Research groups

GC07 Nephrology. Cell Damage in Chronic Inflammation

Our Nephrology Cell Damage in Chronic Inflammation research group is a consolidated group of IMIBIC, bringing together both basic and clinical researchers in various scientific disciplines, including medicine, biology and nursing staff.

Our research group is focused on different aspects of uremia, hemodialysis, chronic inflammation and endothelial dysfunction. Our primary area of research is chronic kidney disease (CKD). We study CD14+CD16+ and endothelial cell interaction mediated induction of vascular calcification in patients with chronic kidney disease. We investigate the effect of the endothelial cell and production of microparticles as mediators of this process. We have also performed experimental models of cell culture to study microparticles, CD14 +CD16+ and endothelial cells by flow cytometry and proteomics (mass spectrometry) to analyze the role of these biological biomarkers on microinflammation and the mechanisms involved in vascular calcification on chronic kidney disease.

The main aim of our research is to study the mechanisms of cell damage and repair conditioning in the response to stress caused by chronic inflammation. The working model focuses on immunocompetent cells and vascular wall cells. In addition, we analyze the mechanisms regulating the stress response in circulating progenitor cells in peripheral blood.

Results derived from our research may lead to determine the benefits of different dialysis or pharmacological treatments (chelators, calcimimetic, and vitamin D) on morbidity and mortality of CKD2-4 CKD5 and CKD5D patients. Support tools at diagnosis and possible therapeutic targets will be identified.

In the last three year, our group has published manuscripts that are contributing to the understanding of Cell Damage in Chronic Inflammation and endothelial dysfunction on chronic kidney disease. We are also evaluated new biological biomarkers and the effect of different uremic toxins on the pathogenesis and development of vascular calcification and cardiovascular risk.

Our group is collaborating with the Spanish Renal Research Network (REDinREN). Other collaborations include research projects with companies of pharmaceutical/dialysis industry (Fresenius Medical Care, Vifor and Medtronic).

Research Lines

The latest technological advances in the treatment of chronic kidney disease have helped minimize the inflammation associated with the disease and improve our patients’ survival rates and quality of life. However, in these patients a microinflammatory state persists accompanied by a high percentage of activated cells that are capable of producing a sustained inflammatory response and can produce pathological complications when combined with other low-intensity stimuli. Our team assesses the effectiveness of pharmacological therapies, hemodialysis and kidney transplantation in improving this chronic microinflammatory state associated with kidney disease.

Mechanisms of cell damage and repair conditions the response to stress caused by chronic inflammation. The working model focuses on immunocompetent cells and vascular wall cells. In addition, we analyze the mechanisms regulating the stress response in circulating progenitor cells in peripheral blood.

Our aim is to determinate the role of pro-inflammatory monocytes in the induction of endothelial damage and vascular calcification (VCa) in patients with chronic kidney disease. The role of the endothelial cell and production of microparticles (MP) as mediators of this process will be characterized. In experimental models of cell culture, MP of pro-inflammatory monocytes (mMP) and endothelial cells (eMP) will be characterized by flow cytometry and proteomics (mass spectrometry). MicroRNA content to MP will be analyzed by qrtPCR. The effect of these MP on CaV smooth muscle cells will be analyzed by quantification of calcium and alkaline phosphatase. It will be also considered if the uremic serum stimulus modifies this activity.

A prospective study in patients from the Nephrology Unit of Reina Sofia University Hospital (Córdoba, Spain) will be performed. It will be analyzed if there is a relationship between the CaV, determined by a score of CaV developed by our group, and the number CD14 + CD16 +, MPM, MPE (Flow Cytometry) or microRNA profile (qRT-PCR) expressed in these MP or plasma of CKD patients.

In experimental models of cell culture, we evaluate the interactions between mononuclear and endothelial cells.  Additionally, we are comparing two dialysis techniques (on-line HDF and high-flux hemodialysis) in a prospective randomized study in incident and prevalent hemodialysis patients.  Preliminary results from in vitro studies show that uremic factors, indoxyl sulfate and p-Cresol, increase the adhesion and migration capacity of mononuclear cells, THP1. In addition, in vivo studies indicate that the dialysis procedure increases the expression of cell activation and adhesion markers. Uremic toxins bound--proteins could determine an increase in vascular disease associated with uremia.

Chronic kidney disease is currently a major public health around the world. Although hemodialysis increases survival of patients with end-stage renal disease, kidney transplantation remains the only potentially curative treatment. However, transplantation as a therapeutic option is limited by availability of suitable donor organs. This situation highlights the urgent need to find new and potentially inexhaustible sources of transplantable organs. Perfusion decellularization of whole organs is a novel approach to organ engineering and regeneration. In the present research, we use a continuous perfusion decellularization protocol to eliminate cellular componet of kidney and evaluate residual scaffold components after decellularization process by proteomics analysis. Our proteomic data shows that this protocol results in incomplete removal of cellular proteins. However, unlike other authors, we assume that proteins retained within decellularized kidney scaffold could be the basis for specific homing and celular differentation in the recellularization process.

