Research groups

GA04 Endocrinology and Nutrition. Insulin Resistance, Diabetes and Metabolism

Our associated research group is focused on translational research and personalized medicine in endocrinology, diabetes and obesity. Specifically, our research lines are:

  • Pituitary and neuroendocrine tumors:  novel predictive and prognostic markers for diagnosis, treatment and followup; as well as the potential use of novel therapeutic options (ketoconazole, metformin, etc) for these tumors. This research line is performed in collaboration with the collaboration of the research groups of Dr. Castaño and Dr. Luque.
  • Obesity and bariatric surgery: evaluation of predictive factors for short, medium- and long-term clinical response. The study of the relation between weight changes, splicing machinery and other signaling pathways that might be related to insulin resistance and tumorigenesis. These studies are performed in collaboration with the research group of Dr. Luque
  • Obesity and reproductive function: there are two projects in this line: 1. nutritional interventions in obese women evaluated in the “Reproductive Unit” in collaboration with that unit and the research group of Dr Tena; 2. Hypogonadism in obese patients with type 2 diabetes, this project is also performed in collaboration with Dr Tena.

Our group is constituted by specialists if the Endocrinology and Nutrition Unit and hopes to integrate pre- and post-doctoral researchers, as well as other professionals (data manager, nurses). Recently, a new researcher has been incorporated in our group, Dr Herrera (Rio Hortega researcher) is responsible for the first two research lines. We also expect to start a new project for improving the non-invasive diagnosis for thyroid nodules.

We also have collaborations with the research group of Dr. Quesada Gómez; particularly, the relation between vitamin D and bone stem cells. Additionally, some multicenter, clinical trials are currently being performed in our unit.

The prevalence of endocrine disorders, diabetes and obesity are increasing worldwide, to this aim, research that may improve the clinical outcome and evolution of these diseases has a high impact in our patients and our current society.

Research Lines

Expression of different hormone receptors and intracellular mediators in the onset and development of pituitary tumors.

Evaluation of novel receptors, hormones and intracellular mediators in the development of neuroendocrine tumors. Evaluation of the effects of several drugs on cell proliferation, secretion or mRNA modifications.

Evaluation of predictor markers for clinical evolution, as well as the underlying mechanisms of the beneficial metabolic effect of the surgery.

Evaluation of the underlying mechanisms related with fertility, hypogonadism and obesity, as well as the identification of novel targets for the development of therapeutic options.

Networks

Keywords

  • Insulin resistance
  • β-pancreatic dysfunction
  • prediabetes
  • metabolic syndrome
  • adipotoxicity
  • adipose tissue
  • inflammation
  • oxidative stress
  • gene expression
  • metabolomics
  • pituitary adenoma
  • somatostatin receptors
  • vitamin D
  • metabolic syndrome
  • neuroendocrine tumors
  • bariatric surgery
  • adipose tissue
  • hormones
  • diabetes mellitus
  • fertility
  • pregnancy

Additional Information

Patent application

(10/2018): MÉTODO PARA EL DIAGNÓSTICO, PRONÓSTICO Y TRATAMIENTO DE LOS TUMORES NEUROENDOCRINOS (TNEs). Application nr: P201831039

Clinical guideline

Chico A, Aguilera E, Ampudia-Blasco FJ, Bellido V, Cardona-Hernández R, Escalada FJ, Palomares R, González-Blanco C. (2019). Clinical Approach to Flash Glucose Monitoring: An Expert Recommendation. Journal of Diabetes Science and Technology. 2019. https://doi.org/10.1177/1932296819841911

GA04 Endocrinology and Nutrition. Insulin Resistance, Diabetes and Metabolism

Principal Investigator
Mª Ángeles Gálvez Moreno

Researchers
Juan Antonio Paniagua González
Alfonso Calañas Continente
Mª José Molina Puerta
Rafael Palomares Ortega
Aura Dulcinea Herrera Martínez

