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Research groups

GA01 Lung Transplants. Thoracic Neoplasms

Our group develops research directed to the most prevalent health problems in thoracic pathologies. We are an associated group in IMIBIC composed by several emerging researcher who dedicate their principal work to clinical care in the Reina Sofia University Hospital (RSUH). The objectives of our researches are always oriented in achieving results that have applicability in clinical practice and influence the global management (diagnosis, therapy and monitoring) of the patient with thoracic pathology. We aim at establishing alliances with other groups nationwide and internationally, that carry out research based on omics of thoracic neoplasm and lung transplantation.

We want to consolidate our research in the Identification of early biomarkers in the development of Chronic Pulmonary Graft Dysfunction after lung transplantation, the value of lncRNA FENDRR and FOXF1as a prognostic factor for survival of lung adenocarcinoma, the impact of oxygenator of extracorporeal membrane on dysfunctional lung graft in a standardized porcine model of a lung transplant, the value of ex-vivo lung perfusion for optimizing suboptimal lung grafts, thus expanding the pool of valid lung transplant donors, and the study on the incidence of pulmonary thromboembolism in patients surgically intervened on by bronchogenic carcinoma.   

Our group was a pioneer in demonstrating the usefulness of C1 inhibitor and Antithrombin III in the prevention of primary graft dysfunction after lung transplantation, which is the major cause of early mortality and morbidity after lung transplantation.

Lines of Research

The incidence of graft dysfunction after lung transplantation remains high. Pulmonary graft failure is a form of acute respiratory distress (SDRA) or diffuse alveolar damage what happens in the first moments after the transplant. It is called primary graft failure (PGD) and it is the most frequent cause of death in the first 30 days post-transplant. The treatment of PDG is, essentially, support. The objective of the project is to analyze the results obtained with the use of ECMO as intraoperative support during lung transplantation in a porcine model, and extending its use to immediate post-transplant, compared to transplants performed without ECMO support. In parallel, it is intended to perform a study of both inflammatory markers and the hypoxia pathway in both study groups. With this, you can obtain objective results that allow correlate the function of the pulmonary graft with the clinical-pathological determinations and, in last term, being able to detect the subgroup of transplants that would most benefit from intraoperative cardiorespiratory support with ECMO.

The recent introduction of ex vivo lung perfusion (EVLP) as a technique to assess and recondition lungs from marginal donors represents a new era in the field of lung transplantation. Not only has EVLP enabled an expansion in the availability of transplantable organs; it has also deeply challenged the concept of lung suitability itself. In fact, organs previously not considered for transplantation are now safely used with outcomes like those of standard donor lungs.  We intend to demonstrate the value of EVLP for optimizing suboptimal lung grafts, thus expanding our pool of valid lung transplant donors.

Networks

    SEPAR - Sociedad española de neumología y cirugía torácica

    NEUMOSUR - Asociación de neumología y cirugía torácica del sur

    SECT - Sociedad española de cirugía torácica

    PAIDI BIO-304 - Immunopharmacology and Molecular Virology

Key Words

  • lung preservation
  • chronic rejection
  • bronchiolitis obliterans
  • endothelium
  • inflammation
  • oxidative stress
  • proteomics
  • genomics
  • lung cancer
  • biomarkers
  • ECMO
  • ex-vivo lung perfusion

Publications

Publications in 2023

Munoz-Fos A, Moreno P, Gonzalez FJ, Ruiz E, Vaquero JM, Baamonde C, Cerezo F, Algar J, Ramos-Izquierdo R, Salvatierra A, Alvarez A. Airway Complications after Lung Transplantation-A Contemporary Series of 400 Bronchial Anastomoses from a Single Center. JOURNAL OF CLINICAL MEDICINE. 2023. DOI: 10.3390/jcm12093061.         IF: 3,9       Q2 D4

Blázquez-Encinas R, García-Vioque V, Caro-Cuenca T, Moreno-Montilla MT, Mangili F, Alors-Pérez E, Ventura S, Herrera-Martínez AD, Moreno-Casado P, Calzado MA, Salvatierra A, Gálvez-Moreno MA, Fernandez-Cuesta L, Foll M, Luque RM, Alcala N, Pedraza-Arevalo S, Ibáñez-Costa A, Castaño JP. Altered splicing machinery in lung carcinoids unveils NOVA1, PRPF8 and SRSF10 as novel candidates to understand tumor biology and expand biomarker discovery. JOURNAL OF TRANSLATIONAL MEDICINE. 2023. DOI: 10.1186/s12967-023-04754-8.         IF: 7,4       Q1 D3

