Our group (Immunology and Allergy, GC-01) is an interdisciplinary and consolidated group, integrated by clinicians and basic researchers. Our research is focused on Immunotherapy initiatives for several pathologies from cancer to allergy treatment. We aim to improve our understanding and the treatment and prevention of different immunopathologies bringing closer immunology basic research to the clinical practice. We are specialized in finding biomarkers with a potential use as immunotherapy targets to develop new treatment strategies.
We have several research areas:
- Our group studies the process of senescence of the immune system in different models: chronological aging, cancer, cardiovascular disease, inflammatory diseases, viral infection and other situations of chronic activation of the immune system. Particularly, we analyse the receptors involved in the regulation of cytotoxicity in T (CTL) and NK cells and their ligands in these models, and the role of CMV.
- We also study the Immunological mechanisms involved in allergic diseases in response to natural sources: pollen, foods, Hymenoptera, drugs and mites. Allergy is a worldwide disease of high prevalence. There is a natural evolution to seriousness, negative impact in the life quality (childhood and adult) and a high cost in economic and health resources. Symptoms involved in this disease are associated with high airways chronic inflammation, urticaria problems, and food allergies reactions that can produce anaphylaxis and even death in severe cases.
Therefore, our research aims to solve clinical problems by studying the underlying role of the immune system. Our studies are directed towards a translational research with a high clinical applicability.
Our research contributes to the Programs “Antimicrobial Resistance” and “Infections in Transplanted Patients” of the Spanish Network for Research in Infectious Diseases (REIPI, http://reipi.org/) supported by the Institute of Health Carlos III (ISCIII) and to the Spanish Network for asthma, adverse and allergic reactions (Asma, Reacciones ADversas y ALergicas) (PI Carmen Moreno Aguilar). Furthermore, our group has stable collaborative research with national and international groups. We are in active search for new collaborations with other European groups for concurring to the H2020 framework program. Moreover, are committed to the training of students and new researchers and to incorporating and stabilizing postdoctoral researchers to enrich and expand our group research lines.
Líneas de Investigación
In particular, biomarkers of senescence and clonal depletion in T and NK cells are analysed and study activating and inhibitory receptors (checkpoints) of T and NK function and their ligands are studied in these models.
The symptoms involved in this disease are associated with chronic inflammation of the upper respiratory tract, urticaria and feeding problems.
REIPI - Spanish Network for Research in Infectious Diseases (Collaborator)
ARADyAL - Spanish Network for Asthma, Adverse and Allergic Reactions
PAIDI CTS-208 - Molecular immunology
- NK cells
- NKT cells
- NK receptors
- cytotoxic T lymphocytes (CTL)
- cardiovascular disease
- pro-inflammatory cells