Research Groups

Endocrinology and Nutrition. Insulin Resistance, Diabetes and Metabolism

Scientific Production and Human Team

Associated Researcher

Dr. Juan Antonio Paniagua González

PAIDI CTS-651 scientific group

Endocrinology and Nutrition. Insulin Resistance, Diabetes and Metabolism

Scientific Activity

This research group investigates the effect of different nutrients on insulin resistance and body fat distribution in patients with metabolic syndrome from two points of view:

1.- Line of research of Endocrinology and Nutrition, on which several groups work: Along with Dr.Justo Castaño Fuentes' group, we investigate the expression of different hormone receptors and intracellular mediators in the onset and development of pituitary tumors. In line with transactional research principles, this group applies the findings of its research to real clinical practice using inhibitors or stimulators in order to inhibit hormone production and / or reduce their size when surgery is not fully successful.

Also, this group collaborates with Dr. Quesada Gómez’s group in the investigation of osteoporosis, particularly, vitamin D and bone stem cells. This group also collaborates with Dr. Soriguer in the performance of epidemiological studies of diabetes mellitus type 2 and in the prevention of diabetes through a behaviour modification programme which is being implemented in a village in southern Cordoba. This group also collaborates with Dr. Caballero in the study of bone metabolism in pregnant women with diabetes.

2.- Line of research: insuline resistance, diabetes and metabolism. This group studies the effect of diet components and pharmacologic interventions on the insuline resistance syndrome and the risk of developing diabetes in patients with "prediabetes". For such purpose, this group characterizes the specific effect of macronutrients on the release of digestive tract incretins and the subsequent signalling. In addition, this group also investigates the effect of diets with different macronutrient contents on body composition and body fat redistribution, and its relationship with insulin sensitivity and secretion. This group studies the role of adipose tissue expansion as a pathogenic factor of insulin resistance, beta-cell failure and diabetes. Finally, this group examines the transcription of metabolic, inflammatory and adipokine pathways in peripheral adipose tissue into diet models, macronutrients and different pharmacologic agents.

Keywords

Insulin resistance, ß-pancreatic dysfunction, prediabetes, metabolic syndrome, and adipotoxicidad adipose tissue, inflammation, oxidative stress, gene expression, metabolomics. Pituitary Adenoma. Somatostatin receptors, Vitamin D, Metabolic Sindome, Prevalence of Diabetes Mellitus Type 2, Diabetes Mellitus and Pregnancy