Fernández AM, Ruiz E, Cantador B, González FJ, Baamonde C, Alvarez A. Case Report of Complex Chest Wall Repair for Sternal Dehiscence After Bilateral Lung Transplantation. TRANSPLANTATION PROCEEDINGS. 2023. 2307-2308. DOI: 10.1016/j.transproceed.2023.08.031.         IF: 0,9       Q4 D

Ruiz E, Moreno P, Gonzalez FJ, Fernandez AM, Cantador B, Parraga JL, Salvatierra A, Alvarez A. Influence of De Novo Malignancies on Long-Term Survival after Lung Transplantation. CANCERS. 2023. DOI: 10.3390/cancers15154011.         IF: 5,2       Q2 D3

Cantador B, Moreno P, González FJ, Ruiz E, Fernández AM, Alvarez A. Influence of Donor Type-Donation After Brain Death Versus Donation After Circulatory Death-on Lung Transplant Outcomes. TRANSPLANTATION PROCEEDINGS. 2023. 2292-2294. DOI: 10.1016/j.transproceed.2023.09.001.         IF: 0,9       Q4 D

de la Fuente C, Rodriguez M, Merino N, Carmona P, Machuca I, Cordoba-Fernandez M, Guzman-Puche J, Dominguez A, Lopez-Vinau T, Garcia L, Vaquero JM, Robles JC, Martinez-Martinez L, Torre-Cisneros J. Real-life use of cefiderocol for salvage therapy of severe infections due to carbapenem-resistant Gram-negative bacteria. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. 2023. DOI: 10.1016/j.ijantimicag.2023.106818.         IF: 10,8       Q1 D2

Ruiz E, Fernandez AM, Parragaa JL, Cantador B, Salvatierra A, Alvarez A. Surgical Complications After Lung Transplantation: The Reina Sofía Hospital Experience. TRANSPLANTATION PROCEEDINGS. 2023. 2289-2291. DOI: 10.1016/j.transproceed.2023.08.027.         IF: 0,9       Q4 D

Marro M, Leiva-Juarez MM, D'Ovidio F, Chan JS, Van Raemdonck D, Ceulemans LJ, Moreno P, Kindelan AA, Krueger T, Koutsokera A, Ehrsam JP, Inci I, Yazicioglu A, Yekeler E, Boffini M, Brioude G, Thomas PA, Pizanis N, Aigner C, Schiavon M, Rea F, Anile M, Venuta F, Keshavjee S. Lung Transplantation for Primary Ciliary Dyskinesia and Kartagener Syndrome: A Multicenter Study. TRANSPLANT INTERNATIONAL. 2023. DOI: 10.3389/ti.2023.10819.         IF: 3,1       Q1 D3

de la Cruz JLCC, Minambres E, Coll E, Padilla M, Antolin GS, de la Rosa G, Rosado J, Garcia FJG, Carrasco SC, Badia GS, Costa EMF, Salcedo JAG, Mora V, de la Torre C, Badenes R, Bizkarguenaga LA, Dominguez-Gil B. Outcomes of lung and liver transplantation after simultaneous recovery using abdominal normothermic regional perfusion in donors after the circulatory determination of death versus donors after brain death. AMERICAN JOURNAL OF TRANSPLANTATION. 2023. 996-1008. DOI: 10.1016/j.ajt.2023.04.016.         IF: 8,8       Q1 D1

Publications in 2022

Ruiz E, Moreno P, Poveda DS, Fernandez AM, Gonzalez FJ, Algar FJ, Cerezo F, Baamonde C, Salvatierra A, Alvarez A. TRANSPLANTATION PROCEEDINGS. 2022. DOI: 10.1016/j.transproceed.2021.09.062

Fernandez AM, Poveda DS, Ruiz E, Alvarez E, Gonzalez FJ, Moreno P, Salvatierra A, Alvarez A. TRANSPLANTATION PROCEEDINGS. 2022. DOI: 10.1016/j.transproceed.2021.10.009

Poveda D, Ruiz E, Fernandez AM, Gonzalez FJ, Moreno P, Algar FJ, Cerezo F, Baamonde C, Salvatierra A, Alvarez A. TRANSPLANTATION PROCEEDINGS. 2022. DOI: 10.1016/j.transproceed.2021.09.068

Ramos AC, Almanzar SF, Castro RL, Hernandez NJM, Perez LM, Casado PM, Jimenez JZ. CIRUGIA ESPANOLA. 2022. DOI: 10.1016/j.ciresp.2021.08.003