Networks

    REDinREN - Spanish Renal Research Network

    Optimising Results in Dialysis - ORD group

Keywords

  • Cell activation
  • chronic renal failure
  • microinflammation
  • cell therapy
  • hemodialysis
  • renal transplantation
  • inflammation
  • cellular stress
  • genomic damage
  • endothelium

Additional Information

Highlighted recent publications:

Espinosa M, Ortega R, Sánchez M, Segarra A, Salcedo MT, González F, Camacho R, Valdivia MA, Cabrera R, López K, Pinedo F, Gutierrez E, Valera A, Leon M, Cobo MA, Rodriguez R, Ballarín J, Arce Y, García B, Muñoz MD, Praga M; Spanish Group for Study of Glomerular Diseases (GLOSEN). Association of C4d deposition with clinical outcomes in IgA nephropathy. Clin J Am SocNephrol. 2014.  9 (5). 897-904. PMID: 24578331
IF: 5,25.
Q: 1  D: 1

Buendia-Bello P; Carracedo J; Soriano S; Madueño JA; Ortiz, A; Martin-Malo A; Aljama P, Ramirez Rl. Klotho Prevents NFkB Translocation and Protects Endothelial Cell From Senescence Induced by Uremia. J Gerontol A Biol Sci Med Sci. 2015 Oct;70(10):1198-209. PMID: 25246106
IF: 5,416
Q: 1   D: 1

Buendia-Bello, P; Montes De Oca, Addy R; Madueño JA; Merino A; Martin-Malo A; Aljama P; Ramirez, R; Rodriguez M; Carracedo J. Endothelial microparticles mediate inflammation-induced vascular calcification. FASEB J. 2015 Jan;29(1):173-81. PMID: 25342130
IF: 5,704
Q: 1   D: 1

Cantisán S, Rodelo-Haad C, Páez-Vega A, Nieto A, Vaquero JM, Poyato A, Montejo M, Fariñas MC, Rivero A, Solana R, Martín-Malo A, Torre-Cisneros J. Factors related to the development of CMV-specific CD8+ T cell response in CMV-seropositive solid organ transplant candidates. Am J Transplant. 2015 Mar;15(3):715-22. PMID: 25648131
IF: 5,683
Q: 1   D: 1

Rabasco C, Cavero T, Román E, Rojas-Rivera J, Olea T, Espinosa M, Cabello V, Fernández-Juarez G, González F, Ávila A, Baltar JM, Díaz M,Alegre R, Elías S, Antón M, Frutos MA, Pobes A, Blasco M, Martín F, Bernis C, Macías M, Barroso S, de Lorenzo A, Ariceta G, López-Mendoza M, Rivas B, López-Revuelta K, Campistol JM, Mendizábal S, de Córdoba SR, Praga M. Effectiveness of mycophenolate mofetil in C3 glomerulonephritis. Kidney Int. 2015. 88(5): 1153-1160. PMID: 26221755
IF: 8,52
Q: 1   D: 1

Fernández-Ruiz M, Corrales I, Arias M, Campistol JM, Giménez E, Crespo J, López-Oliva MO, BeneytoI,Martín-Moreno PL, Llamas-Fuente F, Gutiérrez A, García-Álvarez T, Guerra-Rodríguez R, Calvo N,Fernández-Rodríguez A, Tabernero-Romo JM, Navarro MD, Ramos-Verde A, Aguado JM, Navarro D;OPERA StudyGroup. Association between individual and combined SNPs in genes related toinnate immunity and incidence of CMV infection in seropositive kidneytransplant recipients. Am J Transplant. 2015 May;15(5):1323-35. PMID: 25777542
IF: 5,683
Q: 1    D: 1

Maduell F, Ramos R, Varas J, Martin-Malo A, Molina M, Pérez-Garcia R, Marcelli D, Moreso F, Aljama P, Merello JI. Hemodialysis patients receiving a greater Kt dose than recommended have reduced mortality and hospitalization risk. Kidney Int. 2016 Dec;90(6):1332-134. PMID: 27780586
IF: 7,683
Q: 1   D: 1

Fakhouri F, Hourmant M, Campistol JM, Cataland SR, Espinosa M, Gaber AO, Menne J, Minetti EE, Provôt F, Rondeau E, RuggenentiP,Weekers LE, Ogawa M, Bedrosian CL, Legendre CM. Terminal Complement Inhibitor Eculizumab in Adult Patients With Atypical Hemolytic Uremic Syndrome: A Single-Arm, Open-Label Trial. Am J Kidney Dis. 2016 Jul;68(1):84-93. PMID: 27012908
IF: 7,623 
Q: 1

Molina J, Navas A, Agüera ML, Rodelo-Haad C, Alonso C, Rodríguez-Benot A, Aljama P, Solana R. Impact of Preformed Donor-Specific Antihuman leukocyte Antigen Antibody C1q-Binding Abilityon Kidney Allograft Outcome. Front Immunol. 2017 Oct 31;8:1310. PMID: 29163462
IF: 6,429
Q: 1   D: 2

Tortajada A, Gutiérrez E, Goicoechea de Jorge E, Anter J, Segarra A, Espinosa M, Blasco M, Roman E, Marco H, Quintana LF, Gutiérrez J, Pinto S, Lopez-Trascasa M, Praga M, Rodriguez de Córdoba S. Elevated factor H-related protein 1 and factor H pathogenic variants decrease complement regulation in IgA nephropathy. Kidney Int. 2017 Oct;92(4):953-963. PMID:28637589
IF: 8,395
Q: 1   D: 1

Huerta A, Arjona E, Portoles J, Lopez-Sanchez P, Rabasco C, Espinosa M, Cavero T, Blasco M, Cao M, Manrique J, Cabello-Chavez V, Suñer M, Heras M, Fulladosa X, Belmar L, Sempere A, Peralta C, Castillo L, Arnau A, Praga M, Rodriguez de Cordoba S17. A retrospective study of pregnancy-associated atypical hemolytic uremic syndrome. Kidney Int. 2018 Feb;93(2):450-459. PMID: 28911789
IF: 8,395
Q: 1   D: 1

