenotipo grave y reacciones sistemicas durante la inmunoterapia. Funding Agency: Consejeria de Salud de la Junta de Andalucia. Reference: PC-0278-2017. End Date: 31/12/2020.

Ruiz León, MB. Role of Microbioma by lipid transfer proteins in allergic disease. Funding agency: Regional Ministry of Equality, Health and Social Policies (CISPS). Reference: PI-0119-2016. End Date: 31/12/2020.

National

Pera, A. Inmunopatología de la estenosis aórtica (Isao). Funding agency: National Institute of Health Carlos III (ISCIII). Reference: PI19/00075. End date: 31/12/2022.

Barber, D. Subproyecto 1: Patología alérgica grave: validación de biomarcadores y nuevas estrategias de intervención en alergia (VABMAN). Saiz, V. (Responsable HURS). Funding agency: National Institute of Health Carlos III Health (ISCIII). Reference: PI19/00044. End date: 31/12/2022.

Moreno, C. Study of bee venom immunotherapy after discontinuation. Does the protective effect remain? Funding agency: National Institute of Health Carlos III (ISCIII). Reference: PI18/00313. En date: 31/12/2021.

Alonso Diaz, C. Relevance of immunosenescence in the design of new NK cell-based immunotherapy protocols in melanoma and acute myeloid leukaemia models. Funding agency: National Institute of Health Carlos III (ISCIII). Reference: PI16/01615. End date: 31/12/2020.

Moreno, C. Spanish Network for asthma, adverse reactions and allergic (ARADYAL). Funding agency: National Institute of Health Carlos III (ISCIII). Reference: RD16/0006/0018. End Date: 31/12/2022.

Publications

Publications in 2020

Oeo-Santos C, Lopez-Rodriguez JC, Garcia-Mouton C, San Segundo-Acosta P, Jurado A, Moreno-Aguilar C, Garcia-Alvarez B, Perez-Gil J, Villalba M, Barderas R, Cruz A. Biophysical and biological impact on the structure and IgE-binding of the interaction of the olive pollen allergen Ole e 7 with lipids. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 2020. 1862 (6):- DOI: 10.1016/j.bbamem.2020.183258
IF: 3,411 Q: 2

Valhondo I, Hassouneh F, Lopez-Sejas N, Pera A, Sanchez-Correa B, Guerrero B, Bergua JM, Arcos MJ, Banas H, Casas-Aviles I, Sanchez-Garcia J, Serrano J, Martin C, Duran E, Alonso C, Solana R, Tarazona R. Characterization of the DNAM-1, TIGIT and TACTILE Axis on Circulating NK, NKT-Like and T Cell Subsets in Patients with Acute Myeloid Leukemia. CANCERS. 2020. 12 (8):- DOI: 10.3390/cancers12082171
IF: 6,126 Q: 1

Jurado A, Martin MC, Abad-Molina C, Orduna A, Martinez A, Ocana E, Yarce O, Navas AM, Trujillo A, Fernandez L, Vergara E, Rodriguez B, Quirant B, Martinez-Caceres E, Hernandez M, Perurena-Prieto J, Gil J, Cantenys S, Gonzalez-Martinez G, Martinez-Saavedra. COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study. IMMUNITY & AGEING. 2020. 17 (1):- DOI: 10.1186/s12979-020-00194-w
IF: 2,804 Q: 2

Tarazona R, Lopez-Sejas N, Guerrero B, Hassouneh F, Valhondo I, Pera A, Sanchez-Correa B, Pastor N, Duran E, Alonso C, Solana R. Current progress in NK cell biology and NK cell-based cancer immunotherapy. CANCER IMMUNOLOGY IMMUNOTHERAPY. 2020. 69 (5):879-899 DOI: 10.1007/s00262-020-02532-9
IF: 5,442 Q: 1

de Mier MVPR, Ojeda R, Alvarez-Lara MA, Navas A, Alonso C, Caballero-Villarraso J, Aljama P, Alvarez MA, Soriano S, Rodriguez M, Martin-Malo A. Hemodiafiltration with ultrafiltrate regeneration reduces free light chains without albumin loss in multiple myeloma patients. BMC NEPHROLOGY. 2020. 21 (1):227- DOI: 10.1186/s12882-020-01885-8
IF: 1,913 Q: 3

