Research Groups

T and NK cell Immunosenescence Antiviral Immune Response

Scientific Production and Human Team

Principal Investigator

Dr. Rafael Solana Lara

Spanish Network for Research inn Infectious Pathology (REIPI) (Collaborator)

T and NK cell Immunosenescence Antiviral Immune Response

Scientific Activity

The process of senescence of the immune system in different models: chronological aging, cancer, inflammatory diseases, viral infection and other situations of chronic activation of the immune system. In particular, we analyze the receptors involved in the regulation of cytotoxicity in T (CTL) and NK cells and their ligands in these models, and the role of CMV. We also analyze the immunopathogenesis of HIV infection and the impact that different therapeutic situations have on it as well as the innate immune response in HIV-1 + patients treated with “ex vivo” autologous dendritic cells as part of the protocol of developing a preventive vaccine.

Keywords

AIDS, HIV-1, HAART, preventive vaccine. Immunosenescence, aging, melanoma, NK cells, NKT cells, NK receptors, CMV, cytotoxic T lymphocytes (CTL)