Research groups

GC10 Hormonal Regulation of Energy Balance, Puberty and Reproduction

Our team is a consolidated group at IMIBIC, currently composed of 20 members, including three professors, seven postdoctoral researchers, seven predoctoral fellows and PhD students and three technicians. We are a basic/translational group, aiming to explore the pathophysiological basis of the complex interactions between key bodily functions, such as those controlling body weight, metabolism, puberty and reproduction.

While a substantial component of our research deals with the investigation of physiological and molecular mechanisms and their contribution to disease, in the areas of our interest, we have recently undertaken also a number of more clinically-oriented projects with the overall goal of translating the basic knowledge stemming from our research activity into clinical practice. The results of our research may advance in particular the definition of better tools and markers for the diagnosis, stratification and management of highly prevalent metabolic and reproductive disorders, ranging from obesity to altered puberty, polycystic ovary syndrome and infertility. We are funded by competitive projects from regional, national and European agencies, as well as by cooperative agreements with biotech and pharma companies.

Our group collaborates with numerous groups within IMIBIC, Spain and internationally, which help us to deploy an ambitious research program covering a wide range of topics and activities within the area of hormonal regulation of energy balance, puberty and reproduction. As demonstration of active interaction and networking, our group is currently cooperating with other IMIBIC research groups in three different competitive projects, coordinating one of the nodes of the Spanish Network for Research in Obesity & Nutrition (CIBEROBN), and hold long-lasting and productive collaborations with reference groups in Finland and other countries in Europe and the USA.

Research Lines

Our team aims to unveil novel central mechanisms for the dynamic control of puberty, as key maturational event, and reproduction. Notably, prevalence of pubertal and reproductive disorders is increasing due to as yet unknown mechanisms. We are particularly focusing on the characterization of the roles of neuropeptide pathways (e.g. kisspeptins) as potential druggable targets, as well as novel molecular mechanisms (e.g. epigenetics and microRNAs).

There is strong evidence that nutritional and metabolic cues markedly influence the age of puberty and fertility. The translational implications of such phenomenon are high, since obesity has been blamed as one of the major causes for the trends of perturbed puberty and increasing infertility rates. Yet, the underlying mechanisms remain largely unknown. Our group is devoted to identify novel pathways and mechanisms whereby metabolic signals participate in the precise control of the systems governing puberty and reproduction, with the ultimate aim of providing valuable pathophysiological knowledge that may serve to set more rational strategies for the management of pubertal and reproductive disorders.

By a combination of preclinical and clinical studies, our group investigates both the mechanisms and consequences of gonadal dysfunction associated to metabolic diseases, such as obesity and diabetes. The ultimate aim of this research line is to unveil how obesity and other metabolic pathologies perturb the function of the reproductive axis, thereby resulting in insufficient secretion of sex steroid hormones, and to what extent impaired sex hormone milieu predisposes to or aggravates the metabolic complications of obesity.

Our team is applying high-throughput analytical techniques to clinical samples in order to identify novel biomarkers of common reproductive pathologies, such as polycystic ovary syndrome (PCOS), endometriosis, perturbed puberty and obesity-associated hypogonadism. The ultimate aim is to define novel tools for better diagnosis, prognosis and stratification of patients of these prevalent diseases.

Networks

    CIBEROBN - Physiopathology of Obesity and Nutrition

    Reproductive Endocrinology Thematic Area of the European Society of Endocrinology (Manuel Tena-Sempere, Basic Lead)

    FiDiPro Program – Finnish Academy

Keywords

  • Puberty
  • fertility
  • obesity
  • metabolism
  • energy sensors
  • kisspeptins
  • neuropeptides
  • gonadotropins
  • gonads
  • polycystic ovary syndrome
  • endometriosis
  • hypogonadism
  • microRNAs
  • epigenetics

Additional Information

Relevant Publications

1. Heras V, Sangiao-Alvarellos S, Manfredi-Lozano M, Sanchez-Tapia MJ, Ruiz-Pino F, Roa J, Lara-Chica M, Morrugares-Carmona R, Jouy N, Abreu AP, Prevot V, Belsham D, Vazquez MJ, Calzado MA, Pinilla L, Gaytan F, Latronico AC, Kaiser UB, Castellano JM, Tena-Sempere M 2019 Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3. PLoS Biology 17(11):e3000532. (IF: 8.38).

