Research Groups

New Cancer Therapies

Scientific Production and Human Team

Principal Investigator

Dr. Enrique Aranda Aguilar

Cooperative Research Thematic Network on Cancer (RETICC)

Co-Principal Investigator

Dr. Antonio Rodríguez Ariza

Nicolás Monardes Contract

New Cancer Therapies

Scientific Activity

Our research group conducts its scientific activities in several areas of both clinical and experimental research. The first area is related to the identification of clinical or molecular factors useful in predicting clinical evolution, response or toxicity in cancer treatment.

In this area we have published clinical evolutionary models for predicting colon and breast cancer; in addition, we have conducted studies on polymorphisms such as UGT1A1, GSTT1 and CYP2D6, and neoplasms in relation to both their toxicity and response. We participate very actively in the development of new therapeutic strategies using drugs aimed at specific targets. To achieve this, we are currently carrying out research studies to develop response markers to this type of (mostly anti-angiogenic) therapies. The development of these markers will optimize the use of new therapies in cancer patients. Another research area looks into the role of nitrosative stress and the regulation of nitrosothiol homeostasis in different experimental models and diseases. Our research is aimed at exploring pathogenic mechanisms and identifying new therapeutic options and targets. Using the latest proteomic approaches to identify posttranslational nitrosative modifications, notably the S-nitrosylation of proteins, we analyse the importance of maintaining the homeostasis of nitrosothiols and the formation of S-nitrosoproteins. Our research has focused so far on different models of hepatocellular injury. However, given the importance of inflammation and nitric oxide production in cancer, we are also conducting studies in experimental models of colon and breast cancer and in clinical samples of patients with this type of neoplasm undergoing different antitumoural treatments.

Keywords

Colon Cancer, Breast Cancer, Polymorphisms, Gene Expression, Pharmacogenomics, Predictive Models, Angiogenesis, Angiotensins, anti Her-2 therapies, anti-EGFR Therapy. Clinical Trial, Nitric Oxide, Nitrosative Stress, S-nitrosylation, Proteomics, Genomics.