Ayasreh N, Bullich G, Miquel R, Furlano M, Ruiz P, Lorente L, Valero O, García-González MA, Arhda N, Garin I, Martínez V, Pérez-Gómez V, Fulladosa X, Arroyo D, Martínez-Vea A, Espinosa M, Ballarín J, Ars E, Torra R. Autosomal Dominant Tubulointerstitial Kidney Disease: Clinical Presentation of Patients With ADTKD-UMOD and ADTKD-MUC1. Am J Kidney Dis. 2018 May 18. pii: S0272-6386(18)30606-1. PMID:29784615 IF: 7,129
Q: 1   D: 1

Díaz-Tocados JM, Rodríguez-Ortiz ME, Almadén Y, Pineda C, Martínez-Moreno JM, Herencia C, Vergara N, Pendón-Ruiz de Mier MV, Santamaría R, Rodelo-Haad C, Casado-Díaz A, Lorenzo V, Carvalho C, Frazão JM, Felsenfeld AJ, Richards WG1, Aguilera-Tejero E, Rodríguez M, López I, Muñoz-Castañeda JR. Calcimimetics maintain bone turnover in uremic rats despite the concomitant decrease in parathyroid hormone concentration. Kidney Int. 2019 Mar 12. pii: S0085-2538(19)30043-2. PMID 30878213
IF: 8,52
Q: 1   D: 1

Fernández-Ruiz M, Giménez E, Vinuesa V, Ruiz-Merlo T, Parra P, Amat P, Montejo M, Paez-Vega A, Cantisán S, Torre-Cisneros J, Fortún J, Andrés A, San Juan R, López-Medrano F, Navarro D, Aguado JM; Group for Study of Infection in Transplantation of the Spanish Society of Infectious Diseases and Clinical Microbiology (GESITRA-SEIMC) and the Spanish Network for Research in Infectious Diseases (REIPI). Regular monitoring of cytomegalovirus-specific cell-mediated immunity in intermediate-risk kidney transplant recipients: predictive value of the immediate post-transplant assessment. Clin Microbiol Infect. 2019 Mar;25(3):381. PMID 29803844
IF 5,394
Q: 1   D: 1

Varas J, Pérez-Sáez MJ, Ramos R, Merello JI, de Francisco ALM, Luño J, Praga M, Aljama P, Pascual J; Optimizing Results in Dialysis (ORD) group. Returning to haemodialysis after kidney allograft failure: a survival study with propensity score matching. Nephrol Dial Transplant. 2019 Apr 1;34(4):667-672. PMID  30053152
IF: 4,6
Q: 1    D: 2

Patents:

Método de obtención de datos útiles para el diagnóstico de la calcifiacción vascular. Carracedo J, Soriano S, Rodriguez-Portillo JM, Ramirez-Chamond R, Aljama P.

Recent Research Projects:

Actividad inflamatoria mediada por la interacción de CD14+CD16+ con el endotelio; Un proceso implicado en la inducción de calcificación vascular en pacientes con enfermedad renal crónica. (PI15/01785. FONDO DE INVESTIGACIÓN SANITARIA (FIS). 01/01/2016 - 31/12/2018)
PI: Aljama-Garcia, Pedro

Red de Investigación Renal (RD12/0021/0011 Subdirección de Redes Temáticas de investigación cooperativa. Fondo de Investigación Sanitaria (FIS) del Instituto de Salud Carlos III. 01/01/2014 - 31/12/2017)
PI: Aljama-Garcia, Pedro

Inteligencia Artificial: Una Nueva Alternativa para Analizar las Asociaciones Entre las Concentraciones  de Calcio, Fosforo y Pth en Los Pacientes en Hemodiálisis y Predecir el Riesgo Cardio-vascular. (PI-0311-2014. Proyectos de Investigación en Biomédica y en Ciencias de la Salud en Andalucía.  03/08/2015 – 03/08/2017)
PI: Martín Malo, Alejandro

Mecanismos moleculares implicados en los procesos de adhesión y migración celular: Efecto del tratamiento de enfermedad renal crónica sobre la disfunción endotelial. (PI 17/01785. FONDO DE INVESTIGACIÓN SANITARIA (FIS). 01/01/2018 – 31/12/2020)
PI: Martín Malo, Alejandro

GC07 Nephrology. Cell Damage in Chronic Inflammation

Principal Investigator
Alejandro Martín Malo

Co-Principal Investigator
Pedro Aljama García

Researchers
Mario Espinosa Hernández
Alberto Rodríguez Benot
Sagrario Soriano Cabrera
María Luisa Agüera Morales
María Dolores Navarro Cabello
Rafael Santamaría Olmo
Fátima Guerrero Pavón

Post-Doctoral Researchers
Francisco Javier Ariza Fuentes

Pre-Doctoral Researchers
Francisco Amaral Neiva
Inmaculada Ansio Vázquez
Isabel López López
María López Andreu
Cayetana Moyano Pelegrín
Raquel Ojeda López
Pedro Rosa Guerrero
Cristina Rabasco Ruiz
Marina Sánchez-Agesta Martínez

Technical, Nursing and Administrative Staff
María José Jiménez Moral

Projects

Active Projects

Regional

Guerrero Pavón, F; Bioingeniería Regenerativa: Modelo in vitro de recelularización de un scaffold renal con células mesenquimales.; Funding Agency: FIBICO. FUNDACION PARA LA INVESTIGACIÓN BIOMÉDICA DE CÓRDOBA; Reference: PI-0268-2018-FIB      

National

Aljama García, P.Kidney Research Network REDINREN. Funding agency: National Institute of Health Carlos III (ISCIII). Reference: RD16/0009/0034     

Martin Malo, A. Mecanismos moleculares implicados en los procesos de adhesión y migración celular: Efecto  del tratamiento de enfermedad renal crónica sobre la disfunción endotelial. Funding agency: National Institute of Health Carlos III (ISCIII). Reference:  PI17/01785

