Research Groups

Systemic Autoimmune and Chronic Inflammatory Diseases of the Musculoskeletal System and Connective Tissue

Scientific Production and Human Team

Principal Investigator

Dra. Rosario López Pedrera

Nicolás Monardes Contract

Co-Principal Investigator

Dr. Eduardo Collantes Estévez

Professor at University of Cordoba. Head of the Clinical Management Unit of Rheumatology

Systemic Autoimmune and Chronic Inflammatory Diseases of the Musculoskeletal System and Connective Tissue

Scientific Activity

Our research team uses synergistical clinical-therapeutic, molecular and cellular approaches. Its main objectives are as follows:

  1. To analyze the cellular and molecular mechanisms regulating the effect of statins and other drugs on development (biological therapy) in preventing thrombosis and atherothrombosis in systemic autoimmune diseases (SAD), such as Primary Antiphospholipid Syndrome (APS), Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA). We also conduct studies on mitochondrial dysfunction and oxidative stress in atherothrombosis associated with SAD; in addition, we perform proteomic analyses aimed at identifying new genes/proteins whose expression in patients with APS, SLE or RA and atherosclerosis is altered, and determining the variations in expression patterns as a result of different treatments.
  2. To register, describe and analyze the clinical, epidemiological, demographic, genetic and radiographic characteristics of the physiological and therapeutic response in patients with ankylosing spondylitis in Spain and compare them with data from Latin American patients. The most interesting point will be to ascertain whether the possible differences in clinical expression are due to the genetic load we assume comes from the same genotype (in terms of HLA-B27) and its relationship with the interaction with the environment. Moreover, in this same area: to design, develop and validate a new mobility measurement system (the most important expression of structural damage) in these patients.

Keywords

Systemic autoimmune diseases (Primary Antiphospholipid Syndrome, Systemic Lupus Erythematosus, Rheumatoid Arthritis), oxidative stress, inflammation, cardiovascular disease, new therapies, spondyloarthropathies, epidemiology,diagnostic criteria, structural damage