Research groups

GA01 Lung Transplants. Thoracic Neoplasms

Our group develops research directed to the most prevalent health problems in thoracic pathologies. We are an associated group in IMIBIC composed by several emerging researcher who dedicate their principal work to clinical care in the Reina Sofia University Hospital (RSUH). The objectives of our researches are always oriented in achieving results that have applicability in clinical practice and influence the global management (diagnosis, therapy and monitoring) of the patient with thoracic pathology. We aim at establishing alliances with other groups nationwide and internationally, that carry out research based on omics of thoracic neoplasm and lung transplantation.

We want to consolidate our research in the Identification of early biomarkers in the development of Chronic Pulmonary Graft Dysfunction after lung transplantation, the value of lncRNA FENDRR and FOXF1as a prognostic factor for survival of lung adenocarcinoma, the impact of oxygenator of extracorporeal membrane on dysfunctional lung graft in a standardized porcine model of a lung transplant, the value of ex-vivo lung perfusion for optimizing suboptimal lung grafts, thus expanding the pool of valid lung transplant donors, and the study on the incidence of pulmonary thromboembolism in patients surgically intervened on by bronchogenic carcinoma.   

Our group was a pioneer in demonstrating the usefulness of C1 inhibitor and Antithrombin III in the prevention of primary graft dysfunction after lung transplantation, which is the major cause of early mortality and morbidity after lung transplantation.

Research Lines

The incidence of graft dysfunction after lung transplantation remains high. Pulmonary graft failure is a form of acute respiratory distress (SDRA) or diffuse alveolar damage what happens in the first moments after the transplant. It is called primary graft failure (PGD) and it is the most frequent cause of death in the first 30 days post-transplant. The treatment of PDG is, essentially, support. The objective of the project is to analyze the results obtained with the use of ECMO as intraoperative support during lung transplantation in a porcine model, and extending its use to immediate post-transplant, compared to transplants performed without ECMO support. In parallel, it is intended to perform a study of both inflammatory markers and the hypoxia pathway in both study groups. With this, you can obtain objective results that allow correlate the function of the pulmonary graft with the clinical-pathological determinations and, in last term, being able to detect the subgroup of transplants that would most benefit from intraoperative cardiorespiratory support with ECMO.

The recent introduction of ex vivo lung perfusion (EVLP) as a technique to assess and recondition lungs from marginal donors represents a new era in the field of lung transplantation. Not only has EVLP enabled an expansion in the availability of transplantable organs; it has also deeply challenged the concept of lung suitability itself. In fact, organs previously not considered for transplantation are now safely used with outcomes like those of standard donor lungs.  We intend to demonstrate the value of EVLP for optimizing suboptimal lung grafts, thus expanding our pool of valid lung transplant donors.

Networks

    SEPAR - Sociedad española de neumología y cirugía torácica

    NEUMOSUR - Asociación de neumología y cirugía torácica del sur

    SECT - Sociedad española de cirugía torácica

Keywords

  • Lung preservation
  • chronic rejection
  • bronchiolitis obliterans. Endothelium
  • inflammation
  • oxidative stress
  • proteomics
  • genomics
  • lung cancer
  • biomarkers
  • ECMO
  • ex-vivo lung perfusion

GA01 Lung Transplants. Thoracic Neoplasms

Principal Investigator
Ángel Salvatierra Velázquez

Emerging Researcher
Paula Moreno Casado

Researchers
Antonio Álvarez Kindelán
Javier Algar Algar
Carlos Baamonde Laborda
Francisco Cerezo Madueño
Javier González García
Antonio Herrera Merchán
Anna Muñoz Fos
Juan Carlos Robles Arista

Technical and Administrative Staff
Manuela Mendoza Porcuna

Projects

Active projects

Regional

Moreno Casado, P. Impact of oxigenator of extracorporeal membrane on dysfunctional lung graft in a standardized porcine model of a unipulmonary transplant. Funding agency: Andalusian Progress and Health and Social Policies (FPS). Reference: PI-0296-2014

Moreno Casado, P. Value of ex-vivo lung perfusion for optimising suboptimal lung grafts, thus expanding the pool of valid lung transplant donors. Funding agency: Fundación Mutua Madrileña. Reference: FMM16_002.