Valle-Arroyo J, Aguado R, Paez-Vega A, Perez AB, Gonzalez R, Fornes G, Torre-Cisneros J, Cantisan S. Lack of cytomegalovirus (CMV)-specific cell-mediated immune response using QuantiFERON-CMV assay in CMV-seropositive healthy volunteers: fact not artifact. SCIENTIFIC REPORTS. 2020. 10 (1):- DOI: 10.1038/s41598-020-64133-x
IF: 3,998 Q: 1

Oeo-Santos C, Navas A, Benede S, Ruiz-Leon B, Diaz-Perales A, Vogel L, Moreno-Aguilar C, Jurado A, Villalba M, Barderas R. New insights into the sensitization to nonrelated nsLTPs from pollen and food: New role of the allergen Ole e 7. ALLERGY. 2020. 75 (4):798-807 DOI: 10.1111/all.14086
IF: 6,771 Q: 1

Mira E, Yarce OA, Ortega C, Fernandez S, Pascual NM, Gomez C, Alvarez MA, Molina IJ, Lama R, Santamaria M. Rapid recovery of a SARS-CoV-2-infected X-linked agammaglobulinemia patient after infusion of COVID-19 convalescent plasma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2020. 8 (8):2793-2795 DOI: 10.1016/j.jaip.2020.06.046
IF: 7,574 Q: 1

Ruiz-Leon B, Navas A, Serrano P, Espinazo M, Labrador-Horrillo M, Monsalve RI, Jurado A, Moreno-Aguilar C. Successful Adaptation of Bee Venom Immunotherapy in a Patient Monosensitized to Api m 10. JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY. 2020. 30 (4):296-297 DOI: 10.18176/jiaci.0498
IF: 3,488 Q: 2

Conde C, Escribano BM, Luque E, Aguilar-Luque M, Feijoo M, Ochoa JJ, LaTorre M, Giraldo AI, Lillo R, Aguera E, Santamaria A, Tunez I. The protective effect of extra-virgin olive oil in the experimental model of multiple sclerosis in the rat. NUTRITIONAL NEUROSCIENCE. 2020. 23 (1):37-48 DOI: 10.1080/1028415X.2018.1469281
IF: 4,028 Q: 2

Publications in 2019

Gastaminza G, Ruiz-Canela M, Andres-Lopez B, Villarejo MJB, Cabanas R, Garcia-Nunez I, Goikoetxea MJ, Laguna JJ, Lobera T, Lopez-San Martin M, Martin-Lazaro J, Mielgo-Ballesteros R, Moreno E, Moya-Quesada MD, Ortega-Rodriguez N, Rojas-Perez-Ezquerra P, Rosado A, Salas M, Sanchez-Morillas L, Vila-Albelda C, Corominas M.. Quality of Life in Patients with Allergic Reactions to Medications: Influence of a Drug Allergy Evaluation. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2019; 7(8):2714-2721.
IF: 7,550 Q: 1 D :1

Eguiluz-Gracia I, Testera-Montes A, Gonzalez M, Perez-Sanchez N, Ariza A, Salas M, Moreno-Aguilar, C, Campo P, Jose Torres M, Rondon C. Safety and reproducibility of nasal allergen challenge. ALLERGY. 2019 Jun;74(6):1125-1134. doi: 10.1111/all.13728.
IF: 6,771 Q: 1

Sanchez-Solares J, Delgado-Dolset MI, Mera-Berriatua L, Hormias-Martin G, Cumplido JA, Saiz V, Carrillo T, Moreno-Aguilar C, Escribese MM, Gomez-Casado C, Barber D. Respiratory allergies with no associated food allergy disrupt oral mucosa integrity. ALLERGY. 2019 Nov;74(11):2261-2265. doi: 10.1111/all.13860.
IF: 6,771 Q: 1

Sanchez-Correa B, Valhondo I, Hassouneh F, Lopez-Sejas N, Pera A, Bergua JM, Arcos MJ, Bañas H, Casas-Avilés I, Durán E, Alonso C, Solana R*, Tarazona R. DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy. Cancers (Basel). 2019 Jun 23;11(6). pii: E877. doi: 10.3390/cancers11060877.
IF: 6,162 Q: 1

