Research Groups

Clinical and Molecular Biology

Scientific Production and Human Team

Principal Investigator

Luis Martínez Martínez

Clinical and Molecular Biology

Scientific Activity

Our research activities focus on two scientific areas:

  • Study of resistance to antimicrobials and in vitro activity of new antibiotics. The group is particularly interested in biological and clinical aspects of multiresistance.
  • Development, implementation and evaluation of new methods (genomics and proteomics) for microbiological diagnostics.

Our group has vast experience in the biochemical and genetic characterization of the mechanism of resistance to antimicrobials of the main multiresistant pathogens (Enterobacteriaceae, Pseudomonas spp., Acinetobacter spp., Staphylococcus aureus, Enterococcus spp., etc.). Many of our studies focus, on low level of resistance mechanisms (porins, efflux pumps, Qnr proteins). We have developed various studies related with extended-spectrum β-lactamases, carbapenemases, plasmid and chromosomal genes coding for quinolone resistance and aminoglycoside-modifying enzymes. In addition, the group has participated and collaborated in studies about molecular typing and recognition of multiresistant bacterial clones. Other projects of the group include studies of the relation between resistance and virulence, and in vitro studies of new antimicrobials.