Martín Malo A; Análisis de la eficacia depuradora de diferentes técnicas de hemodiálisis sobre los niveles de miRNAs circulares en pacientes con Enfermedad Renal Crónica (Ayuda a la investigación en Diálisis Baxter 2018); Funding Agency: SOCIEDAD ESPAÑOLA DE NEFROLOGÍA; Reference: SEN18/02

Publications

Main Publications 2019

Cavero T, Arjona E, Soto K, Caravaca-Fontán F, Rabasco C, Bravo L, de la Cerda F, Martín N, Blasco M, Ávila A, Huerta A, Cabello V, Jarque A, Alcázar C, Fulladosa X, Carbayo J, Anaya S, Cobelo C, Ramos N, Iglesias E, Baltar J, Martínez-Gallardo R, Pérez L, Morales E, González R, Macía M, Draibe J, Pallardó L, Quintana LF, Espinosa M, Barros X, Pereira F, Cao M, Moreno JA, Rodríguez de Córdoba S, Praga M. Severe and malignant hypertension are common in primary atypical hemolytic uremic síndrome. Kidney Int. 2019 Oct;96(4):995-1004. PMID: 31420192
IF: 8,306
Q: 1 D: 1

Sevillano AM, Diaz M, Caravaca-Fontán F, Barrios C, Bernis C, Cabrera J6, Calviño J, Castillo L, Cobelo C, Delgado-Mallén P, Espinosa M, Fernandez-Juarez G, Fernandez-Reyes MJ, Garcia-Osuna R, Garcia P, Goicoechea M, Gonzalez-Cabrera F, Guzmán DA, Heras M, Martín-Reyes G, Martinez A, Olea T, Peña JK, Quintana LF, Rabasco C, López Revuelta K, Rodas L, Rodriguez-Mendiola N, Rodriguez E, San Miguel L, Sanchez de la Nieta MD22, Shabaka A, Sierra M, Valera A, Velo M, Verde E, Ballarin J, Noboa O, Moreno JA, Gutiérrez E, Praga M. IgA Nephropathy in Elderly Patients. Clin J Am Soc Nephrol. 2019 Aug 7;14(8):1183-1192 PMID: 31311818
IF: 6,243
Q: 1 D: 1

Díaz-Tocados JM, Rodríguez-Ortiz ME, Almadén Y, Pineda C, Martínez-Moreno JM, Herencia C, Vergara N, Pendón-Ruiz de Mier MV, Santamaría R, Rodelo-Haad C, Casado-Díaz A, Lorenzo V, Carvalho C, Frazão JM, Felsenfeld AJ, Richards WG1, Aguilera-Tejero E, Rodríguez M, López I, Muñoz-Castañeda JR. Calcimimetics maintain bone turnover in uremic rats despite the concomitant decrease in parathyroid hormone concentration. Kidney Int. 2019 Mar 12. pii: S0085-2538(19)30043-2. PMID 30878213.
IF: 8,306
Q: 1 D: 1

Rodelo-Haad C, Santamaria R, Muñoz-Castañeda J, Pendón-RuizdeMier MV, Martin-Malo A, Rodriguez M. FGF23, Biomarker or Target? Toxins (Basel). 2019 Mar 22;11(3). pii: E175. PMID 30909513.
IF: 3,895
Q: 1

Fernández-Ruiz M, Giménez E, Vinuesa V, Ruiz-Merlo T, Parra P, Amat P, Montejo M, Paez-Vega A, Cantisán S, Torre-Cisneros J, Fortún J, Andrés A, San Juan R, López-Medrano F, Navarro D, Aguado JM; Group for Study of Infection in Transplantation of the Spanish Society of Infectious Diseases and Clinical Microbiology (GESITRA-SEIMC) and the Spanish Network for Research in Infectious Diseases (REIPI). Regular monitoring of cytomegalovirus-specific cell-mediated immunity in intermediate-risk kidney transplant recipients: predictive value of the immediate post-transplant assessment. Clin Microbiol Infect. 2019 Mar;25(3):381. PMID 29803844.
IF: 5,394
Q: 1 D: 1

Main Publications 2018

Pérez-García R, Varas J, Cives A, Martín-Malo A, Aljama P, Ramos R, Pascual J, Stuard S, Canaud B, Merello JI. Increased mortality in haemodialysis patients administered high doses of erythropoiesis-stimulating agents: a propensity score-matched analysis. Nephrol Dial Transplant. 2018 Jan 1;33(1):187. PMID: 29077898
IF: 4,470
Q: 1   D: 1

Varas J, Ramos R, Aljama P, Pérez-García R, Moreso F, Pinedo M, Ignacio Merello J, Stuard S, Canaud B, Martín-Malo A. Relationships between iron dose, hospitalizations and mortality in incident haemodialysispatients: a propensity-score matched approach. Nephrol Dial Transplant. 2018 Jan 1;33(1):160-170. PMID:28992120
IF: 4,470.
Q: 1   D: 1

Huerta A, Arjona E, Portoles J, Lopez-Sanchez P, Rabasco C, Espinosa M, Cavero T, Blasco M, Cao M, Manrique J, Cabello-Chavez V, Suñer M, Heras M, Fulladosa X, Belmar L, Sempere A, Peralta C, Castillo L, Arnau A, Praga M, Rodriguez de Cordoba S. A retrospective study of pregnancy-associated atypical hemolytic uremic syndrome. Kidney Int. 2018 Feb;93(2):450-459. PMID: 28911789
IF: 8,395
Q: 1   D: 1

