Research Groups

Physiopathology of Endocrine Vitamin D System Biotechnology and Aging

Scientific Production and Human Team

Principal Investigator

Dr. José Manuel Quesada Gómez

Thematic Network of Research Partnerships on Aging-Frailty (RETICEF).

PAIDI CTS-413 scientific group

Physiopathology of Endocrine Vitamin D System Biotechnology and Aging

Scientific Activity

Our group studies:

1. Osteoporosis: related risk factors, genetics and epidemiology. Endocrine system of vitamin D, other liposoluble vitamins, carotenoids, fatty acids related to osteoporosis and aging.

2. Differentiation of mesenchymal stem cells into osteoblasts, adipocytes or vessels. Study of genes and related factors. Its application in human clinical medicine.

a) Evaluation of compounds that may influence the differentiation of mesenchymal stem cells to osteoblasts and adipocytes. By following this line, we intend to evaluate the differentiation capacity of mesenchymal stem cells into adipocytes and osteoblasts in drugs and natural compounds in order to determine what may favour or hinder the formation of new bone. The results obtained in this area may open up new therapeutic strategies to prevent and counter osteoporosis.

b) Studies of gene expression of genes related to osteogenesis and adipogenesis.

The aim of this research is to identify human stem cells, which are genes involved in the differentiation into osteoblasts and adipocytes, and sociated with osteoporosis. To achieve this, we hope to carry out functional genomics studies to compare gene expression profiles between stem cells originating from both osteoporotic and non-osteoporotic women.

Keywords

Osteoporosis, vitamin D, carotenoids, fatty acids, human mesenchymal stem cells (MSCh) of adult adipocytes, osteoblasts, polyphenols, gene expression, proteomics, nutrigenetics, and nutrigenomics