Pre-Doctoral researchers
Rosa María Alhambra Expósito
Concepción Muñoz Jiménez
José Carlos Padillo Cuenca
Ángel Rebollo Martín

Projects

Active in 2019

Molina Puerta, MJ. Beca SANCYD-VEGENAT de investigación al mejor proyecto en obesidad 2016: Uso de las TIC para control del peso en pacientes con sobrepeso y obesidad. Funding agency: FUNDACION ANDALUZA DE NUTRICIÓN CLÍNICA Y DIETÉTICA. Reference: SANCYD-VEGENAT_001           

Finished projects

Calañas Continente, A. Intervention study on lifestyle in obese women with infertility who need assisted reproduction techniques. Funding agency: Sociedad Andaluza de Endocrinología, Diabetes y Nutrición. Reference: SAEDYN15_002

Publications

Publications 2019

Remacha L, Pirman D, Mahoney CE, Coloma J, Calsina B, Curras-Freixes M, Leton R, Torres-Perez R, Richter S, Pita G, Herraez B, Cianchetta G, Honrado E, Maestre L, Urioste M, Aller J, Garcia-Uriarte O, Galvez MA, Luque RM, Lahera M, Moreno-Rengel C, Eisenh; Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas. AMERICAN JOURNAL OF HUMAN GENETICS. 2019 Apr 4;104(4):651-664. doi: 10.1016/j.ajhg.2019.02.017. 
IF: 9,924
D: 1

Vazquez-Borrego MC, Fuentes-Fayos AC, Venegas-Moreno E, Rivero-Cortes E, Dios E, Moreno-Moreno P, Madrazo-Atutxa A, Remon P, Solivera J, Wildemberg LE, Kasuki L, Lopez-Fernandez JM, Gadelha MR, Galvez-Moreno MA, Soto-Moreno A, Gahete MD, Castano JP, Luque R; Splicing Machinery is Dysregulated in Pituitary Neuroendocrine Tumors and is Associated with Aggressiveness Features. CANCERS. 2019 Sep 26;11(10):1439. doi: 10.3390/cancers11101439.
IF: 6,162
Q: 1 D: 2

Herrera-Martinez AD, Pedraza-Arevalo S, L-Lopez F, Gahete MD, Galvez-Moreno MA, Castano JP, Luque RM; Type 2 Diabetes in Neuroendocrine Tumors: Are Biguanides and Statins Part of the Solution?. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2019 Jan 1;104(1):57-73. doi: 10.1210/jc.2018-01455.
IF: 5,605
Q: 1

Vazquez-Borrego MC, Fuentes-Fayos AC, Herrera-Martinez AD, L-Lopez F, Ibanez-Costa A, Moreno-Moreno P, Alhambra-Exposito MR, Barrera-Martin A, Blanco-Acevedo C, Dios E, Venegas-Moreno E, Solivera J, Gahete MD, Soto-Moreno A, Galvez-Moreno MA, Castano JP, ; Biguanides Exert Antitumoral Actions in Pituitary Tumor Cells Through AMPK-Dependent and -Independent Mechanisms. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2019 Aug 1;104(8):3501-3513. doi: 10.1210/jc.2019-00056.
IF: 5,605
Q: 1

Herrera-Martinez AD, Hofland J, Hofland LJ, Brabander T, Eskens FALM, Moreno MAG, Luque RM, Castano JP, de Herder WW, Feelders RA; Targeted Systemic Treatment of Neuroendocrine Tumors: Current Options and Future Perspectives. DRUGS. 2019 Jan;79(1):21-42. doi: 10.1007/s40265-018-1033-0.
IF: 4,993
Q: 1

Herrera-Martinez AD, van den Dungen R, Dogan-Oruc F, van Koetsveld PM, Culler MD, de Herder WW, Luque RM, Feelders RA, Hofland LJ; Effects of novel somatostatin-dopamine chimeric drugs in 2D and 3D cell culture models of neuroendocrine tumors. ENDOCRINE-RELATED CANCER. 2019 Jun;26(6):585-599. doi: 10.1530/ERC-19-0086.
IF: 4,774
Q: 1