Publications

Publications 2019

Filosso PL, Guerrera F, Falco NR, Thomas P, Yuste MG, Rocco G, Welter S, Casado PM, Rendina EA, Venuta F, Ampollini L, Nosotti M, Raveglia F, Rena O, Stella F, Larocca V, Ardissone F, Brunelli A, Margaritora S, Travis WD, Sagan D, Sarkaria I, Evangelista, Lim, Eric, Papagiannopoulos, Konstantinos, Asamura, Hisao. Anatomical resections are superior to wedge resections for overall survival in patients with Stage 1 typical carcinoids. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY. 2019 Feb 1;55(2):273-279. doi: 10.1093/ejcts/ezy250.
IF: 3.847
Q: 1

Ruiz EJ, Diefenbacher ME, Nelson JK, Sancho R, Pucci F, Chakraborty A, Moreno P, Annibaldi A, Liccardi G, Encheva V, Mitter R, Rosenfeldt M, Snijders AP, Meier P, Calzado MA, Behrens A.  LUBAC determines chemotherapy resistance in squamous cell lung cáncer. JOURNAL OF EXPERIMENTAL MEDICINE. 2019 Feb 4;216(2):450-465. doi: 10.1084/jem.20180742.
IF: 10.892
Q: 1 D: 1

Mazo C, Pont T, Ballesteros MA, Lopez E, Rellan L, Robles JC, Rello J. Pneumonia versus graft dysfunction as the cause of acute respiratory failure after lung transplant: a 4-year multicentre prospective study in 153 adults requiring intensive care admission. EUROPEAN RESPIRATORY JOURNAL. 2019 Oct 1;54(3):1801512. doi: 10.1183/13993003.01512-2018.
IF: 11.807
Q: 1 D: 1

Alvarez A, Moreno P. Demographic ageing and its influence on current lung transplant practice. JOURNAL OF THORACIC DISEASE. 2019 Sep;11(Suppl 15):S1992-S1994. doi: 10.21037/jtd.2019.06.71.
IF: 2.027
Q: 3

Broncano J, Alvarado-Benavides AM, Bhalla S, Alvarez-Kindelan A, Raptis CA, Luna A. Role of advanced magnetic resonance imaging in the assessment of malignancies of the mediastinum. WORLD JOURNAL OF RADIOLOGY. 2019 Mar 28;11(3):27-45. doi: 10.4329/wjr.v11.i3.27.

Publications 2018

Moreno P, Jimenez-Jimenez C, Garrido-Rodriguez M, Calderon-Santiago M, Molina S, Lara-Chica M, Priego-Capote F, Salvatierra A, Munoz E, Calzado MA. Metabolomic profiling of human lung tumor tissues - nucleotide metabolism as a candidate for therapeutic interventions and biomarkers. MOLECULAR ONCOLOGY. 2018.12(10):1778-1796.
IF: 5,264
Q: 1

Publications 2017

Herrera-Martinez AD, Gahete MD, Sanchez-Sanchez R, Salas RO, Serrano-Blanch R, Salvatierra A, Hoflandi LJ, Luque RM, Galvez-Moreno MA, Castano JP. The components of somatostatin and ghrelin systems are altered in neuroendocrine lung carcinoids and associated to clinical-histological features. LUNG CANCER. 2017.109():128-136.
IF: 4,294
Q: 1

Gonzalez-Garcia FJ, Guzman-Puche J, Redel-Montero J, Moreno P. Fatal bilateral haemopneumothoraces following double-lung transplantation caused by pretransplant colonization by Scedosporium apiospermum .EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY. 2017.51(6):1209-1209.
IF: 3,759
Q: 2

Clinical Research

Active in 2018

Study on the incidence of pulmonary thromboembolsism in patients surgically intervened on by bronchogenic carcinoma
PI: Dr Álvarez Kindelán, Antonio

Members

Dr. Ángel Salvatierra Velázquez

Principal Investigator

angel.salvatierra.sspa@juntadeandalucia.es

Team

Antonio Álvarez Kindelán, Paula Moreno Casado, Carlos Baamonde Laborda, Javier Algar Algar, Francisco Cerezo Madueño, Juan Carlos Robles Arista, Javier González García, Anna Muñoz Fos, Antonio Herrera Merchán, Manuela Mendoza Porcuna