Ayasreh N, Bullich G, Miquel R, Furlano M, Ruiz P, Lorente L, Valero O, García-González MA, Arhda N, Garin I, Martínez V, Pérez-Gómez V, Fulladosa X, Arroyo D, Martínez-Vea A, Espinosa M, Ballarín J, Ars E, Torra R. Autosomal Dominant Tubulointerstitial Kidney Disease: Clinical Presentation of Patients With ADTKDUMOD and ADTKD-MUC1. Am J Kidney Dis. 2018 May 18. pii: S0272-6386(18)30606-1. PMID: 29784615
IF: 7,129
Q: 1   D: 1

Santamaría R, Díaz-Tocados JM, Pendón-Ruiz de Mier MV, Robles A, Salmerón-Rodríguez MD, Ruiz E, Vergara N, Aguilera-Tejero E, Raya A, Ortega R, Felsenfeld A, Muñoz-Castañeda JR, Martín-Malo A, Aljama P, Rodríguez M. Increased Phosphaturia Accelerates The Decline in Renal Function: A Search for Mechanisms. Sci Rep. 2018 Sep 12;8(1):13701. PMID 30209259
IF: 4,122.
Q: 1   D: 2

Other Publications 2018

Sánchez-Agesta Martínez M, Rabasco Ruiz C, Sánchez Sánchez R, Ortega Salas R, López Andreu M, Aljama García P, Espinosa Hernández M. C3 deposits worsens the prognosis in type iii extracapillary glomerulonephritis. Nefrologia. 2018 Mar - Apr;38(2):213-219. PMID:28988671
IF: 1,183
Q: 4

Del Pino M, Andrés A, Bernabéu AÁ, de Juan-Rivera J, Fernández E, de Dios García Díaz J, Hernández D, Luño J, Fernández IM, Paniagua J, Posada de la Paz M, Rodríguez-Pérez JC, Santamaría R, Torra R, Ambros JT, Vidau P, Torregrosa JV. Fabry Nephropathy: An Evidence-Based Narrative Review. Kidney Blood Press Res. 2018 Mar 16;43(2):406-421. PMID:29558749
IF: 3,104
Q: 2

Sánchez-Hidalgo JM, Rodríguez-Ortiz L, Arjona-Sánchez A, Ruiz-Rabelo J, Salamanca-Bustos JJ, Rodríguez-Benot A, Márquez-López FJ, Briceño-Delgado J. Pancreas Donor Hypernatremia: Is it Really a Risk Factor for Simultaneous Pancreas-kidney Transplantation? TransplantProc. 2018 Mar;50(2):676-678. PMID:29579886
IF: 0,908
Q: 4

Arjona-Sánchez A, Rodríguez-Ortiz L, Sánchez-Hidalgo JM, Ruiz Rabelo J, Salamanca-BustosJJ, Rodríguez-Benot A, Campos-Hernández P, Briceño-Delgado J. Intraoperative Heparinization During Simultaneous Pancreas-Kidney Transplantation: Is It Really Necessary? TransplantProc. 2018 Mar;50(2):673-675. PMID:29579885
IF: 0,908
Q: 4

Pendón-Ruiz de Mier MV, Agüera ML, Navarro MD, Rodriguez-Benot A, Aljama P. Prevalence and Survival of Cancer After Pancreas-Kidney Transplantation. Transplant Proc. 2018 Mar;50(2):669-672. PMID:29579884
IF: 0,908
Q: 4

Sánchez-Hidalgo JM, Salamanca-Bustos JJ, Arjona-Sánchez Á, Campos-Hernández JP, Ruiz Rabelo J, Rodríguez-Benot A, Requena-Tapia MJ, Briceño-Delgado J. What Is the Influence of Both Risk Donor and Risk Receiver on Simultaneous Pancreas-Kidney Transplantation? TransplantProc. 2018 Mar;50(2):664-668. PMID:29579883
IF: 0,908
Q: 4

Rodelo-Haad C, Esquivias-Motta E, Agüera ML, Aljama P, Rodríguez-Benot A. 24-Hour Proteinuria Versus Spot Protein-Creatinine Ratio for Kidney Transplant Management in Clinical Practice. TransplantProc. 2018 Mar;50(2):560-564. PMID:29579852
IF: 0,908
Q: 4

Rodelo-Haad C, Agüera ML, Ortega R, Martinez-Lopez A, Navarro MD, Rodriguez-Benot A, Aljama P. Lithium-associated nephropathy in the renal allograft. Kidney Int. 2018 Jan;93(1):273. PMID:29291824
IF: 8,395
Q: 1   D: 1

Ojeda Lopez, Raquel; Esquivias de Motta, Elvira; Carmona, Andres; Garcia Montemayor, Victoria; Berdud, Isabel; Martin Malo, Alejandro; Aljama Garcia, Pedro. Correction of 25-OH-vitamin D deficiency improves control of secondary hyperparathyroidism and reduces the inflammation in stable haemodialysis patients. Nefrologia. 2018 Jan - Feb;38(1):41-47. PMID:28673686
IF: 1,183
Q: 4

Alberto Rodríguez Benot, Juan José Amenábar, Natividad Calvo, Laura Cañas, José Francisco Crespo, Roberto Gallego, Domingo Marrero-Miranda, Emilio Rodrigo, Manuel Ángel Rodríguez, Carmen Sánchez-gonzález, M. Luisa Suárez-Fernández. Prevención del cáncer postrasplante renal: de los factores clásicos a la inmunosupresión. NefrologiaSup Ext 2018;9(1):55-64
IF: 0,887
Q: 4