Herrera-Martinez AD, Hofland LJ, Moreno MAG, Castano JP, de Herder WW, Feelders RA; Neuroendocrine neoplasms: current and potential diagnostic, predictive and prognostic markers. ENDOCRINE-RELATED CANCER. 2019 Mar 1;26(3):R157-R179. doi: 10.1530/ERC-18-0354.
IF: 4,774
Q: 1

Lecube A, Sanchez E, Andres A, Saldana C, Morales MJ, Calanas A, Minambres I, Pellitero S, Cordido F, Bueno M, Caixas A, Vilarrasa N; Assessing Motivational Stages and Processes of Change for Weight Management Around Bariatric Surgery: a Multicenter Study. OBESITY SURGERY. 2019 Oct;29(10):3348-3356. doi: 10.1007/s11695-019-04001-4.
IF: 3,603
D:2 Q:1

Morillas C, Escalada J, Palomares R, Bellido D, Gomez-Peralta F, Perez A; Treatment of Type 2 Diabetes by Patient Profile in the Clinical Practice of Endocrinology in Spain: Delphi Study Results from the Think Twice Program. DIABETES THERAPY. 2019 Oct;10(5):1893-1907. doi: 10.1007/s13300-019-0671-x.
IF: 2,827
Q: 3

Herrera-Martinez AD, Feelders RA, de Herder WW, Castano JP, Moreno MAG, Dogan F, van Dungen R, van Koetsveld P, Hofland LJ; Effects of Ketoconazole on ACTH-Producing and Non-ACTH-Producing Neuroendocrine Tumor Cells. HORMONES & CANCER. 2019 Jun;10(2-3):107-119. doi: 10.1007/s12672-019-00361-6. 
IF: 2,581
Q: 3

Fuentes-Fayos AC, Garcia-Martinez A, Herrera-Martinez AD, Jimenez-Vacas JM, Vazquez-Borrego MC, Castano JP, Pico A, Gahete MD, Luque RM; Molecular determinants of the response to medical treatment of growth hormone secreting pituitary neuroendocrine tumors. MINERVA ENDOCRINOLOGICA. 2019 Jun;44(2):109-128. doi: 10.23736/S0391-1977.19.02970-5.
IF: 1,817
Q: 4

Alvarez-Escola C, Venegas-Moreno EM, Garcia-Arnes JA, Blanco-Carrera C, Marazuela-Azpiroz M, Galvez-Moreno MA, Menendez-Torre E, Aller-Pardo J, Salinas-Vert I, Resmini E, Torres-Vela EM, Gonzalo-Redondo MA, Vilchez-Joya R, de Miguel-Novoa MP, Halperin-Rab; ACROSTART: A retrospective study of the time to achieve hormonal control with lanreotide Autogel treatment in Spanish patients with acromegaly. ENDOCRINOLOGIA DIABETES Y NUTRICION. 2019 May;66(5):320-329. doi: 10.1016/j.endinu.2018.12.004. 
IF: 0,934
Q: 4

Exposito MRA, Puerta MJM, Olveira G, Irigoyen CA, Soto MF, Almeida JMG, Luna PPG, Perez AMG, Rocamora JAI, Soria JBM, Cunill JLP, Restrepo JMR, Perez IR, Aguayo PS, Lopez FJV; Recommendations of the GARIN group for dietary managing of patient with chronic kidney disease. NUTRICION HOSPITALARIA. 2019 Mar 7;36(1):183-217. doi: 10.20960/nh.1823.
IF: 0,759
Q: 4

Rebollo-Roman A, de Damas-Medina M, Molina-Puerta MJ, Calanas-Continente A, Manzano-Garcia G; Nutritional approach in systemic sclerosis: report of a case. NUTRICION HOSPITALARIA. 2019 Oct 17;36(5):1231-1234. doi: 10.20960/nh.02732.
IF: 0,754
Q: 4

