Research groups

GA03 Pneumology

Our group develops research directed to the most prevalent health problems in respiratory pathologies. We are an associated group in IMIBIC composed by several emerging researcher who dedicate their principal work to clinical care in HURS. The objectives of our researches are always oriented in achieving results that have applicability in clinical practice and influence the global management (diagnosis, therapy and monitoring) of the patient with respiratory pathology. We aim at establishing alliances with other groups nationwide and internationally, that carry out research based on omics of chronic respiratory diseases. On institutional level, we welcome new researchers in the group through which to establish alliances between other IMIBIC groups and to create synergies in the common areas of research. We want to consolidate our research in the screening for lung cancer as a more effective tool to reduce the mortality of this tumor. In addition, we are beginning with new research lines to implement platforms based on the new omics for the therapeutic control and prognosis of chronic inflammatory diseases of the respiratory system (COPD-asthma); and other to determine the effect of the inhalation of toxic particles (environmental contamination) in respiratory pathology.

Our group was a pioneer in demonstrating the usefulness of human sweat analysis in lung cancer. In addition we have collaborated in the investigation of the effect of intermittent hypoxemia with the IMIBIC group of 'Nutrigenomics, Metabolic Syndrome' in patients with vascular risk factors to determine the consequences of the effect of hypoxemia on the effect of the Mediterranean diet and the vascular risk.

Currently, we collaborate with Dr. Antonio Rodríguez Ariza (Coordinator of Oncover study, GC-06 New therapies in cancer) and Dr. Mª Dolores Luque de Castro (GC-21 Metabolomics. Identification of bioactive components) in the identification and quantification of useful compounds in the diagnosis of Lung cancer in the condensate of the exhaled air. In this same line, we also collaborated with the group of Dr. Mª Dolores Luque de Castro in the identification of clinical phenotypes through metabolomic studies in exhaled air condensate, and in the search for new markers in lung cancer in various biofluids.

We are carrying out two multicenter studies, one with the San Pedro Alcántara Hospital from Cáceres and others, in which we analyse the influence of suffering Sleep Apnea in the worsening of Kidney Disease, as well as the improvement of the CKD if these apneas are corrected with either AutoCPAP or other treatments. Another collaborative study we are involved in is with the Valme Hospital in Seville and others, in which we study the association of sleep apnea with impaired metabolism and prostate tumor prognosis.

Research Lines

Exhaled breath condensate (EBC) is one of the less employed biofluids when searching for clinical markers, despite its non-invasive sampling and the potential relationship between its composition and respiratory disease. Two studies using metabolomics are underway: i) We use EBC as clinical sample to develop a screening tool for lung cancer discrimination, and ii) perform untargeted analysis of EBC with a cohort of patients with lung cancer, risk factor individuals and control group of healthy individuals in order to identify compounds that contribute to discrimination between the different groups and a relevant role for lipids, such as monoacylglycerols and squalene. The results of these studies may support the ability of metabolomics for the study of lung. Within this line of study, we also explore whether proteomic analysis of exhaled breath condensate (EBC) may provide biomakers for non-invasive screening for the early detection of lung cancer.

Sweat has recently gained popularity as a potential tool for diagnostics and biomarker monitoring as it is a non-invasive biofluid the composition of which could be modified by certain pathologies. We have compared different simple preparation protocols as well as different chromatographic modes for global metabolomics profiling analysis of sweat. Although sweat is scarcely used in metabolomics studies, its potential for discrimination of metabolic profiles correlated with different pathologies would make this biofluid interesting to explore. Thus, we are interested in applying a method based on metabolite analysis of sweat to discriminate between patients with lung cancer vs smokers as control group

Bronchoalveolar lavage fluid (BALF) analysis can contribute to clinical practice with more sensitive biomarkers, thus complementing cytohistological studies in order to aid in the diagnosis, prognosis, and subtyping of lung cancer, as well as the monitoring of treatment response. Our studies in this area focus on candidate protein biomarkers for adenocarcinoma in BALF. The preliminary results are encouraging in terms of the number of identified and quantified proteins, demonstrating that the analysis of BALF proteins by a SWATH approach is a useful method for the discovery of potential biomarkers of pulmonary diseases.