Gorostidi M, Sánchez-Martínez M, Ruilope LM, Graciani A, de la Cruz JJ, Santamaría R, Del Pino MD, Guallar-Castillón P, de Álvaro F, Rodríguez-Artalejo F, Banegas JR. Chronic kidney disease in Spain: Prevalence and impact of accumulation of cardiovascular risk factors. Nefrologia. 2018 Jun 18. pii: S0211-6995(18)30075-4. PMID: 29914761
IF: 0,887
Q: 4

Bover Sanjuán J, Navarro-González JF, Arenas MD, Torregrosa JV, Tamargo Menéndez J, de Francisco ALM, González-Parra E, Lloret Cora MJ, Sánchez Álvarez JE, Martín-Malo A, Molina Vila P, Bajo MA, DaSilva Santos I. Pharmacological interactions of phosphate binders. Nefrología.  2018 Nov - Dec;38(6):573-578. PMID: 30473007
IF: 0,887
Q: 4

Lopez-Lopez I, Rodelo-Haad C, Agüera ML, Cabello-Jabalquinto R, Esquivias-Motta E, Navarro MD, Aljama P, Rodriguez-Benot, A. Administration of mycophenolic acid is not associated with malformations in descendants from kidney transplanted males. PLoS One. 2018 Sep 12;13(9):e0202589. PMID 30208043
IF: 2,766
Q: 1   D: 3

Varas J, Pérez-Sáez MJ, Ramos R, Merello JI, de Francisco ALM, Luño J, Praga M, Aljama P, Pascual J; Optimizing Results in Dialysis (ORD) group. Returning to haemodialysis after kidney allograft failure: a survival study with propensity score matching. Nephrol Dial Transplant. 2018 Jul 19. doi: 10.1093/ndt/gfy215. [Epub ahead of print PMID 30053152
IF: 4,47
Q: 1   D: 1

Calvillo-Arbizu J, Pérez-Valdivia MA, Gentil-Govantes MA, Castro-de-la-Nuez P, Mazuecos-Blanca A, Rodríguez-Benot A, Gracia-Guindo MC, Borrego-Utiel F, Cabello-Díaz M, Bedoya-Pérez R, Alonso-Gil M, Salgueira-Lazo M, Roa-Romero LM. Does the Kidney Donor Profile Index (KDPI) predict graft and patient survival in a Spanish population? Nefrologia. 2018 Nov - Dec;38(6):587-595. PMID 30243494
IF: 0,887
Q: 4

Páez-Vega A, Poyato A, Rodriguez-Benot A, Guirado L, Fortún J, Len O, Abdala E, Fariñas MC, Cordero E, de Gracia C, Hernández D, González R, Torre-Cisneros J, Cantisán S; Spanish Network for Research in Infectious Diseases (REIPI) (RD16/0016); Spanish Renal Disease Network (REDinREN, RD16/0009). Analysis of spontaneous resolution of cytomegalovirus replication after transplantation in CMV-seropositive patients with pretransplant CD8+IFNG+ response. Antiviral Res. 2018 Jul;155:97-105. PMID 29782877
IF: 4,307
Q: 1   D: 2

Soriano ML, Rodríguez-Benot A, Valcárcel M. Nanotechnological foundations of a «new» Nephrology. Nefrologia. 2018 Jul - Aug;38(4):368-378. PMID 29778557
IF: 0,887
Q: 4

Rodelo-Haad C, Gimenez RFD, Ortega R, Rodriguez M, Aljama P. Calcific arteriolopathy beyond chronic kidney diseases. The role hemochromatosis and vitamin K antagonist. CLINICAL CASES IN MINERAL AND BONE METABOLISM 2018 15(1):85-88

Helve J, Kramer A, Abad-Diez JM, Couchoud C, de Arriba G, de Meester J, Evans M, Glaudet F, Grönhagen-Riska C, Heaf JG, Lezaic V, Nordio M, Palsson R, Pechter Ü, Resic H, Santamaria R, Santiuste de Pablos C, Massy ZA, Zurriaga Ó, Jager KJ, Finne P. Factors associating with differences in the incidence of renal replacement therapy among elderly: data from the ERA-EDTA Registry. Nephrol Dial Transplant. 2018 Aug 1;33(8):1428-1435. PMID 29684185
IF: 4,6
Q: 1   D: 2

Aguado R, Páez-Vega A, Agüera ML, Montejo M, Guirado L, Fortún J, Suárez-Benjumea A, Len O, Fariñas MC, de Gracia C, Hernández D, Cobos-Ceballos MJ, Torre-Cisneros J, Cantisán S; Spanish Network for Research in Infectious Diseases and the Spanish Renal Disease Network; Spanish Transplantation Infection Study Group (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC). Lack of evidence of association between IFNG and IL28B polymorphisms and QuantiFERON-CMV test results in seropositive transplant patients. Hum Immunol. 2018 Jun;79(6):499-505. PMID 29605690
IF: 1,994
Q: 4

C Rodelo-Haad, ME Rodríguez-Ortiz, A Martín-Malo, MV Pendón-RuizdeMier, ML Agüera, JR Muñoz-Castañeda, S Soriano, F Caravaca, MA Álvarez-Lara, A Felsenfeld, P Aljama, M Rodríguez. Phosphate control in reducing FGF23 levels in hemodialysis patients. PLoS One. 2018 Aug 7;13(8):e0201537. PMID 30086150
IF: 2,766
Q: 1   D: 3

Stel VS, Awadhpersad R, Pippias M, Ferrer-Alamar M, Finne P, Fraser SD, Heaf JG, Hemmelder MH, Martínez-Castelao A, de Meester J, Palsson R, Prischl FC, Segelmark M, Traynor JP, Santamaria R, Reisaeter AV, Massy ZA, Jager KJ. International comparison of trends in patients commencing renal replacement therapy by primary renal disease. Nephrology (Carlton). 2018 Nov 19 [Epub ahead of print]. PMID 30456883

de Francisco ALM, Varas J, Ramos R, Merello JI, Canaud B, Stuard S, Pascual J, Aljama P; Optimizing Results in Dialysis (ORD) group. Proton Pump Inhibitor usage and the risk of mortality in hemodialysis patients. Kidney Int. Rep. 2018; 3(2):374-384

