Our group is made up of professionals from different levels and specialties (graduates and doctors in medicine, nurses, engineers, biologists and research managers) for the realization of basic biomedical research, clinical research, development of technology and cellular and genetic therapy research, in the field of cardiovascular diseases.
The research activities are formally associated with the clinical and teaching activities of the Clinical Unit of Cardiovascular Surgery of the Reina Sofia University Hospital, which provides clinical support to research projects carried out at IMIBIC.
Our objectives are to carry out and manage high level research projects and clinical trials, funded by national and international agencies, and to collaborate with private companies to conduct pre-commercial clinical trials or projects to develop new biomedical technologies and treatments in the field of cardiovascular diseases.
The approach to cardiovascular pathology research is performed in a holistic way:
- Basic research
- Cell therapy
- Gene therapy and diagnosis
- Technological development applied to cardiovascular diseases
- Telemedicine and prevention of cardiovascular disease
As a result of our basic and clinical research activities and teaching, numerous scientific articles in high-impact journals will be published every year, and doctoral theses awarded. Furthermore, we collaborate in patents for new products or utility models, as well as in projects focusing on the initial development of novel biomedical technologies.
Lines of Research
- Role of proinflammatory immune cells in the development of aortic valve stenosis in collaboration with Dr. Alejandra Pera Rojas, development of autologous human tissues for the subsequent creation of autologous heart valves.
- Clinical research.
- "SIRS" project for the evaluation of adsorption systems for the prevention and treatment of systemic inflammatory response syndrome in cardiac surgery and in diseases with systemic inflammatory response in critical care.
- European STARS project for the empowerment of the surgical patient for the prevention and treatment of stress associated with the process of cardiac surgery. At collaboration with four other European hospitals as a European Project of Innovative Public Procurement.
- Therapeutic possibilities of senile aortic stenosis and its clinical and economic impact. Assessment of initial results and long-term follow-up compared to other treatment options.
- "Rexgenero" cell therapy project for the treatment of patients with critical lower limb ischaemia, by using mesenchymal cells intra-arterially.
- "Cellvie" project for treatment with autologous mitochondria concentrates for advanced stages of heart failure and heart transplantation
- Project to detect the expression and modulation of genetic material related to the development and evolution of idiopathic heart failure.
- "QRK309" project to evaluate the efficacy of the drug QPI-002 in the prevention of renal failure after heart surgery with extracorporeal circulation by modulating the gene expression that causes the disease.
- Project for the construction of a fluid dynamics system as a simulator of the human circulatory system, for the creation and evolution of elements and systems related to diseases of the circulatory system, as well as for the physiological and pathological knowledge of the same.
- Assessment of variations in skin thermography parameters during the immediate postoperative period in heart surgery with extracorporeal circulation. Implications and correlation with clinical parameters and with the generation of complications and alterations of organs and systems.
- Study and development of an implantable extravascular defibrillator system of the MEDTRONIC company.
- Preclinical phase REINHEART artificial heart, total artificial heart.
- REINVAD left ventricular assist preclinical phase.
- Pre-clinical phase RAS-Q device of the company ENMODES for home extracorporeal oxygenation of patients with end-stage respiratory failure.
- "AVERROES" project for the development of a small, energy-autonomous left ventricular assist device, in collaboration with the University of Cordoba, the Cordoba School of Technology and the Technological Innovation Unit of IMIBIC.
- Development of cardiac tissues and valves by differentiation of autologous mesenchymal cell cultures and native aortic valve cells and subsequent bioprinting of the resulting cell cultures (Regemat 3D).
- CARELINK consultation for remote monitoring and non-face-to-face reviews of implantable devices.
Networks
For more information, please visit the section of Clinical Management Unit of Cardiovascular Surgery of the Reina Sofia University hospital's website.
Key Words
- cardiovascular
- cardiac surgery
- pathology
- vascular surgey
Información Adicional
STARS - Empowering Patients by Professional Stress Avoidance and Recovery Services, a H2020 funded project to design and develop a resilient support tool, to be applied in the field of patients, planned for surgery, with the aim of reducing stress and anxiety as well as improving the health condition of the patient during the complete care path (2017-2021)