Main publications 2018

Rebollo-Roman A, Barrera-Martin A, Alcantara-Laguna MD, Iglesias-Flores E, Canada-Sanz E, Padillo-Cuenca JC, Molina-Puertas MJ, Calanas-Continente A. Non-oropharyngeal dysphagia with frequent Emergency Room attendance. NUTRICION HOSPITALARIA. 2018; 35(4):996-998.
IF: 0,845
Q: 4

Exposito MRA, Herrera-Martinez AD, Garcia GM, Calvo ME, Serrano CMB, Moreno MAG. Early nutrition support therapy in patients with head-neck cancer. NUTRICION HOSPITALARIA. 2018; 35(3):505-510.
IF: 0,747
Q: 4

Herrera-Martinez AD, Ortega RP, Opazo RB, Moreno-Moreno P, Puerta MJM, Galvez-Moreno MA. Hyperlipidemia during gestational diabetes and its relation with maternal and offspring complications. NUTRICION HOSPITALARIA. 2018; 35(3):698-706.
IF: 0,747
Q: 4

Herrera-Martinez AD, Gahete MD, Sanchez-Sanchez R, Alors-Perez E, Pedraza-Arevalo S, Serrano-Blanch R, Martinez-Fuentes AJ, Galvez-Moreno MA, Castano JP, Luque RM. Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Novel Potential Biomarker in Gastroenteropancreatic Neuroendocrine Tumors. CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY. 2018; 9:Núm artículo 196
IF: 4,621
Q: 1  D: 1

Alhambra-Exposito MR, Ibanez-Costa A, Moreno-Moreno P, Rivero-Cortes E, Vazquez-Borrego MC, Blanco-Acevedo C, Toledano-Delgado A, Lombardo-Galera MS, Vallejo-Casas JA, Gahete MD, Castano JP, Galvez MA, Luque RM. Association between radiological parameters and clinical and molecular characteristics in human somatotropinomas. SCIENTIFIC REPORTS. 2018; 8:Núm artículo 6173
IF: 4,122
Q: 1

Herrera-Martinez AD, Gahete MD, Pedraza-Arevalo S, Sanchez-Sanchez R, Ortega-Salas R, Serrano-Blanch R, Luque RM, Galvez-Moreno MA, Castano JP. Clinical and functional implication of the components of somatostatin system in gastroenteropancreatic neuroendocrine tumors. ENDOCRINE. 2018; 59(2):426-437.
IF: 3,179
Q: 2

Bernabeu I, Aller J, Alvarez-Escola C, Fajardo-Montanana C, Galvez-Moreno A, Guillin-Amarelle C, Sesmilo G. Criteria for diagnosis and postoperative control of acromegaly, and screening and management of its comorbidities: Expert consensus. ENDOCRINOLOGIA DIABETES Y NUTRICION. 2018; 65(5):297-305.
IF: n/a
Q: 4

Main publications 2017

Alhambra-Exposito MR, Molina-Puerta MJ, Prior-Sanchez MI, Manzano-Garcia G, Calanas-Continente A, Galvez-Moreno MA. Variations in diabetes remission rates after bariatric surgery in Spanish adults according to the use of different diagnostic criteria for diabetes. BMC ENDOCRINE DISORDERS. 2017.17(1):-51.
IF: 2,275
Q: 3

Herrera-Martinez AD, Cuenca JCP, Opazo RB, Martin AB, Roman AR, Iglesia CD, Moreno MAG. ACTH Producing Pancreatic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1. JOURNAL OF THE PANCREAS. 2017.18(2):175-180.

Paniagua JA, Bahamondes R, Cano-Sanchez A, Velasco F. Unexpected papilledema in a young male with Type 1 diabetes. CLINICAL CASE REPORTS. 2017.5(8):1333-1338.