2. Ruiz-Pino F, Miceli D, Franssen D, Vazquez MJ, Farinetti A, Castellano JM, Panzica G, Tena-Sempere M 2019 Environmentally Relevant Perinatal Exposures to Bisphenol A Disrupt Postnatal Kiss1/NKB Neuronal Maturation and Puberty Onset in Female Mice. Environmental Health Perspectives 127(10):107011 (IF: 7.73).

3. Romero-Ruiz A, Avendaño MS, Dominguez F, Lozoya T, Molina-Abril H, Sangiao-Alvarellos S, Gurrea M, Lara-Chica M, Fernandez-Sanchez M, Torres-Jimenez E, Perdices-Lopez C, Abbara A, Steffani L, Calzado MA, Dhillo WS, Pellicer A, Tena-Sempere M. 2019. Deregulation of miR-324/KISS1/kisspeptin in early ectopic pregnancy: mechanistic findings with clinical and diagnostic implications. American Journal Obstetrics & Gynecology 220(5):480. (IF: 5.73)

4. Roa J, Barroso A, Ruiz-Pino F, Vázquez MJ, Seoane-Collazo P, Martínez-Sanchez N, García-Galiano D, Ilhan T, Pineda R, León S, Manfredi-Lozano M, Heras V, Poutanen M, Castellano JM, Gaytan F, Diéguez C, Pinilla L, López M, Tena-Sempere M. 2018. Metabolic regulation of female puberty via hypothalamic AMPK-kisspeptin signaling. Proceedings National Academy Sciences USA 115(45):E10758-E10767 (IF: 9.5)

5. Vazquez MJ, Toro CA, Castellano JM, Ruiz-Pino F, Roa J, Beiroa D, Heras V, Velasco I, Dieguez C, Pinilla L, Gaytan F, Nogueiras R, Bosch MA, Rønnekleiv OK, Lomniczi A, Ojeda SR, Tena-Sempere M. 2018. SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression. Nature Communications 9:4194 (IF: 12.35)

6. Seoane-Collazo P, Roa J, Rial-Pensado E, Liñares-Pose L, Beiroa D, Ruíz-Pino F, López-González T, Morgan DA, Pardavila JÁ, Sánchez-Tapia MJ, Martínez-Sánchez N, Contreras C, Fidalgo M, Diéguez C, Coppari R, Rahmouni K, Nogueiras R, Tena-Sempere M, López M. 2018. SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity. Diabetes. 67(11):2213-2226. (IF: 7.27)

7. Avendaño MS, Vazquez MJ, Tena-Sempere M. 2017. Disentangling puberty: novel neuro-endocrine pathways and mechanisms for the control of mammalian puberty. Human Reproduction Update 23: 737-763. (IF: 11.748)

8. Manfredi-Lozano M, Roa J, Ruiz-Pino F, Piet R, Garcia-Galiano D, Pineda R, Zamora A, Leon S, Sanchez-Garrido MA, Romero-Ruiz A, Dieguez C, Vazquez MJ, Herbison AE, Pinilla L, Tena-Sempere M. 2016. Defining a novel leptin-melanocortin-kisspeptin path-way involved in the metabolic control of puberty. Molecular Metabolism 5: 844-857. (IF: 6.79)

9. Messina A, Langlet F, Chachlaki K, Roa J, Rasika S, Jouy N, Gallet S, Gaytan F, Parkash J, Tena-Sempere M, Giacobini P, Prevot V. 2016. A microRNA switch regulates the rise in hypothalamic GnRH production before puberty. Nature Neuroscience 19: 835-844. (IF: 17.83)

10. Lopez M, Tena-Sempere M. 2015. Estrogens and the control of energy balance: A brain perspective. Trends Endocrinol Metab 26: 411-421. (IF: 8.96)

11. Martínez de Morentin PB, González-García I, Martíns L, Lage R, Fernández-Mallo D, Martínez-Sánchez N, Ruíz-Pino F, Liu J, Morgan DA, Pinilla L, Gallego R, Saha AK, Kalsbeek A, Fliers E, Bisschop PH, Diéguez C, Nogueiras R, Rahmouni K, Tena-Sempere M, López M. 2014. Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK. Cell Metabolism 20: 41-53. (IF: 16.74)

12. Pinilla L, Aguilar E, Dieguez C, Millar RP, Tena-Sempere M. 2012. Kisspeptins and reproduction: Physiological roles and regulatory mechanisms. Physiological Reviews 92: 1235-1316. (IF: 30.17)