Oeo-Santos C, Navas A, Benede S, Ruiz-Leon B, Diaz-Perales A, Vogel L, Moreno Aguilar C, Jurado A, Villalba M, Barderas R. New insights into the sensitization to nonrelated nsLTPs from pollen and food: New role of allergen Ole e 7. Allergy 2020 Apr;75(4):798-807. doi: 10.1111/all.14086.
IF: 6,771 Q: 1

Sanchez-Correa B, Lopez-Sejas N, Duran E, Labella F, Alonso C, Solana R*, Tarazona R. Modulation of NK cells with checkpoint inhibitors in the context of cancer immunotherapy. Cancer Immunol Immunother. 2019 May;68(5):861-870. doi: 10.1007/s00262-019-02336-6.
IF: 4,900 Q: 1

Navas A, Molina J, Agüera ML, Guler I, Jurado A, Rodríguez-Benot A, Alonso C, Solana R. Characterization of the C1q-Binding Ability and the IgG1-4 Subclass Profile of Preformed Anti-HLA Antibodies by Solid-Phase Assays. Front Immunol. 2019 Aug 2;10:1712. doi: 10.3389/fimmu.2019.01712.
IF: 4.716 Q :2

Almeida, JN; Couceiro, P; Lopez-Sejas, N; Alves, V; Růžičková, L; Tarazona, R; Solana, R; Freitas-Tavares, P; Santos-Rosa, M and Rodrigues, P. NKT-Like (CD3+CD56+) Cells in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors. Frontiers in Immunology. 2019 Oct 22;10:2493. doi: 10.3389/fimmu.2019.0249.
IF: 4,716 Q: 2

San Segundo-Acosta P, Oeo-Santos C, Navas A, Jurado A, Villalba M, Barderas R. Ole e 15 and its human counterpart -PPIA- chimeras reveal an heterogeneous IgE response in olive pollen allergic patients. SCIENTIFIC REPORTS. 2019 Oct 21;9(1):15027. doi: 10.1038/s41598-019-51005-2.
IF: 4,011 Q: 2

San Segundo-Acosta P, Oeo-Santos C, Benede S, de los Rios V, Navas A, Ruiz-Leon B, Moreno C, Pastor-Vargas C, Jurado A, Villalba M, Barderas R. Delineation of the Olive Pollen Proteome and Its Allergenome Unmasks Cyclophilin as a Relevant Cross-Reactive Allergen. JOURNAL OF PROTEOME RESEARCH 2019 Aug 2;18(8):3052-3066. doi: 10.1021/acs.jproteome.9b00167.
IF: 3,780 Q: 1

Ariza A, Torres MJ, Moreno-Aguilar C, Fernandez-Santamaria R, Fernandez TD. Early Biomarkers for Severe Drug Hypersensitivity Reactions. CURRENT PHARMACEUTICAL DESIGN. 2019;25(36):3829-3839. doi: 10.2174/1381612825666191107105440.
IF: 2,412 Q: 4

Publications in 2018

Rodrigues-Santos P, Lopez-Sejas N, Almeida JS, Ruzickova L, Couceiro P, Alves V, Campos C, Alonso C, Tarazona R, Freitas-Tavares P, Solana R*, Santos-Rosa M. Effect of Age on NK Cell Compartment in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors. FRONTIERS IN IMMUNOLOGY. 2018; 9:Núm artículo 2587. Co-senior author.
IF: 5,511 Q: 1

Solana C, Tarazona R, Solana R. Immunosenescence of Natural Killer Cells, Inflammation, and Alzheimer's Disease. Int J Alzheimers Dis. 2018 Nov 1;2018:3128758. doi: 10.1155/2018/3128758. eCollection 2018. Review. PubMed PMID: 30515321; PubMed Central PMCID: PMC6236558.