Nosotti M, Leiva-Juarez M, D'Ovidio F, Van Raemdonck D, Ceulemans L, Keshavjee S, Rackauskas M, Paladini P, Luzzi L, Casado PM, Alvarez A, Inci I, Ehrsam J, Krueger T, Roth A, Rea F, Schiavon M, Rosso L. TRANSPLANT INTERNATIONAL. 2022. DOI: 10.3389/ti.2022.10450

Publications in 2021

Gonzalez FJ, Alvarez E, Moreno P, Poveda D, Ruiz E, Fernandez AM, Salvatierra A, Alvarez A. The influence of the native lung on early outcomes and survival after single lung transplantation. PLOS ONE. 2021.  16(4):-. DOI: 10.1371/journal.pone.0249758.                    IF: 3,24         Q2     D4

Pozo-Laderas JC, Guler I, Rodriguez-Peralvarez M, Robles JC, Mula A, Lopez-Cillero P, de la Fuente C. Early postoperative mortality in liver transplant recipients involving indications other than hepatocellular carcinoma. A retrospective cohort study. MEDICINA INTENSIVA. 202  45(7):395-410. DOI: 10.1016/j.medin.2020.02.004.                    IF: 2,491         Q3    

Duenas-Jurado JM, Gutierrez PA, Casado-Adam A, Santos-Luna F, Salvatierra-Velazquez A, Carcel S, Robles-Arista CJC, Hervas-Martinez C. New models for donor-recipient matching in lung transplantations. PLOS ONE. 2021.  16(6):-. DOI: 10.1371/journal.pone.0252148.                   

IF: 3,24         Q2     D4

Roman AR, de la Cruz JLCC, Macia I, Campuzano IE, Almanzar SF, Roel MD, Munoz CG, Fontan EMG, Trueba IM, Vielva LR, Garcia JRC, Tellez EM, Gonzalez CP, Lopez MFJ, Maestre UJ, Poce RM, Lorente DS, Kindelan AA, Pulla MP. Outcomes of surgical resection after neoadjuvant chemoimmunotherapy in locally advanced stage IIIA non-small-cell lung cancer. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY. 2021.  60(1):81-88. DOI: 10.1093/ejcts/ezab007.                   

IF: 4,191         Q1     D2

Sarceda JRJ, Nadal SB, Poce RM, de Castro PL, Balsalobre RM, Cuesta JCP, Flor RE, Ferrer JP, Algar FJA, Garcia APG, Jimenez MF, Sales-Badia JG, Pereira E, Massuti B, Provencio M, Trancho FH. Spanish Lung Cancer Group SCAT trial: surgical audit to lymph node assessment based on IASLC recommendations. TRANSLATIONAL LUNG CANCER RESEARCH. 2021.  10(4):1761-1772. DOI: 10.21037/tlcr-20-1055.                   

IF: 6,498         Q1     D2

Publications in 2020

Fos AM, Madueno FC, Cosano J, Redel J, Garcia JG, Poveda D, Ruiz E, Casado PM, Algar JA, Kindelan AA, Laborda CB, Velazquez AS. Early Surgical Management of Bronchial Dehiscence After Single-Lung Transplantation: A Case Report. TRANSPLANTATION PROCEEDINGS. 2020. 52 (2):596-598 DOI: 10.1016/j.transproceed.2019.09.021 
IF: 0,784 Q: 4

Nosotti M, D'Ovidio F, Leiva-Juarez M, Keshavjee S, Rackauskas M, Van Raemdonck D, Ceulemans LJ, Krueger T, Koutsokera A, Schiavon M, Rea F, Iskender I, Moreno P, Alvarez A, Luzzi L, Paladini P, Rosso L, Bertani A, Venuta F, Pecoraro Y, Al-Kattan K, Kubisa B, Inci I. Rare indications for a lung transplant. A European Society of Thoracic Surgeons survey. INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY. 2020. 31 (5):638-643 DOI: 10.1093/icvts/ivaa165 
IF: 1,675 Q: 3

Gonzalez FJ, Alvarez A, Cantador B, Moreno P, Baamonde C, Munoz A, Poveda D, Algar FJ, Cerezo F, Salvatierra A. Relationship Among Radiological Measurements of Anterior Mediastinal Fat and Outcomes of Lung Transplantation in Fibrotic Patients. ARCHIVOS DE BRONCONEUMOLOGIA. 2020. 56 (11):710-717 DOI: 10.1016/j.arbres.2019.12.002 
IF: 4,957 Q: 1