13. Navarro VM, Ruiz-Pino F, Sánchez-Garrido MA, García-Galiano D, Hobbs SJ, Manfredi-Lozano M, León S, Sangiao-Alvarellos S, Castellano JM, Clifton DK, Pinilla L, Steiner RA, Tena-Sempere M. 2012. Role of neurokinin B in the control of female puberty and its control by metabolic status. Journal of Neuroscience 32: 2388-2397. (IF: 6.90)

14. García-Galiano D, Navarro VM, Roa J, Ruiz-Pino F, Sánchez-Garrido MA, Pineda R, Castellano JM, Romero M, Aguilar E, Gaytán F, Diéguez C, Pinilla L, Tena-Sempere M. 2010. The anorexigenic neuropeptide, Nesfatin-1, is indispensable for normal puberty onset in the female rat. Journal of Neuroscience 30: 7783-7792. (IF: 7.27)

GC10 Hormonal Regulation of Energy Balance, Puberty and Reproduction

Principal Investigator
Manuel Tena Sempere

Researchers
María Soledad Avendaño Herrador
Francisco Gaytan Luna
Leonor Pinilla Jurado
Juan Roa Rivas
Maria Jesus Vazquez Villar

Post-Doctoral Researchers
Alexia Barroso Romero
Juan Manuel Castellano Rodríguez
David García Galiano
Silvia León Téllez
Rafael Pineda Reyes
Francisco Ruiz Pino
Miguel A. Sánchez-Garrido Nogueras
Verónica Sobrino Cabello
Inmaculada Velasco Aguayo

Pre-Doctoral Researchers
Cecilia María Perdices López
Miguel Ruiz Cruz
Elvira Rodríguez Vázquez
Encarnación Torres Jiménez

Technical Staff
Rocío Onieva Jiménez
Ana Belén Rodríguez Sánchez
María Jesús Sánchez Tapia

Projects

Active Projects

Regional

Tena-Sempere, M. MicroRNAs and reproductive health: Mechanistic and Translational studies. Funding agency: Regional Ministry of Economy, Innovation, Science and Employment (CEICE). Reference: FQM1943

Avendaño Herrador, M.S. Pathophysiological, prognosis and diagnosis role of circulating MicroRNAs in hypogonadism associated with obesity. Funding agency: Regional Ministry of Equality, Health and Social Policies (CISPS). Reference: PI-0370-2016  

Sanchez-Garrido Nogueras, M.A. Efectos Del Tratamiento Con Glp-1 Sobre La Función Gonadal Masculina En Condiciones De Diabesidad: Análisis Mecanísticos E Implicaciones Terapéuticas Para El Hipogonadismo Asociado A Enfermedad Metabólica. Funding Agency:FIBICO.Reference:PI-0358-2018-FIB                 

National          

Tena-Sempere, M. Kisspeptin signaling and Puberty- Novel physiological features and pathophysiological implications for pubertal disorders associated to obesity. Funding agency: Spanish Ministry of Economy and Competitiveness (MINECO). Reference: BFU2017-83934-P BFU2014-57581-P

Roa Rivas J. Puberty and metabolic risk in obese children: Epigenetic alterations and pathophysiological and diagnostic implications. PUBMEP Study. Funding agency: National Institute of Health Carlos III (ISCIII). Reference, PI16/01243        

International

Tena-Sempere, M. New Frontiers in Reproductive medicine: Exploring novel mechanisms for the control of puberty and fertility, and their interplay with metabolic homeostasis and disease. Funding agency: FiDiPro Program (Finnish Distinguished Professorship Program) 2015-2020, Academy of Finland

Pineda Reyes, R. Society for Endocrinology Early Career Grant for Rafael Pineda Reyes. Funding Agency: SOCIETY FOR ENDOCRINOLOGY. Reference: SfE-ECG-2017-001

Publications

Main Publications 2019

Heras V, Sangiao-Alvarellos S, Manfredi-Lozano M, Sanchez-Tapia MJ, Ruiz-Pino F, Roa J, Lara-Chica M, Morrugares-Carmona R, Jouy N, Abreu AP, Prevot V, Belsham D, Vazquez MJ, Calzado MA, Pinilla L, Gaytan F, Latronico AC, Kaiser UB, Castellano JM, Tena-Sempere M. Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3. PLOS BIOLOGY 2019. 17(11):e3000532.
IF: 8,38
Q: 1   D: 1

