Research Groups

Cell Biology in Haematology. Hypercoagulability

Scientific Production and Human Team

Principal Investigator

Dr. Joaquín Sánchez García

Spanish Myelodysplastic Syndrome Registry (Resmd) (Collaborator)

Co-Principal Investigator

Dr. Francisco Velasco Gimena

Observational Immune Tolerance Induction research program (ObsITI) (Collaborator)

PAIDI CTS-620 scientific group

Cell Biology in Haematology. Hypercoagulability

Scientific Activity

Our cell biology group in Hematology works in two areas:

1. The immunological mechanisms of the phenomena of graft versus host disease and graft versus leukemia occurring after hematopoietic transplantation for hematologic malignancies. This study covers antigen presenting cells, lymphocyte effectors and regulatory populations in quantitative and functional studies.

2. In addition, the group studies the mechanisms of leukemogenesis through the study of normal and leukemic primitive quiescent precursors (G0, Side population). The main methods used are cell culture, multiparameter flow cytometry with cell sorting and complete Western blot proteomics for intracellular signalling proteins.

The group also studies the mechanisms of hypercoagulability associated with oncohematologic processes. Its members participate in groups of the region (GASMD, GALA, GNL), of the country (PETHEMA, SEHOP, GETH, RESMD) and in the international group focused on transplantation (EBMT) for the study and treatment of

Keywords

Inmunology of hematopoietic transplantation. Cell biology of acute leukemias