Pera A, Caserta S, Albanese F, Blowers P, Morrow G, Terrazzini N, Smith HE, Rajkumar C, Reus B, Msonda JR, Verboom M, Hallensleben M, Blasczyk R, Davies KA, Kern F. CD28(null) pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death. THERANOSTICS. 2018; 8(16):4509-4519.
IF: 8,537 Q: 1 D: 1

Burgos AMC, Torres-Borrego J, Teran ABM, Corzo JL, Garcia BE, Pacheco RR, Aguilar CM, Davila I. Molecular sensitization patterns and influence of molecular diagnosis in immunotherapy prescription in children sensitized to both grass and olive pollen. PEDIATRIC ALLERGY AND IMMUNOLOGY. 2018; 29(4):369-374.
IF: 4,137 Q: 1 D: 1

Rodrigues-Santos P, Lopez-Sejas N, Almeida JS, Ruzickova L, Couceiro P, Alves V, Campos C, Alonso C, Tarazona R, Freitas-Tavares P, Solana R, Santos-Rosa M. Effect of Age on NK Cell Compartment in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors. FRONTIERS IN IMMUNOLOGY. 2018; 9:Núm artículo 2587
IF: 5,511 Q: 1

Frias M, Rivero-Juarez A, Rodriguez-Cano D, Camacho A, Lopez-Lopez P, Risalde MA, Manzanares-Martin B, Brieva T, Machuca I, Rivero A. HLA-B, HLA-C and KIR improve the predictive value of IFNL3 for Hepatitis C spontaneous clearance. SCIENTIFIC REPORTS. 2018; 8:Núm artículo 659
IF: 4,122 Q: 1

Schiener M, Hilger C, Eberlein B, Pascal M, Kuehn A, Revets D, Planchon S, Pietsch G, Serrano P, Moreno-Aguilar C, de la Roca F, Biedermann T, Darsow U, Schmidt-Weber CB, Ollert M, Blank S. The high molecular weight dipeptidyl peptidase IV Pol d 3 is a major allergen of Polistes dominula venom. SCIENTIFIC REPORTS. 2018; 8:Núm artículo 1318
IF: 4,122 Q: 1

Paez-Vega A, Poyato A, Rodriguez-Benot A, Guirado L, Fortun J, Len O, Abdala E, Farinas MC, Cordero E, de Gracia C, Hernandez D, Gonzalez R, Torre-Cisneros J, Cantisan S. Analysis of spontaneous resolution of cytomegalovirus replication after transplantation in CMV-seropositive patients with pretransplant CD8+IFNG + response. ANTIVIRAL RESEARCH. 2018; 155:97-105.
IF: 4,307 Q: 1

Misra MK, Augusto DG, Martin GM, Nemat-Gorgani N, Sauter J, Hofmann JA, Traherne JA, Gonzalez-Quezada B, Gorodezky C, Bultitude WP, Marin W, Vierra-Green C, Anderson KM, Balas A, Caro-Oleas JL, Cisneros E, Colucci F, Dandekar R, Elfishawi SM, Fernandez-Vina MA, Fouda M, Gonzalez-Fernandez R, Grosser A, Herrero-Mata MJ, Hollenbach SQ, Marsh SGE, Mentzer A, Middleton D, Moffett A, Moreno-Hidalgo MA, Mossallam GI, Nakimuli A, Oksenberg JR, Oppenheimer SJ, Parham P, Petzl-Erler ML, Planelles D, Sanchez-Garcia F, Sanchez-Gordo F, Schmidt AH, Trowsdale J, Vargas LB, Vicario JL, Vilches C, Norman PJ, Hollenbach JA. Report from the Killer-cell Immunoglobulin-like Receptors (KIR) component of the 17th International HLA and Immunogenetics Workshop. HUMAN IMMUNOLOGY. 2018; 79(12):825-833.
IF: 1,994 Q: 4

Antolin-Amerigo D, Ruiz-Leon B, Boni E, Alfaya-Arias T, Alvarez-Mon M, Barbarroja-Escudero J, Gonzalez-de-Olano D, Moreno-Aguilar C, Rodriguez-Rodriguez M, Sanchez-Gonzalez MJ, Sanchez-Morillas L, Vega-Castro A. Component-resolved diagnosis in hymenoptera allergy. ALLERGOLOGIA ET IMMUNOPATHOLOGIA. 2018; 46(3):253-262.
IF: 1,644 Q: 4