Ruiz-Pino F, Miceli D, Franssen D, Vazquez MJ, Farinetti A, Castellano JM, Panzica G, Tena-Sempere M. Environmentally Relevant Perinatal Exposures to Bisphenol A Disrupt Postnatal Kiss1/NKB Neuronal Maturation and Puberty Onset in Female Mice. ENVIRONMENTAL HEALTH PERSPECTIVES. 2019. 127. 10. 107011 DOI: 10.1289/EHP5570.
IF: 7,736
Q: 1   D: 1

Romero-Ruiz A, Avendano MS, Dominguez F, Lozoya T, Molina-Abril H, Sangiao-Alvarellos S, Gurrea M, Lara-Chica M, Fernandez-Sanchez M, Torres-Jimenez E, Perdices-Lopez C, Abbara A, Steffani L, Calzado MA, Dhillo WS, Pellicer A, Tena-Sempere M. Deregulation of miR-324/KISS1/kisspeptin in early ectopic pregnancy: mechanistic findings with clinical and diagnostic implications. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 2019. 220. 5.  480.e1-480.e17. DOI:10.1016/j.ajog.2019.01.228.
IF: 6,12
Q: 1   D: 1

Romero-Ruiz A, Skorupskaite K, Gaytan F, Torres E, Perdices-Lopez C, Mannaerts BM, Qi S, Leon S, Manfredi-Lozano M, Lopez-Rodriguez C, Avendaño MS, Sanchez-Garrido MA, Vazquez MJ, Pinilla L, van Duin M, Kohout TA, Anderson RA, Tena-Sempere M. Kisspeptin treatment induces gonadotropic responses and rescues ovulation in a subset of preclinical models and women with polycystic ovary syndrome. HUMAN REPRODUCTION 2019. 34(12):2495-2512.
IF: 5,50
Q: 1   D: 1

Velasco I, León S, Barroso A, Ruiz-Pino F, Heras V, Torres E, León M, Ruohonen ST, García-Galiano D, Romero-Ruiz A, Sánchez-Garrido MA, Olhsson C, Castellano JM, Roa J, Poutanen M, Pinilla L, Vázquez MJ, Tena-Sempere M. Gonadal hormone-dependent vs. -independent effects of kisspeptin signaling in the control of body weight and metabolic homeostasis. METABOLISM 2019. 98:84-94

Main Publications 2018

Vazquez MJ, Toro CA, Castellano JM, Ruiz-Pino F, Roa J, Beiroa D, Heras V, Velasco I, Dieguez C, Pinilla L, Gaytan F, Nogueiras R, Bosch MA, Ronnekleiv OK, Lomniczi A, Ojeda SR, Tena-Sempere M. SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression. NATURE COMMUNICATIONS. 2018; 9: 4194
IF: 12,353  
Q: 1   D: 1

Roa J, Barroso A, Ruiz-Pino F, Vazquez MJ, Seoane-Collazo P, Martinez-Sanchez N, Garcia-Galiano D, Ilhan T, Pineda R, Leon S, Manfredi-Lozano M, Heras V, Poutaneng M, Castellano JM, Gaytan F, Dieguez C, Pinilla L, Lopez M, Tena-Sempere M. Metabolic regulation of female puberty via hypothalamic AMPK-kisspeptin signaling. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018; 115(45):E10758-E10767.
IF: 9,504  
Q: 1   D: 1

Manfredi-Lozano M, Roa J, Tena-Sempere M. Connecting metabolism and gonadal function: Novel central neuropeptide pathways involved in the metabolic control of puberty and fertility. FRONTIERS IN NEUROENDOCRINOLOGY. 2018; 48:37-49.
IF: 6,875  
Q: 1   D: 1

Gaytan F, Morales C, Roa J, Tena-Sempere M. Changes in keratin 8/18 expression in human granulosa cell lineage are associated to cell death/survival events: potential implications for the maintenance of the ovarian reserve. HUMAN REPRODUCTION. 2018; 33(4):680-689.
IF: 4,99  
Q: 1   D: 1