Garcia FJG, Carlos BL, Fos AM, Casado PM, Montero JR, Algar JA, Madueno FC, Chaves DP, Lopez ER, Velazquez AS, Kindelan AA. Surgical Treatment of Chylothorax After Lung Transplantation for Lymphangioleiomyomatosis. ARCHIVOS DE BRONCONEUMOLOGIA. 2020. 56 (5):335-336 DOI: 10.1016/j.arbres.2019.11.012 
IF: 4,957 Q: 1

Lopez ER, Madueno FC, Garcia FJG, Fos AM, Chavez DP, Kindelan AA, Velazquez AS, Casado PM. Thoracotomy Wound Dehiscence After Lung Transplant Is an Effective Surgical Solution: A Case Report. TRANSPLANTATION PROCEEDINGS. 2020. 52 (2):584-586 DOI: 10.1016/j.transproceed.2019.11.035 
IF: 0,784 Q: 4

Fos AM, Cosano J, Wins R, Galan G. Tracheobronchoplasty after a trial with a silicone Y-stent in a patient with Mounier-Kuhn syndrome. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY. 2020. 57 (6):1221-1223 DOI: 10.1093/ejcts/ezz317 
IF: 3,486 Q: 1

Publications in 2019

Filosso PL, Guerrera F, Falco NR, Thomas P, Yuste MG, Rocco G, Welter S, Casado PM, Rendina EA, Venuta F, Ampollini L, Nosotti M, Raveglia F, Rena O, Stella F, Larocca V, Ardissone F, Brunelli A, Margaritora S, Travis WD, Sagan D, Sarkaria I, Evangelista, Lim, Eric, Papagiannopoulos, Konstantinos, Asamura, Hisao. Anatomical resections are superior to wedge resections for overall survival in patients with Stage 1 typical carcinoids. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY. 2019 Feb 1;55(2):273-279. doi: 10.1093/ejcts/ezy250.
IF: 3.847Q: 1

Ruiz EJ, Diefenbacher ME, Nelson JK, Sancho R, Pucci F, Chakraborty A, Moreno P, Annibaldi A, Liccardi G, Encheva V, Mitter R, Rosenfeldt M, Snijders AP, Meier P, Calzado MA, Behrens A.  LUBAC determines chemotherapy resistance in squamous cell lung cáncer. JOURNAL OF EXPERIMENTAL MEDICINE. 2019 Feb 4;216(2):450-465. doi: 10.1084/jem.20180742.
IF: 10.892 Q: 1 D: 1

Mazo C, Pont T, Ballesteros MA, Lopez E, Rellan L, Robles JC, Rello J. Pneumonia versus graft dysfunction as the cause of acute respiratory failure after lung transplant: a 4-year multicentre prospective study in 153 adults requiring intensive care admission. EUROPEAN RESPIRATORY JOURNAL. 2019 Oct 1;54(3):1801512. doi: 10.1183/13993003.01512-2018.
IF: 11.807 Q: 1 D: 1

Alvarez A, Moreno P. Demographic ageing and its influence on current lung transplant practice. JOURNAL OF THORACIC DISEASE. 2019 Sep;11(Suppl 15):S1992-S1994. doi: 10.21037/jtd.2019.06.71.
IF: 2.027 Q: 3

Broncano J, Alvarado-Benavides AM, Bhalla S, Alvarez-Kindelan A, Raptis CA, Luna A. Role of advanced magnetic resonance imaging in the assessment of malignancies of the mediastinum. WORLD JOURNAL OF RADIOLOGY. 2019 Mar 28;11(3):27-45. doi: 10.4329/wjr.v11.i3.27.

Publications in 2018

Moreno P, Jimenez-Jimenez C, Garrido-Rodriguez M, Calderon-Santiago M, Molina S, Lara-Chica M, Priego-Capote F, Salvatierra A, Munoz E, Calzado MA. Metabolomic profiling of human lung tumor tissues - nucleotide metabolism as a candidate for therapeutic interventions and biomarkers. MOLECULAR ONCOLOGY. 2018.12(10):1778-1796.
IF: 5,264 Q: 1

Members

Principal Investigator
Ángel Salvatierra Velázquez

Emerging Researcher
Paula Moreno Casado

Researcher
Antonio Álvarez Kindelan

Post-Doctoral Researchers
Francisco Javier Algar Algar
Francisco Cerezo Madueño
Juan Carlos Robles Arista

Pre-Doctoral Researcher
Alba María Fernández González
Eloísa Ruiz López
Benito Cantador Huertos
Francisco Javier González García