Main Publications 2017

Carmona A, Guerrero F, Buendia P, Obrero T, Aljama P, Carracedo J. Microvesicles Derived from Indoxyl Sulfate Treated Endothelial Cells Induce Endothelial Progenitor Cells Dysfunction. FRONTIERS IN PHYSIOLOGY. 2017.8():-666.
IF: 4,134
Q: 1 

Carmona A, Aguera ML, Luna-Ruiz C, Buendia P, Calleros L, Garcia-Jerez A, Rodriguez-Puyol M, Arias M, Arias-Guillen M, de Arriba G, Ballarin J, Bernis C, Fernandez E, Garcia-Rebollo S, Mancha J, del Peso G, Perez E, Poch E, Portoles JM, Rodriguez-Puyol D, Sanchez-Villanueva R, Sarro F, Torres A, Martin-Malo A, Aljama P, Ramirez R, Carracedo J. Markers of endothelial damage in patients with chronic kidney disease on hemodialysis. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2017.312(4):F673-F681.
IF: 3,611
Q: 1 

Esquivias-Motta E, Martin-Malo A, Buendia P, Alvarez-Lara MA, Soriano S, Crespo R, Carracedo J, Ramirez R, Aljama P. Hemodiafiltration With Endogenous Reinfusion Improved Microinflammation and Endothelial Damage Compared With Online-Hemodiafiltration: A Hypothesis Generating Study. ARTIFICIAL ORGANS. 2017.41(1):88-98.
IF: 2,403
Q: 2 

Other Publications 2017

Tortajada A, Gutierrez E, de Jorge EG, Anter J, Segarra A, Espinosa M, Blasco M, Roman E, Marco H, Quintana LF, Gutierrez J, Pinto S, Lopez-Trascasa M, Praga M, de Cordoba SR. Elevated factor H-related protein 1 and factor H pathogenic variants decrease complement regulation in IgA nephropathy. KIDNEY INTERNATIONAL. 2017.92(4):953-963.
IF: 8,395
Q: 1  D: 1

Diaz-Tocados JM, Peralta-Ramirez A, Rodriguez-Ortiz ME, Raya AI, Lopez I, Pineda C, Herencia C, de Oca AM, Vergara N, Steppan S, de Mier MVPR, Buendia P, Carmona A, Carracedo J, Alcala-Diaz JF, Frazao J, Martinez-Moreno JM, Canalejo A, Felsenfeld A, Rodriguez M, Aguilera-Tejero E, Almaden Y, Munoz-Castaneda JR. Dietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic rats. KIDNEY INTERNATIONAL. 2017.92(5):1084-1099.
IF: 8,395
Q: 1  D: 1

Molina J, Navas A, Aguera ML, Rodelo-Haad C, Alonso C, Rodriguez-Benot A, Aljama P, Solana R. Impact of Preformed Donor-Specific Anti-Human Leukocyte Antigen Antibody C1q-Binding Ability on Kidney Allograft Outcome. FRONTIERS IN IMMUNOLOGY. 2017.8():-1310.
IF: 6,429
Q: 1 

Alique M, Ruiz-Torres MP, Bodega G, Noci MV, Troyano N, Bohorquez L, Luna C, Luque R, Carmona A, Carracedo J, Ramirez R. Microvesicles from the plasma of elderly subjects and from senescent endothelial cells promote vascular calcification. AGING-US. 2017.9(3):778-789.
IF: 4,867
Q: 2 

Cavero T, Rabasco C, Lopez A, Roman E, Avila A, Sevillano A, Huerta A, Rojas-Rivera J, Fuentes C, Blasco M, Jarque A, Garcia A, Mendizabal S, Gavela E, Macia M, Quintana LF, Romera AM, Borrego J, Arjona E, Espinosa M, Portoles J, Gracia-Iguacel C, Gonzalez-Parra E, Aljama P, Morales E, Cao M, de Cordoba SR, Praga M. Eculizumab in secondary atypical haemolytic uraemic syndrome. NEPHROLOGY DIALYSIS TRANSPLANTATION. 2017.32(3):466-474.
IF: 4,47
Q: 1 

Valencia-Nunez DM, Kreutler W, Moya-Gonzalez J, Alados-Arboledas P, Munoz-Carvajal I, Carmona A, Ramirez-Chamond R, Carracedo-Anon J. Endothelial vascular markers in coronary surgery. HEART AND VESSELS. 2017.32(11):1390-1399.
IF: 3,434
Q: 2 

Cantisan S, Paez-Vega A, Santos F, Rodriguez-Benot A, Aguado R, Rivero A, Montejo M, Torre-Cisneros J, Solana R, Spanish Network Res Infect Dis. Impact of age and cytomegalovirus on CD8(+) T-cell compartment remodeling after solid organ transplantation: A one-year follow-up study.EXPERIMENTAL GERONTOLOGY. 2017.95():98-106.
IF: 3,34
Q: 1 

Maduell F, Varas J, Ramos R, Martin-Malo A, Perez-Garcia R, Berdud I, Moreso F, Canaud B, Stuard S, Gauly A, Aljama P, Merello JI. Hemodiafiltration Reduces All-Cause and Cardiovascular Mortality in Incident Hemodialysis Patients: A Propensity-Matched Cohort Study. AMERICAN JOURNAL OF NEPHROLOGY. 2017.46(4):288-297.
IF: 2,542
Q: 2 

Luno J, Varas J, Ramos R, Merello I, Aljama P, Martin Malo A, Pascual J, Praga M, ORD Grp. The Combination of Beta Blockers and Renin-Angiotensin System Blockers Improves Survival in Incident Hemodialysis Patients: A Propensity-Matched Study. KIDNEY INTERNATIONAL REPORTS. 2017.2(4):665-675.