Leon S, Velasco I, Vazquez MJ, Barroso A, Beiroa D, Heras V, Ruiz-Pino F, Manfredi-Lozano M, Romero-Ruiz A, Sanchez-Garrido MA, Dieguez C, Pinilla L, Roa J, Nogueiras R, Tena-Sempere M. Sex-Biased Physiological Roles of NPFF1R, the Canonical Receptor of RFRP-3, in Food Intake and Metabolic Homeostasis Revealed by its Congenital Ablation in mice. METABOLISM-CLINICAL AND EXPERIMENTAL. 2018; 87:87-97.
IF: 5,963  
Q: 1

Other Publications 2018

Poutanen M, Tena-Sempere M. Animal Models for Human Endocrine Disorders Preface. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM. 2018; 32(3):215-218.
IF: 4,417  
Q: 1

Franssen D, Tena-Sempere M. The kisspeptin receptor: A key G-protein-coupled receptor in the control of the reproductive axis. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM. 2018; 32(2):107-123.
IF: 4,417  
Q: 1

Sanchez-Garrido MA, Ruiz-Pino F, Velasco I, Barroso A, Fernandois D, Heras V, Manfredi-Lozano M, Vazquez MJ, Castellano JM, Roa J, Pinilla L, Tena-Sempere M. Intergenerational Influence of Paternal Obesity on Metabolic and Reproductive Health Parameters of the Offspring: Male-Preferential Impact and Involvement of Kiss1-Mediated Pathways. ENDOCRINOLOGY. 2018; 159(2):1005-1018.
IF: 3,961  
Q: 2

Roa J, Tena-Sempere M. Unique Features of a Unique Cell: The Wonder World of GnRH Neurons. ENDOCRINOLOGY. 2018; 159(12):3895-3896.
IF: 3,961  
Q: 2

Seoane-Collazo P, Roa J, Rial-Pensado E, Linares-Pose L, Beiroa D, Ruiz-Pino F, Lopez-Gonzalez T, Morgan DA, Pardavila JA, Sanchez-Tapia MJ, Martinez-Sanchez N, Contreras C, Fidalgo M, Dieguez C, Coppari R, Rahmouni K, Nogueiras R, Tena-Sempere M, Lopez M. SF1-Specific AMPK alpha 1 Deletion Protects Against Diet-Induced Obesity. DIABETES. 2018; 67(11):2213-2226.
IF: 7,273  
Q: 1   D: 1

Gonzalez-Garcia I, Contreras C, Estevez-Salguero A, Ruiz-Pino F, Colsh B, Pensado I, Linares-Pose L, Rial-Pensado E, de Morentin PBM, Ferno J, Dieguez C, Nogueiras R, Le Stunff H, Magnan C, Tena-Sempere M, Lopez M. Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress. CELL REPORTS. 2018; 25(2):413-423.
IF: 8,032  
Q: 1

Palomares B, Ruiz-Pino F, Navarrete C, Velasco I, Sanchez-Garrido MA, Jimenez-Jimenez C, Pavicic C, Vazquez MJ, Appendino G, Bellido ML, Calzado MA, Tena-Sempere M, Munoz E. VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity. SCIENTIFIC REPORTS. 2018; 8:Núm artículo 16092
IF: 4,122  
Q: 1

Santos-Marcos, JA; Rangel-Zuniga, OA; Jimenez-Lucena, R; Quintana-Navarro, GM; Garcia-Carpintero, S; Malagon, MM; Landa, BB; Tena-Sempere, M; Perez-Martinez, P; Lopez-Miranda, J; Perez-Jimenez, F; Camargo, A. Influence of gender and menopausal status on gut microbiota. MATURITAS. 2018; 116:43-53.
IF: 3,315  
Q: 1

Gonzalez-Garcia I, de Morentin PBM, Estevez-Salguero A, Contreras C, Romero-Pico A, Ferno J, Nogueiras R, Dieguez C, Tena-Sempere M, Tovar S, Lopez M. mTOR signaling in the arcuate nucleus of the hypothalamus mediates the anorectic action of estradiol. JOURNAL OF ENDOCRINOLOGY. 2018; 238(3):177-186.
IF: 4,012  
Q: 2

Argente-Arizon P, Diaz F, Ros P, Barrios V, Tena-Sempere M, Garcia-Segura LM, Argente J, Chowen JA. The Hypothalamic Inflammatory/Gliosis Response to Neonatal Overnutrition Is Sex and Age Dependent. ENDOCRINOLOGY. 2018; 159(1):368-387.
IF: 3,961  
Q: 2