Networks

Keywords

  • Cancer
  • hypoxemia
  • cell damage
  • chronic respiratory disease
  • metabolomics
  • proteomics
  • telecare
  • telemedicine
  • respiratory therapies

Additional Information

Highlighted publications

  • López-Sánchez LM, Jurado-Gámez B, Feu-Collado N, Valverde A, Cañas A, Fernández-Rueda JL, Aranda E, Rodríguez-Ariza A. Exhaled breath condensate biomarkers for the early diagnosis of lung cancer using proteomics. Am J Physiol Lung Cell Mol Physiol. 2017 Oct 1;313(4):L664-L676. doi: 10.1152/ajplung.00119.2017.
  • Ortea I, Rodríguez-Ariza A, Chicano-Gálvez E, Arenas Vacas MS, Jurado Gámez B. Discovery of potential protein biomarkers of lung adenocarcinoma in bronchoalveolar lavage fluid by SWATH MS data-independent acquisition and targeted data extraction. J Proteomics. 2016 Apr 14;138:106-14. Q1
  • Peralbo-Molina A, Calderón-Santiago M, Priego-Capote F, Jurado-Gámez B, Luque de Castro MD. Identification of metabolomics panels for potential lung cancer screening by analysis of exhaled breath condensate. Journal of Breath Research. 2016. 10(2):026002. FI=4.318; Q1
  • Calderón-Santiago M, Priego-Capote F, Turck N, Robin X, Jurado-Gámez B, Sanchez JC, Luque de Castro MD. Human sweat metabolomics for lung cancer screening. Analytical and bioanalytical chemistry. 2015. 407(18):5381-92. FI=3.436; Q1

GA03 Pneumology

Principal Investigator
Bernabé Jurado Gámez

Emerging Researchers
Natalia Pascual Martínez
María del Sol Arenas de Larriva

Researchers
Francisco Santos Luna
Nuria Feu Collado
Francisco Luis García Gil
Rafael Lama Martínez
Javier Redel Montero

Post-Doctoral Researchers
Luis Manuel Entrenas Costa
Antonio Pablo Arenas Vacas

Nursing and Technical Staff
Ana María Vega Rojas

Projects

Finished projects

Feu Collado, MN. Proyecto nº 6/2014. Funding agency: Fundación Neumosur. Reference: Proyecto Neumosur 6.

Jurado Gámez, B. Application of metabolomics platforms in the analysis of non-invasive biofluids for the search of biomarkers in respiratory pathology. Funding agency: Neumosur. Reference: Neumosur 16-01.

Publications

Publications 2019

Pérez de Llano LA, Cosío BG, Domingo C, Urrutia I, Bobolea I, Valero A, Entrenas Costa LM, Quirce S, Barranco P, Marina Malanda N, Andrés LP, Alvarez-Gutiérrez FJ. Efficacy and Safety of Reslizumab in Patients with Severe Asthma with Inadequate Response to Omalizumab: A Multicenter, Open-Label Pilot Study. J Allergy Clin Immunol Pract. 2019 Sep-Oct;7(7):2277-2283.e2. doi: 10.1016/j.jaip.2019.01.017.
IF: 7,55 
D: 1

Costa LME, Casas-Maldonado F, Campos JGS, Padilla-Galo A, Levy A, Gutierrez FJA, Fernandez APGB, Morales-Garcia C, Dominguez RG, Sanchez GV, Caballero LM, Pereira-Vega A, Polo CG, Chica GP, Villasclaras JJM. Economic Impact and Clinical Outcomes of Omalizumab Add-On Therapy for Patients with Severe Persistent Asthma: A Real-World Study. Pharmacoeconomics Open 2019 Sep;3(3):333-342. doi: 10.1007/s41669-019-0117-4.
IF: 6,966
D: 1