Clinical Research

Active in 2019

An international, multicenter, randomized, double-blind, parallel-group, placebo-controlled study of the effect of atrasentan on kidney outcomes in subjects with diabetes type 2 and nephropathy. SONAR trial of diabetic nephropathy.
PI: Dr. Rafael Santamaría Olmo

A randomized, double-blind, placebo-controlled, phase II study to assess the efficacy and safety of the ASP0113 vaccine in CMV-seronegative donors.
PI: Dr. María Dolores Navarro Cabello

National Registry of Humoral Rejection. An epidemiological, multicenter, observational, prospective study to assess the clinical, serological and histological characteristics and five-year evolution of humoral rejection after renal transplantation in Spain.
PI: Dr. Mª Luisa Agüera Morales

A 6 year, multicentre, non-interventional, post-authorisation safety study for patients prescribed Jinarc for autosomal dominant polycystic kidney disease.
PI: Dr. Mario Espinosa Hernández

Estudio de la carga de la enfermedad en pacientes con enfermedad de fabry. ESTUDIO CAR E-FABRY.
PI: Dr. Rafael Santamaría Olmo

Ensayo Multicéntrico, Aleatorizado, Controlado y Abierto para Evaluar la Eficacia del Tratamiento Secuencial con Tacrolimus-Rituximab versus Esteroides más Ciclofosfamida en Pacientes con Nefropatía Membranosa Primaria.
PI: Dr. Mario Espinosa Hernández

Estudio fase III, aleatorizado, doble ciego, controlado con placebo, de grupos paralelos, multicéntrico, dirigido por eventos, para evaluar la eficacia y seguridad de finerenona, asociada al tratamiento estándar, en la progresión de la enfermedad renal en.
PI: Dr. Rafael Santamaría Olmo

Estudio fase III, aleatorizado, doble ciego, controlado con placebo, de grupos paralelos, multicéntrico, dirigido por eventos, para evaluar la eficacia y seguridad de finerenona, asociada al tratamiento estándar, en la reducción de la morbilidad y mortali.
PI: Dr. Rafael Santamaría Olmo

A randomized, double-blind, placebo-controlled, Phase III Study of the Safety and Efficacy of OMS721 in Patients with Inmunoglobin A (IgA) Nefropathy (ARTEMIS-IGAN).
PI: Dr. Mario Espinosa Hernández

Estudio fase I. An observer-blind, multi-center, placebo-controlled, parallel group study to assess the safety and tolerability and to characterize the pharmacokinetics and the pharmacodynamics of different doses of BAY 1213790 in patients with end-stage renal disease.
PI: Dr. Alejandro Martín Malo

Estudio controlado con principio activo, aleatorizado, multicéntrico, doble ciego y paralelo de los efectos de esparsentán, un receptor dual de endotelina y un bloqueador del receptor de angiotensina, sobre los resultados renales en pacientes con glomerul.
PI: Dr. Mario Espinosa Hernández

Estudio de fase 2, aleatorizado, doble ciego y controlado con placebo de cemdisirán en pacientes adultos con nefropatía por IgA.
PI: Dr. Mario Espinosa Hernández

Estudio de fase IIb, multicéntrico, aleatorizado, doble ciego y controlado con placebo de verinurad y alopurinol en pacientes con nefropatía crónica e hiperuricemia.
PI: Dr. Rafael Santamaría Olmo

A Phase Ib/IIa, Open-Label, Multicenter Clinical Trial to Assess Safety and Efficacy of the Human Anti-CD38 Antibody MOR202 in Anti-PLA2R Antibody Positive Membranous Nephropathy (aMN). M-PLACE.
PI: Dr. Mario Espinosa Hernández

Estudio multicéntrico, abierto, prospectivo, aleatorizado para explorar a morbi-mortalidad en pacientes dializados con hemodiálisis extendida en comparación con la hemodiafiltración en línea.
PI: Dr. Raquel Ojeda López

Impacto de los niveles de tacrolimus en la prevención del rechazo en pacientes de edad avanzada receptores de trasplante renal de novo: estudio observacional prospectivo en las condiciones de la práctica clínica habitual (BITÁCORA).
PI: Dr. Alberto Manuel Rodríguez Benot

A randomized, double-blind, parallel-group, multi-center study to assess the safety and tolerability of monthly subcutaneous administrations of a low and high dose cohort of osocimab to ESRD patients on regular hemodialysis in comparison to placebo.
PI: Dr. Alejandro Martín Malo

Members

Dr. Alejandro Martín Malo

Principal Investigator

alejandro.martin.sspa@juntadeandalucia.es
Dr. Pedro Aljama García

Co-Principal Investigator

Team

Mario Espinosa Hernández, Alberto Rodríguez Benot, Sagrario Soriano Cabrera, María Luisa Agüera Morales, María Dolores Navarro Cabello, Rafael Santamaría Olmo, Fátima Guerrero Pavón, Francisco Javier Ariza Fuentes, Francisco Amaral Neiva, Inmaculada Ansio Vázquez, Isabel López López, María López Andreu, Cayetana Moyano Pelegrín, Raquel Ojeda López, Pedro Rosa Guerrero, Cristina Rabasco Ruiz, Marina Sánchez-Agesta Martínez, María José Jiménez Moral