Argente-Arizon P, Castro-Gonzalez D, Diaz F, Fernandez- Gomez MJ, Sanchez-Garrido MA, Tena-Sempere M, Argente J, Chowen JA. Neonatal Overnutrition Increases Testicular Size and Expression of Luteinizing Hormone beta-Subunit in Peripubertal Male Rats. FRONTIERS IN ENDOCRINOLOGY. 2018; 9:Núm artículo 168
IF: 3,519  
Q: 2

Lehman MN, Coolen LM, Steiner RA, Neal-Perry G, Wang L, Moenter SM, Moore AM, Goodman RL, Yeo SH, Padilla SL, Kauffman AS, Garcia J, Kelly MJ, Clarkson J, Radovick S, Babwah AV, Leon S, Tena-Sempere M, Comninos AN, Seminara S, Dhillo WS, Levine J, Terasawa E, Negron A, Navarro VM, Herbison AE. The 3rd World Conference on Kisspeptin, Kisspeptin 2017: Brain and Beyond: Unresolved questions, challenges and future directions for the field. JOURNAL OF NEUROENDOCRINOLOGY. 2018; 30(5):Núm artículo UNSP e12600
IF: 3,392  
Q: 2

Main Publications 2017

Tena-Sempere M. Neuroendocrinology in 2016: Neuroendocrine control of metabolism and reproduction. NATURE REVIEWS ENDOCRINOLOGY. 2017.13(2):67-68.
IF: 18,318
Q: 1  D: 1

Avendaño S, Vazquez MJ, Tena-Sempere M. Disentangling puberty: novel neuroendocrine pathways and mechanisms for the control of mammalian puberty. HUMAN REPRODUCTION UPDATE. 2017.23(6):737-763.
IF: 11,748
Q: 1  D: 1

Lopez M, Tena-Sempere M. Estradiol effects on hypothalamic AMPK and BAT thermogenesis: A gateway for obesity treatment? PHARMACOLOGY & THERAPEUTICS. 2017.178:109-122.
IF: 11,127
Q: 1  D: 1

Gaytan F, Morales C, Leon S, Heras V, Barroso A, Avendaño MS, Vazquez MJ, Castellano JM, Roa J, Tena-Sempere M. Development and validation of a method for precise dating of female puberty in laboratory rodents: The puberty ovarian maturation score (Pub-Score). SCIENTIFIC REPORTS. 2017.7:46381.
IF: 4,259
Q: 1

Other Publications in 2017

Martinez-Sanchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buque X, Aurrekoetxea I, Delgado TC, Vazquez-Martinez R, Gonzalez-Garcia I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, de Morentin PBM, Lopez-Gonzalez T, Linares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gomez G, Davis RJ, Casals N, Oresic M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagon MM, Dieguez C, Martinez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, Lopez M. Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. CELL METABOLISM. 2017.26(1):212-229.e12.
IF: 18,164
Q: 1  D: 1

Tommiska J, Kansakoski J, Skibsbye L, Vaaralahti K, Liu XN, Lodge EJ, Tang CY, Yuan L, Fagerholm R, Kanters JK, Lahermo P, Kaunisto M, Keski-Filppula R, Vuoristo S, Pulli K, Ebeling T, Valanne L, Sankila EM, Kivirikko S, Laaperi M, Casoni F, Giacobini P, Phan-Hug F, Buki T, Tena-Sempere M, Pitteloud N, Veijola R, Lipsanen-Nyman M, Kaunisto K, Mollard P Andoniadou CL, Hirsch JA, Varjosalo M, Jespersen T, Raivio T. Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis. NATURE COMMUNICATIONS. 2017.8(1): 1289.
IF: 12,124
Q: 1  D: 1

Xu C, Messina A, Somm E, Miraoui H, Kinnunen T, Acierno J, Niederlander NJ, Bouilly J, Dwyer AA, Sidis Y, Cassatella D, Sykiotis GP, Quinton R, De Geyter C, Dirlewanger M, Schwitzgebel V, Cole TR, Toogood AA, Kirk JMW, Plummer L, Albrecht U, Crowley WF, Mohammadi M, Tena-Sempere M, Prevot V, Pitteloud N. KLB, encoding beta-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism. EMBO MOLECULAR MEDICINE. 2017.9(10):1379-1397.
IF: 9,249
Q: 1  D: 1