Campos-Rodriguez F, Asensio-Cruz MI, Cordero-Guevara J, Jurado-Gamez B, Carmona-Bernal C, Gonzalez-Martinez M, Troncoso MF, Sanchez-Lopez V, Arellano-Orden E, Garcia-Sanchez MI, Martinez-Garcia MA; Spanish Sleep Network. Effect of continuous positive airway pressure on inflammatory, antioxidant, and depression biomarkers in women with obstructive sleep apnea: a randomized controlled trial. Sleep. 2019 Oct 9;42(10):zsz145. doi: 10.1093/sleep/zsz145.
IF: 4,571
Q: 1 D: 2

Campos-Rodriguez F, Reyes-Nuñez N, Queipo-Corona C, Sanchez-Armengol A, Jurado-Gamez B, Cordero-Guevara J, et al. Spanish Sleep Network; Spanish Sleep Network is composed of the following individuals. Continuous Positive Airway Pressure Treatment Does not Reduce Uric Acid Levels in OSA Women. Arch Bronconeumol. 2019 Apr;55(4):201-207. English, Spanish. doi: 10.1016/j.arbres.2018.09.012.
IF: 4,214
Q: 1

Sarramea F, Jaén-Moreno MJ, Feu N, et al. Prepare the smoking cessation in severe mental illness: Early diagnosis and prevention opportunities. Preparar la cesación tabáquica en el trastorno mental grave: diagnóstico precoz y oportunidades de prevención. Rev Psiquiatr Salud Ment. 2019;12(2):133–134. doi:10.1016/j.rpsm.2018.08.001
IF: 2,927
Q: 2

Jaén-Moreno MJ, Feu N, Redondo-Écija J, et al. Smoking cessation opportunities in severe mental illness (tobacco intensive motivational and estimate risk - TIMER-): study protocol for a randomized controlled trial. Trials. 2019;20(1):47. Published 2019 Jan 14. doi:10.1186/s13063-018-3139-9.
IF: 1,975
Q: 3

Entrenas Costa LM, Casas-Maldonado F, Soto Campos JG, et al. Economic Impact and Clinical Outcomes of Omalizumab Add-On Therapy for Patients with Severe Persistent Asthma: A Real-World Study. Pharmacoecon Open. 2019;3(3):333–342. doi:10.1007/s41669-019-0117-4.

Main Publications 2018

Barrios JMV, Luna FS, Velazquez AS. Lung Re-Transplantation. The Opposite View Point. ARCHIVOS DE BRONCONEUMOLOGIA. 2018; 54(6):311-312.
IF: 2,633
Q: 2

Merino JS, de Torres LAP, Bardwell WA, Gomez RM, Villalobos AR, Collado NF, Ruiz-Moral R, Jurado-Gamez B. Impact of Positive Pressure Treatment of the Airway on Health-Related Quality of Life in Elderly Patients With Obstructive Sleep Apnea. BIOLOGICAL RESEARCH FOR NURSING. 2018; 20(4):452-461.
IF: 1,579
Q: 2

Ballesteros FM, Fernandez JJS, Barrios JMV, Montero JR, Ceballos MJC, Amarilla CE, Muriana AMP, Luna FS. Long-term Prognosis After Lung Transplantation: A Monocentric Study in 510 Patients. TRANSPLANTATION PROCEEDINGS. 2018; 50(2):658-660.
IF: 0,806
Q: 4

Martinez-Gonzalez C, Casanova C, de-Torres JP, Marin JM, de Lucas P, Fuster A, Cosio BG, Calle M, Peces-Barba G, Solanes I, Aguero R, Feu-Collado N, Alfageme I, Plaza AR, Balcells E, de Diego A, Royo MM, Moreno A, Casanovas AL, Galdiz JB, Golpe R, Bautista CL, Cabrera C, Marin A, Soriano JB, Lopez-Campos JL. Changes and Clinical Consequences of Smoking Cessation in Patients With COPD A Prospective Analysis From the CHAIN Cohort. CHEST. 2018; 154(2):274-285.
IF: 7,652
Q: 1

