Research Groups

Metabolism and Adipocyte Differentiation Metabolic Syndrome

Scientific Production and Human Team

Principal Investigator

Dra. Mª del Mar Malagón Poyato

CIBER on Obesity and Nutrition (CIBERobn) (Collaborate)

Co-Principal Investigator

Dr. Francisco Gracia Navarro

PAIDI BIO-139 scientific group

Metabolism and Adipocyte Differentiation Metabolic Syndrome

Scientific Activity

This research group investigates the cellular and molecular mechanisms that control adipose tissue activity. Thus, this group is focused on the central role of adipose tissue in lipid metabolism regulation and in body response to insuline, as well as on its role as an endocrine organ producing a number of signalling molecules. Specifically, this group analyzes the different components of adipose tissue, mature adipocytes and stromal vascular fraction, including the study of pre-adipocytes and adypogenesis. Additionally, this group is interested in other fundamental processes in adipocyte disfunction, such as intracellular lipid and organelle traffic and their relationship with the cytoskeleton, oxidative stress, inflammation, etc. These studies are performed in the context of disorders associated with adipose-tissue dysfunction, obesity and lipodystrophy that result in the development of metabolic disease. Finally, this group also investigates the interventions that best improve the metabolic profile (bariatric surgery, diet). To address these studies, this group uses multiple experimental approaches such as the application of comparative proteomics to the adipose tissue under different experimental conditions or to other tissues related to the control of metabolism. In addition, gene expression, protein interaction, confocal microscopy, real-time videomicroscopy for the localization of proteins and functional studies of gene overexpression or silencing using primary or cell line cultures are also performed.

Keywords

Adipose tissue, adipocyte, lipid metabolism, adipogenesis, proteomics, intracellular trafficking, intracellular signaling, adipokines, receptors, obesity, lipodystrophy, insulin resistance, metabolic syndrome