Contreras C, Gonzalez-Garcia I, Seoane-Collazo P, Martinez-Sanchez N, Linares-Pose L, Rial-Pensado E, Ferno J, Tena-Sempere M, Casals N, Dieguez C, Nogueiras R, Lopez M. Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity. DIABETES. 2017.66(1):87-99.
IF: 8,684
Q: 1  D:1

Moreno-Navarrete JM, Lopez-Navarro E, Candenas L, Pinto F, Ortega FJ, Sabater-Masdeu M, Fernandez-Sanchez M, Blasco V, Romero-Ruiz A, Fontan M, Ricart W, Tena-Sempere M, Fernandez-Real JM. Ferroportin mRNA is down-regulated in granulosa and cervical cells from infertile women. FERTILITY AND STERILITY. 2017.107(1):236-242.
IF: 4,737
Q: 1  D:1

Skrede S, González-García I, Martins L, Berge RK, Nogueiras R, Tena-Sempere M, Mellgren G, Steen VM, López M, Fernø J. Lack of ovarian secretions reverts the anabolic action of olanzapine in female rats. INTERNATIONAL JOURNAL OF NEURO-PSYCHOPHARMACOLOGY. 2017.20(12):1005-1012.
IF: 4,71
Q: 1

Jokela H, Hakkarainen J, Katkanaho L, Pakarinen P, Ruohonen ST, Tena-Sempere M, Zhang FP, Poutanen M. Deleting the mouse Hsd17b1 gene results in a hypomorphic Naglu allele and a phenotype mimicking a lysosomal storage disease. SCIENTIFIC REPORTS. 2017.7(1): 16406.
IF: 4,259
Q: 1

Novelle MG, Vazquez MJ, Peinado JR, Martinello KD, Lopez M, Luckman SM, Tena-Sempere M, Malagon MM, Nogueiras R, Dieguez C. Sequential Exposure to Obesogenic Factors in Females Rats: From Physiological Changes to Lipid Metabolism in Liver and Mesenteric Adipose Tissue. SCIENTIFIC REPORTS. 2017.7:46194.
IF: 4,259
Q: 1

Macchi C, Steffani L, Oleari R, Lettieri A, Valenti L, Dongiovanni P, Romero-Ruiz A, Tena-Sempere M, Cariboni A, Magni P, Ruscica M. Iron overload induces hypogonadism in male mice via extrahypothalamic mechanisms. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2017.454(C):135-145.
IF: 3,754
Q: 2

Rangel-Zuniga OA, Cruz-Teno C, Haro C, Quintana-Navarro GM, Camara-Martos F, Perez-Martinez P, Garcia-Rios A, Garaulet M, Tena-Sempere M, Lopez-Miranda J, Perez-Jimenez F, Camargo A. Differential menopause-versus aging-induced changes in oxidative stress and circadian rhythm gene markers. MECHANISMS OF AGEING AND DEVELOPMENT. 2017.164:41-48.
IF: 3,087
Q: 3

Ibanez L, Oberfield SE, Witchel SF, Auchus RJ, Chang RJ, Codner E, Dabadghao P, Darendeliler F, Elbarbary NS, Gambineri A, Rudaz CG, Hoeger KM, Lopez-Bermejo A, Ong K, Pena AS, Reinehr T, Santoro N, Tena-Sempere M, Tao R, Yildiz BO, Alkhayyat H, Deeb A, Joel D, Horikawa R, de Zegher F, Lee PA.An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence. HORMONE RESEARCH IN PAEDIATRICS. 2017.88(6):371-395.
IF: 1,844
Q: 2

Members

Team

María Soledad Avendaño Herrador, Francisco Gaytan Luna, Leonor Pinilla Jurado, Juan Roa Rivas, Maria Jesus Vazquez Villar, Alexia Barroso Romero, Juan Manuel Castellano Rodríguez, David García Galiano, Silvia León Téllez, Rafael Pineda Reyes, Francisco Ruiz Pino, Miguel A. Sánchez-Garrido Nogueras, Verónica Sobrino Cabello, Inmaculada Velasco Aguayo, Cecilia María Perdices López, Miguel Ruiz Cruz, Elvira Rodríguez Vázquez, Encarnación Torres Jiménez, Rocío Onieva Jiménez, Ana Belén Rodríguez Sánchez, María Jesús Sánchez Tapia