Plaza V, Cosio BG, Entrenas LM, Olaguibel JM, de Llano LP, Quirce S.The Role of FENO in the Diagnosis and Control of Asthma. Expert Multidisciplinary Group Debate during the Asthma Meeting Point 2017. ARCHIVOS DE BRONCONEUMOLOGIA. 2018; 54(4):237-238.
IF: 2,633
Q: 2

Sanchez AR, de Torres LAP, Luna FS, Ruiz-Moral R. Prevalence of tobacco consumption among young physicians at a regional university hospital in southern Spain: a cross-sectional study. BMJ OPEN. 2018; 8(2): e018728
IF: 2,413
Q: 2

Main Publications 2017

Merino JS, de Torres LAP, Gomez RM, Villalobos AR, Collado MNF, Ruiz-Moral R, Jurado-Gamez B. Collaborative Grp CVCPAP Study Impact of CPAP therapy on health-related quality of life in elderly patients with apnoea-hypopnea syndrome: a systematic review of randomised clinical trials. EUROPEAN RESPIRATORY JOURNAL. 2017.49(1):-1601644.
IF: 10,569
Q: 1  D: 1

Lopez-Sanchez LM, Jurado-Gamez B, Feu-Collado N, Valverde A, Canas A, Fernandez-Rueda JL, Aranda E, Rodriguez-Ariza A. Exhaled breath condensate biomarkers for the early diagnosis of lung cancer using proteomics. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2017.313(4):L664-L676.
IF: 4,281
Q: 1

Peralbo-Molina A, Calderon-Santiago M, Jurado-Gamez B, de Castro MDL, Priego-Capote F. Exhaled breath condensate to discriminate individuals with different smoking habits by GC-TOF/MS.SCIENTIFIC REPORTS. 2017.7.art 1421.
IF: 4,259
Q: 1 

Other Publications 2017

Casanova C, Celli BR, de-Torres JP, Martinez-Gonzalez C, Cosio BG, Pinto-Plata V, de Lucas-Ramos P, Divo M, Fuster A, Peces-Barba G, Calle-Rubio M, Solanes I, Aguero R, Feu-Collado N, Alfageme I, De Diego A, Romero A, Balcells E, Llunell A, Galdiz JB, Marin M, Moreno A, Cabrera C, Golpe R, Lacarcel C, Soriano JB, Lopez-Campos JL, Soler-Cataluna JJ, Marin JM. Prevalence of persistent blood eosinophilia: relation to outcomes in patients with COPD. EUROPEAN RESPIRATORY JOURNAL. 2017.50(5):-1701162.
IF: 10,569
Q: 1  D: 1

Campos-Rodriguez F, Gonzalez-Martinez M, Sanchez-Armengol A, Jurado-Gamez B, Cordero-Guevara J, Reyes-Nunez N, Troncoso MF, Abad-Fernandez A, Teran-Santos J, Caballero-Rodriguez J, Martin-Romero M, Encabo-Motino A, Sacristan-Bou L, Navarro-Esteva J, Somoza-Gonzalez M, Masa JF, Sanchez-Quiroga MA, Jara-Chinarro B, Orosa-Bertol B, Martinez-Garcia MA, Spanish Sleep Network. Effect of continuous positive airway pressure on blood pressure and metabolic profile in women with sleep apnoea. EUROPEAN RESPIRATORY JOURNAL. 2017.50(2):-1700257.
IF: 10,569
Q: 1  D: 1

Gonzalez-Garcia FJ, Guzman-Puche J, Redel-Montero J, Moreno P. Fatal bilateral haemopneumothoraces following double-lung transplantation caused by pretransplant colonization by Scedosporium apiospermum. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY. 2017.51(6):1209-1209.
IF: 3,759
Q: 2