Torrijos EG, Gonzalez-Mendiola R, Alvarado M, Avila R, Prieto-Garcia A, Valbuena T, Borja J, Infante S, Lopez MP, Marchan E, Prieto P, Moro M, Rosado A, Saiz V, Somoza ML, Uriel O, Vazquez A, Mur P, Poza-Guedes P, Bartra J. Eosinophilic Esophagitis: Review and Update. FRONTIERS IN MEDICINE. 2018; 5:Núm artículo 247

Publications in 2017

Pera A, Broadley I, Davies KA, Kern F. Cytomegalovirus as a Driver of Excess Cardiovascular Mortality in Rheumatoid Arthritis A Red Herring or a Smoking Gun? CIRCULATION RESEARCH. 2017.120(2):274-277.
IF: 13,965 Q: 1 D: 1

Martinez-Losada C, Martin C, Gonzalez R, Manzanares B, Garcia-Torres E, Herrera C. Patients lacking a Kir-ligand of HLA group C1 or C2 have a Better Outcome after Umbilical cord Blood Transplantation. FRONTIERS IN IMMUNOLOGY. 2017.8.art.810.
IF: 6,429 Q: 1

Hassouneh F, Lopez-Sejas N, Campos C, Sanchez-Correa B, Tarazona R, Solana R, Pera A. Differential effect of cytomegalovirus infection with age on the expression of CD57, CD300a, and CD161 on T-cell subpopulations. FRONTIERS IN IMMUNOLOGY. 2017.8.art.-649.
IF: 6,429 Q: 1

Molina J, Navas A, Aguera ML, Rodelo-Haad C, Alonso C, Rodriguez-Benot A, Aljama P, Solana R. Impact of Preformed Donor-Specific Anti-Human Leukocyte Antigen Antibody C1q-Binding Ability on Kidney Allograft Outcome. FRONTIERS IN IMMUNOLOGY. 2017.8. .art.1310.
IF: 6,429 Q: 1

Tarazona R, Sanchez-Correa B, Casas-Aviles I, Campos C, Pera A, Morgado S, Lopez-Sejas, N, Hassouneh, F, Bergua, JM, Arcos, MJ, Banas, H, Casado, JG, Duran, E, Labella, F, Solana, R. Immunosenescence: limitations of natural killer cell-based cancer immunotherapy. CANCER IMMUNOLOGY IMMUNOTHERAPY. 2017.66(2):233-245.
IF: 4,711 Q: 1

Pera A, Vasudev A, Tan C, Kared H, Solana R, Larbi A.CMV induces expansion of highly polyfunctional CD4(+) T cell subset coexpressing CD57 and CD154. JOURNAL OF LEUKOCYTE BIOLOGY. 2017.101(2):555-566.
IF: 4,018 Q: 2

Frias M, Rodriguez-Cano D, Cuenca-Lopez F, Macias J, Gordon A, Manzanares-Martin B, Pineda JA, Camacho A, Torre-Cisneros J, Pena J, Rivero-Juarez A, Rivero A. HLA-B18 as a risk factor of short-term progression to severe liver fibrosis in HIV/HCV co-infected patients with absent or minimal fibrosis: implications for timing of therapy. PHARMACOGENOMICS JOURNAL. 2017.17(6):551-555.
IF: 3,815 Q: 1

Frias M, Rodriguez-Cano D, Cuenca-Lopez F, Macias J, Gordon A, Manzanares-Martin B, Pineda JA, Camacho A, Torre-Cisneros J, Pena J, Rivero-Juarez A, Rivero A. HLA-B18 as risk factor of liver fibrosis progression in HIV/HCV treatment-experienced patients. PHARMACOGENOMICS JOURNAL. 2017.17(6):479-480.
IF: 3,815 Q: 1

Rivero-Juarez A, Gonzalez R, Frias M, Manzanares-Martin B, Rodriguez-Cano D, Perez-Camacho I, Gordon A, Cuenca F, Camacho A, Pineda JA, Pena J, Rivero A. KIR2DS2 as predictor of thrombocytopenia secondary to pegylated interferon-alpha therapy. PHARMACOGENOMICS JOURNAL. 2017.17(4):360-365.
IF: 3,815 Q: 1