Other Publications 2017

Wanden-Berghe C, Luengo LM, Alvarez J, Burgos R, Cuerda C, Matia P, Candela CG, Olmos MAM, Gonzalo M, Calleja A, Campos C, de la Cruz AP, Irles JA, Leyes P, Sanchez R, Roman DD, Cardona D, Santacruz N, Suarez JP, Ballesta C, Sales J, Penacho MA, Gardez C, Martinez MJ, Canovas B, Moreno JM, del Olmo D, Carabana F, Virgili N, Higuera I, Mauri S, Sanchez-Vilar O, Miserachs N, Ponce MA, Garcia Y, Moran JM, Apezetxea A, Tejera C, Calanas A, Canton A, Diaz P, Nadya-Senpe G. Spanish home enteral nutrition registry of the year 2014 and 2015 from the NADYA-SENPE Group. NUTRICION HOSPITALARIA. 2017.34(1):15-18.
IF: 0,747
Q: 4

Herrera-Martinez AD, Gahete MD, Sanchez-Sanchez R, Salas RO, Serrano-Blanch R, Salvaderra A, Hoflandi LJ, Luque RM, Galvez-Moreno MA, Castano JP. The components of somatostatin and ghrelin systems are altered in neuroendocrine lung carcinoids and associated to clinical-histological features. LUNG CANCER. 2017.109():128-136.
IF: 4,294
Q: 1

Ibanez-Costa A, Lopez-Sanchez LM, Gahete MD, Rivero-Cortes E, Vazquez-Borrego MC, Galvez MA, de la Riva A, Venegas-Moreno E, Jimenez-Reina L, Moreno-Carazo A, Tinahones FJ, Maraver-Selfa S, Japon MA, Garcia-Arnes JA, Soto-Moreno A, Webb SM, Kineman RD, Culler MD, Castano JP, Luque RM.BIM-23A760 influences key functional endpoints in pituitary adenomas and normal pituitaries: molecular mechanisms underlying the differential response in adenomas. SCIENTIFIC REPORTS. 2017.7():-42002.
IF: 4,259
Q: 1

Prior-Sanchez I, Martin AB, Ortega EM, Casas JAV, Moreno MAG.Is a second recombinant human thyrotropin stimulation test useful? The value of postsurgical undetectable stimulated thyroglobulin level at the time of remnant ablation on clinical outcome. CLINICAL ENDOCRINOLOGY. 2017.86(1):97-107.
IF: 3,327
Q: 2

Clinical Research

Active in 2019

Effect and safety of semaglutide 2,4 mg once-a-week in obese or overweight patients with type 2 diabetes.
PI: Dr María Angeles Gálvez Moreno

Randomized, controlled with placebo study to evaluate the clinical improvement and metabolic control of adults with symptomatic hypoparathyroidism treated with human recombinant parathyroid hormone [PTHhr(1-84)].
PI: Dr María Angeles Gálvez Moreno

Observational, European study of pasireotide-LAR in acromegaly patients. Acronis study.
PI: Dr María Angeles Gálvez Moreno

Ensayo clínico multicéntrico, aleatorizado, controlado, con evaluador ciego, para evaluar la eficacia y la seguridad de un hidrogel que contiene extracto de hoja de olivo como tratamiento de úlceras cutáneas.
PI: Dr. Paloma Moreno Moreno

Observational, transversal, multicenter study to evaluate the severity of acromegaly in Spanish patients using the ACRODAT scale. ACRODAT Study.
PI: Dr María Angeles Gálvez Moreno

Members

Dra. Mª Ángeles Gálvez Moreno

Principal Investigator

Team

Juan Antonio Paniagua González, Alfonso Calañas Continente, Mª José Molina Puerta, Rafael Palomares Ortega, Ángel Rebollo Martín, Concepción Muñoz Jiménez, José Carlos Padillo Cuenca, Rosa María Alhambra Expósito, Aura Dulcinea Herrera Martínez