Cantisan S, Paez-Vega A, Santos F, Rodriguez-Benot A, Aguado R, Rivero A, Montejo M, Torre-Cisneros J, Solana R, Spanish Network Res Infect Dis. Impact of age and cytomegalovirus on CD8(+) T-cell compartment remodeling after solid organ transplantation: A one-year follow-up study. EXPERIMENTAL GERONTOLOGY. 2017.95:98-106.
IF: 3,34
Q: 1

Quirce S, Delgado J, Entrenas LM, Grande M, Llorente C, Vina AL, Moragon EM, Mascaros E, Molina J, Olaguibel JM, de Llano LAP, Tordera MP, Quintano JA, Rodriguez M, Roman-Rodriguez M, Sastre J, Trigueros JA, Valero AL, Zoni AC, Plaza V, ASMAFORUM II Grp. Quality Indicators of Asthma Care Derived From the Spanish Guidelines for Asthma Management (GEMA 4.0): A Multidisciplinary Team Report. JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY .2017.27(1):69-73.
IF: 3,094
Q: 3

López-Campos JL, Abad Arranz M, Calero-Acuña C, Romero-Valero F, Ayerbe-García R, Hidalgo-Molina A, Aguilar-Pérez-Grovas RI, García-Gil F, Casas-Maldonado F, Caballero-Ballesteros L, Sánchez-Palop M, Pérez-Tejero D, Segado Soriano A, Calvo-Bonachera J, Hernández-Sierra B, Doménech A, Arroyo-Varela M, González-Vargas F, Cruz-Rueda JJ. Seasonal variability in clinical care of COPD outpatients: results from the Andalusian COPD audit. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE. 2017.12:785-792
IF: 2,912
Q: 2

Guirao-Arrabal E, Santos F, Redel J, Vaquero JM, Torre-Cisneros J. Efficacy and safety of short-term treatment with isoniazid and rifampicin for latent tuberculosis infection in lung transplant candidates. CLINICAL TRANSPLANTATION. 2017.31(3):-e12901.
IF: 1,865
Q: 2 

Monforte V, Sintes H, Lopez-Gallo C, Delgado M, Santos F, Zurbano F, Sole A, Gavalda J, Borro JM, Redel-Montero J, Cifrian JM, Pastor A, Roman A, Ussetti P. Risk factors, survival, and impact of prophylaxis length in cytomegalovirus-seropositive lung transplant recipients: A prospective, observational, multicenter study. TRANSPLANT INFECTIOUS DISEASE.2 017.19(3):-UNSP e12694.
IF: 1,719
Q: 4

Martinez-Moragon E, Entrenas LM, Plaza V, Quirce S. Attitudes and barriers uncontrolled asthma in Spain. Abanico study. REVISTA CLINICA ESPANOLA. 2017.217(1):60-62.
IF: 0,971
Q: 3 

Clinical Research

Active in 2019

Estudio observacional para describir la prevalencia de asma grave en centros hospitalarios españoles.
PI: Dr Luis Manuel Entrenas Costa

Importance of responsiveness evaluation and standardization with proteomics on obstruction aiming for novel and significant endpoint.
PI: Dr María Nuria Feu Collado

Ensayo clínico de fase III, prospectivo, multicéntrico, aleatorizado y controlado para demostrar la eficacia y la seguridad de Ciclosporina A Liposómica (L-CsA) solución para inhalación administrada mediante el dispositivo en investigación eFlow® de PARI.
PI: Dr. Javier Redel Montero

Ensayo clínico de fase III, prospectivo, multicéntrico, aleatorizado y controlado para demostrar la eficacia y la seguridad de Ciclosporina A Liposómica (L-CsA) solución para inhalación administrada mediante el dispositivo en investigación eFlow® de PARI.
PI: Dr. Javier Redel Montero

 

Members

Dr. Bernabé Jurado Gámez

Principal Investigator

Team

Francisco Santos Luna, Nuria Feu Collado, Francisco Luis García Gil, Rafael Lama Martínez, Natalia Pascual Martínez, Javier Redel Montero, Luis Manuel Entrenas Costa, Antonio Pablo Arenas Vacas, María del Sol Arenas de Larriva, Ana María Vega Rojas