Cantisan S, Paez-Vega A, Santos F, Rodriguez-Benot A, Aguado R, Rivero A, Montejo M, Torre-Cisneros J, Solana R, Spanish Network for Research in Infectious Diseases (REIPI). Impact of age and cytomegalovirus on CD8(+) T-cell compartment remodeling after solid organ transplantation: A one-year follow-up study. EXPERIMENTAL GERONTOLOGY. 2017.95():98-106.
IF: 3,34 Q: 1

Hassouneh F, Lopez-Sejas N, Campos C, Sanchez-Correa B, Tarazona R, Pera A, Solana R. Effect of Cytomegalovirus (CMV) and Ageing on T-Bet and Eomes Expression on T-Cell Subsets. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2017.18(7)art.1391.
IF: 3,226 Q: 2

Puente LG, Flores EI, Benitez JM, Medina RM, Rodriguez IS, Melero PA, Aranzana MJC, Fernandez RG, Martin BM, Garcia-Sanchez V. Evolution after switching to biosimilar infliximab in inflammatory bowel disease patients in clinical remission. GASTROENTEROLOGIA Y HEPATOLOGIA. 2017.40(9):595-604.
IF: 0,917 Q: 4

Schiener M, Eberlein B, Moreno-Aguilar C, Pietsch G, Serrano P, McIntyre M, Schwarze L, Russkamp D, Biedermann T, Spillner E, Darsow U, Ollert M, Schmidt-Weber CB, Blank S. Application of recombinant antigen 5 allergens from seven allergy-relevant Hymenoptera species in diagnostics. ALLERGY. 2017.72(1):98-108.
IF: 7,631 Q: 1 D: 1

Broadley I, Pera A, Morrow G, Davies KA, Kem F. Expansions of Cytotoxic CD4(+)CD28(-) T Cells Drive Excess Cardiovascular Mortality in Rheumatoid Arthritis and Other Chronic Inflammatory Conditions and Are Triggered by CMV Infection FRONTIERS IN IMMUNOLOGY. 2017.8.art.1-10195.
IF: 6,429 Q: 1

Sanchez-Correa B, Bergua JM, Pera A, Campos C, Arcos MJ, Banas H, Duran E, Solana R, Tarazona R. In Vitro culture with interleukin-15 leads to expression of activating receptors and recovery of natural Killer cell Function in acute Myeloid Leukemia Patients. FRONTIERS IN IMMUNOLOGY. 2017.8():-931.
IF: 6,429 Q: 1

Goldeck D, Theeten H, Hassouneh F, Oettinger L, Wistuba-Hamprecht K, Cools N, Tsitsilonis OE, Pawelec G. Frequencies of peripheral immune cells in older adults following seasonal influenza vaccination with an adjuvanted vaccine. VACCINE. 2017.35(34):4330-4338.
IF: 3,235 Q: 2

Cebrino J, de la Cruz SP, Barasona MJ, Alcazar P, Moreno C, Dominguez-Vilches E, Galan C.Airborne pollen in Cordoba City (Spain) and its implications for pollen allergy. AEROBIOLOGIA. 2017.33(2):281-291.
IF: 2,212 Q: 2

Arias TA, Gomis VS, Mera TS, Castro AV, Gutierrez JMV, Llamazares AA, Amerigo DA, Gonzalez FJC, Noche CD, Fernandez DG, Amat LM, Arcediano AM, Ireneo MMS, Ancillo AM, Crespo YP, Leon BR, Morillas LS, Hymenoptera Allergy Committee of the SEAIC. Key Issues in Hymenoptera Venom Allergy: An Update. JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY. 2017.27(1):19-31.
IF: 3,094 Q: 3

Clinical Research

Active in 2019

Effect of antihypertensive medication in the severity of anaphylaxis and side effects during venom immunotherapy Hymenoptera insects. EADOAS.
PI: Dr Moreno Aguilar, Carmen

Insect sting anaphylaxis. Search for biomarkers of early response to hymenoptera venom immunotherapy.
PI: Dr Moreno Aguilar, Carmen

Analysis Of The Sensitization Profile By Skin Test, Determination Of IgE To Complete Extract And Molecular Diagnosis In Patients With Allergic Disease Respiratory For Sensitization To Pollen.
PI: Dr Moreno Aguilar, Carmen

Research groups